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The map label for this gene is lysA [H]

Identifier: 85373232

GI number: 85373232

Start: 450394

End: 451656

Strand: Reverse

Name: lysA [H]

Synonym: ELI_02025

Alternate gene names: 85373232

Gene position: 451656-450394 (Counterclockwise)

Preceding gene: 85373233

Following gene: 85373231

Centisome position: 14.8

GC content: 65.48

Gene sequence:

>1263_bases
ATGGACCATTTTTCCCTCAATAGCGGCGTCTTGCATGCCGAGGACGTGCCGCTTCCGCAGATTGCGGAGGAGGTCGGTAC
GCCGGTCTACGTCTATTCGCGCGCTACGCTCGAGCGCCATGCGCGTGTTTTCACTGAGGGGCTGGCCGAGGTTCCGGACA
AGCTGATCGCCTTCGCGGTCAAGTCCAATCCCAACCTAGCCGTTCTCAAGGTGCTACAGAAAGCGGGCTTCGGGGCCGAT
GTCGTCTCAGGTGGCGAACTACGGCGCGCCCTGGCGGCGGGAATGGCACCGGCCAAGATCGTGTTTTCGGGCGTCGGCAA
GACCCGCGCGGAGCTGATGCTCGGCCTCGATGAAGGCATCGGACAATTCAACATCGAGTCGCGCGAAGAAGGCCGCGAAC
TGGCAGAGCTTGCAGCCGCGCGGGGGGAACTGGCACCGGCCTGCCTGCGCATCAATCCCGACGTCGACGCCAAGACCCAC
GAGAAGATTTCGACCGGCAAGGCGGAGAACAAGTTCGGCATCCCGCTGGTCCATGCCCGTGAGGTGTTCGCGGAATTGGT
GCAGCTCGACGGGCTGCACCTGCGCGGCATTGCGGTTCACATCGGTAGCCAGCTGGGCGACCTCGAGCCTCTGGAGACCG
CATTCGGGAAAGTCGGAAAGCTCGTCGCCGATTTGCGCGAAGCGGGGCACCTCATCACGCATGTCGATCTCGGCGGCGGC
CTGGGCGTCCCCTACAAGGCAGGCGAGGAATTCCCCTCGCCCGCCGACTATGGCGCGATGGTGGCGCGGGTCACGCGGGA
CTGGCGCGTGCACCTGACGTTCGAGCCGGGCCGCGTGATCGCAGGCAATGCCGGTATCCTTCTGACGCGGGTGATCCGTG
TGAAGCGCGGCGGCAACGGGCCGCCCTTCGTGATCGTCGATGCTGCAATGAACGACCTGGCCCGACCTGCGCTCTATGGC
GCGTGGCACGATTTCGACGCAGTCGAACCGAGCGGCGAACACATGACCGCGAATATCGTCGGCCCGATCTGCGAGACGGG
CGATACGTTCGCGCGCGACCGCAAGTGCGACGCTTTGCAGTCGGGCGACCTCGCCGTGTTCCGCACCGCCGGGGCCTATG
GCGCGACCATGGCGAGCAGCTACAACTCGCGCGGTTTCGTCGCAGAGGTGCTGGTCGACGGGGACCAGTTCGCTGTCGTC
GCCGACCGGATCGATGCGGGCGCGATCATGGATGCCGAGCGCGTGCCCGAATGGCTGGCCTGA

Upstream 100 bases:

>100_bases
GGCCGAACCCGAACGCAGCGTCGAACTGCGCCGTCGTTCAGAGACTCGCGAAGACGATCCCTTCGACCTGCCACCCGAAT
AACGCCTGACCGATCGCCCA

Downstream 100 bases:

>100_bases
TCCGGCCATGATCGGCTCGCTGCCTCTCTTCCACCGGGTACGCGGCAAACGCGTCGTGGTGGTCGGTGAAGGCGAGATGG
GCGAAGCCAAGACCCGGCTC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MDHFSLNSGVLHAEDVPLPQIAEEVGTPVYVYSRATLERHARVFTEGLAEVPDKLIAFAVKSNPNLAVLKVLQKAGFGAD
VVSGGELRRALAAGMAPAKIVFSGVGKTRAELMLGLDEGIGQFNIESREEGRELAELAAARGELAPACLRINPDVDAKTH
EKISTGKAENKFGIPLVHAREVFAELVQLDGLHLRGIAVHIGSQLGDLEPLETAFGKVGKLVADLREAGHLITHVDLGGG
LGVPYKAGEEFPSPADYGAMVARVTRDWRVHLTFEPGRVIAGNAGILLTRVIRVKRGGNGPPFVIVDAAMNDLARPALYG
AWHDFDAVEPSGEHMTANIVGPICETGDTFARDRKCDALQSGDLAVFRTAGAYGATMASSYNSRGFVAEVLVDGDQFAVV
ADRIDAGAIMDAERVPEWLA

Sequences:

>Translated_420_residues
MDHFSLNSGVLHAEDVPLPQIAEEVGTPVYVYSRATLERHARVFTEGLAEVPDKLIAFAVKSNPNLAVLKVLQKAGFGAD
VVSGGELRRALAAGMAPAKIVFSGVGKTRAELMLGLDEGIGQFNIESREEGRELAELAAARGELAPACLRINPDVDAKTH
EKISTGKAENKFGIPLVHAREVFAELVQLDGLHLRGIAVHIGSQLGDLEPLETAFGKVGKLVADLREAGHLITHVDLGGG
LGVPYKAGEEFPSPADYGAMVARVTRDWRVHLTFEPGRVIAGNAGILLTRVIRVKRGGNGPPFVIVDAAMNDLARPALYG
AWHDFDAVEPSGEHMTANIVGPICETGDTFARDRKCDALQSGDLAVFRTAGAYGATMASSYNSRGFVAEVLVDGDQFAVV
ADRIDAGAIMDAERVPEWLA
>Mature_420_residues
MDHFSLNSGVLHAEDVPLPQIAEEVGTPVYVYSRATLERHARVFTEGLAEVPDKLIAFAVKSNPNLAVLKVLQKAGFGAD
VVSGGELRRALAAGMAPAKIVFSGVGKTRAELMLGLDEGIGQFNIESREEGRELAELAAARGELAPACLRINPDVDAKTH
EKISTGKAENKFGIPLVHAREVFAELVQLDGLHLRGIAVHIGSQLGDLEPLETAFGKVGKLVADLREAGHLITHVDLGGG
LGVPYKAGEEFPSPADYGAMVARVTRDWRVHLTFEPGRVIAGNAGILLTRVIRVKRGGNGPPFVIVDAAMNDLARPALYG
AWHDFDAVEPSGEHMTANIVGPICETGDTFARDRKCDALQSGDLAVFRTAGAYGATMASSYNSRGFVAEVLVDGDQFAVV
ADRIDAGAIMDAERVPEWLA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=412, Percent_Identity=32.2815533980583, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17562780, Length=345, Percent_Identity=22.6086956521739, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=376, Percent_Identity=22.8723404255319, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24586472, Length=359, Percent_Identity=24.5125348189415, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24586474, Length=371, Percent_Identity=23.989218328841, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44696; Mature: 44696

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFSLNSGVLHAEDVPLPQIAEEVGTPVYVYSRATLERHARVFTEGLAEVPDKLIAFAV
CCCCCCCCCEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCHHHHEEEEE
KSNPNLAVLKVLQKAGFGADVVSGGELRRALAAGMAPAKIVFSGVGKTRAELMLGLDEGI
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHHHEEHHCCC
GQFNIESREEGRELAELAAARGELAPACLRINPDVDAKTHEKISTGKAENKFGIPLVHAR
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCCHHHH
EVFAELVQLDGLHLRGIAVHIGSQLGDLEPLETAFGKVGKLVADLREAGHLITHVDLGGG
HHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
LGVPYKAGEEFPSPADYGAMVARVTRDWRVHLTFEPGRVIAGNAGILLTRVIRVKRGGNG
CCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEECCCCHHHHHHHHHHCCCCC
PPFVIVDAAMNDLARPALYGAWHDFDAVEPSGEHMTANIVGPICETGDTFARDRKCDALQ
CCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHCCCCHHHHCCCCCHHC
SGDLAVFRTAGAYGATMASSYNSRGFVAEVLVDGDQFAVVADRIDAGAIMDAERVPEWLA
CCCEEEEEECCCCCHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHCHHHCC
>Mature Secondary Structure
MDHFSLNSGVLHAEDVPLPQIAEEVGTPVYVYSRATLERHARVFTEGLAEVPDKLIAFAV
CCCCCCCCCEEECCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCHHHHEEEEE
KSNPNLAVLKVLQKAGFGADVVSGGELRRALAAGMAPAKIVFSGVGKTRAELMLGLDEGI
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCHHHHHHHEEHHCCC
GQFNIESREEGRELAELAAARGELAPACLRINPDVDAKTHEKISTGKAENKFGIPLVHAR
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCCHHHH
EVFAELVQLDGLHLRGIAVHIGSQLGDLEPLETAFGKVGKLVADLREAGHLITHVDLGGG
HHHHHHHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
LGVPYKAGEEFPSPADYGAMVARVTRDWRVHLTFEPGRVIAGNAGILLTRVIRVKRGGNG
CCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCEEEECCCCHHHHHHHHHHCCCCC
PPFVIVDAAMNDLARPALYGAWHDFDAVEPSGEHMTANIVGPICETGDTFARDRKCDALQ
CCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHCCCCHHHHCCCCCHHC
SGDLAVFRTAGAYGATMASSYNSRGFVAEVLVDGDQFAVVADRIDAGAIMDAERVPEWLA
CCCEEEEEECCCCCHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA