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The map label for this gene is serS

Identifier: 85372949

GI number: 85372949

Start: 154571

End: 155851

Strand: Reverse

Name: serS

Synonym: ELI_00610

Alternate gene names: 85372949

Gene position: 155851-154571 (Counterclockwise)

Preceding gene: 85372952

Following gene: 85372948

Centisome position: 5.11

GC content: 64.56

Gene sequence:

>1281_bases
ATGCACGATATTCGCCAGATCAGGGACAATCCCGAAGCTTTCGATGCCGCGCTGGCCCGCCGCGGGCACGAACCGGTGGC
TGCCGAAATCCTCGCGCTCGACGAGCAGTGCCGCGCGGTCACGACGAAGATGCAGGAGGCGCAGAGCCGCCGCAACGAAG
CCTCCAAGGCGATCGGCCAGGCGATGGGCCAGGGCAATACCGAGAAGGCCGAAGCGCTGAAGGCCGAAGTCGCCGATTTG
AAGCAGACCTTGCCGCGATTGGAAGACGAGGATCGCGAGCTCAAAATGAGACTAGAGAACGCGCTCGCTGTCATACCCAA
CCTCCCTCTCGACGACGTGCCGGACGGCGCAGACGAAAGCGACAATATCGAGGTCGGCACCTGGGGCACCAAGCGCGAGT
TCAGCTTCGAACCCCGTGAGCATGCCGACATCGGCCCCGCGCTCGGCATGGATTTCGAGACCGGCGCCAGGCTTTCCGGC
GCGCGCTTCACTTTCCTGCGCGGCGGAATGGCGCGGCTGCACCGCGCACTCGGCCAGTTCATGCTCGACCGGCAGGTGAG
CGAATACGGCTATGCCGAATGCGCGCCGCCCGTGCTAGTGCGGGACGAGGCAATGTACGGCACCGACAAGCTGCCCAAAT
TTGCCGAAGACAGCTTTCAGACCACCGACGGTCGCTGGCTCATCCCCACCGCCGAAGTCAGCCTGACTGCTTCGGTGATG
GACCAGATCCTCGACGATGCCGCCCTCCCCATGCGGCTTACTGCGCTGACGCCGTGTTTCCGCAGCGAGGCGGGCGCGGC
GGGCAAGGACACGCGCGGCTTCATTCGCCAGCACCAGTTCGAGAAATGCGAGTTGGTCAGCATCGTCAGGCCCGAGAACA
GCGCCGCCGAGCACGAGCGCATGACCGAAGCGGCGGAAAGCGTGCTGCAGGCGCTCGACCTGCCCTATCGCAAGATGCTG
TTGTGTACCGGCGATATGGGCTTCGGCGCGCGCAAGACCTACGATCTCGAAGTCTGGCTGCCCGGCCAGGGCGCCTATCG
CGAGATCAGTTCGTGCTCCAACACCGGCGATTTCCAGGCCCGGCGGATGAATGCGCGGTATCGGCCCGAAGGCGAGAAGA
AGACTGCTTTCGTGCACACGCTCAATGGCTCCGGCCTTGCCGTGGGGCGCACGCTGGTGGCGGTGATCGAGAACTATCAG
GAAGAGGATGGGAGTGTGGCGGTGCCCGAGGTGCTGGCCCCGTATATGGGCGGCGCTATGAAGCTCGAACCTACCCCCTG
A

Upstream 100 bases:

>100_bases
CGCGATACGTTCCCTTCCCCAAGCGGACCGCGCGGCGGATCGTGCACCGGCGCAGATCGCCACTGGCATTTGCGCAGGCG
AAACGGCATAGCGCAGCGCC

Downstream 100 bases:

>100_bases
ACCGTTCGGGCTGAGCTTGTCGAAGCCCTGTCCTTCCCTTGAGAGCAACGTACGTAAGAAAGAGCAGCCCTTCGACAGGC
TCAGGGCGAACGGAATAGAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MHDIRQIRDNPEAFDAALARRGHEPVAAEILALDEQCRAVTTKMQEAQSRRNEASKAIGQAMGQGNTEKAEALKAEVADL
KQTLPRLEDEDRELKMRLENALAVIPNLPLDDVPDGADESDNIEVGTWGTKREFSFEPREHADIGPALGMDFETGARLSG
ARFTFLRGGMARLHRALGQFMLDRQVSEYGYAECAPPVLVRDEAMYGTDKLPKFAEDSFQTTDGRWLIPTAEVSLTASVM
DQILDDAALPMRLTALTPCFRSEAGAAGKDTRGFIRQHQFEKCELVSIVRPENSAAEHERMTEAAESVLQALDLPYRKML
LCTGDMGFGARKTYDLEVWLPGQGAYREISSCSNTGDFQARRMNARYRPEGEKKTAFVHTLNGSGLAVGRTLVAVIENYQ
EEDGSVAVPEVLAPYMGGAMKLEPTP

Sequences:

>Translated_426_residues
MHDIRQIRDNPEAFDAALARRGHEPVAAEILALDEQCRAVTTKMQEAQSRRNEASKAIGQAMGQGNTEKAEALKAEVADL
KQTLPRLEDEDRELKMRLENALAVIPNLPLDDVPDGADESDNIEVGTWGTKREFSFEPREHADIGPALGMDFETGARLSG
ARFTFLRGGMARLHRALGQFMLDRQVSEYGYAECAPPVLVRDEAMYGTDKLPKFAEDSFQTTDGRWLIPTAEVSLTASVM
DQILDDAALPMRLTALTPCFRSEAGAAGKDTRGFIRQHQFEKCELVSIVRPENSAAEHERMTEAAESVLQALDLPYRKML
LCTGDMGFGARKTYDLEVWLPGQGAYREISSCSNTGDFQARRMNARYRPEGEKKTAFVHTLNGSGLAVGRTLVAVIENYQ
EEDGSVAVPEVLAPYMGGAMKLEPTP
>Mature_426_residues
MHDIRQIRDNPEAFDAALARRGHEPVAAEILALDEQCRAVTTKMQEAQSRRNEASKAIGQAMGQGNTEKAEALKAEVADL
KQTLPRLEDEDRELKMRLENALAVIPNLPLDDVPDGADESDNIEVGTWGTKREFSFEPREHADIGPALGMDFETGARLSG
ARFTFLRGGMARLHRALGQFMLDRQVSEYGYAECAPPVLVRDEAMYGTDKLPKFAEDSFQTTDGRWLIPTAEVSLTASVM
DQILDDAALPMRLTALTPCFRSEAGAAGKDTRGFIRQHQFEKCELVSIVRPENSAAEHERMTEAAESVLQALDLPYRKML
LCTGDMGFGARKTYDLEVWLPGQGAYREISSCSNTGDFQARRMNARYRPEGEKKTAFVHTLNGSGLAVGRTLVAVIENYQ
EEDGSVAVPEVLAPYMGGAMKLEPTP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=341, Percent_Identity=36.3636363636364, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI8923421, Length=408, Percent_Identity=30.6372549019608, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI225579074, Length=329, Percent_Identity=33.1306990881459, Blast_Score=166, Evalue=5e-41,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=53.864168618267, Blast_Score=448, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17539260, Length=455, Percent_Identity=32.0879120879121, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=350, Percent_Identity=30, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=455, Percent_Identity=31.2087912087912, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321799, Length=362, Percent_Identity=33.9779005524862, Blast_Score=196, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24581334, Length=433, Percent_Identity=30.715935334873, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17737985, Length=400, Percent_Identity=29, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ERYLH (Q2NDM7)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457011.1
- ProteinModelPortal:   Q2NDM7
- SMR:   Q2NDM7
- STRING:   Q2NDM7
- GeneID:   3870999
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_00610
- NMPDR:   fig|314225.3.peg.2970
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q2NDM7
- ProtClustDB:   PRK05431
- BioCyc:   ELIT314225:ELI_00610-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47017; Mature: 47017

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIRQIRDNPEAFDAALARRGHEPVAAEILALDEQCRAVTTKMQEAQSRRNEASKAIGQ
CCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMGQGNTEKAEALKAEVADLKQTLPRLEDEDRELKMRLENALAVIPNLPLDDVPDGADES
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNIEVGTWGTKREFSFEPREHADIGPALGMDFETGARLSGARFTFLRGGMARLHRALGQF
CCEEECCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHH
MLDRQVSEYGYAECAPPVLVRDEAMYGTDKLPKFAEDSFQTTDGRWLIPTAEVSLTASVM
HHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHHH
DQILDDAALPMRLTALTPCFRSEAGAAGKDTRGFIRQHQFEKCELVSIVRPENSAAEHER
HHHHHHCCCCCHHHHHCHHHHHCCCCCCCCHHHHHHHHCCCHHCEEEEECCCCCHHHHHH
MTEAAESVLQALDLPYRKMLLCTGDMGFGARKTYDLEVWLPGQGAYREISSCSNTGDFQA
HHHHHHHHHHHHCCCCHHEEEEECCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCHH
RRMNARYRPEGEKKTAFVHTLNGSGLAVGRTLVAVIENYQEEDGSVAVPEVLAPYMGGAM
HHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCE
KLEPTP
EECCCC
>Mature Secondary Structure
MHDIRQIRDNPEAFDAALARRGHEPVAAEILALDEQCRAVTTKMQEAQSRRNEASKAIGQ
CCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMGQGNTEKAEALKAEVADLKQTLPRLEDEDRELKMRLENALAVIPNLPLDDVPDGADES
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNIEVGTWGTKREFSFEPREHADIGPALGMDFETGARLSGARFTFLRGGMARLHRALGQF
CCEEECCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHH
MLDRQVSEYGYAECAPPVLVRDEAMYGTDKLPKFAEDSFQTTDGRWLIPTAEVSLTASVM
HHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCCCCCEEEEECCCHHHHHHHH
DQILDDAALPMRLTALTPCFRSEAGAAGKDTRGFIRQHQFEKCELVSIVRPENSAAEHER
HHHHHHCCCCCHHHHHCHHHHHCCCCCCCCHHHHHHHHCCCHHCEEEEECCCCCHHHHHH
MTEAAESVLQALDLPYRKMLLCTGDMGFGARKTYDLEVWLPGQGAYREISSCSNTGDFQA
HHHHHHHHHHHHCCCCHHEEEEECCCCCCCCEEEEEEEEECCCCHHHHHHHCCCCCCCHH
RRMNARYRPEGEKKTAFVHTLNGSGLAVGRTLVAVIENYQEEDGSVAVPEVLAPYMGGAM
HHCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCE
KLEPTP
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA