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The map label for this gene is hslU

Identifier: 85372871

GI number: 85372871

Start: 52117

End: 53418

Strand: Direct

Name: hslU

Synonym: ELI_00220

Alternate gene names: 85372871

Gene position: 52117-53418 (Clockwise)

Preceding gene: 85372870

Following gene: 85372872

Centisome position: 1.71

GC content: 60.83

Gene sequence:

>1302_bases
ATGACCGAAGCACTCACCCCCAAGGCGATTGTCGCCGCGCTCGACGAGCACATTATTGGTCAGAAAGACGCCAAACGCGC
CGTTGCCGTTGCGCTTCGCAATCGCTGGCGCCGCTTGCAGCTTGGCGCGGAACTCCGCGACGAAGTCACGCCCAAGAACA
TCCTCATGATTGGCCCGACCGGCTGCGGTAAAACCGAGATCAGCCGCCGTCTGGCCAAGCTTGCCGAAGCGCCTTTCATC
AAGGTCGAAGCGACCAAGTTCACCGAAGTCGGCTATGTGGGTCGCGATGTCGAGCAGATCGCGCGCGACCTGGTCGAAGA
AGCAATCCGGCTTGAGAAAGATCGCCGGCGCGAAGCGGTTCGTGAAGCCGCCAGCACGGCCGCCATGGAGCGGCTGCTGG
ATGCGCTGGTCGGCGATAATGCCAGTGAAGCAACCCGCGAGAGCTTTCGCGAACGGGTCGTCCAGAACGCGATGAACGAT
GTCGAGGTAGAAGTCGAAGTCTCCGATAGCCCGAGCATGCCGATGGAAATTCCCGGCCTCGGCGGCAATGTCGGCATGAT
CGACCTCAGCGACATGATGGGCAAGGCGCTGGGCCGCAACAACAAGAAGCGGCGCAAGCTCAAGGTGCCGGACGCTTGGG
ACAAGCTGGTCGAGGAAGAGGCCGAAAAGCGCATGGACCAGGACGACGTGTCGCGCGTCGCGCTGGAAAATGCCGAAACC
AACGGCATCGTCTTCCTCGATGAGATCGACAAGATCGCCGTGAGCGACGTGCGCGGCGGCTCGGTCAGCCGCGAAGGCGT
ACAGCGCGATTTATTGCCCCTTATCGAGGGTACAACTGTGTCAACCAAGCACGGACCGATGAAGACCGACCACGTCCTGT
TCATTGCCAGTGGCGCTTTCCATGTTTCCAAGCCGAGCGACATGTTGCCCGAACTGCAGGGCCGCCTGCCGATCCGCGTC
GAATTGCGCGCGCTTGAGATCGAGGACTTTGTCCGCATCCTCAGCGAGACCCGCGCCAACCTCGTCGAACAATACAAGGC
CCTGCTGGGCACCGAGGACGTGACGGTCGAAATCACCGACGACGCGATCCGCGAAGTCGCGACGATCGCCGCGCAGGTCA
ACGAGAGCGTCGAGAATATCGGTGCCCGCCGCTTGCAGACAGTGATGGAGCGGCTGCTCGAGGAATTGAGTTTCGAAGCC
GAAGAGCACAAGGGCGAGACCATCGTGATCGATGCGGCCTATGTGAAGGACAAGCTTTCCGAACTCGCCGAGGATAGCGA
CCTCAGCAAATATATCCTGTGA

Upstream 100 bases:

>100_bases
GTTTAATTTGCCGTCATCCCAGCGAACGCTGGGATCTGCTTCCACTTGTGAAGCGCCCGATTGACAGAGATCCCAGCGTT
CGCTGGGATGACGAGAGTAA

Downstream 100 bases:

>100_bases
CGCGGCCCGTCGCCGAAACCGCAGCGACGATCGCCGGGATGGATCCGGTGCTCGACGAGCCGCTGTGGTGTTTTGTCGGC
GGGTACGAGCCGGAGCTGGT

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTEALTPKAIVAALDEHIIGQKDAKRAVAVALRNRWRRLQLGAELRDEVTPKNILMIGPTGCGKTEISRRLAKLAEAPFI
KVEATKFTEVGYVGRDVEQIARDLVEEAIRLEKDRRREAVREAASTAAMERLLDALVGDNASEATRESFRERVVQNAMND
VEVEVEVSDSPSMPMEIPGLGGNVGMIDLSDMMGKALGRNNKKRRKLKVPDAWDKLVEEEAEKRMDQDDVSRVALENAET
NGIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVSTKHGPMKTDHVLFIASGAFHVSKPSDMLPELQGRLPIRV
ELRALEIEDFVRILSETRANLVEQYKALLGTEDVTVEITDDAIREVATIAAQVNESVENIGARRLQTVMERLLEELSFEA
EEHKGETIVIDAAYVKDKLSELAEDSDLSKYIL

Sequences:

>Translated_433_residues
MTEALTPKAIVAALDEHIIGQKDAKRAVAVALRNRWRRLQLGAELRDEVTPKNILMIGPTGCGKTEISRRLAKLAEAPFI
KVEATKFTEVGYVGRDVEQIARDLVEEAIRLEKDRRREAVREAASTAAMERLLDALVGDNASEATRESFRERVVQNAMND
VEVEVEVSDSPSMPMEIPGLGGNVGMIDLSDMMGKALGRNNKKRRKLKVPDAWDKLVEEEAEKRMDQDDVSRVALENAET
NGIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVSTKHGPMKTDHVLFIASGAFHVSKPSDMLPELQGRLPIRV
ELRALEIEDFVRILSETRANLVEQYKALLGTEDVTVEITDDAIREVATIAAQVNESVENIGARRLQTVMERLLEELSFEA
EEHKGETIVIDAAYVKDKLSELAEDSDLSKYIL
>Mature_432_residues
TEALTPKAIVAALDEHIIGQKDAKRAVAVALRNRWRRLQLGAELRDEVTPKNILMIGPTGCGKTEISRRLAKLAEAPFIK
VEATKFTEVGYVGRDVEQIARDLVEEAIRLEKDRRREAVREAASTAAMERLLDALVGDNASEATRESFRERVVQNAMNDV
EVEVEVSDSPSMPMEIPGLGGNVGMIDLSDMMGKALGRNNKKRRKLKVPDAWDKLVEEEAEKRMDQDDVSRVALENAETN
GIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVSTKHGPMKTDHVLFIASGAFHVSKPSDMLPELQGRLPIRVE
LRALEIEDFVRILSETRANLVEQYKALLGTEDVTVEITDDAIREVATIAAQVNESVENIGARRLQTVMERLLEELSFEAE
EHKGETIVIDAAYVKDKLSELAEDSDLSKYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=92, Percent_Identity=38.0434782608696, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790366, Length=441, Percent_Identity=54.875283446712, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1786642, Length=104, Percent_Identity=45.1923076923077, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648291, Length=263, Percent_Identity=30.7984790874525, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24648289, Length=263, Percent_Identity=30.7984790874525, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2 [H]

EC number: NA

Molecular weight: Translated: 48074; Mature: 47943

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEALTPKAIVAALDEHIIGQKDAKRAVAVALRNRWRRLQLGAELRDEVTPKNILMIGPT
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCEEEECCC
GCGKTEISRRLAKLAEAPFIKVEATKFTEVGYVGRDVEQIARDLVEEAIRLEKDRRREAV
CCCHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
REAASTAAMERLLDALVGDNASEATRESFRERVVQNAMNDVEVEVEVSDSPSMPMEIPGL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEECCCC
GGNVGMIDLSDMMGKALGRNNKKRRKLKVPDAWDKLVEEEAEKRMDQDDVSRVALENAET
CCCCCEEEHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
NGIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVSTKHGPMKTDHVLFIASGAF
CCEEEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCE
HVSKPSDMLPELQGRLPIRVELRALEIEDFVRILSETRANLVEQYKALLGTEDVTVEITD
ECCCCHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECH
DAIREVATIAAQVNESVENIGARRLQTVMERLLEELSFEAEEHKGETIVIDAAYVKDKLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEHHHHHHHHH
ELAEDSDLSKYIL
HHHCCCCHHHHCC
>Mature Secondary Structure 
TEALTPKAIVAALDEHIIGQKDAKRAVAVALRNRWRRLQLGAELRDEVTPKNILMIGPT
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCEEEECCC
GCGKTEISRRLAKLAEAPFIKVEATKFTEVGYVGRDVEQIARDLVEEAIRLEKDRRREAV
CCCHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
REAASTAAMERLLDALVGDNASEATRESFRERVVQNAMNDVEVEVEVSDSPSMPMEIPGL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEECCCC
GGNVGMIDLSDMMGKALGRNNKKRRKLKVPDAWDKLVEEEAEKRMDQDDVSRVALENAET
CCCCCEEEHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
NGIVFLDEIDKIAVSDVRGGSVSREGVQRDLLPLIEGTTVSTKHGPMKTDHVLFIASGAF
CCEEEEECCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCE
HVSKPSDMLPELQGRLPIRVELRALEIEDFVRILSETRANLVEQYKALLGTEDVTVEITD
ECCCCHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECH
DAIREVATIAAQVNESVENIGARRLQTVMERLLEELSFEAEEHKGETIVIDAAYVKDKLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEHHHHHHHHH
ELAEDSDLSKYIL
HHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA