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The map label for this gene is wecA [H]

Identifier: 85060363

GI number: 85060363

Start: 4089944

End: 4091059

Strand: Reverse

Name: wecA [H]

Synonym: SG2385

Alternate gene names: 85060363

Gene position: 4091059-4089944 (Counterclockwise)

Preceding gene: 85060364

Following gene: 85060362

Centisome position: 98.08

GC content: 54.66

Gene sequence:

>1116_bases
GTGAACATACTCAATATGAGTACTGATTTTGTTGCTATTTTTCTGTTTTCTTTGCTCTTTTTGTTTTTAGCGCGCAAGGT
TGCCAAAAAAATAGGCCTGGTTGACAAGCCCAACTACCGCAAACGCCATCAGGGGCAGATCCCCCTGGTCGGCGGCATTT
CCATTTATGCCGGCATCTGTTTCGCCTTTCTCTATACTGATCATTATATTCCCCATGTCGCGCTGTATCTTATGTGCGCG
GGCGTCCTGGTAGTGACCGGCGCGCTCGACGATCGATTTGATATCAGCGTGGTAGCGCGCGCCATTATCCAGGCCTTGGT
CGCGGTGGCGATGATGGTGTTCAGCGGCCGCTATATCAATAGCCTGGGCTATATCTTCGGACCGTGGGAGATGGTGCTGG
GTCCTTTTGGCTATCTGGTGACGCTGTTTGCCGTCTGGGCGGCGATCAACGCCTTCAATATGGTGGACGGTATCGACGGA
CTGCTGGGCGGGCTCTCCTGCGTGTCCCTCGGCGCGATGGGTATCCTGCTTACGCTTGATAATAATCCCGGCCTGGCGCT
GTGGTGCTTTGCAATGATTGCTGCCATTTTGCCCTATATTTTACTGAACCTGGGGGGTTTCGGCCGGCGCTATAAAGTGT
TTATGGGCGATGCCGGCAGCACAATGATTGGCTTTACCATCATCTGGCTGCTGCTGCAAAGCACCCAGGGCTGGGGGCAT
CCGATGAATCCCGTGACCGCGCTGTGGATTATCGCCGTGCCGCTGATGGATATGATCGCCATCATGTATCGCCGGATGCG
CAAAGGCATGAGCCCGTTTGCGCCGGACAGGCAGCATATCCACCATCTCATCATGCGCGCGGGTTTCAGCTCGCGCCAGG
CGTTTATCATTATCACGCTTACCGCCGCGCTGTTAGCGTTTTTCGGCGTGGCGGGAGAGCGTTGGCTGCGCTGGCCGGAG
TCGGTCATGCTGTTGCTGTGGATCGGAGTGTTTTTGTTGTATGGCTATGTACTGAAATGCGCCTGGCGGGTTGCCCGCTT
CGTCAAGCGGACCAAGCGACGGCTCAGCCAATATAAAAAAAGCACCACCTTAAACGGAAATTCAGGGCGAAAATGA

Upstream 100 bases:

>100_bases
TTCGTTGTCACAAAACTCAGTGACGGGTAAGGCATCGGAGTTAAGGCATAAACTATGGTGACGCATTGAACGGCCTGATG
GATGCAGAGAGCTTTCTATT

Downstream 100 bases:

>100_bases
CACCTGCAAGCTCACCATCTTCCGCCGGCCGGGAACAGGCTATCGACAATGAACTGGACTTGCGCGGCCTGCTGTGTTCC
CTGTGGCGCGGCAAACTCAC

Product: undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MNILNMSTDFVAIFLFSLLFLFLARKVAKKIGLVDKPNYRKRHQGQIPLVGGISIYAGICFAFLYTDHYIPHVALYLMCA
GVLVVTGALDDRFDISVVARAIIQALVAVAMMVFSGRYINSLGYIFGPWEMVLGPFGYLVTLFAVWAAINAFNMVDGIDG
LLGGLSCVSLGAMGILLTLDNNPGLALWCFAMIAAILPYILLNLGGFGRRYKVFMGDAGSTMIGFTIIWLLLQSTQGWGH
PMNPVTALWIIAVPLMDMIAIMYRRMRKGMSPFAPDRQHIHHLIMRAGFSSRQAFIIITLTAALLAFFGVAGERWLRWPE
SVMLLLWIGVFLLYGYVLKCAWRVARFVKRTKRRLSQYKKSTTLNGNSGRK

Sequences:

>Translated_371_residues
MNILNMSTDFVAIFLFSLLFLFLARKVAKKIGLVDKPNYRKRHQGQIPLVGGISIYAGICFAFLYTDHYIPHVALYLMCA
GVLVVTGALDDRFDISVVARAIIQALVAVAMMVFSGRYINSLGYIFGPWEMVLGPFGYLVTLFAVWAAINAFNMVDGIDG
LLGGLSCVSLGAMGILLTLDNNPGLALWCFAMIAAILPYILLNLGGFGRRYKVFMGDAGSTMIGFTIIWLLLQSTQGWGH
PMNPVTALWIIAVPLMDMIAIMYRRMRKGMSPFAPDRQHIHHLIMRAGFSSRQAFIIITLTAALLAFFGVAGERWLRWPE
SVMLLLWIGVFLLYGYVLKCAWRVARFVKRTKRRLSQYKKSTTLNGNSGRK
>Mature_371_residues
MNILNMSTDFVAIFLFSLLFLFLARKVAKKIGLVDKPNYRKRHQGQIPLVGGISIYAGICFAFLYTDHYIPHVALYLMCA
GVLVVTGALDDRFDISVVARAIIQALVAVAMMVFSGRYINSLGYIFGPWEMVLGPFGYLVTLFAVWAAINAFNMVDGIDG
LLGGLSCVSLGAMGILLTLDNNPGLALWCFAMIAAILPYILLNLGGFGRRYKVFMGDAGSTMIGFTIIWLLLQSTQGWGH
PMNPVTALWIIAVPLMDMIAIMYRRMRKGMSPFAPDRQHIHHLIMRAGFSSRQAFIIITLTAALLAFFGVAGERWLRWPE
SVMLLLWIGVFLLYGYVLKCAWRVARFVKRTKRRLSQYKKSTTLNGNSGRK

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55). It is the first lipid-linked intermediate involved in enterobacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=349, Percent_Identity=73.9255014326648, Blast_Score=492, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012750
- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 41416; Mature: 41416

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILNMSTDFVAIFLFSLLFLFLARKVAKKIGLVDKPNYRKRHQGQIPLVGGISIYAGIC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCEECHHHHHHHHH
FAFLYTDHYIPHVALYLMCAGVLVVTGALDDRFDISVVARAIIQALVAVAMMVFSGRYIN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
SLGYIFGPWEMVLGPFGYLVTLFAVWAAINAFNMVDGIDGLLGGLSCVSLGAMGILLTLD
HCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
NNPGLALWCFAMIAAILPYILLNLGGFGRRYKVFMGDAGSTMIGFTIIWLLLQSTQGWGH
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
PMNPVTALWIIAVPLMDMIAIMYRRMRKGMSPFAPDRQHIHHLIMRAGFSSRQAFIIITL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHH
TAALLAFFGVAGERWLRWPESVMLLLWIGVFLLYGYVLKCAWRVARFVKRTKRRLSQYKK
HHHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STTLNGNSGRK
HCCCCCCCCCC
>Mature Secondary Structure
MNILNMSTDFVAIFLFSLLFLFLARKVAKKIGLVDKPNYRKRHQGQIPLVGGISIYAGIC
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCEECHHHHHHHHH
FAFLYTDHYIPHVALYLMCAGVLVVTGALDDRFDISVVARAIIQALVAVAMMVFSGRYIN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
SLGYIFGPWEMVLGPFGYLVTLFAVWAAINAFNMVDGIDGLLGGLSCVSLGAMGILLTLD
HCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEC
NNPGLALWCFAMIAAILPYILLNLGGFGRRYKVFMGDAGSTMIGFTIIWLLLQSTQGWGH
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCC
PMNPVTALWIIAVPLMDMIAIMYRRMRKGMSPFAPDRQHIHHLIMRAGFSSRQAFIIITL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEHHH
TAALLAFFGVAGERWLRWPESVMLLLWIGVFLLYGYVLKCAWRVARFVKRTKRRLSQYKK
HHHHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
STTLNGNSGRK
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]