Click here to switch to the map view.

The map label for this gene is glpG

Identifier: 85060305

GI number: 85060305

Start: 3996437

End: 3997285

Strand: Reverse

Name: glpG

Synonym: SG2327

Alternate gene names: 85060305

Gene position: 3997285-3996437 (Counterclockwise)

Preceding gene: 85060306

Following gene: 85060304

Centisome position: 95.83

GC content: 60.07

Gene sequence:

>849_bases
ATGATTCGAGTTACCGCCTTGTCTAATGCGCGCCTGGCCCTGGCCTTCATTGATTATATGAAAACGCAGGGGGTGGACAT
GGAGCTGCGCCCGCAGGGGCGTTATGCCGAGTTGTGGCTGGCGCAGGACGAGAAACTGGCACAGGTTGAATCAGCGCTGG
AAGCGTTTCTGCTTGACCCGCAGCATCCCCGTTATCAAGCCGCCAGCTGGCGCACCGGCTCATTACATTACCGCGGCGAG
ACCGGCGCCGGTCTGCGTGGCTGGCTGCCGGCGCTACGCCAGCAGGCGGGCCCTTTAACGCTAGGCGTGACGGCGCTGTG
CGTGCTGGTGTTTTTCCTCATGGCGCTAATCGGTGACGATCGGGTAATGGCCGCGCTGTTGTATCCCGCCGGTCCGGCCC
AATACGGTCAGATTTGGCGCTGGGTCAGCCATGCCTTTTTGCATTTCTCACTATTGCATCTGCTGTTCAATGTGGTGTGG
TGGTGGTATCTGGCCGGCCTGACGGAGCGCTATCGCGGCAGGGCGTCATTGGCTATTTTGTTCGTGCTCTCTGCGGTGGT
CAGCGGCATGGTGCAGTCGCACTTCAGCGGGATTTTTTTCGGCGGTCTGTCCGGCGTGGTGTATGCGCTAATGGGCTATG
TCTGGTGGCACGGCGAGAAAAATCCGGGCGGGCCGCTGTTTATGCCGCTCGGGGTCATCGTTTTCGCCCTGTTGTGGCTT
ATCGCCGGCTATTTCAATATTTTGGGTATCGCCATTGCCAATGCCGCGCACGTGGCGGGTCTGGTCACGGGCCTGCTAAT
GGCATTCTGGCAAACGCGGCGGGGTCAGAGTCACGGCTATCAGCGCTGA

Upstream 100 bases:

>100_bases
GCGTCGGCGCCAGGGGTGAATCGTTGTCGGACCGCACGTCCAGTCTGCGGATCCTGTATTTTGTTCCCCCATTACCTCAT
TATGGAAGCGTAAGAGAACC

Downstream 100 bases:

>100_bases
TCGGCCGGCAGCAGAGGAATCAACGTGAAGCAAACGCAGCGGCATGATGCCATCATCGATCTGGTTCGCCAGCAGGGCTA
CGTCAGCACCGAGGAACTGG

Product: intramembrane serine protease GlpG

Products: NA

Alternate protein names: Intramembrane serine protease

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MIRVTALSNARLALAFIDYMKTQGVDMELRPQGRYAELWLAQDEKLAQVESALEAFLLDPQHPRYQAASWRTGSLHYRGE
TGAGLRGWLPALRQQAGPLTLGVTALCVLVFFLMALIGDDRVMAALLYPAGPAQYGQIWRWVSHAFLHFSLLHLLFNVVW
WWYLAGLTERYRGRASLAILFVLSAVVSGMVQSHFSGIFFGGLSGVVYALMGYVWWHGEKNPGGPLFMPLGVIVFALLWL
IAGYFNILGIAIANAAHVAGLVTGLLMAFWQTRRGQSHGYQR

Sequences:

>Translated_282_residues
MIRVTALSNARLALAFIDYMKTQGVDMELRPQGRYAELWLAQDEKLAQVESALEAFLLDPQHPRYQAASWRTGSLHYRGE
TGAGLRGWLPALRQQAGPLTLGVTALCVLVFFLMALIGDDRVMAALLYPAGPAQYGQIWRWVSHAFLHFSLLHLLFNVVW
WWYLAGLTERYRGRASLAILFVLSAVVSGMVQSHFSGIFFGGLSGVVYALMGYVWWHGEKNPGGPLFMPLGVIVFALLWL
IAGYFNILGIAIANAAHVAGLVTGLLMAFWQTRRGQSHGYQR
>Mature_282_residues
MIRVTALSNARLALAFIDYMKTQGVDMELRPQGRYAELWLAQDEKLAQVESALEAFLLDPQHPRYQAASWRTGSLHYRGE
TGAGLRGWLPALRQQAGPLTLGVTALCVLVFFLMALIGDDRVMAALLYPAGPAQYGQIWRWVSHAFLHFSLLHLLFNVVW
WWYLAGLTERYRGRASLAILFVLSAVVSGMVQSHFSGIFFGGLSGVVYALMGYVWWHGEKNPGGPLFMPLGVIVFALLWL
IAGYFNILGIAIANAAHVAGLVTGLLMAFWQTRRGQSHGYQR

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family

Homologues:

Organism=Escherichia coli, GI48994938, Length=273, Percent_Identity=45.7875457875458, Blast_Score=250, Evalue=9e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLPG_SODGM (Q2NQH3)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_456007.1
- ProteinModelPortal:   Q2NQH3
- SMR:   Q2NQH3
- STRING:   Q2NQH3
- GeneID:   3867312
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2327
- NMPDR:   fig|343509.6.peg.5055
- eggNOG:   COG0705
- HOGENOM:   HBG495087
- OMA:   WYLGGKI
- PhylomeDB:   Q2NQH3
- ProtClustDB:   PRK10907
- BioCyc:   SGLO343509:SG2327-MONOMER
- HAMAP:   MF_01594
- InterPro:   IPR022732
- InterPro:   IPR002610
- InterPro:   IPR022764
- PANTHER:   PTHR22936

Pfam domain/function: PF12122 DUF3582; PF01694 Rhomboid

EC number: =3.4.21.105

Molecular weight: Translated: 31398; Mature: 31398

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: ACT_SITE 204-204 ACT_SITE 257-257

Signals:

None

Transmembrane regions:

HASH(0x10b1dfa0)-; HASH(0x107ceea8)-; HASH(0xcf25f3c)-; HASH(0x10f41be8)-; HASH(0x108a77fc)-; HASH(0x10d12cec)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVTALSNARLALAFIDYMKTQGVDMELRPQGRYAELWLAQDEKLAQVESALEAFLLDP
CEEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCC
QHPRYQAASWRTGSLHYRGETGAGLRGWLPALRQQAGPLTLGVTALCVLVFFLMALIGDD
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
RVMAALLYPAGPAQYGQIWRWVSHAFLHFSLLHLLFNVVWWWYLAGLTERYRGRASLAIL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FVLSAVVSGMVQSHFSGIFFGGLSGVVYALMGYVWWHGEKNPGGPLFMPLGVIVFALLWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IAGYFNILGIAIANAAHVAGLVTGLLMAFWQTRRGQSHGYQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure
MIRVTALSNARLALAFIDYMKTQGVDMELRPQGRYAELWLAQDEKLAQVESALEAFLLDP
CEEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCC
QHPRYQAASWRTGSLHYRGETGAGLRGWLPALRQQAGPLTLGVTALCVLVFFLMALIGDD
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
RVMAALLYPAGPAQYGQIWRWVSHAFLHFSLLHLLFNVVWWWYLAGLTERYRGRASLAIL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FVLSAVVSGMVQSHFSGIFFGGLSGVVYALMGYVWWHGEKNPGGPLFMPLGVIVFALLWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IAGYFNILGIAIANAAHVAGLVTGLLMAFWQTRRGQSHGYQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA