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The map label for this gene is fkpA [H]

Identifier: 85060269

GI number: 85060269

Start: 3941629

End: 3942471

Strand: Reverse

Name: fkpA [H]

Synonym: SG2291

Alternate gene names: 85060269

Gene position: 3942471-3941629 (Counterclockwise)

Preceding gene: 85060271

Following gene: 85060268

Centisome position: 94.52

GC content: 58.72

Gene sequence:

>843_bases
ATGAAATCATTGATTAAAGTATCGCTGCTGGCCTCTACTATGGCATTTGCCTTTAACACGAGCAACGCCCTGGCCGCCGA
TGCGGCGCCTAGTGCTACCCCGCTGGCGACCGCAGCACCCGCCAGCGTCACCTCGGACAAATTCAAAAGCAGCGAAGATC
AGGCCGCCTATGCCCTGGGCGCCTCCCTGGGACGTTACATGGATAATTCGCTGAAAGAGCAGGAGAAGCTGGGTATCAAG
CTGAGTAAAGATCAGCTGATCACCGGCGTTCAGGACGCTTTCGCCAACAGCAGCAAGCTGTCCGATCAGGAAATTGAAGC
CACGCTGCAAAGCTTTGAAGCGCGCGTGAAGCAGGCCGCCCAAACCAAAATGGAGCAGGAGGCCAAGGACAACGCCGCCA
AAGGCGACAAATACCGCGTCGACTACGTCAACGAAAAGGGCGTGAAGAAAACCGCCAACGGCGTCCTGTATAAAGTGGAT
AAGGCCGGCACCGGCAACGCGCCGACCGATAGCGATACCGTCGTGGTGAACTATAAAGGCACCCTGGTCGACGGGACGGA
ATTCGATAATTCCTACAAGCGCGGCGAGCCTCTGTCCTTCCGCCTGGACGGCGTTATTCCTGGCTGGACCGAAGGGCTGA
AACACATTAAGAAAGGCGGGAAAATACAGCTGGTTATCCCGCCGGAGCAGGCTTACGGCAAGACCAGCGTTCCCGGTATC
CCGGCCAACTCGACGCTGGTGTTTGATGTGGAACTGCTGGACATCAAACCGGCCCCGGCCGCCCCGGCCGCCGGCGACGC
CGATGCCGGTCAGTCCCCGGACGCGGGCGCGCAGCAGAAATAA

Upstream 100 bases:

>100_bases
ACCGGCATAGCGATTGTGTTGTGTTTATGCTTACAGCTATAGTATTTGCCTGACTTTGCTATCGACCCTCGGGACCGCTT
ACCCAGGAAAATGGAGATTT

Downstream 100 bases:

>100_bases
CGCTGCCGTCCCACCCAAAAGGGCCGCTGCCCGTATGCGTTTTGCAAGCCATCCCCGTGGGATGGCTTTTTTTTCGCCGC
GCTGCCGGCCAAACGCTTCC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKSLIKVSLLASTMAFAFNTSNALAADAAPSATPLATAAPASVTSDKFKSSEDQAAYALGASLGRYMDNSLKEQEKLGIK
LSKDQLITGVQDAFANSSKLSDQEIEATLQSFEARVKQAAQTKMEQEAKDNAAKGDKYRVDYVNEKGVKKTANGVLYKVD
KAGTGNAPTDSDTVVVNYKGTLVDGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKHIKKGGKIQLVIPPEQAYGKTSVPGI
PANSTLVFDVELLDIKPAPAAPAAGDADAGQSPDAGAQQK

Sequences:

>Translated_280_residues
MKSLIKVSLLASTMAFAFNTSNALAADAAPSATPLATAAPASVTSDKFKSSEDQAAYALGASLGRYMDNSLKEQEKLGIK
LSKDQLITGVQDAFANSSKLSDQEIEATLQSFEARVKQAAQTKMEQEAKDNAAKGDKYRVDYVNEKGVKKTANGVLYKVD
KAGTGNAPTDSDTVVVNYKGTLVDGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKHIKKGGKIQLVIPPEQAYGKTSVPGI
PANSTLVFDVELLDIKPAPAAPAAGDADAGQSPDAGAQQK
>Mature_280_residues
MKSLIKVSLLASTMAFAFNTSNALAADAAPSATPLATAAPASVTSDKFKSSEDQAAYALGASLGRYMDNSLKEQEKLGIK
LSKDQLITGVQDAFANSSKLSDQEIEATLQSFEARVKQAAQTKMEQEAKDNAAKGDKYRVDYVNEKGVKKTANGVLYKVD
KAGTGNAPTDSDTVVVNYKGTLVDGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKHIKKGGKIQLVIPPEQAYGKTSVPGI
PANSTLVFDVELLDIKPAPAAPAAGDADAGQSPDAGAQQK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=111, Percent_Identity=45.045045045045, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI224809327, Length=111, Percent_Identity=45.045045045045, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI4758384, Length=111, Percent_Identity=45.045045045045, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI224809331, Length=111, Percent_Identity=45.045045045045, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4503729, Length=111, Percent_Identity=42.3423423423423, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI17149836, Length=92, Percent_Identity=46.7391304347826, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4503725, Length=92, Percent_Identity=46.7391304347826, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4503727, Length=191, Percent_Identity=33.5078534031414, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI206725530, Length=117, Percent_Identity=41.8803418803419, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI17149844, Length=117, Percent_Identity=41.8803418803419, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI17149842, Length=117, Percent_Identity=41.8803418803419, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4758380, Length=92, Percent_Identity=43.4782608695652, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI8923659, Length=96, Percent_Identity=39.5833333333333, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI33469985, Length=87, Percent_Identity=39.0804597701149, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789745, Length=263, Percent_Identity=70.3422053231939, Blast_Score=334, Evalue=3e-93,
Organism=Escherichia coli, GI87082390, Length=214, Percent_Identity=35.981308411215, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17540882, Length=123, Percent_Identity=40.650406504065, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=113, Percent_Identity=40.7079646017699, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=41.7582417582418, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=91, Percent_Identity=49.4505494505495, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324194, Length=104, Percent_Identity=43.2692307692308, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323482, Length=105, Percent_Identity=40, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323566, Length=85, Percent_Identity=43.5294117647059, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24655568, Length=92, Percent_Identity=45.6521739130435, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583150, Length=113, Percent_Identity=41.5929203539823, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356629, Length=90, Percent_Identity=46.6666666666667, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281363946, Length=94, Percent_Identity=42.5531914893617, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17352457, Length=94, Percent_Identity=42.5531914893617, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 29490; Mature: 29490

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLIKVSLLASTMAFAFNTSNALAADAAPSATPLATAAPASVTSDKFKSSEDQAAYALG
CCCHHHHHHHHHHHHHEECCCCCEECCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHH
ASLGRYMDNSLKEQEKLGIKLSKDQLITGVQDAFANSSKLSDQEIEATLQSFEARVKQAA
HHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
QTKMEQEAKDNAAKGDKYRVDYVNEKGVKKTANGVLYKVDKAGTGNAPTDSDTVVVNYKG
HHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCEEEEEECCCCCCCCCCCCEEEEEECC
TLVDGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKHIKKGGKIQLVIPPEQAYGKTSVPGI
EEECCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHCCCCCCCCC
PANSTLVFDVELLDIKPAPAAPAAGDADAGQSPDAGAQQK
CCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKSLIKVSLLASTMAFAFNTSNALAADAAPSATPLATAAPASVTSDKFKSSEDQAAYALG
CCCHHHHHHHHHHHHHEECCCCCEECCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHH
ASLGRYMDNSLKEQEKLGIKLSKDQLITGVQDAFANSSKLSDQEIEATLQSFEARVKQAA
HHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
QTKMEQEAKDNAAKGDKYRVDYVNEKGVKKTANGVLYKVDKAGTGNAPTDSDTVVVNYKG
HHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCEEEEEECCCCCCCCCCCCEEEEEECC
TLVDGTEFDNSYKRGEPLSFRLDGVIPGWTEGLKHIKKGGKIQLVIPPEQAYGKTSVPGI
EEECCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHCCCCCCCCC
PANSTLVFDVELLDIKPAPAAPAAGDADAGQSPDAGAQQK
CCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]