Click here to switch to the map view.

The map label for this gene is mutM

Identifier: 85060184

GI number: 85060184

Start: 3838547

End: 3839356

Strand: Reverse

Name: mutM

Synonym: SG2206

Alternate gene names: 85060184

Gene position: 3839356-3838547 (Counterclockwise)

Preceding gene: 85060185

Following gene: 85060177

Centisome position: 92.05

GC content: 60.74

Gene sequence:

>810_bases
ATGCCGGAATTACCGGAAGTGGAAACCAGCCGCCGGGGAATTGAACCTTGGGTAGCGGGGCAGACCATCCTGCGGGCGGA
GGTGCGCAATGCGCGGCTGCGCTGGCCGGTGGATGAAGAAATCATCGCGCTGCGGGACCAGCGGGTGCTGAGCGTACAGC
GCCGGGCGAAATATCTGCTGTTGGAGCTGGAGAAGGGCTGGATCATTATCCATCTCGGCATGTCGGGACGTTTGCGCGTG
CTGCCGCAGCCGCAGCCGCCGGAAAAGCACGACCATGTTGATTTGGTTATCGGCAACGGCTGCATCATCCGCTACACCGA
TCCCCGGCGCTTCGGCGCCTGGCTGTGGAGCGATGATCTGCGCACCAGTCGGGCACTGGCCCACCTGGGACCTGAGCCGC
TGAGCGATAAGTTCGATGGTCGCTGGCTGTACCAAAAGTCGCACAATAAACGCACGTCAATCAAACCTTGGCTGATGGAT
AACACGCTGGTGGTCGGCGTCGGTAATATTTACGCCAGCGAATCCTTGTTTGTCGCCGGTATTCTGCCCGGCCGCGCCGC
CGGTTCATTGAGCGAAGAAGAAGCGGGATTGTTGGCTGAGAGTATCAAGGCGGTGCTGCTGCGCTCCATTGAGCAGGGCG
GCACCACGCTGCGGGATTTTTTGCAGTCCGACGGCAAGCCGGGCTATTTTGTGCAGGAGCTCCAGGTTTACGGTCGCGGG
GGCGAACCCTGCCGGGTATGTGGGACGCCAATACAGATGGCCAAGCACGGCCAGCGCAGCACCTTTTTCTGTCCTGCATG
CCAACACTAG

Upstream 100 bases:

>100_bases
TTGGCGACTGGTTAAAAAACCCGGCTTCGGCCGGGTTTTTTATGGGCCGCCGGGCGTGCTATTCTCGGCCGGCGGACATC
CCGCTGACATGGAGCATCAG

Downstream 100 bases:

>100_bases
AAGGGCGGCGCTAACGGGGCCGCCATACGCTGAGCCGATTCGCGGCCGCGTCAGGGGTGCAGCCGCGCCCGGACTTCTTT
GGCGATGGGCGCAGGCAGAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPELPEVETSRRGIEPWVAGQTILRAEVRNARLRWPVDEEIIALRDQRVLSVQRRAKYLLLELEKGWIIIHLGMSGRLRV
LPQPQPPEKHDHVDLVIGNGCIIRYTDPRRFGAWLWSDDLRTSRALAHLGPEPLSDKFDGRWLYQKSHNKRTSIKPWLMD
NTLVVGVGNIYASESLFVAGILPGRAAGSLSEEEAGLLAESIKAVLLRSIEQGGTTLRDFLQSDGKPGYFVQELQVYGRG
GEPCRVCGTPIQMAKHGQRSTFFCPACQH

Sequences:

>Translated_269_residues
MPELPEVETSRRGIEPWVAGQTILRAEVRNARLRWPVDEEIIALRDQRVLSVQRRAKYLLLELEKGWIIIHLGMSGRLRV
LPQPQPPEKHDHVDLVIGNGCIIRYTDPRRFGAWLWSDDLRTSRALAHLGPEPLSDKFDGRWLYQKSHNKRTSIKPWLMD
NTLVVGVGNIYASESLFVAGILPGRAAGSLSEEEAGLLAESIKAVLLRSIEQGGTTLRDFLQSDGKPGYFVQELQVYGRG
GEPCRVCGTPIQMAKHGQRSTFFCPACQH
>Mature_268_residues
PELPEVETSRRGIEPWVAGQTILRAEVRNARLRWPVDEEIIALRDQRVLSVQRRAKYLLLELEKGWIIIHLGMSGRLRVL
PQPQPPEKHDHVDLVIGNGCIIRYTDPRRFGAWLWSDDLRTSRALAHLGPEPLSDKFDGRWLYQKSHNKRTSIKPWLMDN
TLVVGVGNIYASESLFVAGILPGRAAGSLSEEEAGLLAESIKAVLLRSIEQGGTTLRDFLQSDGKPGYFVQELQVYGRGG
EPCRVCGTPIQMAKHGQRSTFFCPACQH

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=268, Percent_Identity=75.3731343283582, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1786932, Length=275, Percent_Identity=23.6363636363636, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_SODGM (Q2NQU4)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455886.1
- HSSP:   P42371
- ProteinModelPortal:   Q2NQU4
- SMR:   Q2NQU4
- STRING:   Q2NQU4
- GeneID:   3868751
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2206
- NMPDR:   fig|343509.6.peg.4851
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q2NQU4
- ProtClustDB:   PRK01103
- BioCyc:   SGLO343509:SG2206-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30282; Mature: 30151

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 57-57 ACT_SITE 259-259 BINDING 90-90 BINDING 109-109 BINDING 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETSRRGIEPWVAGQTILRAEVRNARLRWPVDEEIIALRDQRVLSVQRRAKYLL
CCCCCCCCHHCCCCCCHHHCHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHEEEE
LELEKGWIIIHLGMSGRLRVLPQPQPPEKHDHVDLVIGNGCIIRYTDPRRFGAWLWSDDL
EEECCCEEEEEECCCCCEEECCCCCCCCCCCCEEEEECCCEEEEECCCCHHCCEEECCHH
RTSRALAHLGPEPLSDKFDGRWLYQKSHNKRTSIKPWLMDNTLVVGVGNIYASESLFVAG
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCEEEEEECCEECCCCEEEEE
ILPGRAAGSLSEEEAGLLAESIKAVLLRSIEQGGTTLRDFLQSDGKPGYFVQELQVYGRG
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEHEECCC
GEPCRVCGTPIQMAKHGQRSTFFCPACQH
CCCEEECCCHHHHHHCCCCCEEECCCCCC
>Mature Secondary Structure 
PELPEVETSRRGIEPWVAGQTILRAEVRNARLRWPVDEEIIALRDQRVLSVQRRAKYLL
CCCCCCCHHCCCCCCHHHCHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHEEEE
LELEKGWIIIHLGMSGRLRVLPQPQPPEKHDHVDLVIGNGCIIRYTDPRRFGAWLWSDDL
EEECCCEEEEEECCCCCEEECCCCCCCCCCCCEEEEECCCEEEEECCCCHHCCEEECCHH
RTSRALAHLGPEPLSDKFDGRWLYQKSHNKRTSIKPWLMDNTLVVGVGNIYASESLFVAG
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCEEEEEECCEECCCCEEEEE
ILPGRAAGSLSEEEAGLLAESIKAVLLRSIEQGGTTLRDFLQSDGKPGYFVQELQVYGRG
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEHEECCC
GEPCRVCGTPIQMAKHGQRSTFFCPACQH
CCCEEECCCHHHHHHCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA