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The map label for this gene is argH

Identifier: 85060137

GI number: 85060137

Start: 3760704

End: 3762077

Strand: Reverse

Name: argH

Synonym: SG2159

Alternate gene names: 85060137

Gene position: 3762077-3760704 (Counterclockwise)

Preceding gene: 85060138

Following gene: 85060136

Centisome position: 90.19

GC content: 59.68

Gene sequence:

>1374_bases
ATGGCACTTTGGGGCGGACGATTCAGTCAGGCGGCGGATCAACGTTTTAAATCTTTTAACGACTCGCTGCGGTTCGACTA
CCGTCTGACCGAACAGGACATTGTCGGCTCCGTGGCTTGGTCCCGCGCGCTGGTGACCGTGGGGGTGTTGAGCGAAACGG
AGCAGCAACAGCTGGAAGACGCTCTGAACGTGACCCTGGAGGAGGTGCGCACCGCGCCGGAAGCCATCCTCGCGAGCGAT
GCAGAAGATATCCATAGCTGGGTAGAGCAGTGCTTGATTGATAAAGTGGGCGATTTAGGCAAAAAGTTGCACACCGGACG
CAGCCGAAACGATCAGGTGGCGACCGATCTCAAGCTGTGGTGTAGAGCGCAGGTCACCGAGCTGCTTGGCGCGATACACT
TATTGCAGCAGGCGCTGGTCATGACCGCCGAGGCCCATCAGGATGTGGTGATGCCCGGCTATACCCATTTACAGCGCGCG
CAACCCATCACCTTCGCCCACTGGTGTCTGGCCTACAGCGAAATGCTCGCCCGCGATGAAAGCCGCCTGCGCGACACGTT
GACGCGTCTTGACGTCAGCCCACTCGGCGCCGGCGCGCTGGCCGGTACCGCCTATGCTATCGATCGCGACAAGCTGGCCG
GCTGGCTGGGTTTTGCTTCTGCGACACGCAATAGTCTGGATAGCGTTTCCGATCGCGATCATGTTCTTGAACTCCTGTCG
TATGCGGCGATTGGCATGGTGCACCTTTCCCGCTTCGCCGAAGATCTGATTTTCTTTAATACCGGCGAGGCGGGCTTCAT
CGAATTATCGGATCGCGTCACTTCCGGTTCGTCGCTGATGCCGCAGAAGAAAAATCCCGATGCGCTGGAGCTTATCCGCG
GCAAATGCGGACGAGTACAGGGAGCGTTGACCGGCATGATGATGACGTTGAAGGGCCTGCCGCTGGCCTATAACAAGGAT
ATGCAGGAAGATAAAGAGGGACTTTTCGACGCGCTGGATACTTGGCTTGACTGTCTGCATATGGCGGCGCTGGTGCTCGA
TGGGATCCAACTGAAATCGCCGCGCTGCCGCGAAGCGGCGCAGCAGGGTTATGCCAACGCCACCGAATTGGCGGATTATC
TGGTGGCGCGGGGGATCCCTTTTCGCGAAGCGCACCATATTGTCGGCGAGGCAGTGGTGGAAGCTATCCGTCAGGGAGTG
CCCCTGGAAACGCTACCGCTGGCGCGACTGCAGGCTTTCAGCCCGGTGATCGATGAGGATGTCTATCCGGTCCTGGCGCT
GGCGTCGTGCCTGGCGCAGCGCAAGGCGAAAGGCGGCGTGGCGCCGGAGCAGATCGCGCAGGCTATCGCCGAGGCAAAAC
AGCGGCTGGCATAA

Upstream 100 bases:

>100_bases
CCGGCCGGTTCGTTTTACCCTCTTACGGCGCGGCACGAGGCCGCGTACGCACCTTTACCGCGCGCGGTGCGCGTCAGCAT
CGTTTTCAGGAGAGCAGGTT

Downstream 100 bases:

>100_bases
AGGCCGCGGTGCGGCGCCTGCCGATTGCTATTACCCGGCAGATGGGTGGGTTGACGCGGTGGGTCAGCGTGGCCGGACAT
TGGCCCGCGGAGGCCACTTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MALWGGRFSQAADQRFKSFNDSLRFDYRLTEQDIVGSVAWSRALVTVGVLSETEQQQLEDALNVTLEEVRTAPEAILASD
AEDIHSWVEQCLIDKVGDLGKKLHTGRSRNDQVATDLKLWCRAQVTELLGAIHLLQQALVMTAEAHQDVVMPGYTHLQRA
QPITFAHWCLAYSEMLARDESRLRDTLTRLDVSPLGAGALAGTAYAIDRDKLAGWLGFASATRNSLDSVSDRDHVLELLS
YAAIGMVHLSRFAEDLIFFNTGEAGFIELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKD
MQEDKEGLFDALDTWLDCLHMAALVLDGIQLKSPRCREAAQQGYANATELADYLVARGIPFREAHHIVGEAVVEAIRQGV
PLETLPLARLQAFSPVIDEDVYPVLALASCLAQRKAKGGVAPEQIAQAIAEAKQRLA

Sequences:

>Translated_457_residues
MALWGGRFSQAADQRFKSFNDSLRFDYRLTEQDIVGSVAWSRALVTVGVLSETEQQQLEDALNVTLEEVRTAPEAILASD
AEDIHSWVEQCLIDKVGDLGKKLHTGRSRNDQVATDLKLWCRAQVTELLGAIHLLQQALVMTAEAHQDVVMPGYTHLQRA
QPITFAHWCLAYSEMLARDESRLRDTLTRLDVSPLGAGALAGTAYAIDRDKLAGWLGFASATRNSLDSVSDRDHVLELLS
YAAIGMVHLSRFAEDLIFFNTGEAGFIELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKD
MQEDKEGLFDALDTWLDCLHMAALVLDGIQLKSPRCREAAQQGYANATELADYLVARGIPFREAHHIVGEAVVEAIRQGV
PLETLPLARLQAFSPVIDEDVYPVLALASCLAQRKAKGGVAPEQIAQAIAEAKQRLA
>Mature_456_residues
ALWGGRFSQAADQRFKSFNDSLRFDYRLTEQDIVGSVAWSRALVTVGVLSETEQQQLEDALNVTLEEVRTAPEAILASDA
EDIHSWVEQCLIDKVGDLGKKLHTGRSRNDQVATDLKLWCRAQVTELLGAIHLLQQALVMTAEAHQDVVMPGYTHLQRAQ
PITFAHWCLAYSEMLARDESRLRDTLTRLDVSPLGAGALAGTAYAIDRDKLAGWLGFASATRNSLDSVSDRDHVLELLSY
AAIGMVHLSRFAEDLIFFNTGEAGFIELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQGALTGMMMTLKGLPLAYNKDM
QEDKEGLFDALDTWLDCLHMAALVLDGIQLKSPRCREAAQQGYANATELADYLVARGIPFREAHHIVGEAVVEAIRQGVP
LETLPLARLQAFSPVIDEDVYPVLALASCLAQRKAKGGVAPEQIAQAIAEAKQRLA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=45.6762749445676, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=45.6762749445676, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=43.4589800443459, Blast_Score=343, Evalue=3e-94,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=42.7937915742794, Blast_Score=336, Evalue=3e-92,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=85.1203501094092, Blast_Score=802, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=457, Percent_Identity=45.0765864332604, Blast_Score=379, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=44.2953020134228, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=44.2953020134228, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_SODGM (Q2NQZ1)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455839.1
- ProteinModelPortal:   Q2NQZ1
- SMR:   Q2NQZ1
- STRING:   Q2NQZ1
- GeneID:   3868268
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2159
- NMPDR:   fig|343509.6.peg.4760
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   Q2NQZ1
- ProtClustDB:   PRK04833
- BioCyc:   SGLO343509:SG2159-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50153; Mature: 50022

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFSQAADQRFKSFNDSLRFDYRLTEQDIVGSVAWSRALVTVGVLSETEQQQLED
CCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNVTLEEVRTAPEAILASDAEDIHSWVEQCLIDKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CRAQVTELLGAIHLLQQALVMTAEAHQDVVMPGYTHLQRAQPITFAHWCLAYSEMLARDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLRDTLTRLDVSPLGAGALAGTAYAIDRDKLAGWLGFASATRNSLDSVSDRDHVLELLS
HHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YAAIGMVHLSRFAEDLIFFNTGEAGFIELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQ
HHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQLKSPRCREAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
QQGYANATELADYLVARGIPFREAHHIVGEAVVEAIRQGVPLETLPLARLQAFSPVIDED
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHCC
VYPVLALASCLAQRKAKGGVAPEQIAQAIAEAKQRLA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALWGGRFSQAADQRFKSFNDSLRFDYRLTEQDIVGSVAWSRALVTVGVLSETEQQQLED
CCCCCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNVTLEEVRTAPEAILASDAEDIHSWVEQCLIDKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CRAQVTELLGAIHLLQQALVMTAEAHQDVVMPGYTHLQRAQPITFAHWCLAYSEMLARDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLRDTLTRLDVSPLGAGALAGTAYAIDRDKLAGWLGFASATRNSLDSVSDRDHVLELLS
HHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
YAAIGMVHLSRFAEDLIFFNTGEAGFIELSDRVTSGSSLMPQKKNPDALELIRGKCGRVQ
HHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GALTGMMMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLHMAALVLDGIQLKSPRCREAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
QQGYANATELADYLVARGIPFREAHHIVGEAVVEAIRQGVPLETLPLARLQAFSPVIDED
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHCC
VYPVLALASCLAQRKAKGGVAPEQIAQAIAEAKQRLA
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA