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The map label for this gene is nuoH

Identifier: 85059573

GI number: 85059573

Start: 2739913

End: 2740890

Strand: Reverse

Name: nuoH

Synonym: SG1595

Alternate gene names: 85059573

Gene position: 2740890-2739913 (Counterclockwise)

Preceding gene: 85059574

Following gene: 85059572

Centisome position: 65.71

GC content: 58.18

Gene sequence:

>978_bases
ATGAGTTGGTTGACACCGGAGGTCATTGATATCCTCCTGACGGTGGTGAAAGCGGTTGTTATCCTGCTGGTGGTGGTCAC
CTGCGGCGCCTACATGAGCTTTGCCGAGCGGCGCCTGCTAGGGCTGTTCCAAAACCGCTACGGACCCAACCGCGTAGGTT
GGGGCGGTTCGCTGCAGCTCTTGGCCGACGTTTTGAAGATGATGTTTAAAGAGGACTGGATCCCGCCGTTCGCCGATCGG
GGCATTTTCACCCTGGCGCCGGTCATTGCCTTCACGTCGCTGCTGATTACGTTCGCCATCGTTCCGGTAAGTCCGACCTG
GGTGGTGGCCGATTTCAACATCGGCGTGCTGTTCTTCCTGATGATGGCCGGGCTGGCGGTGTACGCCGTGCTGTTCGCCG
GCTGGTCGAGCAACAATAAATACTCGCTCCTGGGTGCTATGCGCGCCTCGGCGCAGACCTTGAGCTATGAAGTGTTTCTC
GGTTTGTCGTTAATGGGAGTGGTGGCTCAGGCCGGTTCGTTCAACCTCGGCGCGATCGTTGAGTCGCAAGCGCATCTGTG
GAACGTGGTGCCGCAATTCTTCGGCTTTGTCACCTTTGCGCTGGCGGGCGTCGCGGTGTGTCACCGCCATCCCTTCGATC
AGCCGGAAGCGGAGCAGGAACTGGCTGACGGCTACCATATCGAATACTCGGGGATGAAATTTGGCCTGTTCTTCGTCGGT
GAATATGTTGGCATTGTGACCATCTCGGCTCTGATGGTGACGCTGTTCTTCGGCGGCTGGCAGGGGCCGTGGTTGCCGCC
GTTTATCTGGTTCTCCATTAAAACCGCTTTCTTTATGATGATGTTCATCCTGATCCGCGCGGCGCTGCCCCGTCCGCGCT
ATGACCAGGTGATGGCGCTGGGCTGGAAAATCTGCCTGCCGCTGACGCTGCTCAATTTGTTGGCGACCGCAGCGGTCATC
TTGTACAACGCGCATTAA

Upstream 100 bases:

>100_bases
ATGACCTGAGCGCCGGACAGGTCGGGCTGCCGCTGGGGCTGCCGGGCATTCCACCGATGCTGGCGGGACAGCGCGTTGAA
AATCTGCGGGAGGCCGCGCT

Downstream 100 bases:

>100_bases
GGGGTGGATGAATCATGACGTTAAAAGAGTTAGCGATCGGCTGCGGGACCACGCTGCGCAGCATCTGGATGATTGGCATG
CAGGCGTTCAACAAGCGTGA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSWLTPEVIDILLTVVKAVVILLVVVTCGAYMSFAERRLLGLFQNRYGPNRVGWGGSLQLLADVLKMMFKEDWIPPFADR
GIFTLAPVIAFTSLLITFAIVPVSPTWVVADFNIGVLFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFL
GLSLMGVVAQAGSFNLGAIVESQAHLWNVVPQFFGFVTFALAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVG
EYVGIVTISALMVTLFFGGWQGPWLPPFIWFSIKTAFFMMMFILIRAALPRPRYDQVMALGWKICLPLTLLNLLATAAVI
LYNAH

Sequences:

>Translated_325_residues
MSWLTPEVIDILLTVVKAVVILLVVVTCGAYMSFAERRLLGLFQNRYGPNRVGWGGSLQLLADVLKMMFKEDWIPPFADR
GIFTLAPVIAFTSLLITFAIVPVSPTWVVADFNIGVLFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFL
GLSLMGVVAQAGSFNLGAIVESQAHLWNVVPQFFGFVTFALAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVG
EYVGIVTISALMVTLFFGGWQGPWLPPFIWFSIKTAFFMMMFILIRAALPRPRYDQVMALGWKICLPLTLLNLLATAAVI
LYNAH
>Mature_324_residues
SWLTPEVIDILLTVVKAVVILLVVVTCGAYMSFAERRLLGLFQNRYGPNRVGWGGSLQLLADVLKMMFKEDWIPPFADRG
IFTLAPVIAFTSLLITFAIVPVSPTWVVADFNIGVLFFLMMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLG
LSLMGVVAQAGSFNLGAIVESQAHLWNVVPQFFGFVTFALAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVGE
YVGIVTISALMVTLFFGGWQGPWLPPFIWFSIKTAFFMMMFILIRAALPRPRYDQVMALGWKICLPLTLLNLLATAAVIL
YNAH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=283, Percent_Identity=40.6360424028269, Blast_Score=195, Evalue=6e-50,
Organism=Escherichia coli, GI1788618, Length=325, Percent_Identity=87.3846153846154, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI1789077, Length=262, Percent_Identity=26.7175572519084, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_SODGM (Q2NSK5)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455275.1
- STRING:   Q2NSK5
- GeneID:   3867890
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1595
- NMPDR:   fig|343509.6.peg.3403
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   MSWLTPE
- PhylomeDB:   Q2NSK5
- ProtClustDB:   PRK06076
- BioCyc:   SGLO343509:SG1595-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 35994; Mature: 35863

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xfa7d558)-; HASH(0xfa20cd8)-; HASH(0xfa1b8cc)-; HASH(0xded60cc)-; HASH(0xf9a1070)-; HASH(0xf2d3a0c)-; HASH(0xf84d494)-; HASH(0xe466094)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWLTPEVIDILLTVVKAVVILLVVVTCGAYMSFAERRLLGLFQNRYGPNRVGWGGSLQL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LADVLKMMFKEDWIPPFADRGIFTLAPVIAFTSLLITFAIVPVSPTWVVADFNIGVLFFL
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHH
MMAGLAVYAVLFAGWSSNNKYSLLGAMRASAQTLSYEVFLGLSLMGVVAQAGSFNLGAIV
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ESQAHLWNVVPQFFGFVTFALAGVAVCHRHPFDQPEAEQELADGYHIEYSGMKFGLFFVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEECCCEEHHHHHH
EYVGIVTISALMVTLFFGGWQGPWLPPFIWFSIKTAFFMMMFILIRAALPRPRYDQVMAL
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
GWKICLPLTLLNLLATAAVILYNAH
HHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SWLTPEVIDILLTVVKAVVILLVVVTCGAYMSFAERRLLGLFQNRYGPNRVGWGGSLQL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH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HHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA