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The map label for this gene is pntB

Identifier: 85059465

GI number: 85059465

Start: 2482273

End: 2483661

Strand: Reverse

Name: pntB

Synonym: SG1487

Alternate gene names: 85059465

Gene position: 2483661-2482273 (Counterclockwise)

Preceding gene: 85059466

Following gene: 85059461

Centisome position: 59.54

GC content: 54.64

Gene sequence:

>1389_bases
ATGTCAGAAGGACTCGTCACGGCGGCTTATATCGCCGCCGCCATTTTATTTATTTTTAGCCTGGCGGGGCTATCCAAGCA
CGAAACATCGCGGCAGGGAAACCTGTTTGGCATTACCGGCATGGCTATCGCGCTTGTCGCGACGGTGTTGGGGCCGGACG
CCGGCAATGTCGGCTGGATTATCGTCGCCATGGTCATCGGCGGCGCCATCGGAATTTATCTGGCGCGCAAAGTTGAGATG
ACCGAAATGCCGGAGCTGGTCGCCATTTTGCACAGCTTTGTCGGTTTGGCGGCGGTGTTGGTCGGTTTTAACAGCTATCC
GGAACATCAGGCCATCAACAACGCGGTCATGGAAAATATCCATTTGACCGAGGTTTTTCTGGGCATTTTTATTGGTGCCG
TCACCTTCACTGGCTCGATTGTGGCCTTTGGCAAGCTGCACGGTAAAATTTCCTCCCGTCCGCTCATGCTGCCGCGGTGC
TATCAAATGAATCTCGCGGCGCTGGTGATTTCGTTTCTGCTGTTGATATTGTTTGTGCGCAGCAACAATATCGGACTGCA
GGTATTGGAGCTATTACTCATGACGATTATTGCCCTGGCGTTCGGTTGGCATTTGGTTGCTTCCATTGGCGGTGCCGATA
TGCCGGTCGTGGTTTCCATGCTCAACTCTTATTCCGGCTGGTCGGCCGCGGCGGCAGGCTTTATGTTGAACAACGATCTG
CTGATTGTCACCGGCGCGCTGGTCGGCTCCTCCGGGGCTATCCTCTCTTATATTATGTGTAAGGCGATGAATCGCTCCTT
TATCAGCGTCATTGCCGGCGGCTTTGGTAACGATATCAGCGTCGGCGACCCTGAGGCTGAAATGGGAGACTATCGCGAGA
CCACGGCGGAGGAGGTGGCCGAACTGCTGAAAAACTCCAGCTCGGTCATCATTACTCCCGGCTACGGTATGGCGGTTGCG
CAGGCGCAGTATCCGGTGCACGATATTACCGCCAAGTTGCGTGCCCGCGGCGTTAACGTGCGCTTCGGCATCCATCCGGT
GGCCGGGCGCTTGCCGGGACACATGAACGTGTTGTTGGCGGAGGCCAAGGTGCCCTACGACATCGTGCTTGAGATGGATG
AAATTAATGAGGATTTCAGCACTACCGATACCGTATTGGTCATTGGCGCTAATGATACCGTTAACCCAGCGGCGCAAGAA
GATCCCCGCAGTCCCATCGCAGGAATGCCGGTGCTGGAAGTATGGAAAGCTCAAAACGTCGTGGTATTTAAGCGTTCGAT
GAATACCGGCTATGCCGGCGTGCAAAATCCGCTGTTCTTTAAGGACAATACGCAAATGCTGTTTGGTGACGCCAAGCAGA
GCGTCGAGGCGATTTTGCGTGCTCTGTAA

Upstream 100 bases:

>100_bases
TCGTTTATCGCCGTGCTGATCGCCAGCATCAATATCTTTGGTGGTTTCACCGTCACTCAGCGCATGCTGAAAATGTTTCG
TAAAAATTAAGGGGTGAACC

Downstream 100 bases:

>100_bases
CTGTTAATCCCCGCTGGCCGGCCCGAGTTTTGTTGTCGGCATGCCTGGCGGTGCGATGTACTATGAGGCTAGGGTCGCGT
CTAGTGCCTTTTCCTGAGTA

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSEGLVTAAYIAAAILFIFSLAGLSKHETSRQGNLFGITGMAIALVATVLGPDAGNVGWIIVAMVIGGAIGIYLARKVEM
TEMPELVAILHSFVGLAAVLVGFNSYPEHQAINNAVMENIHLTEVFLGIFIGAVTFTGSIVAFGKLHGKISSRPLMLPRC
YQMNLAALVISFLLLILFVRSNNIGLQVLELLLMTIIALAFGWHLVASIGGADMPVVVSMLNSYSGWSAAAAGFMLNNDL
LIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDISVGDPEAEMGDYRETTAEEVAELLKNSSSVIITPGYGMAVA
QAQYPVHDITAKLRARGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINEDFSTTDTVLVIGANDTVNPAAQE
DPRSPIAGMPVLEVWKAQNVVVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKQSVEAILRAL

Sequences:

>Translated_462_residues
MSEGLVTAAYIAAAILFIFSLAGLSKHETSRQGNLFGITGMAIALVATVLGPDAGNVGWIIVAMVIGGAIGIYLARKVEM
TEMPELVAILHSFVGLAAVLVGFNSYPEHQAINNAVMENIHLTEVFLGIFIGAVTFTGSIVAFGKLHGKISSRPLMLPRC
YQMNLAALVISFLLLILFVRSNNIGLQVLELLLMTIIALAFGWHLVASIGGADMPVVVSMLNSYSGWSAAAAGFMLNNDL
LIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDISVGDPEAEMGDYRETTAEEVAELLKNSSSVIITPGYGMAVA
QAQYPVHDITAKLRARGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINEDFSTTDTVLVIGANDTVNPAAQE
DPRSPIAGMPVLEVWKAQNVVVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKQSVEAILRAL
>Mature_461_residues
SEGLVTAAYIAAAILFIFSLAGLSKHETSRQGNLFGITGMAIALVATVLGPDAGNVGWIIVAMVIGGAIGIYLARKVEMT
EMPELVAILHSFVGLAAVLVGFNSYPEHQAINNAVMENIHLTEVFLGIFIGAVTFTGSIVAFGKLHGKISSRPLMLPRCY
QMNLAALVISFLLLILFVRSNNIGLQVLELLLMTIIALAFGWHLVASIGGADMPVVVSMLNSYSGWSAAAAGFMLNNDLL
IVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDISVGDPEAEMGDYRETTAEEVAELLKNSSSVIITPGYGMAVAQ
AQYPVHDITAKLRARGVNVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINEDFSTTDTVLVIGANDTVNPAAQED
PRSPIAGMPVLEVWKAQNVVVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKQSVEAILRAL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=453, Percent_Identity=50.1103752759382, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI122939153, Length=453, Percent_Identity=50.1103752759382, Blast_Score=441, Evalue=1e-123,
Organism=Escherichia coli, GI1787886, Length=462, Percent_Identity=84.8484848484848, Blast_Score=792, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17550456, Length=466, Percent_Identity=48.2832618025751, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 49179; Mature: 49048

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEGLVTAAYIAAAILFIFSLAGLSKHETSRQGNLFGITGMAIALVATVLGPDAGNVGWI
CCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHH
IVAMVIGGAIGIYLARKVEMTEMPELVAILHSFVGLAAVLVGFNSYPEHQAINNAVMENI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCH
HLTEVFLGIFIGAVTFTGSIVAFGKLHGKISSRPLMLPRCYQMNLAALVISFLLLILFVR
HHHHHHHHHHHHHHHHHCHHEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SNNIGLQVLELLLMTIIALAFGWHLVASIGGADMPVVVSMLNSYSGWSAAAAGFMLNNDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHCEEECCCE
LIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDISVGDPEAEMGDYRETTAEEVA
EEEEEEHHCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHCCCHHHHHHHHHH
ELLKNSSSVIITPGYGMAVAQAQYPVHDITAKLRARGVNVRFGIHPVAGRLPGHMNVLLA
HHHHCCCCEEEECCCCCEEHHCCCCHHHHHHHHHHCCCEEEECCCHHCCCCCCCCEEEEE
EAKVPYDIVLEMDEINEDFSTTDTVLVIGANDTVNPAAQEDPRSPIAGMPVLEVWKAQNV
CCCCCEEEEEEHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCE
VVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKQSVEAILRAL
EEEEECCCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHHHC
>Mature Secondary Structure 
SEGLVTAAYIAAAILFIFSLAGLSKHETSRQGNLFGITGMAIALVATVLGPDAGNVGWI
CCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHH
IVAMVIGGAIGIYLARKVEMTEMPELVAILHSFVGLAAVLVGFNSYPEHQAINNAVMENI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCH
HLTEVFLGIFIGAVTFTGSIVAFGKLHGKISSRPLMLPRCYQMNLAALVISFLLLILFVR
HHHHHHHHHHHHHHHHHCHHEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
SNNIGLQVLELLLMTIIALAFGWHLVASIGGADMPVVVSMLNSYSGWSAAAAGFMLNNDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHCEEECCCE
LIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDISVGDPEAEMGDYRETTAEEVA
EEEEEEHHCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHCCCHHHHHHHHHH
ELLKNSSSVIITPGYGMAVAQAQYPVHDITAKLRARGVNVRFGIHPVAGRLPGHMNVLLA
HHHHCCCCEEEECCCCCEEHHCCCCHHHHHHHHHHCCCEEEECCCHHCCCCCCCCEEEEE
EAKVPYDIVLEMDEINEDFSTTDTVLVIGANDTVNPAAQEDPRSPIAGMPVLEVWKAQNV
CCCCCEEEEEEHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCE
VVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKQSVEAILRAL
EEEEECCCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]