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The map label for this gene is cvrA

Identifier: 85059321

GI number: 85059321

Start: 2231336

End: 2233066

Strand: Reverse

Name: cvrA

Synonym: SG1343

Alternate gene names: 85059321

Gene position: 2233066-2231336 (Counterclockwise)

Preceding gene: 85059322

Following gene: 85059319

Centisome position: 53.54

GC content: 55.46

Gene sequence:

>1731_bases
TTGGACAGCAGCACCATTATAAGTTTGTTTATTATAGGTTCGATATTGGTGGGGGGAAGTATCCTGCTCAGCGCCTTTTC
CTCACGTCTTGGCATCCCTATTCTGGTGATTTTTCTGGCTATTGGCATGTTGGCAGGAATTGATGGTCTGGGCGGCATTG
CATTTGATAATTATCCTGTAGCCTATCTTATCAGTAACCTGGCGCTGGCGGTGATTTTGCTGGATGGCGGTATGCGTACC
CGCGCCACCGCCTTTCGCGTCGCACTCTGGCCATCGCTTTCGCTTGCGACGGTGGGGGTCATCATCACCGCCGGTTTAAC
CGGTATAGCCGCCGCCTGGCTTTTCGGGCTGGATAAAATTGAAGGCATGCTTATCGGCGCCATTGTCGGCTCTACCGATG
CCGCGGCGGTGTTCTCGCTGTTGGGCGATAAAGGGTTGAACGAGCGTGTGACCTCCACGCTTGAAATTGAATCAGGCAGT
AATGATCCCATGGCGGTGTTTCTGACGATCACGCTTATCGCCATGATTCAAAACGGCCAGATTCACCTTGACTGGCTGTT
TTTGGTGCATCTTATCCGCGAGTTCGGCCTTGGCGTGATCTTGGGCCTGGGCGGAGGCTGGCTGTTGCAGCAGGTCATCA
ACCGCATCACGCTAACCAACGCCCTGTATCCCCTGCTGGCGGTCAGCGGCGGCATCATGATGTTCGCCCTGACCACCGCG
CTGGAAGGTAGCGGCATCCTTGCGGTCTATTTGTGTGGCTTTGTGCTGGGCAATCGGCCGATACGCAACCGATACGGTAT
TTTACAAACGTTCGACGGCATGGCCTGGCTCAGCCAGATTTGCATGTTCCTGGCGCTGGGCCTCCTGGTGACGCCCAGCG
ATTTGTGGATGATTGCTATTCCGGCGCTCATTTTGTCCCTGTGGCTGATGTTGGTCGCCCGTCCTCTCTCGATTTTTGTC
GGTCTGCTGCCGTTTCGCAACTACACCACCCGCGAGCGAGTTTTTCTTTCCTGGGTCGGCCTGCGCGGAGCGGTACCGAT
CATTCTGGCGGTGTTTCCGATGATGGCGGGCCTGGACAATGCGCACATGTATTTTAATGTCGCCTTCTTTATTGTTCTCA
TTTCTTTGCTTTTACAGGGCACCTCACTCGGCTTCGCCGCCCGGCTAGCGAAAGTGGTAGTACCGCCGACCGCGTCGCCG
ATTTCACGCGTGGGGATGGATATTCATCCGGAAAACCCCTGGGAGCAGTTTATATATCAATTGGGAGAGGAAAACTGGTG
TGTGGGAGCGGCGCTGCGCGATCTGAAAATGCCCCGCCATACGCGCATCGCTGCCTTGTTTCGCGATAATGTATTGCTTC
ACCCGACCGCCAACACCCGGCTACGTGAAGGGGATGTGCTTTGCGTCATTGGACGAGAGCGAGATCTCCCCGCACTGGGC
AGATTGTTCAGCCAATCGCCGCCCGTCGCGCTGGATCAGCGTTTCTTCGGGGATTTTATTCTGGAAGCCAGCGCGAATTT
GCGCGATGTGTCGTCCATTTACGGTCTGGAATTCGCCGGCGAAGTGGATGGTGAACTGACCCTCGGTCAATTTGTCATGG
CGTTGCTCGGCGGGGGGGAACCAGTGGTCGGCGATAATGTTGTGGCGGAAGGTGTTGTGTGGACCATCGCGGAAAAGGAT
GAACAGAAGGTCAGCAAAATCGGCATCAAGATTGCCGACGATCCGGCTTGA

Upstream 100 bases:

>100_bases
GCTTTCAGCCAGACAGTCATGGTAGGAATTTCGGGTCACAACGCCTCTGCAGGATAGGCTGAGGCAGGTTATGAAATAGA
AAATCAAAAGGAGACCGCGT

Downstream 100 bases:

>100_bases
AATACCATTAACCCCCGCGCGGTCGGCGCTGACGCGAACGCTTACGGCAAATGACGACCGTCTTCCTCCGTGGAGGGGAT
GTTAAAAGTGCAAGGTCTTA

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MDSSTIISLFIIGSILVGGSILLSAFSSRLGIPILVIFLAIGMLAGIDGLGGIAFDNYPVAYLISNLALAVILLDGGMRT
RATAFRVALWPSLSLATVGVIITAGLTGIAAAWLFGLDKIEGMLIGAIVGSTDAAAVFSLLGDKGLNERVTSTLEIESGS
NDPMAVFLTITLIAMIQNGQIHLDWLFLVHLIREFGLGVILGLGGGWLLQQVINRITLTNALYPLLAVSGGIMMFALTTA
LEGSGILAVYLCGFVLGNRPIRNRYGILQTFDGMAWLSQICMFLALGLLVTPSDLWMIAIPALILSLWLMLVARPLSIFV
GLLPFRNYTTRERVFLSWVGLRGAVPIILAVFPMMAGLDNAHMYFNVAFFIVLISLLLQGTSLGFAARLAKVVVPPTASP
ISRVGMDIHPENPWEQFIYQLGEENWCVGAALRDLKMPRHTRIAALFRDNVLLHPTANTRLREGDVLCVIGRERDLPALG
RLFSQSPPVALDQRFFGDFILEASANLRDVSSIYGLEFAGEVDGELTLGQFVMALLGGGEPVVGDNVVAEGVVWTIAEKD
EQKVSKIGIKIADDPA

Sequences:

>Translated_576_residues
MDSSTIISLFIIGSILVGGSILLSAFSSRLGIPILVIFLAIGMLAGIDGLGGIAFDNYPVAYLISNLALAVILLDGGMRT
RATAFRVALWPSLSLATVGVIITAGLTGIAAAWLFGLDKIEGMLIGAIVGSTDAAAVFSLLGDKGLNERVTSTLEIESGS
NDPMAVFLTITLIAMIQNGQIHLDWLFLVHLIREFGLGVILGLGGGWLLQQVINRITLTNALYPLLAVSGGIMMFALTTA
LEGSGILAVYLCGFVLGNRPIRNRYGILQTFDGMAWLSQICMFLALGLLVTPSDLWMIAIPALILSLWLMLVARPLSIFV
GLLPFRNYTTRERVFLSWVGLRGAVPIILAVFPMMAGLDNAHMYFNVAFFIVLISLLLQGTSLGFAARLAKVVVPPTASP
ISRVGMDIHPENPWEQFIYQLGEENWCVGAALRDLKMPRHTRIAALFRDNVLLHPTANTRLREGDVLCVIGRERDLPALG
RLFSQSPPVALDQRFFGDFILEASANLRDVSSIYGLEFAGEVDGELTLGQFVMALLGGGEPVVGDNVVAEGVVWTIAEKD
EQKVSKIGIKIADDPA
>Mature_576_residues
MDSSTIISLFIIGSILVGGSILLSAFSSRLGIPILVIFLAIGMLAGIDGLGGIAFDNYPVAYLISNLALAVILLDGGMRT
RATAFRVALWPSLSLATVGVIITAGLTGIAAAWLFGLDKIEGMLIGAIVGSTDAAAVFSLLGDKGLNERVTSTLEIESGS
NDPMAVFLTITLIAMIQNGQIHLDWLFLVHLIREFGLGVILGLGGGWLLQQVINRITLTNALYPLLAVSGGIMMFALTTA
LEGSGILAVYLCGFVLGNRPIRNRYGILQTFDGMAWLSQICMFLALGLLVTPSDLWMIAIPALILSLWLMLVARPLSIFV
GLLPFRNYTTRERVFLSWVGLRGAVPIILAVFPMMAGLDNAHMYFNVAFFIVLISLLLQGTSLGFAARLAKVVVPPTASP
ISRVGMDIHPENPWEQFIYQLGEENWCVGAALRDLKMPRHTRIAALFRDNVLLHPTANTRLREGDVLCVIGRERDLPALG
RLFSQSPPVALDQRFFGDFILEASANLRDVSSIYGLEFAGEVDGELTLGQFVMALLGGGEPVVGDNVVAEGVVWTIAEKD
EQKVSKIGIKIADDPA

Specific function: Participates in control of cell volume in low-osmolarity conditions

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain

Homologues:

Organism=Escherichia coli, GI87081854, Length=577, Percent_Identity=75.3899480069324, Blast_Score=809, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CVRA_SODGM (Q2NTA7)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455023.1
- ProteinModelPortal:   Q2NTA7
- STRING:   Q2NTA7
- GeneID:   3866414
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1343
- NMPDR:   fig|343509.6.peg.2751
- eggNOG:   COG3263
- HOGENOM:   HBG359889
- OMA:   SEWELFV
- PhylomeDB:   Q2NTA7
- ProtClustDB:   PRK05326
- BioCyc:   SGLO343509:SG1343-MONOMER
- HAMAP:   MF_01075
- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170
- Gene3D:   G3DSA:3.30.465.10

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C

EC number: NA

Molecular weight: Translated: 61950; Mature: 61950

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS51202 RCK_C

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf3f6c6c)-; HASH(0xf41f598)-; HASH(0xf251dbc)-; HASH(0xee28e28)-; HASH(0xeb7074c)-; HASH(0xf05a5e0)-; HASH(0xe8b287c)-; HASH(0xea09ca8)-; HASH(0xf3cd43c)-; HASH(0xbd3d0e8)-; HASH(0xebaca0c)-; HASH(0xf0f0e30)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSSTIISLFIIGSILVGGSILLSAFSSRLGIPILVIFLAIGMLAGIDGLGGIAFDNYPV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
AYLISNLALAVILLDGGMRTRATAFRVALWPSLSLATVGVIITAGLTGIAAAWLFGLDKI
HHHHHHHHHEEEEECCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGMLIGAIVGSTDAAAVFSLLGDKGLNERVTSTLEIESGSNDPMAVFLTITLIAMIQNGQ
CCEEEEEEECCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCC
IHLDWLFLVHLIREFGLGVILGLGGGWLLQQVINRITLTNALYPLLAVSGGIMMFALTTA
EEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LEGSGILAVYLCGFVLGNRPIRNRYGILQTFDGMAWLSQICMFLALGLLVTPSDLWMIAI
CCCCCHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
PALILSLWLMLVARPLSIFVGLLPFRNYTTRERVFLSWVGLRGAVPIILAVFPMMAGLDN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
AHMYFNVAFFIVLISLLLQGTSLGFAARLAKVVVPPTASPISRVGMDIHPENPWEQFIYQ
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHH
LGEENWCVGAALRDLKMPRHTRIAALFRDNVLLHPTANTRLREGDVLCVIGRERDLPALG
HCCCCCCHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCCEEECCCEEEEECCCCCCHHHH
RLFSQSPPVALDQRFFGDFILEASANLRDVSSIYGLEFAGEVDGELTLGQFVMALLGGGE
HHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCEECCCCCCCEEHHHHHHHHHCCCC
PVVGDNVVAEGVVWTIAEKDEQKVSKIGIKIADDPA
CCCCCCHHHCCEEEEECCCHHHHHHHCCCEECCCCH
>Mature Secondary Structure
MDSSTIISLFIIGSILVGGSILLSAFSSRLGIPILVIFLAIGMLAGIDGLGGIAFDNYPV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
AYLISNLALAVILLDGGMRTRATAFRVALWPSLSLATVGVIITAGLTGIAAAWLFGLDKI
HHHHHHHHHEEEEECCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGMLIGAIVGSTDAAAVFSLLGDKGLNERVTSTLEIESGSNDPMAVFLTITLIAMIQNGQ
CCEEEEEEECCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCC
IHLDWLFLVHLIREFGLGVILGLGGGWLLQQVINRITLTNALYPLLAVSGGIMMFALTTA
EEEHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LEGSGILAVYLCGFVLGNRPIRNRYGILQTFDGMAWLSQICMFLALGLLVTPSDLWMIAI
CCCCCHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
PALILSLWLMLVARPLSIFVGLLPFRNYTTRERVFLSWVGLRGAVPIILAVFPMMAGLDN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
AHMYFNVAFFIVLISLLLQGTSLGFAARLAKVVVPPTASPISRVGMDIHPENPWEQFIYQ
CHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHH
LGEENWCVGAALRDLKMPRHTRIAALFRDNVLLHPTANTRLREGDVLCVIGRERDLPALG
HCCCCCCHHHHHHHCCCCCHHHHHHHHHCCEEEECCCCCEEECCCEEEEECCCCCCHHHH
RLFSQSPPVALDQRFFGDFILEASANLRDVSSIYGLEFAGEVDGELTLGQFVMALLGGGE
HHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCEECCCCCCCEEHHHHHHHHHCCCC
PVVGDNVVAEGVVWTIAEKDEQKVSKIGIKIADDPA
CCCCCCHHHCCEEEEECCCHHHHHHHCCCEECCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA