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The map label for this gene is patB [H]

Identifier: 85059228

GI number: 85059228

Start: 2112276

End: 2112890

Strand: Reverse

Name: patB [H]

Synonym: SG1250

Alternate gene names: 85059228

Gene position: 2112890-2112276 (Counterclockwise)

Preceding gene: 85059230

Following gene: 85059226

Centisome position: 50.65

GC content: 57.56

Gene sequence:

>615_bases
ATGGCATTCAACTTCGATGAATGTATCGACCGGCGTCACAGCGATAGCTATAAATGGCAAAAGTACGCTGGGCGAGATGT
CATTCCGCTGTGGGTGGCCGATACGGATTTCCGGTCGCCGCCCTGTATTCTCGAGGCGTTGCGCGCCCGTGTCGATCATG
GCATCTTTGGTTACGGAGCGCCGCCGACAGCGCTCAGCGAGATATTTATAGAACGGATGCGCGAGCGCTATCAGTGGGAC
GTCAAGGCGGAATGGCTGTTGTTTCTGCCGGGTCTGGTCAGCGGCCTGCATCTGGCGTTCCGCGCGGCCGTCCACAGCGC
CTGGCGCTGGTGCGTTGACTTCGCCGCCGCCGATCCGGCGCTTTCAGGCGACAAACTCCTGCTGATGCTTTGCAACCCCC
ATAATCCCGGCGGCACCTCCTATCGCCGCGAAGAGCTTATGCAGCATCTTGCCTTTGCACAAACGCACGATCTGCTGGTG
TGCTCCGATGAAATTCATTGTGATTTATTACTGACCCCGGGGCTACGCCATATCCCCTTCGCCTCCTTGAATGAGGATGC
GGCGCAGCATTACCCTTATTTCGCCTTCAAAAGAGCTTCAATATCGCCGGCCTAG

Upstream 100 bases:

>100_bases
GGTATACTACTCCTTTCTTGATGGCCCTCATCACTGGCATAGCACATTATGCCAGCAAACGGCGACGTTTTTCGTTTTTC
AATTGTGCAGGGAAATGACT

Downstream 100 bases:

>100_bases
GAGCGTCGGTGGCGGTCATCCCGAACCCACGTTTACGTATGAAATTCGCCGCACAGCGCGCGGGCGTGGTGCCGGTGGTG
GATGTCCTGGCGCTGTGGTC

Product: putative aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MAFNFDECIDRRHSDSYKWQKYAGRDVIPLWVADTDFRSPPCILEALRARVDHGIFGYGAPPTALSEIFIERMRERYQWD
VKAEWLLFLPGLVSGLHLAFRAAVHSAWRWCVDFAAADPALSGDKLLLMLCNPHNPGGTSYRREELMQHLAFAQTHDLLV
CSDEIHCDLLLTPGLRHIPFASLNEDAAQHYPYFAFKRASISPA

Sequences:

>Translated_204_residues
MAFNFDECIDRRHSDSYKWQKYAGRDVIPLWVADTDFRSPPCILEALRARVDHGIFGYGAPPTALSEIFIERMRERYQWD
VKAEWLLFLPGLVSGLHLAFRAAVHSAWRWCVDFAAADPALSGDKLLLMLCNPHNPGGTSYRREELMQHLAFAQTHDLLV
CSDEIHCDLLLTPGLRHIPFASLNEDAAQHYPYFAFKRASISPA
>Mature_203_residues
AFNFDECIDRRHSDSYKWQKYAGRDVIPLWVADTDFRSPPCILEALRARVDHGIFGYGAPPTALSEIFIERMRERYQWDV
KAEWLLFLPGLVSGLHLAFRAAVHSAWRWCVDFAAADPALSGDKLLLMLCNPHNPGGTSYRREELMQHLAFAQTHDLLVC
SDEIHCDLLLTPGLRHIPFASLNEDAAQHYPYFAFKRASISPA

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 23274; Mature: 23143

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFNFDECIDRRHSDSYKWQKYAGRDVIPLWVADTDFRSPPCILEALRARVDHGIFGYGA
CCCCHHHHHHHCCCCCCCHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC
PPTALSEIFIERMRERYQWDVKAEWLLFLPGLVSGLHLAFRAAVHSAWRWCVDFAAADPA
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LSGDKLLLMLCNPHNPGGTSYRREELMQHLAFAQTHDLLVCSDEIHCDLLLTPGLRHIPF
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCCCCC
ASLNEDAAQHYPYFAFKRASISPA
CCCCCHHHHHCCCCEEECCCCCCC
>Mature Secondary Structure 
AFNFDECIDRRHSDSYKWQKYAGRDVIPLWVADTDFRSPPCILEALRARVDHGIFGYGA
CCCHHHHHHHCCCCCCCHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC
PPTALSEIFIERMRERYQWDVKAEWLLFLPGLVSGLHLAFRAAVHSAWRWCVDFAAADPA
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LSGDKLLLMLCNPHNPGGTSYRREELMQHLAFAQTHDLLVCSDEIHCDLLLTPGLRHIPF
CCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCCCCCC
ASLNEDAAQHYPYFAFKRASISPA
CCCCCHHHHHCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]