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The map label for this gene is ltaE [H]

Identifier: 85059076

GI number: 85059076

Start: 1819108

End: 1819737

Strand: Reverse

Name: ltaE [H]

Synonym: SG1098

Alternate gene names: 85059076

Gene position: 1819737-1819108 (Counterclockwise)

Preceding gene: 85059077

Following gene: 85059075

Centisome position: 43.63

GC content: 58.57

Gene sequence:

>630_bases
ATGATTGATTTACGCAGTGATACCGTGACTCTGCACACCGACGCAATACGTCAGGCAATGGCCGCCGCTGACGTCGGCGA
TGATGTTTATGGGGACGATCCCACGGTTGCGGCGCTGAAGGCCGATGGCGCGCGACTGGCCGCTAAAGAGGCCGCGCTGT
TTTTTCCCAGCGGTACCCAGGCCAATCTGGTGGCGTTATTGACCCACTGTCAGCGCGGCGAGGAGTATATCGTCGGGCAG
AAGGCCCATAATTATCTGTTCGAGGCGGGCGGCACCGCGGTGCTCGGCAGTATACAGCCGCAGCCGCTGGATTTTGCCGA
TGACGCCACGCTGCCGCTTGATACGGTGTCTGCCGCCATTAAACCGGACGATTTCCATTTCGCCCGCACGCTGTTGCTCA
GTCTGGAAAACACCCATAACGGCAAGGTCGTTCCCCAGGATTATCTGCGTCAGGCGTGGGAATTGACCCGCGAATGGCAG
CTCTCGCTGTATATCGACGGTGCGCGAGTCTTTAACACCGCGGTGGCGCAGGGCATTCCGCTGAGCGAAATCAGCCAATA
CTGCGAATACGCTGACCATTTGCCTTTCCAAAGGATTGGGTGCCCCGGTAGGATCCCTTTTGTGCGGTAG

Upstream 100 bases:

>100_bases
GCCAAAACCAACTGGCTGCGTTAAGCGCCGGCTGGAATGCTGTTTCCCTGCGCCGGCCCGTCAAAACAGCCGCAAGCCCA
ATACGCAGGATGGAATTAGC

Downstream 100 bases:

>100_bases
CGAAGCCTATATCGCAGGCGCCAGACGCTGGCGGAAAATGGTGGGCGGCGGTATGCGTCAGGCGGGTATCCTGGCCGCCG
GCGCCCGCTACGCGCTGGCG

Product: putative L-allo-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MIDLRSDTVTLHTDAIRQAMAAADVGDDVYGDDPTVAALKADGARLAAKEAALFFPSGTQANLVALLTHCQRGEEYIVGQ
KAHNYLFEAGGTAVLGSIQPQPLDFADDATLPLDTVSAAIKPDDFHFARTLLLSLENTHNGKVVPQDYLRQAWELTREWQ
LSLYIDGARVFNTAVAQGIPLSEISQYCEYADHLPFQRIGCPGRIPFVR

Sequences:

>Translated_209_residues
MIDLRSDTVTLHTDAIRQAMAAADVGDDVYGDDPTVAALKADGARLAAKEAALFFPSGTQANLVALLTHCQRGEEYIVGQ
KAHNYLFEAGGTAVLGSIQPQPLDFADDATLPLDTVSAAIKPDDFHFARTLLLSLENTHNGKVVPQDYLRQAWELTREWQ
LSLYIDGARVFNTAVAQGIPLSEISQYCEYADHLPFQRIGCPGRIPFVR
>Mature_209_residues
MIDLRSDTVTLHTDAIRQAMAAADVGDDVYGDDPTVAALKADGARLAAKEAALFFPSGTQANLVALLTHCQRGEEYIVGQ
KAHNYLFEAGGTAVLGSIQPQPLDFADDATLPLDTVSAAIKPDDFHFARTLLLSLENTHNGKVVPQDYLRQAWELTREWQ
LSLYIDGARVFNTAVAQGIPLSEISQYCEYADHLPFQRIGCPGRIPFVR

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=202, Percent_Identity=67.8217821782178, Blast_Score=284, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI193206522, Length=204, Percent_Identity=41.1764705882353, Blast_Score=162, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI193206520, Length=204, Percent_Identity=41.1764705882353, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI193206524, Length=204, Percent_Identity=41.1764705882353, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320789, Length=219, Percent_Identity=36.986301369863, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355439, Length=197, Percent_Identity=43.6548223350254, Blast_Score=152, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 22844; Mature: 22844

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLRSDTVTLHTDAIRQAMAAADVGDDVYGDDPTVAALKADGARLAAKEAALFFPSGTQ
CCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHCCEEEECCCCCC
ANLVALLTHCQRGEEYIVGQKAHNYLFEAGGTAVLGSIQPQPLDFADDATLPLDTVSAAI
HHHHHHHHHHHCCCCEEECCHHHHHEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHC
KPDDFHFARTLLLSLENTHNGKVVPQDYLRQAWELTREWQLSLYIDGARVFNTAVAQGIP
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHCCCC
LSEISQYCEYADHLPFQRIGCPGRIPFVR
HHHHHHHHHHHHCCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MIDLRSDTVTLHTDAIRQAMAAADVGDDVYGDDPTVAALKADGARLAAKEAALFFPSGTQ
CCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHCCEEEECCCCCC
ANLVALLTHCQRGEEYIVGQKAHNYLFEAGGTAVLGSIQPQPLDFADDATLPLDTVSAAI
HHHHHHHHHHHCCCCEEECCHHHHHEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHC
KPDDFHFARTLLLSLENTHNGKVVPQDYLRQAWELTREWQLSLYIDGARVFNTAVAQGIP
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHCCCC
LSEISQYCEYADHLPFQRIGCPGRIPFVR
HHHHHHHHHHHHCCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]