Click here to switch to the map view.

The map label for this gene is cyoE

Identifier: 85058641

GI number: 85058641

Start: 1126745

End: 1127635

Strand: Reverse

Name: cyoE

Synonym: SG0663

Alternate gene names: 85058641

Gene position: 1127635-1126745 (Counterclockwise)

Preceding gene: 85058642

Following gene: 85058640

Centisome position: 27.03

GC content: 53.09

Gene sequence:

>891_bases
ATGATTAAGCAATACCTGCAAGTAACAAAACCAGGAATTATTTTCGGTAATCTAATTTCTGTCATCGGGGGCTTCTTGCT
GGCCGCAAAGGGCCAGATTGATTATGCCCTGTTTCTCGCCACGCTGCTCGGTGTGTCGCTGGTGGTCGCCTCGGGTTGTG
TGTTTAACAACTATATCGATCGCGATATCGACCGGAAAATGGAAAGGACCAAAAACAGGGTCCTGGTGAAAGGATTAATT
TCTCCGAAAGTCAGTCTGGTTTACGCTACGGTGCTGGGTATTGCCGGTTTTGCGTTGTTGTATCTGGCGGCGAATCCGCT
GGCCATGTGGCTGGCGGTGATGGGCTTTGTCGTCTATGTCGGCGTGTACAGCCTGTATATGAAGCGCAAATCCGTCTACG
GTACGCTTATCGGCAGTTTGTCCGGCGCCGCGCCGCCGGTCATCGGTTACTGCGCCGTCAGCGACGGGTTCGACACCGGC
GCACTGATTCTGCTGCTGATCTTCAGTCTGTGGCAAATGCCTCATTCCTATGCCATTGCCATTTTCCGCTTCAAGGACTA
TCAGGCAGCGTCGATTCCGGTCTTACCGGTCAAACGCGGTATTTCGGTCACGAAACACCACATCACCCTGTATATCATCG
GGTTCATGGTGGCCACGCTGATGCTGACGTTGAGCGGTTATGCCGGCTACAAATACCTGATCGTCGCCGCCTCGGTAAGC
GTTTGGTGGCTGGGCATGGCGTTGCAGGGCTATAAATCAGCCAATGACGATAAAGTGTGGGCGCGCAAGCTGTTCATTTT
CTCGATCGTGGCCATCAACTCGTTGAGCGTGATGATGTCGGTAGACTTCATGGTGCCGTCCGCCAACAACCTGCTCACTT
ACCTCGGGTAA

Upstream 100 bases:

>100_bases
GTTTGCGGTGATGATCATCGCCATCCTGGTAGTCGGCTCCTTGTGGATTATGTGGTACCTCAATCACAACTTGATGGGCC
ACTAACAGAGCACAACGGTA

Downstream 100 bases:

>100_bases
CCCTCGGGGTTACCCGTTCCGGCAGGGCGCACGCCCTGCCCTCTTTCTCACCTTTCACTTCATTAACCGCCAGGGCGTTA
AACGCTTTCCGGTGCCGTGC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MIKQYLQVTKPGIIFGNLISVIGGFLLAAKGQIDYALFLATLLGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLI
SPKVSLVYATVLGIAGFALLYLAANPLAMWLAVMGFVVYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVSDGFDTG
ALILLLIFSLWQMPHSYAIAIFRFKDYQAASIPVLPVKRGISVTKHHITLYIIGFMVATLMLTLSGYAGYKYLIVAASVS
VWWLGMALQGYKSANDDKVWARKLFIFSIVAINSLSVMMSVDFMVPSANNLLTYLG

Sequences:

>Translated_296_residues
MIKQYLQVTKPGIIFGNLISVIGGFLLAAKGQIDYALFLATLLGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLI
SPKVSLVYATVLGIAGFALLYLAANPLAMWLAVMGFVVYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVSDGFDTG
ALILLLIFSLWQMPHSYAIAIFRFKDYQAASIPVLPVKRGISVTKHHITLYIIGFMVATLMLTLSGYAGYKYLIVAASVS
VWWLGMALQGYKSANDDKVWARKLFIFSIVAINSLSVMMSVDFMVPSANNLLTYLG
>Mature_296_residues
MIKQYLQVTKPGIIFGNLISVIGGFLLAAKGQIDYALFLATLLGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLI
SPKVSLVYATVLGIAGFALLYLAANPLAMWLAVMGFVVYVGVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVSDGFDTG
ALILLLIFSLWQMPHSYAIAIFRFKDYQAASIPVLPVKRGISVTKHHITLYIIGFMVATLMLTLSGYAGYKYLIVAASVS
VWWLGMALQGYKSANDDKVWARKLFIFSIVAINSLSVMMSVDFMVPSANNLLTYLG

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=168, Percent_Identity=36.3095238095238, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786631, Length=292, Percent_Identity=84.2465753424658, Blast_Score=490, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71998235, Length=233, Percent_Identity=30.0429184549356, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325085, Length=191, Percent_Identity=29.3193717277487, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921064, Length=274, Percent_Identity=27.7372262773723, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYOE_SODGM (Q2NV87)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454343.1
- STRING:   Q2NV87
- GeneID:   3868009
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG0663
- NMPDR:   fig|343509.6.peg.1457
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- ProtClustDB:   PRK04375
- BioCyc:   SGLO343509:SG0663-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32307; Mature: 32307

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xdfdc5e8)-; HASH(0xcae4b20)-; HASH(0xd6f08b4)-; HASH(0xddb8ef8)-; HASH(0xdf51738)-; HASH(0xc216914)-; HASH(0xd6f09c8)-; HASH(0xcb626a0)-; HASH(0xc2168d8)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQYLQVTKPGIIFGNLISVIGGFLLAAKGQIDYALFLATLLGVSLVVASGCVFNNYID
CCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RDIDRKMERTKNRVLVKGLISPKVSLVYATVLGIAGFALLYLAANPLAMWLAVMGFVVYV
HHHHHHHHHHHHHEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVSDGFDTGALILLLIFSLWQMPHSYAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEE
IFRFKDYQAASIPVLPVKRGISVTKHHITLYIIGFMVATLMLTLSGYAGYKYLIVAASVS
EEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHH
VWWLGMALQGYKSANDDKVWARKLFIFSIVAINSLSVMMSVDFMVPSANNLLTYLG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEECH
>Mature Secondary Structure
MIKQYLQVTKPGIIFGNLISVIGGFLLAAKGQIDYALFLATLLGVSLVVASGCVFNNYID
CCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
RDIDRKMERTKNRVLVKGLISPKVSLVYATVLGIAGFALLYLAANPLAMWLAVMGFVVYV
HHHHHHHHHHHHHEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GVYSLYMKRKSVYGTLIGSLSGAAPPVIGYCAVSDGFDTGALILLLIFSLWQMPHSYAIA
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEE
IFRFKDYQAASIPVLPVKRGISVTKHHITLYIIGFMVATLMLTLSGYAGYKYLIVAASVS
EEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHH
VWWLGMALQGYKSANDDKVWARKLFIFSIVAINSLSVMMSVDFMVPSANNLLTYLG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA