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The map label for this gene is ispA [H]

Identifier: 85058635

GI number: 85058635

Start: 1119858

End: 1120760

Strand: Reverse

Name: ispA [H]

Synonym: SG0657

Alternate gene names: 85058635

Gene position: 1120760-1119858 (Counterclockwise)

Preceding gene: 85058636

Following gene: 85058634

Centisome position: 26.87

GC content: 62.46

Gene sequence:

>903_bases
ATGACTGATTTCGCGCGCGCGCTTGAAAATAGCCGCCAGCAAGTGGACGCGGCGCTGGAACGTTATCTCAGCGTCCTCGC
CAATCCGCAGGCTCCCCTTATCCAGGCCATGCGCCACGGCGCTTTGCTGGGGGGCAAACGGCTGCGCCCGTTCCTGGTGT
ACCAGACCGGCCGGTTGTTCGGGCTTACAGCCGCAAGCCTTGACGCGCCGGCCGCCGCGATTGAGTGTATCCATGCCTAT
TCTCTGATTCATGACGATCTGCCGGCAATGGATAATGATGCGCTGCGCCGCGGGTTACCGACCTGCCACGTCAAATTCGG
CGAAACGACCGCCATTCTGGCCGGCGATGCACTGCAGACGCTGGCCTTCAGCATTCTGGCCGACGTGGAGATGCCGAAGG
TGTCGCCACAGGATCGGCTACAAATGATCTCGGCGCTGGCCGCCGCCAGCGGCGCCGACGGTATGTGTCTTGGACAGGCG
CTGGATTTAGAGGCCGAGGGGCAGCAGGTCTCCGCCGCGCGCCTCGAGACGATTCACCGCCACAAGACAGGCGCGCTTAT
CCGCTCGGCGGTTCGGATGGGTGTTCTGGCGGCCGGGGAACGCGGCGGACCGGCGCTGCGCTATCTCGATCGTTTCGCCG
CCGCCATCGGCCTGGCTTTCCAGGTACAGGACGACATTCTTGATGTCGTGGGCGACAGCCAGACCACCGGCAAACGACAG
GGAGCGGACCAAGCATTGGGTAAAAGCACCTATCCGGCCCTGCTGGGACTGGACATGGCGCGGGCCAAGGCTCAGGATCT
GTATCATGAATCCCTGGCGTCCTTAGAATGTGTCGCCGCGCTCGGTTATGATACCGCCACGCTGATGGCGCTGGCGCGCT
ATATTATTGAACGTGACAAATAA

Upstream 100 bases:

>100_bases
GTCAGAAAACCCTGCAACAGGCAGAACAGCGGGTGCAGATTCTGCTAAACGATACGCCAGACGCCCCGCTCGCTCCCTTT
GCGCCGGAAAATGATGCGCT

Downstream 100 bases:

>100_bases
GTGATGCGGTTTTTTACACCTCAGATATGAGTACCCCATGAGCCTTGATATCAAAAAGTATCCGACGCTGGTCCTAGCCG
ACAATCCTATGGAACTGCGT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTDFARALENSRQQVDAALERYLSVLANPQAPLIQAMRHGALLGGKRLRPFLVYQTGRLFGLTAASLDAPAAAIECIHAY
SLIHDDLPAMDNDALRRGLPTCHVKFGETTAILAGDALQTLAFSILADVEMPKVSPQDRLQMISALAAASGADGMCLGQA
LDLEAEGQQVSAARLETIHRHKTGALIRSAVRMGVLAAGERGGPALRYLDRFAAAIGLAFQVQDDILDVVGDSQTTGKRQ
GADQALGKSTYPALLGLDMARAKAQDLYHESLASLECVAALGYDTATLMALARYIIERDK

Sequences:

>Translated_300_residues
MTDFARALENSRQQVDAALERYLSVLANPQAPLIQAMRHGALLGGKRLRPFLVYQTGRLFGLTAASLDAPAAAIECIHAY
SLIHDDLPAMDNDALRRGLPTCHVKFGETTAILAGDALQTLAFSILADVEMPKVSPQDRLQMISALAAASGADGMCLGQA
LDLEAEGQQVSAARLETIHRHKTGALIRSAVRMGVLAAGERGGPALRYLDRFAAAIGLAFQVQDDILDVVGDSQTTGKRQ
GADQALGKSTYPALLGLDMARAKAQDLYHESLASLECVAALGYDTATLMALARYIIERDK
>Mature_299_residues
TDFARALENSRQQVDAALERYLSVLANPQAPLIQAMRHGALLGGKRLRPFLVYQTGRLFGLTAASLDAPAAAIECIHAYS
LIHDDLPAMDNDALRRGLPTCHVKFGETTAILAGDALQTLAFSILADVEMPKVSPQDRLQMISALAAASGADGMCLGQAL
DLEAEGQQVSAARLETIHRHKTGALIRSAVRMGVLAAGERGGPALRYLDRFAAAIGLAFQVQDDILDVVGDSQTTGKRQG
ADQALGKSTYPALLGLDMARAKAQDLYHESLASLECVAALGYDTATLMALARYIIERDK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=222, Percent_Identity=31.5315315315315, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786623, Length=298, Percent_Identity=66.1073825503356, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1789578, Length=217, Percent_Identity=29.9539170506912, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17505681, Length=188, Percent_Identity=29.2553191489362, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651612, Length=185, Percent_Identity=29.1891891891892, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31998; Mature: 31867

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFARALENSRQQVDAALERYLSVLANPQAPLIQAMRHGALLGGKRLRPFLVYQTGRLF
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEE
GLTAASLDAPAAAIECIHAYSLIHDDLPAMDNDALRRGLPTCHVKFGETTAILAGDALQT
EEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCEEEEEEHHHHHH
LAFSILADVEMPKVSPQDRLQMISALAAASGADGMCLGQALDLEAEGQQVSAARLETIHR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHH
HKTGALIRSAVRMGVLAAGERGGPALRYLDRFAAAIGLAFQVQDDILDVVGDSQTTGKRQ
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GADQALGKSTYPALLGLDMARAKAQDLYHESLASLECVAALGYDTATLMALARYIIERDK
CHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDFARALENSRQQVDAALERYLSVLANPQAPLIQAMRHGALLGGKRLRPFLVYQTGRLF
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEE
GLTAASLDAPAAAIECIHAYSLIHDDLPAMDNDALRRGLPTCHVKFGETTAILAGDALQT
EEEHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCEEEEEEHHHHHH
LAFSILADVEMPKVSPQDRLQMISALAAASGADGMCLGQALDLEAEGQQVSAARLETIHR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHH
HKTGALIRSAVRMGVLAAGERGGPALRYLDRFAAAIGLAFQVQDDILDVVGDSQTTGKRQ
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GADQALGKSTYPALLGLDMARAKAQDLYHESLASLECVAALGYDTATLMALARYIIERDK
CHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2089044; 9278503 [H]