Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 85058603

GI number: 85058603

Start: 1068378

End: 1069223

Strand: Reverse

Name: fabG [C]

Synonym: SG0625

Alternate gene names: 85058603

Gene position: 1069223-1068378 (Counterclockwise)

Preceding gene: 85058605

Following gene: 85058600

Centisome position: 25.63

GC content: 58.87

Gene sequence:

>846_bases
ATGGCCGGCAGCGAGGCTTACGCCGAAACCCAGCCGACCCTTGTCCTCAACGAATCATCACACCATAGCAAAACCCCGAC
AGTGCCGGCAATGGCGCAAAAAATGATCGATGCCCCTTGCGAGACACTCGTCGGCAAGCGGCGCACCGCGCCGCCCTATA
ACAGTTTTTTATTGGAGAAGACAATTATATCAACGTTTCTTTCTACGCCCGATGAAGTGGCTGGCAAAGTGGTGTTGGTC
ACCAGCGCCGCCAGCGGTATCGACCGCAGCATCGCCGAGTTGATGCATCAGCGCGGCGCCCGGGTTATCGCAGAAGATGT
TCAGCCAGAGGTCAACCAGCTTGCCGCCGAAAGCCTGGTCCCGCTGGTGGCCGACATCATCGCCGATGGCGCGGCGGAGC
AGGCGGTGGCCCTGGCCCAGAATGCCTTCGGCCGATTGGACGTCCTGGTTAACTGTGCGGGACGGATCCTTTATAAGCCG
CTGATCGACATAACCCGCGAAGAATGGCACTGGCAGATGGAAACCAACGTTACCGGCGCGTTTCTGCATTCCCGCGAGGC
GATGAAAGCAATAATGCCGCAGCGCAGCGGCGCCATTGTCAATGTCAACATTGCGTCTTATGCCGCCTATTTCGCCTTTC
CCGGCATCGCTGCGTATACCGCCTCCAAAGGCGCGCTGGTACAGCTGAACCGCACCCAGGCGCTGGAAACGATTGCCCAC
GGTATCCGGGTCAATGCTATCGGCGTCGGCAACGTCGTGACCAATATCATCAATCACTTCCGCGAAGACGGGCGGGAATT
TCTTGCCGAACACGGACGCAATGCCCCCATAGGCCGGGCGGCATAA

Upstream 100 bases:

>100_bases
GTCCAGTCGGCGAGGGGTAAGGCGACTTGCTGATAATCATCAAGAATGGCGCAACTTAGGGTCATGGCAGCTCTCTCTGG
TGACAGCAGCAGGGGGAACG

Downstream 100 bases:

>100_bases
GCGTAGAGATAGGCTAACGCCTGCCCTATGGCGCGCTATTGCCGGTAATGGCTGGGTGACAGTCCGACTTCACGCCGGAA
TATCTGCGAGAAATGGCCGG

Product: putative dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MAGSEAYAETQPTLVLNESSHHSKTPTVPAMAQKMIDAPCETLVGKRRTAPPYNSFLLEKTIISTFLSTPDEVAGKVVLV
TSAASGIDRSIAELMHQRGARVIAEDVQPEVNQLAAESLVPLVADIIADGAAEQAVALAQNAFGRLDVLVNCAGRILYKP
LIDITREEWHWQMETNVTGAFLHSREAMKAIMPQRSGAIVNVNIASYAAYFAFPGIAAYTASKGALVQLNRTQALETIAH
GIRVNAIGVGNVVTNIINHFREDGREFLAEHGRNAPIGRAA

Sequences:

>Translated_281_residues
MAGSEAYAETQPTLVLNESSHHSKTPTVPAMAQKMIDAPCETLVGKRRTAPPYNSFLLEKTIISTFLSTPDEVAGKVVLV
TSAASGIDRSIAELMHQRGARVIAEDVQPEVNQLAAESLVPLVADIIADGAAEQAVALAQNAFGRLDVLVNCAGRILYKP
LIDITREEWHWQMETNVTGAFLHSREAMKAIMPQRSGAIVNVNIASYAAYFAFPGIAAYTASKGALVQLNRTQALETIAH
GIRVNAIGVGNVVTNIINHFREDGREFLAEHGRNAPIGRAA
>Mature_280_residues
AGSEAYAETQPTLVLNESSHHSKTPTVPAMAQKMIDAPCETLVGKRRTAPPYNSFLLEKTIISTFLSTPDEVAGKVVLVT
SAASGIDRSIAELMHQRGARVIAEDVQPEVNQLAAESLVPLVADIIADGAAEQAVALAQNAFGRLDVLVNCAGRILYKPL
IDITREEWHWQMETNVTGAFLHSREAMKAIMPQRSGAIVNVNIASYAAYFAFPGIAAYTASKGALVQLNRTQALETIAHG
IRVNAIGVGNVVTNIINHFREDGREFLAEHGRNAPIGRAA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=210, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI19923817, Length=223, Percent_Identity=24.2152466367713, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI7705925, Length=186, Percent_Identity=32.7956989247312, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI32483357, Length=202, Percent_Identity=32.6732673267327, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4504505, Length=194, Percent_Identity=31.4432989690722, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI126723191, Length=196, Percent_Identity=33.1632653061224, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4758504, Length=213, Percent_Identity=31.4553990610329, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI66933014, Length=183, Percent_Identity=29.5081967213115, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI126723750, Length=209, Percent_Identity=28.7081339712919, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI83715985, Length=171, Percent_Identity=32.1637426900585, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI10190704, Length=197, Percent_Identity=29.9492385786802, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=195, Percent_Identity=31.7948717948718, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082100, Length=221, Percent_Identity=29.4117647058824, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082160, Length=190, Percent_Identity=30.5263157894737, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788459, Length=199, Percent_Identity=32.6633165829146, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790717, Length=214, Percent_Identity=30.3738317757009, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1786812, Length=188, Percent_Identity=32.4468085106383, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789208, Length=207, Percent_Identity=29.4685990338164, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI2367175, Length=209, Percent_Identity=33.9712918660287, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786701, Length=196, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789378, Length=214, Percent_Identity=27.1028037383178, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=198, Percent_Identity=31.8181818181818, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=208, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=234, Percent_Identity=32.4786324786325, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=201, Percent_Identity=29.8507462686567, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=191, Percent_Identity=29.8429319371728, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=196, Percent_Identity=32.1428571428571, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=191, Percent_Identity=30.3664921465969, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=213, Percent_Identity=24.8826291079812, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=196, Percent_Identity=30.1020408163265, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=195, Percent_Identity=31.2820512820513, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=235, Percent_Identity=27.6595744680851, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=232, Percent_Identity=28.8793103448276, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=198, Percent_Identity=29.2929292929293, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=204, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=196, Percent_Identity=28.0612244897959, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=199, Percent_Identity=30.1507537688442, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=195, Percent_Identity=29.2307692307692, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=196, Percent_Identity=29.5918367346939, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=225, Percent_Identity=27.1111111111111, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=190, Percent_Identity=32.6315789473684, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=220, Percent_Identity=35.9090909090909, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24643142, Length=189, Percent_Identity=32.8042328042328, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737361, Length=208, Percent_Identity=32.6923076923077, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644339, Length=219, Percent_Identity=31.5068493150685, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571526, Length=189, Percent_Identity=32.8042328042328, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859837, Length=188, Percent_Identity=29.7872340425532, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357041, Length=189, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639444, Length=215, Percent_Identity=29.7674418604651, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=203, Percent_Identity=29.064039408867, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30193; Mature: 30062

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSEAYAETQPTLVLNESSHHSKTPTVPAMAQKMIDAPCETLVGKRRTAPPYNSFLLEK
CCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHH
TIISTFLSTPDEVAGKVVLVTSAASGIDRSIAELMHQRGARVIAEDVQPEVNQLAAESLV
HHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHH
PLVADIIADGAAEQAVALAQNAFGRLDVLVNCAGRILYKPLIDITREEWHWQMETNVTGA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHH
FLHSREAMKAIMPQRSGAIVNVNIASYAAYFAFPGIAAYTASKGALVQLNRTQALETIAH
HHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCHHHHCCCCCCEEEECHHHHHHHHHC
GIRVNAIGVGNVVTNIINHFREDGREFLAEHGRNAPIGRAA
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AGSEAYAETQPTLVLNESSHHSKTPTVPAMAQKMIDAPCETLVGKRRTAPPYNSFLLEK
CCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHH
TIISTFLSTPDEVAGKVVLVTSAASGIDRSIAELMHQRGARVIAEDVQPEVNQLAAESLV
HHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHH
PLVADIIADGAAEQAVALAQNAFGRLDVLVNCAGRILYKPLIDITREEWHWQMETNVTGA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHH
FLHSREAMKAIMPQRSGAIVNVNIASYAAYFAFPGIAAYTASKGALVQLNRTQALETIAH
HHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHCCCHHHHCCCCCCEEEECHHHHHHHHHC
GIRVNAIGVGNVVTNIINHFREDGREFLAEHGRNAPIGRAA
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]