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The map label for this gene is pepD [H]

Identifier: 85058575

GI number: 85058575

Start: 1007306

End: 1008766

Strand: Reverse

Name: pepD [H]

Synonym: SG0597

Alternate gene names: 85058575

Gene position: 1008766-1007306 (Counterclockwise)

Preceding gene: 85058584

Following gene: 85058572

Centisome position: 24.18

GC content: 59.69

Gene sequence:

>1461_bases
GTGTCTGAATTGTCTCAACTTACGCCGCAGCCGCTGTGGGATCTTTTCGCCAACATTTGTTCAATCCCACATCCGTCCTA
CCATGAGGAAGCGCTGGCAGTGCACATCGTGCAGTGGGCGCAGGACAAGGGCCTGTTCGCCGAACGAGACCAGGTAGGCA
ATATCCTCATCCGCAAGCCGGCGACGCCGGGTTACGAAAATCGCCGTCCAGTGGCGATGCAGGCGCATCTGGATATGGTG
CCGCAGAAAAACAGCGATACCCAGCATGATTTCACCCGGGATCCCATCAAGCCCTGGGTAGACGGCGAATGGGTCAAGGC
ACGCGGCACCACGCTCGGCGCCGATAACGGCATCGGCATGGCGTCAGCGCTGGCGGTGCTGGCCGACGACAGCCTGGAGC
ATGGTCCGCTGGAAGTGCTGCTGACCATGACCGAGGAAACCGGTATGGAGGGCGCTTTCGGGCTGCAGCCCGGCTGGCTG
CAGAGCGAGATCCTCATCAATACCGATTCCGAAGAGGAAGGCGAGATTTATATGGGCTGCGCCGGCGGCGTTGACTTCAA
GACCCAGCTGCCGATTAGCCGCGAGGCAATACCGGCCGGGTATCACACGTTGCGGGTGGCGCTGACCGGCTTGAAGGGCG
GCCATTCCGGCGCCAATATCCATCTGGGTCTCGGCAACGCCAATAAGTTGCTGGCTCGCTTCCTGGCAGATTTCTGCGCC
ACGCTGGACATCCGTCTGCTGGATTTGCACGGCGGGACACTGCGCAATGCCATTCCGCGCGAAGCATTCGCCGTTCTGGC
GCTGCCGCAGGAAAACGTCGACAGCTTGCGTCTCCAGGCGCGCACCTTTCTGAGCACCATCGAAAGCGAACTGACGGCGG
TCGAGAAAAAACCAGCGCTTGACGTTAGCGATAGCCAGCCCGGCGAACAGGCGCTGACCAAAGCCTGCAGCGACCGGCTT
ATCGCGTTGCTCCATGCCATGCCGAACGGCGTCATCCGCATGAGCGATGATGTAAAAGGCGTTGTGGAAACGTCGCTGAA
CGTTGGCGTCGTGTCGATAAAGGCCGACAAAGCCGAAATCCGCTGCCTGATCCGCTCGCTTATCGACAGCGGCAAACTAC
AGGTGGAAGGGATGATGCATGCGCTGGGGCGACTGGCCGGCGCGACCACCTTCGCCAAAGGCAGCTATCCGGGCTGGAAG
CCAGACGCTAACTCGCCGGTGATACACTTGGTGCGCGATATTTACCGGCAGCTGTTTGACAAAATGCCCAACATTCAGGT
GATTCATGCGGGTCTGGAATGCGGGCTGTTCAAAAAACCCTATCCCGAGATGGATATGGTCTCCATCGGGCCGACCATTA
CCGGCCCGCATTCGCCGGATGAGCAAGTCCATATCGCGAGCGTCGGCCAATACTGGAAGCTGCTGACCGCGCTGCTGAAA
GCGATTCCCGTCAAGAAATAA

Upstream 100 bases:

>100_bases
GGTAAAGTAAAGTGATATCCTTGGTACACCAGGGTTGCGCCGCCGCCGGCCGCTCACCGCCGCCAGCGCGGTTTTTACGA
TATCACAGGAGTTTTTTATC

Downstream 100 bases:

>100_bases
ACCAGACCGGCGCTGGCCTTTTGGCCGGCGCCGCAACGAGACAGCCTCCCCACCGCCGTTAGGCCCACCGCGTCATTCTC
TTCTACGTGGCTCATCAGCC

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSELSQLTPQPLWDLFANICSIPHPSYHEEALAVHIVQWAQDKGLFAERDQVGNILIRKPATPGYENRRPVAMQAHLDMV
PQKNSDTQHDFTRDPIKPWVDGEWVKARGTTLGADNGIGMASALAVLADDSLEHGPLEVLLTMTEETGMEGAFGLQPGWL
QSEILINTDSEEEGEIYMGCAGGVDFKTQLPISREAIPAGYHTLRVALTGLKGGHSGANIHLGLGNANKLLARFLADFCA
TLDIRLLDLHGGTLRNAIPREAFAVLALPQENVDSLRLQARTFLSTIESELTAVEKKPALDVSDSQPGEQALTKACSDRL
IALLHAMPNGVIRMSDDVKGVVETSLNVGVVSIKADKAEIRCLIRSLIDSGKLQVEGMMHALGRLAGATTFAKGSYPGWK
PDANSPVIHLVRDIYRQLFDKMPNIQVIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIASVGQYWKLLTALLK
AIPVKK

Sequences:

>Translated_486_residues
MSELSQLTPQPLWDLFANICSIPHPSYHEEALAVHIVQWAQDKGLFAERDQVGNILIRKPATPGYENRRPVAMQAHLDMV
PQKNSDTQHDFTRDPIKPWVDGEWVKARGTTLGADNGIGMASALAVLADDSLEHGPLEVLLTMTEETGMEGAFGLQPGWL
QSEILINTDSEEEGEIYMGCAGGVDFKTQLPISREAIPAGYHTLRVALTGLKGGHSGANIHLGLGNANKLLARFLADFCA
TLDIRLLDLHGGTLRNAIPREAFAVLALPQENVDSLRLQARTFLSTIESELTAVEKKPALDVSDSQPGEQALTKACSDRL
IALLHAMPNGVIRMSDDVKGVVETSLNVGVVSIKADKAEIRCLIRSLIDSGKLQVEGMMHALGRLAGATTFAKGSYPGWK
PDANSPVIHLVRDIYRQLFDKMPNIQVIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIASVGQYWKLLTALLK
AIPVKK
>Mature_485_residues
SELSQLTPQPLWDLFANICSIPHPSYHEEALAVHIVQWAQDKGLFAERDQVGNILIRKPATPGYENRRPVAMQAHLDMVP
QKNSDTQHDFTRDPIKPWVDGEWVKARGTTLGADNGIGMASALAVLADDSLEHGPLEVLLTMTEETGMEGAFGLQPGWLQ
SEILINTDSEEEGEIYMGCAGGVDFKTQLPISREAIPAGYHTLRVALTGLKGGHSGANIHLGLGNANKLLARFLADFCAT
LDIRLLDLHGGTLRNAIPREAFAVLALPQENVDSLRLQARTFLSTIESELTAVEKKPALDVSDSQPGEQALTKACSDRLI
ALLHAMPNGVIRMSDDVKGVVETSLNVGVVSIKADKAEIRCLIRSLIDSGKLQVEGMMHALGRLAGATTFAKGSYPGWKP
DANSPVIHLVRDIYRQLFDKMPNIQVIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIASVGQYWKLLTALLKA
IPVKK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=70.5154639175258, Blast_Score=717, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52878; Mature: 52747

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSQLTPQPLWDLFANICSIPHPSYHEEALAVHIVQWAQDKGLFAERDQVGNILIRKP
CCCHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCEEEECC
ATPGYENRRPVAMQAHLDMVPQKNSDTQHDFTRDPIKPWVDGEWVKARGTTLGADNGIGM
CCCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCH
ASALAVLADDSLEHGPLEVLLTMTEETGMEGAFGLQPGWLQSEILINTDSEEEGEIYMGC
HHHHHHHHCCCCCCCCEEEEEEECHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEE
AGGVDFKTQLPISREAIPAGYHTLRVALTGLKGGHSGANIHLGLGNANKLLARFLADFCA
CCCCCCEECCCCCCCCCCCCHHEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHH
TLDIRLLDLHGGTLRNAIPREAFAVLALPQENVDSLRLQARTFLSTIESELTAVEKKPAL
HCCEEEEEECCCHHHHCCCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DVSDSQPGEQALTKACSDRLIALLHAMPNGVIRMSDDVKGVVETSLNVGVVSIKADKAEI
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCEEEEEECCHHHH
RCLIRSLIDSGKLQVEGMMHALGRLAGATTFAKGSYPGWKPDANSPVIHLVRDIYRQLFD
HHHHHHHHCCCCEEEHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KMPNIQVIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIASVGQYWKLLTALLK
HCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
AIPVKK
HCCCCC
>Mature Secondary Structure 
SELSQLTPQPLWDLFANICSIPHPSYHEEALAVHIVQWAQDKGLFAERDQVGNILIRKP
CCHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHCCEEEECC
ATPGYENRRPVAMQAHLDMVPQKNSDTQHDFTRDPIKPWVDGEWVKARGTTLGADNGIGM
CCCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCH
ASALAVLADDSLEHGPLEVLLTMTEETGMEGAFGLQPGWLQSEILINTDSEEEGEIYMGC
HHHHHHHHCCCCCCCCEEEEEEECHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEEEE
AGGVDFKTQLPISREAIPAGYHTLRVALTGLKGGHSGANIHLGLGNANKLLARFLADFCA
CCCCCCEECCCCCCCCCCCCHHEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHH
TLDIRLLDLHGGTLRNAIPREAFAVLALPQENVDSLRLQARTFLSTIESELTAVEKKPAL
HCCEEEEEECCCHHHHCCCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DVSDSQPGEQALTKACSDRLIALLHAMPNGVIRMSDDVKGVVETSLNVGVVSIKADKAEI
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCEEEEEECCHHHH
RCLIRSLIDSGKLQVEGMMHALGRLAGATTFAKGSYPGWKPDANSPVIHLVRDIYRQLFD
HHHHHHHHCCCCEEEHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KMPNIQVIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIASVGQYWKLLTALLK
HCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHH
AIPVKK
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]