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The map label for this gene is panC

Identifier: 85058465

GI number: 85058465

Start: 844640

End: 845494

Strand: Reverse

Name: panC

Synonym: SG0487

Alternate gene names: 85058465

Gene position: 845494-844640 (Counterclockwise)

Preceding gene: 85058466

Following gene: 85058464

Centisome position: 20.27

GC content: 60.12

Gene sequence:

>855_bases
GTGCTGATTATCGAAACGCCGCCAACACTGCGTCAGACGGTTAAACAGTGGAGTCAGGAGCATAAGCGTATCGCCCTGAT
CCCGACCATGGGAAATTTGCACGAAGGCCATATGGCGCTGATTGACGCCGGGCGCGCCCGCGCGGATAAAGTCGTGGTCA
GCGTGTTCGTCAACCCGATGCAGTTCGACCGGCCGGAAGATCTTGCGGCCTACCCGCGAACGCTTCAGGAGGACTGCGAA
CAGCTAACAAGGCGCGGCGTGGACATGGTCTTCGCACCGGCGACGGGGGTAATCTACCCCGACGATCTCGCCAGTCAGAC
CTTTGTCGATGTGCCCCGTTTCGCCAATATCCTGGAAGGTGAAAGCCGGCCGGGCCATTTCCGCGGCGTCGCCACCATTG
TCAGCAAGCTGTTTAATCTGGTTCAGCCGGACGTGGCCTGCTTCGGCGAAAAGGACTTTCAGCAACTGGCGTTTATTCGT
CAACTGGTGCGCGACATGAGCTATGATATCGAGATTATCGGCGTACCAACGGTGCGCGCCGCCGATGGGCTGGCGCTCAG
TTCGCGCAACGGTTATCTGAGCGCCGAGGAGCGCCGCCTGGCGCCGCAGCTCAATCAGGTGCTCATGCGGCTGGTGGCGC
AGTTGCGCGAAGGCGAACGCCACATTGATGGGTTGCTGACCTCAGCGACGGAACAACTGCTTCAGGCCGGGCTCAGGCCG
GATACATTGGTCATTCGCGACGCGCAGACCCTGCAGCCGCTGACGGTCGACAGTCGGCGAGCGGTGGTGTTATTCACCGC
CTGGCTGGGTAAGGCCCGGCTGATTGATAATGCGCAAGTGGATCTCATTTCATAA

Upstream 100 bases:

>100_bases
GCGGGGATATTGCCGCCGCCGTACGCCGCTACGTGCAAGAGGTCGAAACCGGCCAGTTTCCCGCGGCCGAACATAGCTTT
CAATGATGAAGGAGACTCCC

Downstream 100 bases:

>100_bases
CGGTTAAAAGGCTTAAGCTCATGCAACGCACGATGTTACGAGGCAAGCTACACCGGGTGCACGTCACCCAGGTGGATCTC
CATTACGAAGGTTCCTGCGC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLIIETPPTLRQTVKQWSQEHKRIALIPTMGNLHEGHMALIDAGRARADKVVVSVFVNPMQFDRPEDLAAYPRTLQEDCE
QLTRRGVDMVFAPATGVIYPDDLASQTFVDVPRFANILEGESRPGHFRGVATIVSKLFNLVQPDVACFGEKDFQQLAFIR
QLVRDMSYDIEIIGVPTVRAADGLALSSRNGYLSAEERRLAPQLNQVLMRLVAQLREGERHIDGLLTSATEQLLQAGLRP
DTLVIRDAQTLQPLTVDSRRAVVLFTAWLGKARLIDNAQVDLIS

Sequences:

>Translated_284_residues
MLIIETPPTLRQTVKQWSQEHKRIALIPTMGNLHEGHMALIDAGRARADKVVVSVFVNPMQFDRPEDLAAYPRTLQEDCE
QLTRRGVDMVFAPATGVIYPDDLASQTFVDVPRFANILEGESRPGHFRGVATIVSKLFNLVQPDVACFGEKDFQQLAFIR
QLVRDMSYDIEIIGVPTVRAADGLALSSRNGYLSAEERRLAPQLNQVLMRLVAQLREGERHIDGLLTSATEQLLQAGLRP
DTLVIRDAQTLQPLTVDSRRAVVLFTAWLGKARLIDNAQVDLIS
>Mature_284_residues
MLIIETPPTLRQTVKQWSQEHKRIALIPTMGNLHEGHMALIDAGRARADKVVVSVFVNPMQFDRPEDLAAYPRTLQEDCE
QLTRRGVDMVFAPATGVIYPDDLASQTFVDVPRFANILEGESRPGHFRGVATIVSKLFNLVQPDVACFGEKDFQQLAFIR
QLVRDMSYDIEIIGVPTVRAADGLALSSRNGYLSAEERRLAPQLNQVLMRLVAQLREGERHIDGLLTSATEQLLQAGLRP
DTLVIRDAQTLQPLTVDSRRAVVLFTAWLGKARLIDNAQVDLIS

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=282, Percent_Identity=63.8297872340426, Blast_Score=384, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322046, Length=206, Percent_Identity=43.2038834951456, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_SODGM (Q2NVR3)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454167.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q2NVR3
- SMR:   Q2NVR3
- STRING:   Q2NVR3
- GeneID:   3868701
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG0487
- NMPDR:   fig|343509.6.peg.1093
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   DEAHDAK
- PhylomeDB:   Q2NVR3
- ProtClustDB:   PRK00380
- BioCyc:   SGLO343509:SG0487-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31706; Mature: 31706

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 155-155 BINDING 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIIETPPTLRQTVKQWSQEHKRIALIPTMGNLHEGHMALIDAGRARADKVVVSVFVNPM
CEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHEEEECCH
QFDRPEDLAAYPRTLQEDCEQLTRRGVDMVFAPATGVIYPDDLASQTFVDVPRFANILEG
HCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHCCHHHHHHHHHHHHHCC
ESRPGHFRGVATIVSKLFNLVQPDVACFGEKDFQQLAFIRQLVRDMSYDIEIIGVPTVRA
CCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEC
ADGLALSSRNGYLSAEERRLAPQLNQVLMRLVAQLREGERHIDGLLTSATEQLLQAGLRP
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC
DTLVIRDAQTLQPLTVDSRRAVVLFTAWLGKARLIDNAQVDLIS
CEEEEECCCCCCCCEECCCCEEEEEEECCCCHHEECCCCEEECC
>Mature Secondary Structure
MLIIETPPTLRQTVKQWSQEHKRIALIPTMGNLHEGHMALIDAGRARADKVVVSVFVNPM
CEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHEEEECCH
QFDRPEDLAAYPRTLQEDCEQLTRRGVDMVFAPATGVIYPDDLASQTFVDVPRFANILEG
HCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHCCHHHHHHHHHHHHHCC
ESRPGHFRGVATIVSKLFNLVQPDVACFGEKDFQQLAFIRQLVRDMSYDIEIIGVPTVRA
CCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCEEC
ADGLALSSRNGYLSAEERRLAPQLNQVLMRLVAQLREGERHIDGLLTSATEQLLQAGLRP
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCC
DTLVIRDAQTLQPLTVDSRRAVVLFTAWLGKARLIDNAQVDLIS
CEEEEECCCCCCCCEECCCCEEEEEEECCCCHHEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA