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The map label for this gene is nadC [H]

Identifier: 85058442

GI number: 85058442

Start: 800195

End: 801085

Strand: Reverse

Name: nadC [H]

Synonym: SG0464

Alternate gene names: 85058442

Gene position: 801085-800195 (Counterclockwise)

Preceding gene: 85058443

Following gene: 85058441

Centisome position: 19.21

GC content: 60.61

Gene sequence:

>891_bases
ATGTCTACCCGCCGTTACAACGTTGAGCGCCGCCGGGCGGAATTGCTTGCTCGAATTCAACAGGATATCCCGCCGTCGGT
CAGCGCCGCATTGAAAGAAGATCTGGGCGGCGGCACCGACGCTCAGGCCGATATCACCGCGCTGCTGCTGCCAGTGGACA
GTCAGGCCAGCGCCGTGATTATCACTCGCGAAAACGGCGTTTTTTGCGGCCAATGCTGGCTTGAAGAGGTATTCAACCAG
TTAGGCGGCGGCGTGGCGATTGAGTGGTTGGTTGCGGATGGCGATGACATTCTAGCCAATCAACCCCTGTGCCGACTGAG
CGGGCCGGCGCGCCTGCTGCTTACCGGTGAACGGACCACGCTCAATTTCGTCCAGACGCTGTGCGGCGTGGCCAGCGAAG
TGAAACGGTATGTCGCTGCGCTGGCGGGTACCGGTACCACGCTGCTTGATACGCGCAAAACCGTGCCGGGCCTTCGGACC
GCCCTGAAATACGCGGTGCTGTGCGGAGGCGGCAGCAACCACCGGCTTGGACTGGCGGACGCGTTCCTCATCAAGGAAAA
TCATATCATCGCCGCCGGATCCATCGCCAATGCCGTCACCAACGCCGTGGCGCTGCGCGCCGATGTGCCGGTGGAAGTCG
AAGTAGAATCTCTGGACGAGCTGCATCAAGCGCTGGATGCCGGCGCTGATATCATTATGCTCGACAACTTCAGCCGTGAA
GATATGGTGCAAGCAGTGGCGGTAACCCGCCAGCGAGCGGCGCTGGAGGTGTCCGGCAATGTTACGCTCGCTACGCTGCG
CGATTGCGCGCTGACCGGCGTCGATTACATTTCCGTCGGCGCACTGACCAAACATTTACGGGCGCTGGATCTCTCCATGC
GTTTTCATTAA

Upstream 100 bases:

>100_bases
CAACCGCATGGTGACCTCATTTTACCAAGTATGGTACTTCGCCCGGCTTCAGGGTAGCATGAATCCTCGCTTCCCTTTAT
CCGCAGATACGGAGATTTTT

Downstream 100 bases:

>100_bases
CGATCACTATTGCGCGCGGCCACGCAATTTACTTGTCACAACCTGCAGCCGCGCGGTGTAGCGCCGAATCCGTCTGCCAC
TTTTTCTTTCCGCCGCTATC

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSTRRYNVERRRAELLARIQQDIPPSVSAALKEDLGGGTDAQADITALLLPVDSQASAVIITRENGVFCGQCWLEEVFNQ
LGGGVAIEWLVADGDDILANQPLCRLSGPARLLLTGERTTLNFVQTLCGVASEVKRYVAALAGTGTTLLDTRKTVPGLRT
ALKYAVLCGGGSNHRLGLADAFLIKENHIIAAGSIANAVTNAVALRADVPVEVEVESLDELHQALDAGADIIMLDNFSRE
DMVQAVAVTRQRAALEVSGNVTLATLRDCALTGVDYISVGALTKHLRALDLSMRFH

Sequences:

>Translated_296_residues
MSTRRYNVERRRAELLARIQQDIPPSVSAALKEDLGGGTDAQADITALLLPVDSQASAVIITRENGVFCGQCWLEEVFNQ
LGGGVAIEWLVADGDDILANQPLCRLSGPARLLLTGERTTLNFVQTLCGVASEVKRYVAALAGTGTTLLDTRKTVPGLRT
ALKYAVLCGGGSNHRLGLADAFLIKENHIIAAGSIANAVTNAVALRADVPVEVEVESLDELHQALDAGADIIMLDNFSRE
DMVQAVAVTRQRAALEVSGNVTLATLRDCALTGVDYISVGALTKHLRALDLSMRFH
>Mature_295_residues
STRRYNVERRRAELLARIQQDIPPSVSAALKEDLGGGTDAQADITALLLPVDSQASAVIITRENGVFCGQCWLEEVFNQL
GGGVAIEWLVADGDDILANQPLCRLSGPARLLLTGERTTLNFVQTLCGVASEVKRYVAALAGTGTTLLDTRKTVPGLRTA
LKYAVLCGGGSNHRLGLADAFLIKENHIIAAGSIANAVTNAVALRADVPVEVEVESLDELHQALDAGADIIMLDNFSRED
MVQAVAVTRQRAALEVSGNVTLATLRDCALTGVDYISVGALTKHLRALDLSMRFH

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=247, Percent_Identity=36.4372469635627, Blast_Score=137, Evalue=9e-33,
Organism=Escherichia coli, GI1786299, Length=296, Percent_Identity=68.2432432432432, Blast_Score=370, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321162, Length=254, Percent_Identity=34.251968503937, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31572; Mature: 31440

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRRYNVERRRAELLARIQQDIPPSVSAALKEDLGGGTDAQADITALLLPVDSQASAVI
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEE
ITRENGVFCGQCWLEEVFNQLGGGVAIEWLVADGDDILANQPLCRLSGPARLLLTGERTT
EECCCCEEEHHHHHHHHHHHHCCCEEEEEEEECCCHHHCCCCCEEECCCEEEEEECCCHH
LNFVQTLCGVASEVKRYVAALAGTGTTLLDTRKTVPGLRTALKYAVLCGGGSNHRLGLAD
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHCCHHHHHHHHHHEEECCCCCCCCCCCE
AFLIKENHIIAAGSIANAVTNAVALRADVPVEVEVESLDELHQALDAGADIIMLDNFSRE
EEEEECCCEEEECHHHHHHHHHHEEEECCCEEEEHHHHHHHHHHHHCCCCEEEECCCCHH
DMVQAVAVTRQRAALEVSGNVTLATLRDCALTGVDYISVGALTKHLRALDLSMRFH
HHHHHHHHHHHHHEEEECCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure 
STRRYNVERRRAELLARIQQDIPPSVSAALKEDLGGGTDAQADITALLLPVDSQASAVI
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEE
ITRENGVFCGQCWLEEVFNQLGGGVAIEWLVADGDDILANQPLCRLSGPARLLLTGERTT
EECCCCEEEHHHHHHHHHHHHCCCEEEEEEEECCCHHHCCCCCEEECCCEEEEEECCCHH
LNFVQTLCGVASEVKRYVAALAGTGTTLLDTRKTVPGLRTALKYAVLCGGGSNHRLGLAD
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHCCHHHHHHHHHHEEECCCCCCCCCCCE
AFLIKENHIIAAGSIANAVTNAVALRADVPVEVEVESLDELHQALDAGADIIMLDNFSRE
EEEEECCCEEEECHHHHHHHHHHEEEECCCEEEEHHHHHHHHHHHHCCCCEEEECCCCHH
DMVQAVAVTRQRAALEVSGNVTLATLRDCALTGVDYISVGALTKHLRALDLSMRFH
HHHHHHHHHHHHHEEEECCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]