Click here to switch to the map view.

The map label for this gene is prs [H]

Identifier: 84625062

GI number: 84625062

Start: 3865595

End: 3866554

Strand: Reverse

Name: prs [H]

Synonym: XOO_3405

Alternate gene names: 84625062

Gene position: 3866554-3865595 (Counterclockwise)

Preceding gene: 84625063

Following gene: 84625061

Centisome position: 78.27

GC content: 63.65

Gene sequence:

>960_bases
ATGCAAGACCAACGTAATCTGCTGGTGTTCTCCGGCAATGCCAACAAGCCGCTTGCCCAGAGCATCTGCAAGGAGCTGGG
CGTTCGCATGGGTAAGGCCCTGGTCACGCGCTTTTCCGATGGCGAAGTGCAGGTCGAGATCGAAGAGAGCGTGCGCCGGC
AGGAAGTGTTCGTCATCCAGCCGACCTGCGCGCCGAGCGCCGAAAACCTGATGGAACTGCTGGTGCTGATCGACGCGCTC
AAGCGCGCCAGCGCCCAGTCCGTCACTGCGGTGATCCCGTATTTCGGTTATTCGCGTCAGGACCGCCGTATGCGCTCCTC
GCGCGTGCCGATCACTGCCAAGGTCGCGGCCAAGATGATCTGCGCGATGGAAGCCGACCGCGTGTTGACGGTGGACCTGC
ACGCCGACCAGATCCAGGGCTTTTTCGATGTGCCGGTCGACAACGTTTACGCCTCGCCGCTGCTGTTGGCTGATATCTGG
CGCGCCTACGGTACCGACAACCTGATCGTGGTGTCGCCGGACGTGGGCGGTGTGGTGCGTGCGCGGGCCGTCGCCAAGCG
TCTGGACGATGCGGATCTGGCCATCATCGACAAGCGCCGTCCGCGCGCCAACGTCGCCACCGTGATGAACATCATCGGCG
ACGTGCAGGGCAAGACCTGCGTGCTGGTCGACGATCTGGTCGATACCGCCGGCACCTTGTGCGCCGCCGCAGCAGCGCTC
AAGCAGCGCGGCGCGCTCAAGGTCGTGGCCTACATCACCCACCCGGTGCTGTCCGGCCCGGCGGTGGACAACATCAACAA
TTCGCAGCTCGACGAGCTGGTGGTTACCGACACGATTCCGTTGAACGAAGCGGCGCGCATCTGCGCCAAGATTCGTCAGC
TGAGCGTGGCCGAACTGCTGGCCGAGACCATTCGCCGTATTGCCTTCGGCGAATCGGTCAGCTCGCTCTACGTCGACTGA

Upstream 100 bases:

>100_bases
CACATCCCTGTGCGGGGGTTTGAAGGAAAAGCCCGGCATTACGTCGACTTTCTCGCTCCACCATCGACCGCACGCTCTTC
GCCGCCGCCCGAGAGATCTC

Downstream 100 bases:

>100_bases
TGCCGCATTCGGTGCCCGGAGTTCCGGGTGCCGCTACACGTCTCACCTGGTCGCGGGTGAGACGCTTCATCGCCGCGAGG
TGGTGTTCCAAACTAGGTAG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MQDQRNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDAL
KRASAQSVTAVIPYFGYSRQDRRMRSSRVPITAKVAAKMICAMEADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIW
RAYGTDNLIVVSPDVGGVVRARAVAKRLDDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAAL
KQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLNEAARICAKIRQLSVAELLAETIRRIAFGESVSSLYVD

Sequences:

>Translated_319_residues
MQDQRNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDAL
KRASAQSVTAVIPYFGYSRQDRRMRSSRVPITAKVAAKMICAMEADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIW
RAYGTDNLIVVSPDVGGVVRARAVAKRLDDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAAL
KQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLNEAARICAKIRQLSVAELLAETIRRIAFGESVSSLYVD
>Mature_319_residues
MQDQRNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDAL
KRASAQSVTAVIPYFGYSRQDRRMRSSRVPITAKVAAKMICAMEADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIW
RAYGTDNLIVVSPDVGGVVRARAVAKRLDDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAAL
KQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLNEAARICAKIRQLSVAELLAETIRRIAFGESVSSLYVD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=318, Percent_Identity=46.2264150943396, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI84875539, Length=320, Percent_Identity=45.9375, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI4506127, Length=318, Percent_Identity=46.5408805031447, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI28557709, Length=318, Percent_Identity=45.5974842767296, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=36.7052023121387, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI194018537, Length=345, Percent_Identity=37.6811594202899, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI310128524, Length=149, Percent_Identity=28.8590604026846, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI310115209, Length=149, Percent_Identity=28.8590604026846, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI310118259, Length=149, Percent_Identity=28.8590604026846, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI310119946, Length=149, Percent_Identity=28.8590604026846, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=61.2179487179487, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17554702, Length=313, Percent_Identity=46.0063897763578, Blast_Score=280, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=46.0063897763578, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI71989924, Length=313, Percent_Identity=46.0063897763578, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=46.1290322580645, Blast_Score=277, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=340, Percent_Identity=34.4117647058824, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=45.1612903225806, Blast_Score=264, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=44.5512820512821, Blast_Score=252, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=43.4083601286174, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6322667, Length=203, Percent_Identity=37.9310344827586, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6324511, Length=267, Percent_Identity=31.0861423220974, Blast_Score=108, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21355239, Length=318, Percent_Identity=46.8553459119497, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45551540, Length=340, Percent_Identity=43.8235294117647, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.3661971830986, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.3661971830986, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.3661971830986, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.3661971830986, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=31.5508021390374, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=31.5508021390374, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=31.5508021390374, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34642; Mature: 34642

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDQRNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQ
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCEEEEEC
PTCAPSAENLMELLVLIDALKRASAQSVTAVIPYFGYSRQDRRMRSSRVPITAKVAAKMI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHH
CAMEADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIWRAYGTDNLIVVSPDVGGVVR
HHHCCCCEEEEEECHHHHCCEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHH
ARAVAKRLDDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAAL
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
KQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLNEAARICAKIRQLSVAELL
HHCCCEEEEEEHHHHHCCCCCCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHH
AETIRRIAFGESVSSLYVD
HHHHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MQDQRNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQ
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCEEEEEC
PTCAPSAENLMELLVLIDALKRASAQSVTAVIPYFGYSRQDRRMRSSRVPITAKVAAKMI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHH
CAMEADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIWRAYGTDNLIVVSPDVGGVVR
HHHCCCCEEEEEECHHHHCCEECCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHH
ARAVAKRLDDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAAAL
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHH
KQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLNEAARICAKIRQLSVAELL
HHCCCEEEEEEHHHHHCCCCCCCCCCCHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHH
AETIRRIAFGESVSSLYVD
HHHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]