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The map label for this gene is kmo [H]

Identifier: 84623963

GI number: 84623963

Start: 2566780

End: 2568147

Strand: Direct

Name: kmo [H]

Synonym: XOO_2306

Alternate gene names: 84623963

Gene position: 2566780-2568147 (Clockwise)

Preceding gene: 84623962

Following gene: 84623964

Centisome position: 51.96

GC content: 65.42

Gene sequence:

>1368_bases
TTGAGCCCAGTTTCTCCGCGTTCCCTGACCTTGATAGGCGCCGGTCTGGCCGGTTGCCTGCTGGCTATCCTGCTGTCGCG
TCGCGGCTGGCAGATCACCGTGTACGAACGGCGTGGCGACCCGCGCATCAAGGGCTACGAGTGCGGCCGCTCGATCAATC
TGGCGCTGGCCGAACGCGGCCGGCATGCGCTGCGCCAGGCCGGCGCCGAAGAGCTGGTAATGGCCAAGGCTGTGATGATG
CGTGGGCGCATGGTGCACCCGCTGGTCGGCGAACCGCAGTTACAGCGCTACGGGCGCGACGACAGCGAGGTGATCTGGTC
GATCCACCGCGCCGCATTGAATGTCGCACTGCTCGATCTGGCCGAACAGGCCGGCGCGCGCGTGCATTTCTACCGCCGCC
TGCATACGGTGGACTTCGACGCCGGCTACGCGCGCTTCATCGACGACCGCGACGACCAGCCGCACGAAATCCACTTCCAA
AGTCTGATCGGCAGCGATGGCGCCGGCTCGGCATTGCGCGCGGCGATGCAGCGCAAATCGCCGCTGGGCGAACGCACCGA
ATTTCTGGATCACTCTTACAAGGAACTGGAAATTCCACCGTTGCCCGGCGGCGGGTTCCGCATCGAAGGCAACGCGCTGC
ACATCTGGCCGCGCGGGCGCTACATGTTCATCGCGCTGCCCAACGATGGCGGCACGTTTACCGTCACCCTGTTTTTGCCC
AACGCCGGCGAGCCGAGCTTCGCCACTACGCGTAACGGCGATGAAGCATTCGCCTTGTTCGCGCGCGACTTTCCGGATGC
ATTGCCACTGATTCCGCAGCTCAAGCAGCATTGGGAAGAGCATCCGCCCGGGCTGCTCGGCACCCTGACCCTGGACCGCT
GGCATCTGGATGGCCGCGCCTTGTTGATCGGCGACGCCGCACACGCGATGGTGCCCTTCCACGGCCAGGGCATGAATTGC
GCGTTCGAAGATTGCGTGGCGCTGGCGGATCAGCTGGATGCCCACGACGACCTCGCCAGCGCGTTCGCCGCCTTCGAGGC
GGCACGCCGCGACGATGCGGGGGCCATCCAGCAGATGGCGCTGGAAAACTATCTGGAAATGCGCGACCGCGTCGACGACC
CCGAGTTCCTGCTGCAGCGCCAGCTTGAACAGCAGTTGCAGGCGCGTTGGCCCACCCGCTTCGTGCCGCACTACACCATG
GTGACGTTCCTGCGCACGCGCTATTCGATTGCGCTGGCGCGCAGCGAGATCCAGCGCGAGATTCTGGTCGAAGCCACACG
CGGACACAGCGATCTGTCGCGTCTGGATTGGGCTGCGTTGGAGACGATCGTCCATGCGCGCTTGGAGCCGCTGGACGGCG
CGCACTGA

Upstream 100 bases:

>100_bases
CTCCCAGCCCGCCCAGGGCTGATGCGAGGGCGGCTGTCATTACCAGTCGCTGTTTTCCCCTTTTCGCCGGCACTGCGCCC
GGCTGCCGCCGGACATTGCA

Downstream 100 bases:

>100_bases
GGTCGGCCACGGCTGTGGCCGACGGCGTCACTGGCGGCGACGGTAACGTGCCGCCTCCTGCTTGGTGTCATGACCGATGT
CTCGGTGGCCCGGCGTCAGC

Product: kynurenine 3-monooxygenase

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSPVSPRSLTLIGAGLAGCLLAILLSRRGWQITVYERRGDPRIKGYECGRSINLALAERGRHALRQAGAEELVMAKAVMM
RGRMVHPLVGEPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQ
SLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPLPGGGFRIEGNALHIWPRGRYMFIALPNDGGTFTVTLFLP
NAGEPSFATTRNGDEAFALFARDFPDALPLIPQLKQHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNC
AFEDCVALADQLDAHDDLASAFAAFEAARRDDAGAIQQMALENYLEMRDRVDDPEFLLQRQLEQQLQARWPTRFVPHYTM
VTFLRTRYSIALARSEIQREILVEATRGHSDLSRLDWAALETIVHARLEPLDGAH

Sequences:

>Translated_455_residues
MSPVSPRSLTLIGAGLAGCLLAILLSRRGWQITVYERRGDPRIKGYECGRSINLALAERGRHALRQAGAEELVMAKAVMM
RGRMVHPLVGEPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQ
SLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPLPGGGFRIEGNALHIWPRGRYMFIALPNDGGTFTVTLFLP
NAGEPSFATTRNGDEAFALFARDFPDALPLIPQLKQHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNC
AFEDCVALADQLDAHDDLASAFAAFEAARRDDAGAIQQMALENYLEMRDRVDDPEFLLQRQLEQQLQARWPTRFVPHYTM
VTFLRTRYSIALARSEIQREILVEATRGHSDLSRLDWAALETIVHARLEPLDGAH
>Mature_454_residues
SPVSPRSLTLIGAGLAGCLLAILLSRRGWQITVYERRGDPRIKGYECGRSINLALAERGRHALRQAGAEELVMAKAVMMR
GRMVHPLVGEPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQS
LIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPLPGGGFRIEGNALHIWPRGRYMFIALPNDGGTFTVTLFLPN
AGEPSFATTRNGDEAFALFARDFPDALPLIPQLKQHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNCA
FEDCVALADQLDAHDDLASAFAAFEAARRDDAGAIQQMALENYLEMRDRVDDPEFLLQRQLEQQLQARWPTRFVPHYTMV
TFLRTRYSIALARSEIQREILVEATRGHSDLSRLDWAALETIVHARLEPLDGAH

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily [H]

Homologues:

Organism=Homo sapiens, GI187960045, Length=425, Percent_Identity=37.6470588235294, Blast_Score=292, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI17562934, Length=452, Percent_Identity=32.5221238938053, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI212646493, Length=416, Percent_Identity=25.2403846153846, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193208447, Length=369, Percent_Identity=24.1192411924119, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319372, Length=433, Percent_Identity=36.2586605080831, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI28573964, Length=417, Percent_Identity=36.6906474820144, Blast_Score=243, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: =1.14.13.9 [H]

Molecular weight: Translated: 50984; Mature: 50852

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPVSPRSLTLIGAGLAGCLLAILLSRRGWQITVYERRGDPRIKGYECGRSINLALAERG
CCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCEEHHHHHHH
RHALRQAGAEELVMAKAVMMRGRMVHPLVGEPQLQRYGRDDSEVIWSIHRAALNVALLDL
HHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKS
HHHCCCEEEEEHHHEEEECCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
PLGERTEFLDHSYKELEIPPLPGGGFRIEGNALHIWPRGRYMFIALPNDGGTFTVTLFLP
CCCHHHHHHCCCHHHEECCCCCCCCEEEECCEEEEEECCCEEEEEEECCCCEEEEEEEEC
NAGEPSFATTRNGDEAFALFARDFPDALPLIPQLKQHWEEHPPGLLGTLTLDRWHLDGRA
CCCCCCCCCCCCCCHHEEEHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCE
LLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAGAIQQMA
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
LENYLEMRDRVDDPEFLLQRQLEQQLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQRE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILVEATRGHSDLSRLDWAALETIVHARLEPLDGAH
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SPVSPRSLTLIGAGLAGCLLAILLSRRGWQITVYERRGDPRIKGYECGRSINLALAERG
CCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCEEHHHHHHH
RHALRQAGAEELVMAKAVMMRGRMVHPLVGEPQLQRYGRDDSEVIWSIHRAALNVALLDL
HHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AEQAGARVHFYRRLHTVDFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKS
HHHCCCEEEEEHHHEEEECCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
PLGERTEFLDHSYKELEIPPLPGGGFRIEGNALHIWPRGRYMFIALPNDGGTFTVTLFLP
CCCHHHHHHCCCHHHEECCCCCCCCEEEECCEEEEEECCCEEEEEEECCCCEEEEEEEEC
NAGEPSFATTRNGDEAFALFARDFPDALPLIPQLKQHWEEHPPGLLGTLTLDRWHLDGRA
CCCCCCCCCCCCCCHHEEEHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCE
LLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAGAIQQMA
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
LENYLEMRDRVDDPEFLLQRQLEQQLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQRE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILVEATRGHSDLSRLDWAALETIVHARLEPLDGAH
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]