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The map label for this gene is kynU [H]

Identifier: 84623962

GI number: 84623962

Start: 2565337

End: 2566608

Strand: Direct

Name: kynU [H]

Synonym: XOO_2305

Alternate gene names: 84623962

Gene position: 2565337-2566608 (Clockwise)

Preceding gene: 84623961

Following gene: 84623963

Centisome position: 51.93

GC content: 68.24

Gene sequence:

>1272_bases
ATGACCGACCTGCTGTCCCGCGCCCATGCCGATGCCCTGGATGCCGCCGACCCGCTGCGCAGCCTGCGCGATGCCTTCGT
GTTCCCGCAGCACGGCGATCGGGATCAGACGTATCTCGTCGGCAACTCCCTTGGCCTGCAGCCGCGCGCGGCGCGCGCAA
TGGTGGACGAAGTGCTCGATCAGTGGGGCACGTTGGGGGTGGAAGGTCACTTCACCGGCCCCACCCAATGGCTGACCTAT
CACCAGCTGGTACGCGATGCGCTGGCCCGCGTGGTCGGCGCGCAACCCGGCGAGGTGGTGGCGATGAACACCCTCAGCGT
CAATCTGCACCTGATGATGGCGAGCTTTTATCGTCCCACGCACGAACGCGGCGCGATCCTGATCGAAGCCGGCGCGTTTC
CGTCCGACCGTCACGCGGTGGAATCGCAGCTGCGCCTGCGCGGGCTGGACCCGGCCACGCATCTGATCGAAGTGGAGGCC
GACGAACCCAACGGCACGTTATCGATGGCCGCCATTGCCGATGCCATCGCGCAGCATGGTCCGCGCCTGGCGTTGGTGCT
GTGGCCGGGCATCCAGTACCGCACCGGGCAGGCCTTCGACCTGGCCGAGATCGTGCGACTGGCGCGGGCGCAAGGCGCGG
CGGTGGGCTGCGATCTGGCGCATGCGGTGGGCAACATCCCGCTGACCCTGCACGACGATGGCGTGGATTTCGCAGTGTGG
TGCAACTACAAATATCTCAACGCCGGCCCCGGCGCGGTGGGCGGTTGCTTCGTGCACGAACGTCATGCCAACAGCGATCT
GCCGCGTATCGCCGGCTGGTGGGGACATGAGCAGCAGACCCGCTTCCGCATGGACCCGCAGTTCGTGCCCTCGCCCGGCG
CCGAAGGCTGGCAGCTGAGCAATCCACCGGTGCTGGCGCTGGCGCCGCTGCGCGCATCGCTGGCGTTGTTCGACCAGACC
GGCATGGCCGCGCTACGCGCCAAATCCGAACGACTCACCGGGCATCTGGAGCAGTTGATCCACGCGCGCGTGCCGCAGGT
GCTGCAGATCGTCACCCCGGCCGAACCGATGCGCCGCGGCTGCCAGCTGTCGTTGCGGGTGGCCGGCGGACGCGCGCAGG
GGTGCTCGCTGTTCGAGCATCTGCATGCAGCCGGCGTGCTCGGCGACTGGCGCGAACCGGACCTGATCCGCATTGCGCCG
GTGCCGCTGTACAACCGCTTCAGCGATCTGCACACCTTCGTGGGCCAGGTGGAAGCCTGGGCGGCTGCCTGA

Upstream 100 bases:

>100_bases
CCCTGCCCGACCGGCCTGGGCCGAGGTGCCAGCCCTGCATGACGGCGCGCATGATGCCGGCGGGTAAACTGCTGGCCTGA
TCCGTGTTGCGAGCCCGACG

Downstream 100 bases:

>100_bases
GTGCGGCAGGCTGACTGCATTGCCACCAGATCATCTGTCCGGCATGCGGAATCGCCGCACGCCCACGTACACTCCCAGCC
CGCCCAGGGCTGATGCGAGG

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTDLLSRAHADALDAADPLRSLRDAFVFPQHGDRDQTYLVGNSLGLQPRAARAMVDEVLDQWGTLGVEGHFTGPTQWLTY
HQLVRDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPTHERGAILIEAGAFPSDRHAVESQLRLRGLDPATHLIEVEA
DEPNGTLSMAAIADAIAQHGPRLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGCDLAHAVGNIPLTLHDDGVDFAVW
CNYKYLNAGPGAVGGCFVHERHANSDLPRIAGWWGHEQQTRFRMDPQFVPSPGAEGWQLSNPPVLALAPLRASLALFDQT
GMAALRAKSERLTGHLEQLIHARVPQVLQIVTPAEPMRRGCQLSLRVAGGRAQGCSLFEHLHAAGVLGDWREPDLIRIAP
VPLYNRFSDLHTFVGQVEAWAAA

Sequences:

>Translated_423_residues
MTDLLSRAHADALDAADPLRSLRDAFVFPQHGDRDQTYLVGNSLGLQPRAARAMVDEVLDQWGTLGVEGHFTGPTQWLTY
HQLVRDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPTHERGAILIEAGAFPSDRHAVESQLRLRGLDPATHLIEVEA
DEPNGTLSMAAIADAIAQHGPRLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGCDLAHAVGNIPLTLHDDGVDFAVW
CNYKYLNAGPGAVGGCFVHERHANSDLPRIAGWWGHEQQTRFRMDPQFVPSPGAEGWQLSNPPVLALAPLRASLALFDQT
GMAALRAKSERLTGHLEQLIHARVPQVLQIVTPAEPMRRGCQLSLRVAGGRAQGCSLFEHLHAAGVLGDWREPDLIRIAP
VPLYNRFSDLHTFVGQVEAWAAA
>Mature_422_residues
TDLLSRAHADALDAADPLRSLRDAFVFPQHGDRDQTYLVGNSLGLQPRAARAMVDEVLDQWGTLGVEGHFTGPTQWLTYH
QLVRDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPTHERGAILIEAGAFPSDRHAVESQLRLRGLDPATHLIEVEAD
EPNGTLSMAAIADAIAQHGPRLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGCDLAHAVGNIPLTLHDDGVDFAVWC
NYKYLNAGPGAVGGCFVHERHANSDLPRIAGWWGHEQQTRFRMDPQFVPSPGAEGWQLSNPPVLALAPLRASLALFDQTG
MAALRAKSERLTGHLEQLIHARVPQVLQIVTPAEPMRRGCQLSLRVAGGRAQGCSLFEHLHAAGVLGDWREPDLIRIAPV
PLYNRFSDLHTFVGQVEAWAAA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=423, Percent_Identity=42.5531914893617, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI74101437, Length=268, Percent_Identity=42.5373134328358, Blast_Score=228, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17550466, Length=442, Percent_Identity=39.5927601809955, Blast_Score=335, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6323261, Length=439, Percent_Identity=41.6856492027335, Blast_Score=323, Evalue=5e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 46058; Mature: 45927

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLLSRAHADALDAADPLRSLRDAFVFPQHGDRDQTYLVGNSLGLQPRAARAMVDEVLD
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
QWGTLGVEGHFTGPTQWLTYHQLVRDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPT
HHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEHHHCCCC
HERGAILIEAGAFPSDRHAVESQLRLRGLDPATHLIEVEADEPNGTLSMAAIADAIAQHG
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCC
PRLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGCDLAHAVGNIPLTLHDDGVDFAVW
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEECCCCCEEEE
CNYKYLNAGPGAVGGCFVHERHANSDLPRIAGWWGHEQQTRFRMDPQFVPSPGAEGWQLS
EEEEEECCCCCCCCEEEEEECCCCCCCCCHHCCCCCCCCCEECCCCCCCCCCCCCCCCCC
NPPVLALAPLRASLALFDQTGMAALRAKSERLTGHLEQLIHARVPQVLQIVTPAEPMRRG
CCCEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
CQLSLRVAGGRAQGCSLFEHLHAAGVLGDWREPDLIRIAPVPLYNRFSDLHTFVGQVEAW
CEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
AAA
HCC
>Mature Secondary Structure 
TDLLSRAHADALDAADPLRSLRDAFVFPQHGDRDQTYLVGNSLGLQPRAARAMVDEVLD
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHH
QWGTLGVEGHFTGPTQWLTYHQLVRDALARVVGAQPGEVVAMNTLSVNLHLMMASFYRPT
HHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEEEEEHHHCCCC
HERGAILIEAGAFPSDRHAVESQLRLRGLDPATHLIEVEADEPNGTLSMAAIADAIAQHG
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCC
PRLALVLWPGIQYRTGQAFDLAEIVRLARAQGAAVGCDLAHAVGNIPLTLHDDGVDFAVW
CEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEECCCCCEEEE
CNYKYLNAGPGAVGGCFVHERHANSDLPRIAGWWGHEQQTRFRMDPQFVPSPGAEGWQLS
EEEEEECCCCCCCCEEEEEECCCCCCCCCHHCCCCCCCCCEECCCCCCCCCCCCCCCCCC
NPPVLALAPLRASLALFDQTGMAALRAKSERLTGHLEQLIHARVPQVLQIVTPAEPMRRG
CCCEEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
CQLSLRVAGGRAQGCSLFEHLHAAGVLGDWREPDLIRIAPVPLYNRFSDLHTFVGQVEAW
CEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHH
AAA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]