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The map label for this gene is thrB [H]

Identifier: 84623765

GI number: 84623765

Start: 2333309

End: 2334277

Strand: Direct

Name: thrB [H]

Synonym: XOO_2108

Alternate gene names: 84623765

Gene position: 2333309-2334277 (Clockwise)

Preceding gene: 84623764

Following gene: 84623766

Centisome position: 47.23

GC content: 68.63

Gene sequence:

>969_bases
ATGAGCGGTACAGGTCTGTCGTCGCCGCGCGCAGGTGCGGGGCATTCCGCGCCGCGCGAGGCACGCGCGTTCGCTCCGGC
CTCGGTGGCCAACGTGGCGGTCGGGTTCGATCTGCTCGGTTATGCATTGGACGGCGTCGGCGATACGGTGACCGTGCGCC
GTATTGATGCGCCGCAAGTACGCATTGCCGCGATCCGTGGTACCGCCGTCGAGCTTCCGCTGGAGGCCGAACGCAACACC
GCGGGCGCGGCATTGGTCGCGCTGCGTAGCGCGTTGGCATTGCCGTTTGGCTTCGAGCTGGAGATCGACAAGGGGATCGC
GCTCAGTTCCGGCATGGGCGGGTCGGCGGCGTCGTGCGTGGCGGCGCTGGTAGCAGCCAATGCGCTGTTGGAGGCCCCGT
TGTCCCGCGACCAGCTCTATCTGAACGCGCTCGACGGCGAGGCGGTAGCCAGTGGCAGTCGCCATGGCGATAACCTGGGT
CCGATGTTGTTGGGCGGCTTGGTGCTGTCCACGTTGGAGCGGATGGTGCCGGTGCCGGTGCCCGCGGCTTGGCATAGCTT
GGTCGTGCATCCGGATGCGGTGCTGGAAACGCGCCGCGCGCGTGCAGCGCTGGCCGGCAACTATCGGCTCGATGAATTCG
TGGCACAGAGCGCCAATCTTGCCTTGGTGTTGGCGGGCTGCCATGCCGGGGACGAATCGCTGGTTCGCGCAGGCTTGCGC
GATGTGCTGATCGAGCCGCGGCGTGCGGGGTTGATTCTTGGCTTCGGCGCGGCCAAGGCCGCGGCGTTGGCCGCGGGGGC
GATGGGTGCGGGCATTTCCGGAGCTGGCCCCAGCGTGTTTGCCTGGTTCGCCACCCGCGCGGCAGCCGAGGCGGCTGCGG
CGGCGGTGCGGGCGACATTCACCGACGTTGGGTTCGGCAGCCAGAGTTGGGTGTCTGCGCTGAACTGCCCTGGCGCCAGG
CTGCTGTAG

Upstream 100 bases:

>100_bases
ACCCGCTGGTGGTGCAGGGTCCGGGTGCGGGGCCGGAAGTGACCGCAGCAGGCGTGTTCGCCGATCTGCTGCGCGTGGCG
GCAGGCGAGGGTGCGCGGCT

Downstream 100 bases:

>100_bases
CGCGCACCGGCCCTGGTGGTCGGGTGCGCCGCGTTCTTGCGTGTCTTGCGCAAGAACGTCGGAGCGGGAAATGCGATCGT
GCACGCGTTCTGCATGCGGG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSGTGLSSPRAGAGHSAPREARAFAPASVANVAVGFDLLGYALDGVGDTVTVRRIDAPQVRIAAIRGTAVELPLEAERNT
AGAALVALRSALALPFGFELEIDKGIALSSGMGGSAASCVAALVAANALLEAPLSRDQLYLNALDGEAVASGSRHGDNLG
PMLLGGLVLSTLERMVPVPVPAAWHSLVVHPDAVLETRRARAALAGNYRLDEFVAQSANLALVLAGCHAGDESLVRAGLR
DVLIEPRRAGLILGFGAAKAAALAAGAMGAGISGAGPSVFAWFATRAAAEAAAAAVRATFTDVGFGSQSWVSALNCPGAR
LL

Sequences:

>Translated_322_residues
MSGTGLSSPRAGAGHSAPREARAFAPASVANVAVGFDLLGYALDGVGDTVTVRRIDAPQVRIAAIRGTAVELPLEAERNT
AGAALVALRSALALPFGFELEIDKGIALSSGMGGSAASCVAALVAANALLEAPLSRDQLYLNALDGEAVASGSRHGDNLG
PMLLGGLVLSTLERMVPVPVPAAWHSLVVHPDAVLETRRARAALAGNYRLDEFVAQSANLALVLAGCHAGDESLVRAGLR
DVLIEPRRAGLILGFGAAKAAALAAGAMGAGISGAGPSVFAWFATRAAAEAAAAAVRATFTDVGFGSQSWVSALNCPGAR
LL
>Mature_321_residues
SGTGLSSPRAGAGHSAPREARAFAPASVANVAVGFDLLGYALDGVGDTVTVRRIDAPQVRIAAIRGTAVELPLEAERNTA
GAALVALRSALALPFGFELEIDKGIALSSGMGGSAASCVAALVAANALLEAPLSRDQLYLNALDGEAVASGSRHGDNLGP
MLLGGLVLSTLERMVPVPVPAAWHSLVVHPDAVLETRRARAALAGNYRLDEFVAQSANLALVLAGCHAGDESLVRAGLRD
VLIEPRRAGLILGFGAAKAAALAAGAMGAGISGAGPSVFAWFATRAAAEAAAAAVRATFTDVGFGSQSWVSALNCPGARL
L

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=311, Percent_Identity=32.475884244373, Blast_Score=127, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32401; Mature: 32270

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTGLSSPRAGAGHSAPREARAFAPASVANVAVGFDLLGYALDGVGDTVTVRRIDAPQV
CCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCE
RIAAIRGTAVELPLEAERNTAGAALVALRSALALPFGFELEIDKGIALSSGMGGSAASCV
EEEEECCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCHHHHHH
AALVAANALLEAPLSRDQLYLNALDGEAVASGSRHGDNLGPMLLGGLVLSTLERMVPVPV
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
PAAWHSLVVHPDAVLETRRARAALAGNYRLDEFVAQSANLALVLAGCHAGDESLVRAGLR
CHHHHHEEECCHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
DVLIEPRRAGLILGFGAAKAAALAAGAMGAGISGAGPSVFAWFATRAAAEAAAAAVRATF
HHHCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TDVGFGSQSWVSALNCPGARLL
HHCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SGTGLSSPRAGAGHSAPREARAFAPASVANVAVGFDLLGYALDGVGDTVTVRRIDAPQV
CCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCE
RIAAIRGTAVELPLEAERNTAGAALVALRSALALPFGFELEIDKGIALSSGMGGSAASCV
EEEEECCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCEEEECCCCCHHHHHH
AALVAANALLEAPLSRDQLYLNALDGEAVASGSRHGDNLGPMLLGGLVLSTLERMVPVPV
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
PAAWHSLVVHPDAVLETRRARAALAGNYRLDEFVAQSANLALVLAGCHAGDESLVRAGLR
CHHHHHEEECCHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
DVLIEPRRAGLILGFGAAKAAALAAGAMGAGISGAGPSVFAWFATRAAAEAAAAAVRATF
HHHCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TDVGFGSQSWVSALNCPGARLL
HHCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA