Click here to switch to the map view.

The map label for this gene is thrA [H]

Identifier: 84623764

GI number: 84623764

Start: 2330805

End: 2333312

Strand: Direct

Name: thrA [H]

Synonym: XOO_2107

Alternate gene names: 84623764

Gene position: 2330805-2333312 (Clockwise)

Preceding gene: 84623763

Following gene: 84623765

Centisome position: 47.18

GC content: 65.55

Gene sequence:

>2508_bases
ATGTCATTGCCTGCTGTTTCGTTCGAACCCGCCGCTGTTGTTGCGTCCTCTGCGCGCACTGTCGTCCACAAATTTGGCGG
CACCTCGGTGGCCGATGCCGACCGCTATCGGCATGTGGCGCAGCTGCTGCTTGCGCGCGACGAGACGGTGCAAGTCACCG
TGGTCTCGGCAATGAAGGGCGTCACCGATGCCTTGATCGAGCTGGCCGAACTGGCCGCAAAGGATCGTCCCGAGTGGCGC
GATCGCTGGCACGAAACGCGTGCGCGCCATCGCGGTGCCGCGGTGGCCCTGCTGGGTGAGCATTCCGGGCCGACCGTTGA
GTGGCTGGACGAACGCTTCGAACACCTGTCGCAGATCCTCGGCGCATTGGCGGTGATCGGCGAATTGCCGCGCGAGGTGC
TCGACCGCGTGCAGGGCCTGGGCGAGGTGTATTCGGCGCAGTTGCTGGGCGATCACTTTCGCGCGATCGGCGAAGACTGC
GCGGTGCTGGACGCACGCGATGTGCTGGTGGTCAATCGCGGCGAACTCGGTGTGGATGTGGACTGGGAAGTGAGCGCGCA
GCAGCTTGCCACGTGGCGGCAGGCGCATCCGCAAACGCGCGTGGTGGTGACCGGATTCGTGGCGCGCGATCGCGCCGATC
GCATCACCACACTGGGACGCAACGGCAGCGATTACTCCGGTGCGATTTTCGCTGCATTGTTCGATGCCGACGAACTGCAT
ATCTGGACCGATGTGGACGGCGTGCTGTCGGCCGATCCGCGCGTGGTGCCCGAAGCGGTGCAACTGGAAACGCTGAGCTA
CGACGAGGCCTGTGAGCTGGCGTATTTCGGTGCGAAGGTAGTGCATCCGCAAACGATGTCGCCGGCGATCGAACGCGGCC
TGCCGATCATCATCCGTAACACCTTCCAGCCCGAGCATCCCGGCACGCGCATCACTGCCAGCAGTGCGGTCAGGGGGCCG
ATCAAGGGGCTGACGTTGAGCCCGGATCTGGCGGTGCTGAATCTGGAAGGCACCGGTCTGATCGGTGTGCCGGGCACGGC
CGAGCGCGTCTTCGCATCGCTGCGCACCGCGCAGGTGTCGGTGGTGATGATCTCGCAGGGTTCGTCGGAACATTCGATCT
GTTGCGTGGTCAAGCAGCACGAATCCGAGCGTGCACGCAATGCGTTGTTGCAGGCGTTCGCGCATGAACTCACGGTCGGC
CAGGTGCAGCGCGTGCAGCTTACTACCGGCATCAGCGTGCTGGCGGCGGTGGGCGATGGCATGGCCGGACAGCCGGGTGT
GGCGGCACGGCTGTTCGAATCGTTGGGGCGCGCGCACGTCAATATCCTGGCGATTGCGCAGGGCTCGTCCGAACGCAACA
TTTCGGTGGCCATCGATGCGGCGCATGCCACCAAGGCCTTGCGCGCGGCGCATGCCGGTTTCTGGTTGTCGCCGCAGACC
TTCTCTGTCGGCGTAATCGGGCCGGGCAATGTGGGCGCGGCGTTGCTGGATCAACTACGCGTCGCGCAACCGCAGTTGCT
GGGCAAGGCCAATCTGGATCTGCGCCTGCGTGCGGTGGTGTCACGCGGACGCATGCTGCTGGACGAGCGCGGCCTGGTCG
GCGACTGGCGCGATGCGTTTGCATCGGCCGCCACGCCCACCGATCTGGAACGCTTCACCACGCATTTGCTGTCCGCACAT
CTGCCGCACACGGTGATCATTGATTGCAGCGGCAGCGCCGAAGTCGCGGACCGTTATGCAGGCTGGTTGGCTGCCGGCAT
CCATGTGGTGACGCCGAATAAACAGGCGGGTTCCGGCCCGCTCGCGCGTTATGAGGCAATCCGCGCAGCGGCCGATGCCA
GCGGTGCGCGCTTCCGTTACGAAGCCACCGTGGGCGCCGGCTTGCCGGTGATCACCACGCTGCGCGATCTGGTCGATACC
GGCGATACAGTCACCTCCATTGAAGGCATTTTCTCCGGCACGTTGGCCTGGTTGTTCAACAAATACGACGGCAGCGTGCC
GTTCGCCGAACTGGTGACGCAGGCGCGCAGCATGGGCTATACCGAACCGGACCCGCGCGACGATCTGTCCGGCGTGGATG
TGGCACGCAAGCTGGTGATCCTGGCGCGCGAAGCAGGGCGCGCCATCAGCCTGGAAGACGTCCAGGTGGAAAGCCTGGTG
CCAGCGGCATTGCGCCAGTCCAGCGTGGAGGATTTCATGGCGCGTCTGCCGGAAGTGGATGCTGCCTTTGCGCAGCGTCT
GGCCAACGCGCGCGTGCGCGGCAACGTGCTGCGCTACGTGGCGCAGTTGCCGCCGGACCGCGCGCCCAGCGTGGGCCTGG
TCGAGCTGCCGGCCGATCATGCATTCGCCAACTTGCGTCTGACCGACAACGTCGTTCAATTCACCACGCGCCGCTATTGC
CAGAACCCGCTGGTGGTGCAGGGTCCGGGTGCGGGGCCGGAAGTGACCGCAGCAGGCGTGTTCGCCGATCTGCTGCGCGT
GGCGGCAGGCGAGGGTGCGCGGCTATGA

Upstream 100 bases:

>100_bases
CGCGTAACTTCCGAAAACAACGGCCCCGCACCCGGATCAGGATGCGGAGGCTTCCCTCTCTCATCCGATGCGGACGGGGC
CTCCCCAACGAGGTCTTTCG

Downstream 100 bases:

>100_bases
GCGGTACAGGTCTGTCGTCGCCGCGCGCAGGTGCGGGGCATTCCGCGCCGCGCGAGGCACGCGCGTTCGCTCCGGCCTCG
GTGGCCAACGTGGCGGTCGG

Product: bifunctional aspartokinase I/homeserine dehydrogenase I

Products: NA

Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 835; Mature: 834

Protein sequence:

>835_residues
MSLPAVSFEPAAVVASSARTVVHKFGGTSVADADRYRHVAQLLLARDETVQVTVVSAMKGVTDALIELAELAAKDRPEWR
DRWHETRARHRGAAVALLGEHSGPTVEWLDERFEHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDC
AVLDARDVLVVNRGELGVDVDWEVSAQQLATWRQAHPQTRVVVTGFVARDRADRITTLGRNGSDYSGAIFAALFDADELH
IWTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRITASSAVRGP
IKGLTLSPDLAVLNLEGTGLIGVPGTAERVFASLRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVG
QVQRVQLTTGISVLAAVGDGMAGQPGVAARLFESLGRAHVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQT
FSVGVIGPGNVGAALLDQLRVAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAFASAATPTDLERFTTHLLSAH
LPHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDT
GDTVTSIEGIFSGTLAWLFNKYDGSVPFAELVTQARSMGYTEPDPRDDLSGVDVARKLVILAREAGRAISLEDVQVESLV
PAALRQSSVEDFMARLPEVDAAFAQRLANARVRGNVLRYVAQLPPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYC
QNPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL

Sequences:

>Translated_835_residues
MSLPAVSFEPAAVVASSARTVVHKFGGTSVADADRYRHVAQLLLARDETVQVTVVSAMKGVTDALIELAELAAKDRPEWR
DRWHETRARHRGAAVALLGEHSGPTVEWLDERFEHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDC
AVLDARDVLVVNRGELGVDVDWEVSAQQLATWRQAHPQTRVVVTGFVARDRADRITTLGRNGSDYSGAIFAALFDADELH
IWTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRITASSAVRGP
IKGLTLSPDLAVLNLEGTGLIGVPGTAERVFASLRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVG
QVQRVQLTTGISVLAAVGDGMAGQPGVAARLFESLGRAHVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQT
FSVGVIGPGNVGAALLDQLRVAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAFASAATPTDLERFTTHLLSAH
LPHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDT
GDTVTSIEGIFSGTLAWLFNKYDGSVPFAELVTQARSMGYTEPDPRDDLSGVDVARKLVILAREAGRAISLEDVQVESLV
PAALRQSSVEDFMARLPEVDAAFAQRLANARVRGNVLRYVAQLPPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYC
QNPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL
>Mature_834_residues
SLPAVSFEPAAVVASSARTVVHKFGGTSVADADRYRHVAQLLLARDETVQVTVVSAMKGVTDALIELAELAAKDRPEWRD
RWHETRARHRGAAVALLGEHSGPTVEWLDERFEHLSQILGALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCA
VLDARDVLVVNRGELGVDVDWEVSAQQLATWRQAHPQTRVVVTGFVARDRADRITTLGRNGSDYSGAIFAALFDADELHI
WTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRNTFQPEHPGTRITASSAVRGPI
KGLTLSPDLAVLNLEGTGLIGVPGTAERVFASLRTAQVSVVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQ
VQRVQLTTGISVLAAVGDGMAGQPGVAARLFESLGRAHVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQTF
SVGVIGPGNVGAALLDQLRVAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAFASAATPTDLERFTTHLLSAHL
PHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGPLARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDTG
DTVTSIEGIFSGTLAWLFNKYDGSVPFAELVTQARSMGYTEPDPRDDLSGVDVARKLVILAREAGRAISLEDVQVESLVP
AALRQSSVEDFMARLPEVDAAFAQRLANARVRGNVLRYVAQLPPDRAPSVGLVELPADHAFANLRLTDNVVQFTTRRYCQ
NPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=812, Percent_Identity=40.64039408867, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI1790376, Length=818, Percent_Identity=34.841075794621, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI1790455, Length=463, Percent_Identity=29.3736501079914, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322599, Length=363, Percent_Identity=39.6694214876033, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320893, Length=507, Percent_Identity=26.232741617357, Blast_Score=150, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 89235; Mature: 89104

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPAVSFEPAAVVASSARTVVHKFGGTSVADADRYRHVAQLLLARDETVQVTVVSAMKG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
VTDALIELAELAAKDRPEWRDRWHETRARHRGAAVALLGEHSGPTVEWLDERFEHLSQIL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
GALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCAVLDARDVLVVNRGELGVDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCC
DWEVSAQQLATWRQAHPQTRVVVTGFVARDRADRITTLGRNGSDYSGAIFAALFDADELH
CCCCCHHHHHHHHHCCCCCEEEEEEEHHHCCHHHHHCCCCCCCCCCCEEEEEEECCCCEE
IWTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRN
EEECCCCHHCCCCCCCCHHHEEEECCCCHHHHHHHHCCEEECCCCCCHHHHCCCEEEEEC
TFQPEHPGTRITASSAVRGPIKGLTLSPDLAVLNLEGTGLIGVPGTAERVFASLRTAQVS
CCCCCCCCCEEEECCCCCCCCCCCEECCCEEEEEECCCEEEECCCCHHHHHHHHHHHEEE
VVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQVQRVQLTTGISVLAAVGDG
EEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCC
MAGQPGVAARLFESLGRAHVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQT
CCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECHHHHHHHHHHHCCCEECCCC
FSVGVIGPGNVGAALLDQLRVAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAF
EEEEEECCCCHHHHHHHHHHHCCHHHCCCCCCCEEHHHHHHCCHHEECCCCCCCCHHHHH
ASAATPTDLERFTTHLLSAHLPHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGP
HCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
LARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDTGDTVTSIEGIFSGTLAWLFN
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KYDGSVPFAELVTQARSMGYTEPDPRDDLSGVDVARKLVILAREAGRAISLEDVQVESLV
HCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
PAALRQSSVEDFMARLPEVDAAFAQRLANARVRGNVLRYVAQLPPDRAPSVGLVELPADH
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
AFANLRLTDNVVQFTTRRYCQNPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL
CEEEEEECHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SLPAVSFEPAAVVASSARTVVHKFGGTSVADADRYRHVAQLLLARDETVQVTVVSAMKG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHH
VTDALIELAELAAKDRPEWRDRWHETRARHRGAAVALLGEHSGPTVEWLDERFEHLSQIL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
GALAVIGELPREVLDRVQGLGEVYSAQLLGDHFRAIGEDCAVLDARDVLVVNRGELGVDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCCCC
DWEVSAQQLATWRQAHPQTRVVVTGFVARDRADRITTLGRNGSDYSGAIFAALFDADELH
CCCCCHHHHHHHHHCCCCCEEEEEEEHHHCCHHHHHCCCCCCCCCCCEEEEEEECCCCEE
IWTDVDGVLSADPRVVPEAVQLETLSYDEACELAYFGAKVVHPQTMSPAIERGLPIIIRN
EEECCCCHHCCCCCCCCHHHEEEECCCCHHHHHHHHCCEEECCCCCCHHHHCCCEEEEEC
TFQPEHPGTRITASSAVRGPIKGLTLSPDLAVLNLEGTGLIGVPGTAERVFASLRTAQVS
CCCCCCCCCEEEECCCCCCCCCCCEECCCEEEEEECCCEEEECCCCHHHHHHHHHHHEEE
VVMISQGSSEHSICCVVKQHESERARNALLQAFAHELTVGQVQRVQLTTGISVLAAVGDG
EEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCC
MAGQPGVAARLFESLGRAHVNILAIAQGSSERNISVAIDAAHATKALRAAHAGFWLSPQT
CCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECHHHHHHHHHHHCCCEECCCC
FSVGVIGPGNVGAALLDQLRVAQPQLLGKANLDLRLRAVVSRGRMLLDERGLVGDWRDAF
EEEEEECCCCHHHHHHHHHHHCCHHHCCCCCCCEEHHHHHHCCHHEECCCCCCCCHHHHH
ASAATPTDLERFTTHLLSAHLPHTVIIDCSGSAEVADRYAGWLAAGIHVVTPNKQAGSGP
HCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
LARYEAIRAAADASGARFRYEATVGAGLPVITTLRDLVDTGDTVTSIEGIFSGTLAWLFN
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KYDGSVPFAELVTQARSMGYTEPDPRDDLSGVDVARKLVILAREAGRAISLEDVQVESLV
HCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
PAALRQSSVEDFMARLPEVDAAFAQRLANARVRGNVLRYVAQLPPDRAPSVGLVELPADH
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCC
AFANLRLTDNVVQFTTRRYCQNPLVVQGPGAGPEVTAAGVFADLLRVAAGEGARL
CEEEEEECHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]