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The map label for this gene is fkpA [H]

Identifier: 84623602

GI number: 84623602

Start: 2146777

End: 2147673

Strand: Direct

Name: fkpA [H]

Synonym: XOO_1945

Alternate gene names: 84623602

Gene position: 2146777-2147673 (Clockwise)

Preceding gene: 84623601

Following gene: 84623603

Centisome position: 43.46

GC content: 62.21

Gene sequence:

>897_bases
ATGTCGCATCAACCGGCCGCAGCGGCCACCAAGGAGAAGCCAGCTTTGAATGCATCGTCTGAGAAGAGCACGCGCGACAA
CGTCAGCTACGCCATCGGTATGGACGTCGCACGTTCGTTCGAGCCGATTGCTCAGGACATCGACGTGAACGCGATGCAAC
GCGCCATCGAAAATGCATTCAAGGGCGGCAAGCCGCTGTTGTCGGATGAGCAGACCCAGGCCACCGACACCGCACTGCGT
ACCGCGCTCGCTGCCCGCAACGGCCAGCAGGTGCCGGGCGTGGCGCCGGGTGCCGCGCCGGCTGCACCGTCCAAGGAAAA
TGTTGGCCTGATGCTCGGCGATCGCGCTGTTGGTCCGTCGCTGGCCGGCATCAAGGACGAGATCGATCTGTCGATCCTGA
TGGACGCGGTGCGCACCGTGTTCTCCAAGGGCACCACGCGTCTGACCCAGCAGGAAGCGATGGCCACCATGCAGGCGTTC
GCCTCTGCCAAGCAGGGCGCTGCCGGTGCCAAGAATCGCGAAGAAGGCAATGCCTTCCTTGCCAAGAACAAGACCGAGAA
GGGCGTGATCACCACGGCGTCCGGCCTGCAATACATGGTGTTGCGCCAGGGCAGCGGCGAGCGCCCGATGCGGACAAACA
AGGTCCGTGTGAACTACGAGGGCAAGCTGCTCAACGGGCAGGTCTTCGACAGTTCCTACCAGCGCGGCCAGCCGGCGGAG
TTCGGTCTGGATCAAGTCATTCCCGGTTGGACCGAGGGCGTTGCGTTGATGCCGGTCGGTTCGAAATATCGTTTCTGGAT
TCCATCCAACTTGGCCTATGGCCCGAACGGCACGCAGGGGATCGGACCTGACGCAACGTTGACGTTCGATGTTGAACTGA
TGGGTATCCTTCCCTGA

Upstream 100 bases:

>100_bases
GCGTCTTTATCACTTTTGGGAAGTGCATCGAATGAAGATGGGAAAGCGCGGCGCGGCGGCGTCGTTACTGATGGTGGCAA
TGTCGGCATCGATGCCGGCC

Downstream 100 bases:

>100_bases
TCCCCCCCTGAGAGTACCCCCACCCATGCGAGTTGCGATCTTTGGTACCGGTTATGTTGGTCTTGTCACCGGAACCTGTC
TGGCCGAAGTCGGTCATCAC

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSHQPAAAATKEKPALNASSEKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAFKGGKPLLSDEQTQATDTALR
TALAARNGQQVPGVAPGAAPAAPSKENVGLMLGDRAVGPSLAGIKDEIDLSILMDAVRTVFSKGTTRLTQQEAMATMQAF
ASAKQGAAGAKNREEGNAFLAKNKTEKGVITTASGLQYMVLRQGSGERPMRTNKVRVNYEGKLLNGQVFDSSYQRGQPAE
FGLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGIGPDATLTFDVELMGILP

Sequences:

>Translated_298_residues
MSHQPAAAATKEKPALNASSEKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAFKGGKPLLSDEQTQATDTALR
TALAARNGQQVPGVAPGAAPAAPSKENVGLMLGDRAVGPSLAGIKDEIDLSILMDAVRTVFSKGTTRLTQQEAMATMQAF
ASAKQGAAGAKNREEGNAFLAKNKTEKGVITTASGLQYMVLRQGSGERPMRTNKVRVNYEGKLLNGQVFDSSYQRGQPAE
FGLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGIGPDATLTFDVELMGILP
>Mature_297_residues
SHQPAAAATKEKPALNASSEKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAFKGGKPLLSDEQTQATDTALRT
ALAARNGQQVPGVAPGAAPAAPSKENVGLMLGDRAVGPSLAGIKDEIDLSILMDAVRTVFSKGTTRLTQQEAMATMQAFA
SAKQGAAGAKNREEGNAFLAKNKTEKGVITTASGLQYMVLRQGSGERPMRTNKVRVNYEGKLLNGQVFDSSYQRGQPAEF
GLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGIGPDATLTFDVELMGILP

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=130, Percent_Identity=40, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI224809327, Length=130, Percent_Identity=40, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4758384, Length=130, Percent_Identity=40, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI224809331, Length=130, Percent_Identity=40, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI17149836, Length=104, Percent_Identity=44.2307692307692, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4503725, Length=104, Percent_Identity=44.2307692307692, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=38.6792452830189, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87082390, Length=124, Percent_Identity=54.0322580645161, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1789745, Length=183, Percent_Identity=43.1693989071038, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=40.5660377358491, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=93, Percent_Identity=52.6881720430108, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=91, Percent_Identity=47.2527472527472, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323482, Length=95, Percent_Identity=43.1578947368421, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323566, Length=136, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=42.4528301886792, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583150, Length=105, Percent_Identity=39.0476190476191, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=45.4545454545455, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=45.4545454545455, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24647110, Length=110, Percent_Identity=39.0909090909091, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 31575; Mature: 31444

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHQPAAAATKEKPALNASSEKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHH
KGGKPLLSDEQTQATDTALRTALAARNGQQVPGVAPGAAPAAPSKENVGLMLGDRAVGPS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
LAGIKDEIDLSILMDAVRTVFSKGTTRLTQQEAMATMQAFASAKQGAAGAKNREEGNAFL
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
AKNKTEKGVITTASGLQYMVLRQGSGERPMRTNKVRVNYEGKLLNGQVFDSSYQRGQPAE
ECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCEEEEEECCEEECCEEECCCCCCCCCHH
FGLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGIGPDATLTFDVELMGILP
CCHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure 
SHQPAAAATKEKPALNASSEKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAF
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHH
KGGKPLLSDEQTQATDTALRTALAARNGQQVPGVAPGAAPAAPSKENVGLMLGDRAVGPS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
LAGIKDEIDLSILMDAVRTVFSKGTTRLTQQEAMATMQAFASAKQGAAGAKNREEGNAFL
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
AKNKTEKGVITTASGLQYMVLRQGSGERPMRTNKVRVNYEGKLLNGQVFDSSYQRGQPAE
ECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCEEEEEECCEEECCEEECCCCCCCCCHH
FGLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGIGPDATLTFDVELMGILP
CCHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]