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The map label for this gene is btuE [H]

Identifier: 84623601

GI number: 84623601

Start: 2146059

End: 2146616

Strand: Direct

Name: btuE [H]

Synonym: XOO_1944

Alternate gene names: 84623601

Gene position: 2146059-2146616 (Clockwise)

Preceding gene: 84623594

Following gene: 84623602

Centisome position: 43.44

GC content: 57.71

Gene sequence:

>558_bases
ATGTTGCTAAATCGTCTATTAGTTATTGTATTTATTGGATTTTTTGCGAAATCCGCGTTTGCCGCCGGCACTCCGGTGCT
GGATGTGGACTACCGCCCGCTGGCCGGCAAGACACCAATCAACCTGAACCTTACCTACGGGGGCAAGGTCGTCATGGTGG
TCAATACCGCCAGCAAGTGTGGCTACACCCCCCAATACGAAGGCCTGGAAGCGCTCAATCAGCGCTTTGCCAGCCGCGGC
TTCACCGTGCTGGGCTTCCCGTCGAACGATTTCCATGGCCAGGAACCCGGATCTGAGAAACAGATCCAGGAATTCTGCAC
GTTGACCTATGGCGTCAAGTTCCCGATGTTTGAGAAGGTGCATGTGCTGGGTGCAGAGGCAACGCCGCTGTATCAGCGCT
TGACCCAAGCCACCGGCGTGGCGCCGGGCTGGAATTTTCACAAGTACCTGATTGGTCGCGATGGTCGCGTGGTTGCGCAG
TTCCCCAGCAAGATCAAGCCGGACGATCCGAGCGTCCTGGCCGCAATCGAACGCGAGCTCAAGGCGCCGTCGCGCTGA

Upstream 100 bases:

>100_bases
AAACTACAACACCGACACGCAGACAGTCAACTGCTTGTCATCCCCAACTGATGGCACCCCCTCACCGGTGCGCCGCCTCA
ATTATCGAAGGGCCTTGCTC

Downstream 100 bases:

>100_bases
GTGCAGCGCTCGCATCGCCGCGCGCGCATGCGACAATGCGCATTCGGCGCCATCGGTGGCGCGTCTTTATCACTTTTGGG
AAGTGCATCGAATGAAGATG

Product: ABC transporter vitamin B12 uptake permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MLLNRLLVIVFIGFFAKSAFAAGTPVLDVDYRPLAGKTPINLNLTYGGKVVMVVNTASKCGYTPQYEGLEALNQRFASRG
FTVLGFPSNDFHGQEPGSEKQIQEFCTLTYGVKFPMFEKVHVLGAEATPLYQRLTQATGVAPGWNFHKYLIGRDGRVVAQ
FPSKIKPDDPSVLAAIERELKAPSR

Sequences:

>Translated_185_residues
MLLNRLLVIVFIGFFAKSAFAAGTPVLDVDYRPLAGKTPINLNLTYGGKVVMVVNTASKCGYTPQYEGLEALNQRFASRG
FTVLGFPSNDFHGQEPGSEKQIQEFCTLTYGVKFPMFEKVHVLGAEATPLYQRLTQATGVAPGWNFHKYLIGRDGRVVAQ
FPSKIKPDDPSVLAAIERELKAPSR
>Mature_185_residues
MLLNRLLVIVFIGFFAKSAFAAGTPVLDVDYRPLAGKTPINLNLTYGGKVVMVVNTASKCGYTPQYEGLEALNQRFASRG
FTVLGFPSNDFHGQEPGSEKQIQEFCTLTYGVKFPMFEKVHVLGAEATPLYQRLTQATGVAPGWNFHKYLIGRDGRVVAQ
FPSKIKPDDPSVLAAIERELKAPSR

Specific function: Not essential for B12 transport; however, it is an auxiliary component of the transport system [H]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=136, Percent_Identity=41.9117647058824, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI192455698, Length=126, Percent_Identity=41.2698412698413, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI75709200, Length=129, Percent_Identity=41.0852713178295, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI90903240, Length=129, Percent_Identity=41.0852713178295, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI90903238, Length=117, Percent_Identity=41.025641025641, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI41406084, Length=180, Percent_Identity=32.2222222222222, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4557629, Length=143, Percent_Identity=31.4685314685315, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1788003, Length=159, Percent_Identity=44.6540880503145, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17506887, Length=141, Percent_Identity=36.8794326241135, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17535473, Length=143, Percent_Identity=37.7622377622378, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71993584, Length=129, Percent_Identity=34.8837209302326, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193210707, Length=131, Percent_Identity=38.1679389312977, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17550320, Length=166, Percent_Identity=27.1084337349398, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=140, Percent_Identity=45, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322228, Length=139, Percent_Identity=46.7625899280576, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322826, Length=141, Percent_Identity=36.1702127659575, Blast_Score=104, Evalue=7e-24,
Organism=Drosophila melanogaster, GI85726443, Length=142, Percent_Identity=36.6197183098592, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24656772, Length=131, Percent_Identity=37.4045801526718, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24656777, Length=142, Percent_Identity=36.6197183098592, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24656767, Length=142, Percent_Identity=36.6197183098592, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: NA

Molecular weight: Translated: 20357; Mature: 20357

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNRLLVIVFIGFFAKSAFAAGTPVLDVDYRPLAGKTPINLNLTYGGKVVMVVNTASKC
CHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEEECCEEEEEEECHHHC
GYTPQYEGLEALNQRFASRGFTVLGFPSNDFHGQEPGSEKQIQEFCTLTYGVKFPMFEKV
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
HVLGAEATPLYQRLTQATGVAPGWNFHKYLIGRDGRVVAQFPSKIKPDDPSVLAAIEREL
EEECCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHH
KAPSR
CCCCC
>Mature Secondary Structure
MLLNRLLVIVFIGFFAKSAFAAGTPVLDVDYRPLAGKTPINLNLTYGGKVVMVVNTASKC
CHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEEECCEEEEEEECHHHC
GYTPQYEGLEALNQRFASRGFTVLGFPSNDFHGQEPGSEKQIQEFCTLTYGVKFPMFEKV
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
HVLGAEATPLYQRLTQATGVAPGWNFHKYLIGRDGRVVAQFPSKIKPDDPSVLAAIEREL
EEECCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHH
KAPSR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3528129; 9097039; 9278503 [H]