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The map label for this gene is mmuP [H]

Identifier: 84623484

GI number: 84623484

Start: 2010956

End: 2012353

Strand: Direct

Name: mmuP [H]

Synonym: XOO_1827

Alternate gene names: 84623484

Gene position: 2010956-2012353 (Clockwise)

Preceding gene: 84623483

Following gene: 84623485

Centisome position: 40.71

GC content: 63.95

Gene sequence:

>1398_bases
ATGCCAGAACCATCGTCCACCACCGCCCCGCAGTTCCGGCGCAGCATGCAGGTGCGCCATCTGGTGATGCTGTCGCTGGG
CGGCGTGATCGGTACCGGCTTGTTCTTCAATACCGGGTACATCATTGCCAGCACCGGCGCGCTGGGCACGGTGCTCGCAT
ATCTGATCGGCGCGTTGGTGGTGTACCTGGTGATGCAATGCCTGGGCGAGTTGGCGGTGGCGATGCCGCAGACCGGCGCA
TTCCACGTGTATGCCGCGCGTTATCTGGGGCCGGCGACCGGCTACGTGGTTGCGTGGTTGTACTGGCTGACCTGGACGGT
GGCATTGGGCTCGAGCCTAACCGCAGCGGCGTTCTGCATGCAGTACTGGTTTCCGCATAGCCCGGCGTGGCCGTGGTGTC
TGCTGTTCTGCGCGCTGATCTTCGGTTTGAACACGGTCTCGGCGCGCTGGTTTGCAGAAGGCGAGTTCTGGTTTTCGTTG
ATCAAGGTCATCACCATCCTGGTGTTCATCGTGCTTGGCGGTGCGGCGGTGATCGGTCTGCTGCCACTGGCCGATGGTTC
GCCTGCACCCGGGCTGCGTCATCTACGTGCCGATGGCTGGTTTGCGCATGGAACGCTGCCGATCCTGATGACGATGGTGG
CAGTGAATTTTGCATTTTCCGGCACCGAGTTGATTGGTGTGGCCGCCGGCGAAACCGAGCAGCCAGCGCGCGCGATTCCG
CTGGCGATCCGCACAACGCTGATGCGGCTGGTGGTGTTCTTCGTCGGCACGGTGCTGGTGCTGGCAGCGCTGCTGCCTGC
CGAACAAGCGGCAGTGGAGACGAGCCCGTTCGTGCGCGCCTTCGAGCTGTTGGGCATTCCGTATGCGGCCGACCTCTTGA
ATGCGGTGATCCTCACCGCGATCCTGTCGGCGGCCAATTCCGGCCTGTATGCGGCCGCGCGCATGCTGTGGTCGTTGGCC
AACGAAGGCACGTTGCCTTCGGGCCTGACGCGGTTGACCGGCCGCGGCATTCCGTTGCGCGCCGTGTCGTTGAGCATGTT
GGGTGGCTTGCTGGCGCTGCTCACGGGCGTGTATGCGGCCGACACCGTGTTCGTTGCGATCTCGGCGGTTTCGGGGTTTG
CGGTGGTGGTGGTGTGGCTGAGCATCTGCGCGTCGCACTATGTGTTTCGTCGCCAGCTGCTGCGCGATGGCGTTGCGCCA
GAGACGCTGGCGTACCGCGCGCCGTGGTATCCATGGACACCGATCCTCGGCTTTTCGCTGTGTCTGCTGGCCTGTATCGG
GCTGGCATTCGATCCGCAGCAGCGCATCGCGTTGTGGTGCGGCGTTCCGTTCGTTGCGCTGTGCTACGGCGCTTACGCAC
TTACCCAACGGCTTGCGGCCCGGAGACTGCACGCATGA

Upstream 100 bases:

>100_bases
CGCCACGGAGCAGCAGGCCCTGCGTCACAGCTCGGGTGTAAACGGCTGTGCCCGTCTGCGTGCGCGTGGCAGGATGGAGC
GCCCCTGATCGGACGCGCCC

Downstream 100 bases:

>100_bases
CGATTGCTTTCCGCCAACCGCGCGCAGATGCGCCTTTCAGCCAGCTCTTGCAGCACGACGGCTGCGTGCTGCTGGATGGC
GCCCTGGCCACCGAGCTGGA

Product: S-methylmethionine transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MPEPSSTTAPQFRRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALVVYLVMQCLGELAVAMPQTGA
FHVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCMQYWFPHSPAWPWCLLFCALIFGLNTVSARWFAEGEFWFSL
IKVITILVFIVLGGAAVIGLLPLADGSPAPGLRHLRADGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETEQPARAIP
LAIRTTLMRLVVFFVGTVLVLAALLPAEQAAVETSPFVRAFELLGIPYAADLLNAVILTAILSAANSGLYAAARMLWSLA
NEGTLPSGLTRLTGRGIPLRAVSLSMLGGLLALLTGVYAADTVFVAISAVSGFAVVVVWLSICASHYVFRRQLLRDGVAP
ETLAYRAPWYPWTPILGFSLCLLACIGLAFDPQQRIALWCGVPFVALCYGAYALTQRLAARRLHA

Sequences:

>Translated_465_residues
MPEPSSTTAPQFRRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALVVYLVMQCLGELAVAMPQTGA
FHVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCMQYWFPHSPAWPWCLLFCALIFGLNTVSARWFAEGEFWFSL
IKVITILVFIVLGGAAVIGLLPLADGSPAPGLRHLRADGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETEQPARAIP
LAIRTTLMRLVVFFVGTVLVLAALLPAEQAAVETSPFVRAFELLGIPYAADLLNAVILTAILSAANSGLYAAARMLWSLA
NEGTLPSGLTRLTGRGIPLRAVSLSMLGGLLALLTGVYAADTVFVAISAVSGFAVVVVWLSICASHYVFRRQLLRDGVAP
ETLAYRAPWYPWTPILGFSLCLLACIGLAFDPQQRIALWCGVPFVALCYGAYALTQRLAARRLHA
>Mature_464_residues
PEPSSTTAPQFRRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALVVYLVMQCLGELAVAMPQTGAF
HVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCMQYWFPHSPAWPWCLLFCALIFGLNTVSARWFAEGEFWFSLI
KVITILVFIVLGGAAVIGLLPLADGSPAPGLRHLRADGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETEQPARAIPL
AIRTTLMRLVVFFVGTVLVLAALLPAEQAAVETSPFVRAFELLGIPYAADLLNAVILTAILSAANSGLYAAARMLWSLAN
EGTLPSGLTRLTGRGIPLRAVSLSMLGGLLALLTGVYAADTVFVAISAVSGFAVVVVWLSICASHYVFRRQLLRDGVAPE
TLAYRAPWYPWTPILGFSLCLLACIGLAFDPQQRIALWCGVPFVALCYGAYALTQRLAARRLHA

Specific function: Transporter for the intake of S-methylmethionine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=369, Percent_Identity=22.7642276422764, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI115648022, Length=369, Percent_Identity=22.7642276422764, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=72.8260869565217, Blast_Score=696, Evalue=0.0,
Organism=Escherichia coli, GI1788480, Length=470, Percent_Identity=37.6595744680851, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1786302, Length=414, Percent_Identity=35.2657004830918, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1786789, Length=422, Percent_Identity=34.8341232227488, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI48994972, Length=467, Percent_Identity=32.5481798715203, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=35.0993377483444, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI87081915, Length=457, Percent_Identity=32.1663019693654, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1790653, Length=397, Percent_Identity=33.7531486146096, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI1789017, Length=454, Percent_Identity=32.5991189427313, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI87081869, Length=330, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=406, Percent_Identity=21.4285714285714, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=344, Percent_Identity=21.8023255813953, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=418, Percent_Identity=32.0574162679426, Blast_Score=223, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6324553, Length=410, Percent_Identity=33.4146341463415, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324061, Length=427, Percent_Identity=29.9765807962529, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324059, Length=428, Percent_Identity=31.5420560747664, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=477, Percent_Identity=29.1404612159329, Blast_Score=199, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6321629, Length=428, Percent_Identity=30.3738317757009, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320717, Length=427, Percent_Identity=30.2107728337237, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6321053, Length=419, Percent_Identity=29.8329355608592, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6319543, Length=427, Percent_Identity=29.03981264637, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6319824, Length=420, Percent_Identity=28.8095238095238, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=434, Percent_Identity=28.110599078341, Blast_Score=180, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6320251, Length=440, Percent_Identity=26.8181818181818, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=436, Percent_Identity=29.3577981651376, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322967, Length=428, Percent_Identity=28.7383177570093, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324924, Length=437, Percent_Identity=28.604118993135, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324981, Length=427, Percent_Identity=30.9133489461358, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319608, Length=433, Percent_Identity=22.6327944572748, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=547, Percent_Identity=21.7550274223035, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221331183, Length=356, Percent_Identity=21.0674157303371, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647653, Length=356, Percent_Identity=21.0674157303371, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664379, Length=356, Percent_Identity=21.0674157303371, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49798; Mature: 49666

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEPSSTTAPQFRRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
VYLVMQCLGELAVAMPQTGAFHVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCM
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QYWFPHSPAWPWCLLFCALIFGLNTVSARWFAEGEFWFSLIKVITILVFIVLGGAAVIGL
HHHCCCCCCCHHHHHHHHHHHCCCHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLADGSPAPGLRHLRADGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETEQPARAIP
HCCCCCCCCCCHHHHCCCCCEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
LAIRTTLMRLVVFFVGTVLVLAALLPAEQAAVETSPFVRAFELLGIPYAADLLNAVILTA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHH
ILSAANSGLYAAARMLWSLANEGTLPSGLTRLTGRGIPLRAVSLSMLGGLLALLTGVYAA
HHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DTVFVAISAVSGFAVVVVWLSICASHYVFRRQLLRDGVAPETLAYRAPWYPWTPILGFSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHHHHH
CLLACIGLAFDPQQRIALWCGVPFVALCYGAYALTQRLAARRLHA
HHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PEPSSTTAPQFRRSMQVRHLVMLSLGGVIGTGLFFNTGYIIASTGALGTVLAYLIGALV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHH
VYLVMQCLGELAVAMPQTGAFHVYAARYLGPATGYVVAWLYWLTWTVALGSSLTAAAFCM
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
QYWFPHSPAWPWCLLFCALIFGLNTVSARWFAEGEFWFSLIKVITILVFIVLGGAAVIGL
HHHCCCCCCCHHHHHHHHHHHCCCHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLADGSPAPGLRHLRADGWFAHGTLPILMTMVAVNFAFSGTELIGVAAGETEQPARAIP
HCCCCCCCCCCHHHHCCCCCEECCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
LAIRTTLMRLVVFFVGTVLVLAALLPAEQAAVETSPFVRAFELLGIPYAADLLNAVILTA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHH
ILSAANSGLYAAARMLWSLANEGTLPSGLTRLTGRGIPLRAVSLSMLGGLLALLTGVYAA
HHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DTVFVAISAVSGFAVVVVWLSICASHYVFRRQLLRDGVAPETLAYRAPWYPWTPILGFSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCHHHHHHH
CLLACIGLAFDPQQRIALWCGVPFVALCYGAYALTQRLAARRLHA
HHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684 [H]