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The map label for this gene is mmuM [H]

Identifier: 84623485

GI number: 84623485

Start: 2012350

End: 2013327

Strand: Direct

Name: mmuM [H]

Synonym: XOO_1828

Alternate gene names: 84623485

Gene position: 2012350-2013327 (Clockwise)

Preceding gene: 84623484

Following gene: 84623489

Centisome position: 40.73

GC content: 64.62

Gene sequence:

>978_bases
ATGACGATTGCTTTCCGCCAACCGCGCGCAGATGCGCCTTTCAGCCAGCTCTTGCAGCACGACGGCTGCGTGCTGCTGGA
TGGCGCCCTGGCCACCGAGCTGGAACACCGCGGCTGCGATCTCAACGATGCGCTGTGGTCGGCGCGTGTGCTGATAGAGC
AGCCGGAATTGATCTATCAGGTGCATCGCGATTATTTCGCCGCCGGTGCGCAATGCGCGATCACTGCCAGTTACCAGGCC
ACGCCGCTGGGCTTTGCCGCACGCGGGCTGGATGTTGCGCAATCGCAAGCGTTGATCGCACGCAGCGTGGAACTGGCGGT
GCAGGCACGCGCCGATCATCTGCACGCCCAACCGCAGGCTGCGCCGTTGTGGGTGGCAGGCTCGGTGGGGCCATATGGCG
CGTATCTGGCCGATGGCTCGGAATATCGCGGCGACTACGTACTGCCGATCGCCCAATTGATGGACTTCCATCGCCCGCGC
ATCGCTGCGCTGGCGGATGCTGGCGTGGATGTGTTGGCCTGCGAAACGCTGCCATCGGCAAGCGAAATCGTGGCGTTGCG
GCAATTGCTGCAAAGCGAATTTCCGCAGCTGCATGCGTGGTTTTCCTTCACCTTGCGCGATGCTGCGCACTTGAGCGATG
GAACCCCGTTGGCGCAGGTGGTGCCGGCTCTGGATGCGTGTACGCAGGTGATCGCGGTGGGTATCAACTGCATTGCGCTG
GATCAGGTGACGGCTGCACTGCACAGCCTGTCGGCGCTAACCGCACTGCCGCTGGTGGTGTATCCGAACTCGGGCGAGCA
CTACGACGCCAGCGACAAGCGCTGGCATGCCGGTCACGCGTCTGGGCTCACGTTGGCCGACCAGCATGCGCACTGGCTGG
CTGCCGGCGCGCGACTGATCGGTGGCTGCTGCCGCACCACGCCACGCGATATCGCCGCATTGGCGGCGGCGCGTTTGGCG
GACTCACCGGGCCTATGA

Upstream 100 bases:

>100_bases
CGCAGCAGCGCATCGCGTTGTGGTGCGGCGTTCCGTTCGTTGCGCTGTGCTACGGCGCTTACGCACTTACCCAACGGCTT
GCGGCCCGGAGACTGCACGC

Downstream 100 bases:

>100_bases
ACGCGCTCACAATGCATCTGGCGACCAGCCTGCAAAGCTGGGACGGTGCCCGTCGCCAGCGGCTGGCGAGGCGGTGCCGG
CGTTGCGCGGAGCCAAAACG

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTIAFRQPRADAPFSQLLQHDGCVLLDGALATELEHRGCDLNDALWSARVLIEQPELIYQVHRDYFAAGAQCAITASYQA
TPLGFAARGLDVAQSQALIARSVELAVQARADHLHAQPQAAPLWVAGSVGPYGAYLADGSEYRGDYVLPIAQLMDFHRPR
IAALADAGVDVLACETLPSASEIVALRQLLQSEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACTQVIAVGINCIAL
DQVTAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGHASGLTLADQHAHWLAAGARLIGGCCRTTPRDIAALAAARLA
DSPGL

Sequences:

>Translated_325_residues
MTIAFRQPRADAPFSQLLQHDGCVLLDGALATELEHRGCDLNDALWSARVLIEQPELIYQVHRDYFAAGAQCAITASYQA
TPLGFAARGLDVAQSQALIARSVELAVQARADHLHAQPQAAPLWVAGSVGPYGAYLADGSEYRGDYVLPIAQLMDFHRPR
IAALADAGVDVLACETLPSASEIVALRQLLQSEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACTQVIAVGINCIAL
DQVTAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGHASGLTLADQHAHWLAAGARLIGGCCRTTPRDIAALAAARLA
DSPGL
>Mature_324_residues
TIAFRQPRADAPFSQLLQHDGCVLLDGALATELEHRGCDLNDALWSARVLIEQPELIYQVHRDYFAAGAQCAITASYQAT
PLGFAARGLDVAQSQALIARSVELAVQARADHLHAQPQAAPLWVAGSVGPYGAYLADGSEYRGDYVLPIAQLMDFHRPRI
AALADAGVDVLACETLPSASEIVALRQLLQSEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACTQVIAVGINCIALD
QVTAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGHASGLTLADQHAHWLAAGARLIGGCCRTTPRDIAALAAARLAD
SPGL

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=322, Percent_Identity=25.1552795031056, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786456, Length=306, Percent_Identity=66.0130718954248, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1790450, Length=323, Percent_Identity=25.6965944272446, Blast_Score=71, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322966, Length=331, Percent_Identity=28.7009063444109, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324982, Length=336, Percent_Identity=25.8928571428571, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323983, Length=93, Percent_Identity=41.9354838709677, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129603, Length=317, Percent_Identity=36.9085173501577, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24585077, Length=288, Percent_Identity=35.0694444444444, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 34557; Mature: 34426

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAFRQPRADAPFSQLLQHDGCVLLDGALATELEHRGCDLNDALWSARVLIEQPELIYQ
CCEECCCCCCCCCHHHHHHCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHH
VHRDYFAAGAQCAITASYQATPLGFAARGLDVAQSQALIARSVELAVQARADHLHAQPQA
HHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APLWVAGSVGPYGAYLADGSEYRGDYVLPIAQLMDFHRPRIAALADAGVDVLACETLPSA
CCEEEECCCCCCCCEECCCCCCCCCEEEEHHHHHHCCCCHHHHHHHCCCCEEEECCCCCH
SEIVALRQLLQSEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACTQVIAVGINCIAL
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEH
DQVTAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGHASGLTLADQHAHWLAAGARLI
HHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHH
GGCCRTTPRDIAALAAARLADSPGL
HHHHCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TIAFRQPRADAPFSQLLQHDGCVLLDGALATELEHRGCDLNDALWSARVLIEQPELIYQ
CEECCCCCCCCCHHHHHHCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHH
VHRDYFAAGAQCAITASYQATPLGFAARGLDVAQSQALIARSVELAVQARADHLHAQPQA
HHHHHHHCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
APLWVAGSVGPYGAYLADGSEYRGDYVLPIAQLMDFHRPRIAALADAGVDVLACETLPSA
CCEEEECCCCCCCCEECCCCCCCCCEEEEHHHHHHCCCCHHHHHHHCCCCEEEECCCCCH
SEIVALRQLLQSEFPQLHAWFSFTLRDAAHLSDGTPLAQVVPALDACTQVIAVGINCIAL
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEH
DQVTAALHSLSALTALPLVVYPNSGEHYDASDKRWHAGHASGLTLADQHAHWLAAGARLI
HHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHH
GGCCRTTPRDIAALAAARLADSPGL
HHHHCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]