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The map label for this gene is acdA [H]

Identifier: 84623396

GI number: 84623396

Start: 1921092

End: 1922273

Strand: Direct

Name: acdA [H]

Synonym: XOO_1739

Alternate gene names: 84623396

Gene position: 1921092-1922273 (Clockwise)

Preceding gene: 84623395

Following gene: 84623397

Centisome position: 38.89

GC content: 64.3

Gene sequence:

>1182_bases
ATGAACGCAACCATCCAGCTCTATCCCAACGCGGCCGATTTGAACGACGAGCAGCAAGCCTTTCGCGCCGCCGCCCGCGA
TTTTGCCGATAAAGAACTCGCCCCGCACGCGGCGCAGTGGGACGCAGAAGGTCACTTCCCGCGCGAGGCGATCGCCAAGG
CCGCAGCGTTGGGCTTTTGCGGGCTTTACACCGACCACGGCGTGGGCGGCCTGGGCATGCGCCGGCTCGATGCGGCGGTG
GTGTTCGAAGAGCTTGCCACGGTGGATCCATCCACCTCGGCCTTCATCAGCATCCACAACATGGTCACCTGGTTTATTGC
CAGCTACGGCACCGATGCGGTGCGCGCGCAGTGGGGCGAGGCGATGACCAGCGGTGCCAGACTCGGCTCCTACTGCCTGA
CCGAACCGGGCAGCGGCTCGGACGCAGCATCGTTGAAATCCCGTGCACAGCGCGATGGCGACAGCTACGTGCTCAATGGC
AGCAAGGCCTTCATCTCCGGTGCCGGCGCGACCGATGTGCTGGTGGTGATGGCACGCACCGGCGAAGACGGCGCACGCGG
CATCAGCGCGTTCGCGGTGCCGGCCGATGCCCCCGGCATCAGCTATGGCCGCAAGGAAGAAAAGATGGGCTGGAACAGCC
AGCCCACGCGCGGTGTGACCTTAGAAAACGTGCGCATTCCTGCCGAGAACCTGCTTGGCAAGGAAGGCGAAGGTTTCAAG
ATGGCGATGAAGGCGCTGGATGGTGGACGCATCAATATCGCCGCGTGTTCGTTGGGCGCAGCGCAAGGCGCGCTGGATGC
CGCGCGGCGCTACATGGGCGAGCGCCGCCAGTTCGGTAAGACGCTGGCCGATTTCCAGGCCCTGCAGTTCAAGCTGGCCG
ATATGGCCACGCAACTGGTGGCCGCGCGGCAGATGGTGCACACCGCTGCACGCAAGCTCGATGCCGGCAGCCACGATGCC
ACCGTGTGGTGTGCGATGGCCAAGCGCTTCGCCACCGATGCAGGCTTTGCCATCTGCGACGATGCCTTGCAGATCCACGG
CGGCTACGGCTATATCCGCGAGTATCCAATCGAGCGCTTGCTGCGCGACAGCCGCGTGCACCGCATTCTGGAAGGTACCA
ACGAGGTGATGCGCATGATCGTGGCGCGTCATCTGCTCAATGGCGAGGAGGAACTGCGATGA

Upstream 100 bases:

>100_bases
TTCTACACCCAGACCAAGACCGTGACCGCGCGCTGGTTCGACGACGAGACGCTGGACCATGGCGTCAACACCACCATCTC
CCTCAAGTGACCCGATCGCC

Downstream 100 bases:

>100_bases
GCGATTGGGAACAGGGCGTCCATACCGGTCTGCAGGTCGAGCGCGATGGTCACGTGGCCATCGTGACCTTGAGCAACCCA
CCGGCCAACACCTGGACCGT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNATIQLYPNAADLNDEQQAFRAAARDFADKELAPHAAQWDAEGHFPREAIAKAAALGFCGLYTDHGVGGLGMRRLDAAV
VFEELATVDPSTSAFISIHNMVTWFIASYGTDAVRAQWGEAMTSGARLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNG
SKAFISGAGATDVLVVMARTGEDGARGISAFAVPADAPGISYGRKEEKMGWNSQPTRGVTLENVRIPAENLLGKEGEGFK
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKTLADFQALQFKLADMATQLVAARQMVHTAARKLDAGSHDA
TVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERLLRDSRVHRILEGTNEVMRMIVARHLLNGEEELR

Sequences:

>Translated_393_residues
MNATIQLYPNAADLNDEQQAFRAAARDFADKELAPHAAQWDAEGHFPREAIAKAAALGFCGLYTDHGVGGLGMRRLDAAV
VFEELATVDPSTSAFISIHNMVTWFIASYGTDAVRAQWGEAMTSGARLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNG
SKAFISGAGATDVLVVMARTGEDGARGISAFAVPADAPGISYGRKEEKMGWNSQPTRGVTLENVRIPAENLLGKEGEGFK
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKTLADFQALQFKLADMATQLVAARQMVHTAARKLDAGSHDA
TVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERLLRDSRVHRILEGTNEVMRMIVARHLLNGEEELR
>Mature_393_residues
MNATIQLYPNAADLNDEQQAFRAAARDFADKELAPHAAQWDAEGHFPREAIAKAAALGFCGLYTDHGVGGLGMRRLDAAV
VFEELATVDPSTSAFISIHNMVTWFIASYGTDAVRAQWGEAMTSGARLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNG
SKAFISGAGATDVLVVMARTGEDGARGISAFAVPADAPGISYGRKEEKMGWNSQPTRGVTLENVRIPAENLLGKEGEGFK
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKTLADFQALQFKLADMATQLVAARQMVHTAARKLDAGSHDA
TVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERLLRDSRVHRILEGTNEVMRMIVARHLLNGEEELR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=54.5454545454545, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=38.5224274406332, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=38.5224274406332, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI4557233, Length=381, Percent_Identity=41.4698162729659, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=37.9679144385027, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4501857, Length=391, Percent_Identity=36.3171355498721, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI21361497, Length=386, Percent_Identity=36.0103626943005, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=33.2446808510638, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI76496475, Length=390, Percent_Identity=34.1025641025641, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI4557235, Length=390, Percent_Identity=34.1025641025641, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI226958414, Length=331, Percent_Identity=33.8368580060423, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4503943, Length=375, Percent_Identity=29.8666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI7669494, Length=351, Percent_Identity=30.4843304843305, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI38505218, Length=278, Percent_Identity=31.6546762589928, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=29.9651567944251, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=29.9651567944251, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=31.413612565445, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=30.5263157894737, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87082384, Length=268, Percent_Identity=31.7164179104478, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081702, Length=330, Percent_Identity=23.3333333333333, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17533517, Length=365, Percent_Identity=49.5890410958904, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=37.007874015748, Blast_Score=263, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=37.007874015748, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17570075, Length=377, Percent_Identity=37.1352785145889, Blast_Score=261, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI71985184, Length=390, Percent_Identity=35.1282051282051, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=34.9462365591398, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17506239, Length=382, Percent_Identity=33.7696335078534, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=376, Percent_Identity=35.6382978723404, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=37.5451263537906, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=336, Percent_Identity=33.0357142857143, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=37.8260869565217, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=31.3868613138686, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17505929, Length=361, Percent_Identity=29.9168975069252, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17551932, Length=358, Percent_Identity=28.7709497206704, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=380, Percent_Identity=27.8947368421053, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=287, Percent_Identity=28.9198606271777, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=29.5081967213115, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI86563383, Length=350, Percent_Identity=28, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=350, Percent_Identity=27.1428571428571, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531913, Length=169, Percent_Identity=27.810650887574, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24660351, Length=389, Percent_Identity=35.4755784061697, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21356377, Length=376, Percent_Identity=36.7021276595745, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24666513, Length=385, Percent_Identity=35.3246753246753, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.2340425531915, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=36.2433862433862, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI281363737, Length=392, Percent_Identity=33.6734693877551, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI19920834, Length=377, Percent_Identity=29.1777188328912, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI221473076, Length=318, Percent_Identity=24.5283018867925, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550141, Length=318, Percent_Identity=24.5283018867925, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24652780, Length=320, Percent_Identity=22.1875, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42286; Mature: 42286

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATIQLYPNAADLNDEQQAFRAAARDFADKELAPHAAQWDAEGHFPREAIAKAAALGFC
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GLYTDHGVGGLGMRRLDAAVVFEELATVDPSTSAFISIHNMVTWFIASYGTDAVRAQWGE
HHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AMTSGARLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNGSKAFISGAGATDVLVVMART
HHHCCHHHCCCEECCCCCCCHHHHHHHHHHCCCCCEEECCCHHEEECCCCCEEEEEEEEC
GEDGARGISAFAVPADAPGISYGRKEEKMGWNSQPTRGVTLENVRIPAENLLGKEGEGFK
CCCCCCCCEEEECCCCCCCCCCCCCHHHCCCCCCCCCCEEEEEEECCHHHHCCCCCCCHH
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKTLADFQALQFKLADMATQLV
HHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARQMVHTAARKLDAGSHDATVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHEECCHHHCCCCCCHHHHHHHHHH
LRDSRVHRILEGTNEVMRMIVARHLLNGEEELR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
>Mature Secondary Structure
MNATIQLYPNAADLNDEQQAFRAAARDFADKELAPHAAQWDAEGHFPREAIAKAAALGFC
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GLYTDHGVGGLGMRRLDAAVVFEELATVDPSTSAFISIHNMVTWFIASYGTDAVRAQWGE
HHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AMTSGARLGSYCLTEPGSGSDAASLKSRAQRDGDSYVLNGSKAFISGAGATDVLVVMART
HHHCCHHHCCCEECCCCCCCHHHHHHHHHHCCCCCEEECCCHHEEECCCCCEEEEEEEEC
GEDGARGISAFAVPADAPGISYGRKEEKMGWNSQPTRGVTLENVRIPAENLLGKEGEGFK
CCCCCCCCEEEECCCCCCCCCCCCCHHHCCCCCCCCCCEEEEEEECCHHHHCCCCCCCHH
MAMKALDGGRINIAACSLGAAQGALDAARRYMGERRQFGKTLADFQALQFKLADMATQLV
HHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARQMVHTAARKLDAGSHDATVWCAMAKRFATDAGFAICDDALQIHGGYGYIREYPIERL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHEECCHHHCCCCCCHHHHHHHHHH
LRDSRVHRILEGTNEVMRMIVARHLLNGEEELR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]