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The map label for this gene is phr [H]

Identifier: 84623072

GI number: 84623072

Start: 1539959

End: 1541413

Strand: Direct

Name: phr [H]

Synonym: XOO_1415

Alternate gene names: 84623072

Gene position: 1539959-1541413 (Clockwise)

Preceding gene: 84623071

Following gene: 84623073

Centisome position: 31.17

GC content: 64.33

Gene sequence:

>1455_bases
ATGCTGCGCAGCCTCATCGTTCGCTGCCGAGTTCGTATGTCATACGCCATCGTCTGGTTTCGTCGCGATCTGCGTCTGCA
AGACAACCCGGCCTTGCGTGCCGCACTCGATGCGGGGCATCACCCGATTCCGTTGTACATCGACGCACCGCACGAAGAAG
GCGAGTGGACGCCCGGCGCCGCATCGCGTACCTGGCGGCATCGCTCGCTTGCAGCGCTGGAGGATGCGTTGCGTGCGCTT
GGCAGTGGCCTGGTCATCCGCGCCGGCGACAGTGCACAGGTGCTGGATGCGGTGATCGCGCAGACCGGCGCGGTGGCGGT
GTATTGGAACCGCAAATACGAGCCGGCCACGCAGCCGCGCGATGCGCAGATCAAGCGCGCATTGCGCGAGCGCGGGATCG
AGGCACAGAGCTGCAATTGCGCATTGCTGTTCGAGCCGTGGCAGTTGTCCACGCAGCAGGGCGGCCCGTACAAGGTGTTT
ACGCCGTTCTGGCGCAATGCGCTGACACAGCTGCAATTGCCCGCCACAGCGCCTGCGCCGCGCAGCCTGCCGCCGCTGCC
TGCGATGTTGAAGACGGATGCACTCGACACGCTGCAGCTGGTACCTAGCTTGAACTGGGACCAGGGCTTCTGGGAGCACT
GGCACGCCGGTGAAGCCGGCGCGCACGAAATGCTGGAGTTCTTCATCGATGGCGGGCTGTCCGGGTATCGCAAAAACCGC
GACCGCCCCGATCGCGTTGGCACCTCGCAACTTTCGCCGCATCTGCACTTCGGCGAGATTGCGCCGTGGCGCATTGCCAG
CGCGCTGGAAGCGCAGCGCACTGCGCGCAATGGCGCAGAAATCGATGGCTATATCCGCCAGCTGGGCTGGCGCGATTTCG
CCTATCACCTGCTGCATCACTTCCCGGACACCACCAACCAGAACCTCAATCCGCGCTTCGAAGGATTCGACTGGGCGAAG
GTCGATCCGGTTGCACTGCAGGCCTGGCAGCGCGGCCGCACCGGCATCCCGATCGTCGATGCCGGTATGCGTCAGCTCTG
GCACACCGGCTGGATGCACAACCGCGTGCGCATGATCGTCGCCAGTTTTTTGTGCAAGCATCTGCGCATCCACTGGATCG
AAGGCGCGCGCTGGTTCTGGGACACGCTGGTGGATGCGGACCTGGCCAACAACACGCTGGGCTGGCAGTGGGTGGCCGGC
ACCGGCGCCGATGCGGCGCCCTATTTCCGCGTGTTCAATCCAGTGACGCAAGCGGAAAAATTCGATCCGCACGCAACGTA
CATCACGCGCTGGGTGCCCGAGTTGGGCAAGCTTCCGGTGAAAGAACGCTTCGCACCCTGGTTGCATCCCTTGTCGCTGG
CACGCTTCGCACCAGAGTACCCGCGCACGCCGATCATTGGCTTGGCCGAAGGGCGCGACGCGGCGCTGGCAGCCTATTCG
AAATCGCGCGCTTAG

Upstream 100 bases:

>100_bases
TCTGGCGCACGACTCGGTGGGCAGTTTCGAGTAAGCGCAGTGGACCCGCTGGGCGGCCATCCGTCGCCCGGCATCGCGCC
ATCGTTGCGGCCGCTGGCTT

Downstream 100 bases:

>100_bases
AGCGGCGAACAACACGTCGCGAGCAGCTGTCAGGTGGGCGTGGACGGCGCGCTCAGAACCGCAGTGCAGGCGTGGTACAT
GCCGATTCCGGGCACCGGCC

Product: photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MLRSLIVRCRVRMSYAIVWFRRDLRLQDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGAASRTWRHRSLAALEDALRAL
GSGLVIRAGDSAQVLDAVIAQTGAVAVYWNRKYEPATQPRDAQIKRALRERGIEAQSCNCALLFEPWQLSTQQGGPYKVF
TPFWRNALTQLQLPATAPAPRSLPPLPAMLKTDALDTLQLVPSLNWDQGFWEHWHAGEAGAHEMLEFFIDGGLSGYRKNR
DRPDRVGTSQLSPHLHFGEIAPWRIASALEAQRTARNGAEIDGYIRQLGWRDFAYHLLHHFPDTTNQNLNPRFEGFDWAK
VDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIVASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAG
TGADAAPYFRVFNPVTQAEKFDPHATYITRWVPELGKLPVKERFAPWLHPLSLARFAPEYPRTPIIGLAEGRDAALAAYS
KSRA

Sequences:

>Translated_484_residues
MLRSLIVRCRVRMSYAIVWFRRDLRLQDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGAASRTWRHRSLAALEDALRAL
GSGLVIRAGDSAQVLDAVIAQTGAVAVYWNRKYEPATQPRDAQIKRALRERGIEAQSCNCALLFEPWQLSTQQGGPYKVF
TPFWRNALTQLQLPATAPAPRSLPPLPAMLKTDALDTLQLVPSLNWDQGFWEHWHAGEAGAHEMLEFFIDGGLSGYRKNR
DRPDRVGTSQLSPHLHFGEIAPWRIASALEAQRTARNGAEIDGYIRQLGWRDFAYHLLHHFPDTTNQNLNPRFEGFDWAK
VDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIVASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAG
TGADAAPYFRVFNPVTQAEKFDPHATYITRWVPELGKLPVKERFAPWLHPLSLARFAPEYPRTPIIGLAEGRDAALAAYS
KSRA
>Mature_484_residues
MLRSLIVRCRVRMSYAIVWFRRDLRLQDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGAASRTWRHRSLAALEDALRAL
GSGLVIRAGDSAQVLDAVIAQTGAVAVYWNRKYEPATQPRDAQIKRALRERGIEAQSCNCALLFEPWQLSTQQGGPYKVF
TPFWRNALTQLQLPATAPAPRSLPPLPAMLKTDALDTLQLVPSLNWDQGFWEHWHAGEAGAHEMLEFFIDGGLSGYRKNR
DRPDRVGTSQLSPHLHFGEIAPWRIASALEAQRTARNGAEIDGYIRQLGWRDFAYHLLHHFPDTTNQNLNPRFEGFDWAK
VDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIVASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAG
TGADAAPYFRVFNPVTQAEKFDPHATYITRWVPELGKLPVKERFAPWLHPLSLARFAPEYPRTPIIGLAEGRDAALAAYS
KSRA

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=478, Percent_Identity=28.8702928870293, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI4758072, Length=479, Percent_Identity=29.0187891440501, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI188536103, Length=436, Percent_Identity=28.2110091743119, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI1786926, Length=484, Percent_Identity=36.9834710743802, Blast_Score=266, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324962, Length=516, Percent_Identity=28.6821705426357, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17137248, Length=461, Percent_Identity=28.6334056399132, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24585455, Length=461, Percent_Identity=28.6334056399132, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24648152, Length=466, Percent_Identity=27.0386266094421, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54900; Mature: 54900

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSLIVRCRVRMSYAIVWFRRDLRLQDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGA
CHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
ASRTWRHRSLAALEDALRALGSGLVIRAGDSAQVLDAVIAQTGAVAVYWNRKYEPATQPR
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCCCC
DAQIKRALRERGIEAQSCNCALLFEPWQLSTQQGGPYKVFTPFWRNALTQLQLPATAPAP
HHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCEEEECHHHHHHHHEEECCCCCCCC
RSLPPLPAMLKTDALDTLQLVPSLNWDQGFWEHWHAGEAGAHEMLEFFIDGGLSGYRKNR
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCC
DRPDRVGTSQLSPHLHFGEIAPWRIASALEAQRTARNGAEIDGYIRQLGWRDFAYHLLHH
CCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHH
FPDTTNQNLNPRFEGFDWAKVDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAGTGADAAPYFRVFNPVTQAEK
HHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCHHHHHHC
FDPHATYITRWVPELGKLPVKERFAPWLHPLSLARFAPEYPRTPIIGLAEGRDAALAAYS
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
KSRA
CCCC
>Mature Secondary Structure
MLRSLIVRCRVRMSYAIVWFRRDLRLQDNPALRAALDAGHHPIPLYIDAPHEEGEWTPGA
CHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
ASRTWRHRSLAALEDALRALGSGLVIRAGDSAQVLDAVIAQTGAVAVYWNRKYEPATQPR
CCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEEEEECCCCCCCCCCC
DAQIKRALRERGIEAQSCNCALLFEPWQLSTQQGGPYKVFTPFWRNALTQLQLPATAPAP
HHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCEEEECHHHHHHHHEEECCCCCCCC
RSLPPLPAMLKTDALDTLQLVPSLNWDQGFWEHWHAGEAGAHEMLEFFIDGGLSGYRKNR
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCHHHCCC
DRPDRVGTSQLSPHLHFGEIAPWRIASALEAQRTARNGAEIDGYIRQLGWRDFAYHLLHH
CCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHH
FPDTTNQNLNPRFEGFDWAKVDPVALQAWQRGRTGIPIVDAGMRQLWHTGWMHNRVRMIV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ASFLCKHLRIHWIEGARWFWDTLVDADLANNTLGWQWVAGTGADAAPYFRVFNPVTQAEK
HHHHHHHHEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCHHHHHHC
FDPHATYITRWVPELGKLPVKERFAPWLHPLSLARFAPEYPRTPIIGLAEGRDAALAAYS
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHH
KSRA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2681164; 11016950 [H]