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The map label for this gene is creC [H]

Identifier: 84623035

GI number: 84623035

Start: 1506563

End: 1507273

Strand: Direct

Name: creC [H]

Synonym: XOO_1378

Alternate gene names: 84623035

Gene position: 1506563-1507273 (Clockwise)

Preceding gene: 84623022

Following gene: 84623036

Centisome position: 30.5

GC content: 62.73

Gene sequence:

>711_bases
TTGGAACTTGAGTCGGCCCTGGAAGGCAAGGCCTATGTTGTGCAATACCTGCAGTCGTTGACGCACGAGATGAAACGTCC
GCTTGCGGTGATTCGCAGCGCATCCGAGTTGTTGACCGAGCCGGTGCTGGAAACCGATCGCCAGCACTTTGTGGCCAGTA
TCCGCGCGCAGGAACAGCGGCTCACCGAAACCATCGACAAGCTGCTGGCGCTGGCCGAAGTGGAGCAGCATGGCTGGCTG
CAGACGCGCGAACGCATCGGTCTCAGGAGGCTGCCACAGGCTGCTGCGGAGGCGATATCGCTGCGTGCTGCGGCGACTGG
CGTGATGGTGGACGTCGATGCAAGCGCTGCGACCTCAGGCGATCACCACGTACTCGGTGATGGCTTCCTGCTGCGTCAGG
CATTGATCAATCTGCTGGAAAACGCCATCGCGTTTTCGCCGCAGGACAGCTGCGTGCGTCTGCATCCGCAGCTGCACGAT
GAACATTGGGAGTTGGCGGACGAAGACCGTGGCAGCGGCGTGCCGGATTACGCGATCGAGCGCGTCTTCGAGCGTTTCTA
TTCGCTGGCACTCCCGCAGACCGGCCAACGCGGCTCGGGCTTTGGTCTGCCGTTCGTGGGTGAGGTGGCGCGCCTGCATG
GTGGGGACGTCACACCAGGCAATCGCGACGGCGGTGGTGCGATGGCGATGTTGCCCCTGCCAATTGGCTGA

Upstream 100 bases:

>100_bases
GTATGGACGGACAGCCCAGCAGGCCATTGATTGTGCAAAAGTTACGTGAGCCAGTGTTTTGACAGAAAACGCGGGTCTGC
AGTGGAGAAAAGTGTTGCAC

Downstream 100 bases:

>100_bases
GCGGCCGGGCAGGCGCTTTGCAGCGGGTCGCGTTACCGGAGGCGACCTTAGCGCATCCAAGGCTGCGACATGCGCCAAAG
CACATGCCGCAACCGCTTTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MELESALEGKAYVVQYLQSLTHEMKRPLAVIRSASELLTEPVLETDRQHFVASIRAQEQRLTETIDKLLALAEVEQHGWL
QTRERIGLRRLPQAAAEAISLRAAATGVMVDVDASAATSGDHHVLGDGFLLRQALINLLENAIAFSPQDSCVRLHPQLHD
EHWELADEDRGSGVPDYAIERVFERFYSLALPQTGQRGSGFGLPFVGEVARLHGGDVTPGNRDGGGAMAMLPLPIG

Sequences:

>Translated_236_residues
MELESALEGKAYVVQYLQSLTHEMKRPLAVIRSASELLTEPVLETDRQHFVASIRAQEQRLTETIDKLLALAEVEQHGWL
QTRERIGLRRLPQAAAEAISLRAAATGVMVDVDASAATSGDHHVLGDGFLLRQALINLLENAIAFSPQDSCVRLHPQLHD
EHWELADEDRGSGVPDYAIERVFERFYSLALPQTGQRGSGFGLPFVGEVARLHGGDVTPGNRDGGGAMAMLPLPIG
>Mature_236_residues
MELESALEGKAYVVQYLQSLTHEMKRPLAVIRSASELLTEPVLETDRQHFVASIRAQEQRLTETIDKLLALAEVEQHGWL
QTRERIGLRRLPQAAAEAISLRAAATGVMVDVDASAATSGDHHVLGDGFLLRQALINLLENAIAFSPQDSCVRLHPQLHD
EHWELADEDRGSGVPDYAIERVFERFYSLALPQTGQRGSGFGLPFVGEVARLHGGDVTPGNRDGGGAMAMLPLPIG

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=233, Percent_Identity=41.2017167381974, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI48994928, Length=225, Percent_Identity=24, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=25.8474576271186, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=25.1121076233184, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=26.3392857142857, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=23.7442922374429, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=23.0434782608696, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=23.9669421487603, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 25791; Mature: 25791

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELESALEGKAYVVQYLQSLTHEMKRPLAVIRSASELLTEPVLETDRQHFVASIRAQEQR
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTETIDKLLALAEVEQHGWLQTRERIGLRRLPQAAAEAISLRAAATGVMVDVDASAATSG
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCC
DHHVLGDGFLLRQALINLLENAIAFSPQDSCVRLHPQLHDEHWELADEDRGSGVPDYAIE
CCEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHCCCCCCCCCCCCCCCCCHHHHH
RVFERFYSLALPQTGQRGSGFGLPFVGEVARLHGGDVTPGNRDGGGAMAMLPLPIG
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MELESALEGKAYVVQYLQSLTHEMKRPLAVIRSASELLTEPVLETDRQHFVASIRAQEQR
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTETIDKLLALAEVEQHGWLQTRERIGLRRLPQAAAEAISLRAAATGVMVDVDASAATSG
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCC
DHHVLGDGFLLRQALINLLENAIAFSPQDSCVRLHPQLHDEHWELADEDRGSGVPDYAIE
CCEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHCCCCCCCCCCCCCCCCCHHHHH
RVFERFYSLALPQTGQRGSGFGLPFVGEVARLHGGDVTPGNRDGGGAMAMLPLPIG
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]