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The map label for this gene is mro [H]

Identifier: 84622869

GI number: 84622869

Start: 1320446

End: 1321570

Strand: Direct

Name: mro [H]

Synonym: XOO_1212

Alternate gene names: 84622869

Gene position: 1320446-1321570 (Clockwise)

Preceding gene: 84622867

Following gene: 84622871

Centisome position: 26.73

GC content: 65.69

Gene sequence:

>1125_bases
ATGTGCGCAGCAGCATGGTCGGCAGCCGCATCGTGCGGCTATGCTCGCGGGCTTCCCTCATTGGCAGGACGATCCATGCA
GCGAGTGTTCGGGCAGTTGACAGACGGTGTCGAGATTCATGCGCTCACGCTACGCAGCGAGGCCGGTCTCGAGGCGGAGG
TGCTCACCTATGGCGGCATCCTGCATACGCTGCAGTTGACCAGCGCACGGGGCGTGCTGCCCCTGGTGCTGAACTTGCCG
GATCTGCCCGCCTACGCCGCCGACGGCGACAGTCTCAATATCCTGGTGGGCCGCTTCGGCAACCGCATCGCCGGTGCGCG
CTACACGCTGGATGGCGTTACCCACGTGCTGGCGGCCAATGAAGGGCGCAACCAGTTGCATGGCGGTCTGCGCGGTTTTG
GGCGACGCGTGTGGAGTGTGCTGGAGCAGGCGCCGGATCACGTACTGCTGGGCTACGACTCGCCCGATGGCGAAGAAGGT
TACCCCGGCAATCTGCAAGTGCGTGCGCGCCTGCAGCTTCACGGGTTGAGCCTGCAGCTGGATTTCGAAGCGCACTGCGA
CGCCGCTACGGCGTTGAACCTTACCCATCATCCATATTTCAATCTGTCCGGCGACCCGCACCTGCGTGCCGCAGTGCAAG
TGCTGCGCGTGCCGGCCGATCGCTACCTGCCGGTGGATGCCGAATCGATCCCGACCGGCGAGATCGCGTCGGTGGCCGGC
ACCCCATTCGATTTCCGCCAGCCTGCCGCGCTCGCCGATAACACCGATCCGGCCCATCCGCAGGTGGTTCTCGGCAAGGG
CTACGATCAGTGCTTGGTGCTGGCCGCCGACGCGGACTGCGTAGCCGAGTTGTATTCGCCGCACAGTGGCGTGGCGCTAC
GCATCCGCAGCGATGCCCCCGCGGTGCAGTTGTACGAAGGCCAACATCTGGACGCACATCATCCGGGACTGGGGCGCGGC
GTATGCCTGGAGCCGCAGGACTACCCGGACGCGCCCAATCACGCCAACTTCCCTTCGACGATCTTGCGGCCTGGGGAAAC
CTACCGCCGCCGCATCAGCTACCACTTCGCCAGTGCGGGGCAGGACCAGCCCTGGGACATGGTGTGCGCCGCACTGGAGG
GGTGA

Upstream 100 bases:

>100_bases
AGCGTAGTGCGAGTGGTCGCAGTTTGTATTACTGCAGCGCGACCACCGCAGGCGCGTGCGGCAGCCGCCCGACGGCCGTC
GTACCCTTCGCAGGCCAGGG

Downstream 100 bases:

>100_bases
GAGATTTCGCAACTTGAGGAGCTAGCCGGGTTGCATCGTGCGGGCACGTGCAATCCGATGCCGCTGATTGCGTTGTGAGT
TCTGATGTGGCGAGCGCTTC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MCAAAWSAAASCGYARGLPSLAGRSMQRVFGQLTDGVEIHALTLRSEAGLEAEVLTYGGILHTLQLTSARGVLPLVLNLP
DLPAYAADGDSLNILVGRFGNRIAGARYTLDGVTHVLAANEGRNQLHGGLRGFGRRVWSVLEQAPDHVLLGYDSPDGEEG
YPGNLQVRARLQLHGLSLQLDFEAHCDAATALNLTHHPYFNLSGDPHLRAAVQVLRVPADRYLPVDAESIPTGEIASVAG
TPFDFRQPAALADNTDPAHPQVVLGKGYDQCLVLAADADCVAELYSPHSGVALRIRSDAPAVQLYEGQHLDAHHPGLGRG
VCLEPQDYPDAPNHANFPSTILRPGETYRRRISYHFASAGQDQPWDMVCAALEG

Sequences:

>Translated_374_residues
MCAAAWSAAASCGYARGLPSLAGRSMQRVFGQLTDGVEIHALTLRSEAGLEAEVLTYGGILHTLQLTSARGVLPLVLNLP
DLPAYAADGDSLNILVGRFGNRIAGARYTLDGVTHVLAANEGRNQLHGGLRGFGRRVWSVLEQAPDHVLLGYDSPDGEEG
YPGNLQVRARLQLHGLSLQLDFEAHCDAATALNLTHHPYFNLSGDPHLRAAVQVLRVPADRYLPVDAESIPTGEIASVAG
TPFDFRQPAALADNTDPAHPQVVLGKGYDQCLVLAADADCVAELYSPHSGVALRIRSDAPAVQLYEGQHLDAHHPGLGRG
VCLEPQDYPDAPNHANFPSTILRPGETYRRRISYHFASAGQDQPWDMVCAALEG
>Mature_374_residues
MCAAAWSAAASCGYARGLPSLAGRSMQRVFGQLTDGVEIHALTLRSEAGLEAEVLTYGGILHTLQLTSARGVLPLVLNLP
DLPAYAADGDSLNILVGRFGNRIAGARYTLDGVTHVLAANEGRNQLHGGLRGFGRRVWSVLEQAPDHVLLGYDSPDGEEG
YPGNLQVRARLQLHGLSLQLDFEAHCDAATALNLTHHPYFNLSGDPHLRAAVQVLRVPADRYLPVDAESIPTGEIASVAG
TPFDFRQPAALADNTDPAHPQVVLGKGYDQCLVLAADADCVAELYSPHSGVALRIRSDAPAVQLYEGQHLDAHHPGLGRG
VCLEPQDYPDAPNHANFPSTILRPGETYRRRISYHFASAGQDQPWDMVCAALEG

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=342, Percent_Identity=35.3801169590643, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1786971, Length=336, Percent_Identity=35.1190476190476, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17557428, Length=328, Percent_Identity=30.4878048780488, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI115533334, Length=328, Percent_Identity=30.4878048780488, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319493, Length=284, Percent_Identity=27.4647887323944, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322004, Length=351, Percent_Identity=27.3504273504274, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324399, Length=340, Percent_Identity=25.2941176470588, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24659048, Length=347, Percent_Identity=33.7175792507205, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24583720, Length=336, Percent_Identity=30.952380952381, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24668278, Length=353, Percent_Identity=30.3116147308782, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24668282, Length=363, Percent_Identity=29.7520661157025, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24641876, Length=360, Percent_Identity=27.2222222222222, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 40062; Mature: 40062

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCAAAWSAAASCGYARGLPSLAGRSMQRVFGQLTDGVEIHALTLRSEAGLEAEVLTYGGI
CCCCHHHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEECCCE
LHTLQLTSARGVLPLVLNLPDLPAYAADGDSLNILVGRFGNRIAGARYTLDGVTHVLAAN
EEEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHEEEECC
EGRNQLHGGLRGFGRRVWSVLEQAPDHVLLGYDSPDGEEGYPGNLQVRARLQLHGLSLQL
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEEEEEEEEEEEE
DFEAHCDAATALNLTHHPYFNLSGDPHLRAAVQVLRVPADRYLPVDAESIPTGEIASVAG
ECCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHCC
TPFDFRQPAALADNTDPAHPQVVLGKGYDQCLVLAADADCVAELYSPHSGVALRIRSDAP
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECHHHHHHHHCCCCCEEEEEECCCC
AVQLYEGQHLDAHHPGLGRGVCLEPQDYPDAPNHANFPSTILRPGETYRRRISYHFASAG
EEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCC
QDQPWDMVCAALEG
CCCCHHHHHEECCC
>Mature Secondary Structure
MCAAAWSAAASCGYARGLPSLAGRSMQRVFGQLTDGVEIHALTLRSEAGLEAEVLTYGGI
CCCCHHHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEECCCE
LHTLQLTSARGVLPLVLNLPDLPAYAADGDSLNILVGRFGNRIAGARYTLDGVTHVLAAN
EEEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEHHHHHEEEECC
EGRNQLHGGLRGFGRRVWSVLEQAPDHVLLGYDSPDGEEGYPGNLQVRARLQLHGLSLQL
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCEEEEEEEEEEEEEEEE
DFEAHCDAATALNLTHHPYFNLSGDPHLRAAVQVLRVPADRYLPVDAESIPTGEIASVAG
ECCCCCCCEEEEEECCCCEECCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCCHHHHCC
TPFDFRQPAALADNTDPAHPQVVLGKGYDQCLVLAADADCVAELYSPHSGVALRIRSDAP
CCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECHHHHHHHHCCCCCEEEEEECCCC
AVQLYEGQHLDAHHPGLGRGVCLEPQDYPDAPNHANFPSTILRPGETYRRRISYHFASAG
EEEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCC
QDQPWDMVCAALEG
CCCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]