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The map label for this gene is tktA [H]

Identifier: 84622727

GI number: 84622727

Start: 1167463

End: 1169463

Strand: Direct

Name: tktA [H]

Synonym: XOO_1070

Alternate gene names: 84622727

Gene position: 1167463-1169463 (Clockwise)

Preceding gene: 84622726

Following gene: 84622728

Centisome position: 23.63

GC content: 64.42

Gene sequence:

>2001_bases
ATGACCCAGCCCACCCGTCGCCAGCTGGCCAACGCCATCCGTTTTCTTGCCGCAGATGCGGTCGAAGCCGCCAAGTCCGG
TCATCCCGGCATGCCGATGGGCATGGCCGACATCGCCGAAGTGCTGTGGAACGATTTCTTCCGGCACAACCCCAACAATC
CGCAGTGGTTCAACCGCGACCGTTTCGTGCTCTCCAACGGCCACGGTTCGATGCTGCAGTACGCGCTGTTGCACCTGTCC
CGTTACCACCTGCCGATCGAGCAGCTCAAGCAATTCCGTCAGCTGCACAGCAAGACCCCCGGTCACCCCGAGCGCAGCGA
AACCCCCGGAGTGGAGACCACCACCGGTCCGCTCGGGCAGGGGTTTGCAAACGCGGTGGGTTTTGCGCTGGCCGAGAAAT
TGCTGGCGCAGCGCTACAACCGGCCTGAGCTGGAAATCGTCGATCACCGCACCTGGGTGTTCATGGGCGACGGCTGCCTG
ATGGAAGGCATTTCGCACGAAGCCGCCTCGTTGGCCGGCACCTGGGGCCTGGGCAAGCTGGTGGCCTTCTGGGACAACAA
CCAGATTTCCATCGACGGCAATACGGCCGGCTGGTTCAGCGACGACACCCCGGCGCGTTTCCAGGCCTATGGCTGGCATG
TGATCCGTGACGTGGACGGGCACGACGCCGACAAGATCAAGGCCGCCATCGAGACCGCGCTGGAGAACACCGACAAGCCC
ACGCTGATCTGCTGCCGCACCAAGATCGGCTTCGGTGCGCCGACCAAGGCCGGCAAGGAATCCTCGCACGGCGCGCCGCT
GGGCAAGGACGAACTGGAAGGCGCGCGCAAGGCACTGGAATGGCCGTACGGCCCGTTCGAAATTCCCGAAGAGATCTACG
CCGGCTGGCGTGCCGGCGGCACTGGCACTTTGCGTCAGGCCGAATGGGAGCAGCTGTTCGACAAGTACAGCAAGCAGTAC
GCCAGTGAAGCCGATGAGCTGACCCGTCGCTCGCACGGCGAGTTGCCGGCCGACTTCATCGCCAAGGCCGATGCCTACAT
CGCCAAGGCGCAGGAAGAGGGCCAGACCATCGCCTCGCGCAAGGCCTCGCAGCTGGCCATCGAAGCCTTCGCGCCGCTGC
TGCCCGAGTTGATCGGCGGCTCGGCCGACCTGGCGCACTCCAATCTGACCCTGTGGAAGGCCAGCAAGTCGGTGGCGACG
GACGACCCGGACGCCAACTACGTGTATTACGGTGTGCGCGAGTTCGGCATGACCGCCATTGCCAATGGCCTGGCGCTGCA
TGGCGGTTTCATCCCGTTCGACGCCACCTTCCTGGTGTTCAGCGATTACGCCCGCAATGGCGTGCGTATGAGCGCACTGA
ATCCGTCGCATGCCATCCATGTGTACACGCATGACTCGATCGGCCTGGGCGAAGACGGCCCGACCCATCAACCGGTGGAG
CACCTGGCCTCGCTGCGCTACATCCCCAACAACGATGTGTGGCGCCCGGGCGATGCGGTGGAATCGGCAGTGAGCTGGAA
GGCGGCCATTACCCGCAATGGCGGGCCGACCTGCCTGATCTTCAGCCGCCAGAACCTGCAGCACCAGCCGCGCAGCGCCG
AACAGATCAAGTTGATCGAACGCGGTGGCTACGTGCTGGCCGATGCCGAAGGTGGCACGCCGGACGTGATCCTGATCGCC
ACCGGCTCGGAGGTTGGTCTGGCAGTGGAAGCCAAGAAGACGCTGGATACGGCTGGCCTGAAGACACGCGTGGTGTCGAT
GCCGTCGACCGATGTGTTCGATCGTCAGGACGCCGCGTACCGTGAGTCGGTGCTGCCGAACGCCGTGCGCAAGCGCGTGG
CGGTGGAAGCGGGCGTGACCGGCTTCTGGCGCAAGTATGTGGGCCTGGATGGCGATGTGGTCGGCATCGACACCTTCGGC
GCCTCGGCACCGGCGGATCAGCTGTATGCGTATTTCAAGATCACGGCCGAGCATGTGGTTGCGGCAGCCAAGGCGCTGTA
A

Upstream 100 bases:

>100_bases
ACTGCATCCGATTCTCCATTCCCGATTCCCCTAACGCACTGTGTGGGAGAATAAGGGCCTCCGCTTTCTGCGGTGTCCCC
CTCCGCTTCCATAGACGCCC

Downstream 100 bases:

>100_bases
CGCCTTGCGTGGTGCTTGAAAGAAAAAGCCGGCGAAAGCCGGCTTTTTTGTTGGATCTCGTGTGCGATGCGCGGTACGTC
ATCGTTCAACGCACGCCTTG

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLS
RYHLPIEQLKQFRQLHSKTPGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCL
MEGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDDTPARFQAYGWHVIRDVDGHDADKIKAAIETALENTDKP
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYSKQY
ASEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASRKASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVAT
DDPDANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPSHAIHVYTHDSIGLGEDGPTHQPVE
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRNGGPTCLIFSRQNLQHQPRSAEQIKLIERGGYVLADAEGGTPDVILIA
TGSEVGLAVEAKKTLDTAGLKTRVVSMPSTDVFDRQDAAYRESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFG
ASAPADQLYAYFKITAEHVVAAAKAL

Sequences:

>Translated_666_residues
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLS
RYHLPIEQLKQFRQLHSKTPGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCL
MEGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDDTPARFQAYGWHVIRDVDGHDADKIKAAIETALENTDKP
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYSKQY
ASEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASRKASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVAT
DDPDANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPSHAIHVYTHDSIGLGEDGPTHQPVE
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRNGGPTCLIFSRQNLQHQPRSAEQIKLIERGGYVLADAEGGTPDVILIA
TGSEVGLAVEAKKTLDTAGLKTRVVSMPSTDVFDRQDAAYRESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFG
ASAPADQLYAYFKITAEHVVAAAKAL
>Mature_665_residues
TQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRDRFVLSNGHGSMLQYALLHLSR
YHLPIEQLKQFRQLHSKTPGHPERSETPGVETTTGPLGQGFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCLM
EGISHEAASLAGTWGLGKLVAFWDNNQISIDGNTAGWFSDDTPARFQAYGWHVIRDVDGHDADKIKAAIETALENTDKPT
LICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGGTGTLRQAEWEQLFDKYSKQYA
SEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASRKASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVATD
DPDANYVYYGVREFGMTAIANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPSHAIHVYTHDSIGLGEDGPTHQPVEH
LASLRYIPNNDVWRPGDAVESAVSWKAAITRNGGPTCLIFSRQNLQHQPRSAEQIKLIERGGYVLADAEGGTPDVILIAT
GSEVGLAVEAKKTLDTAGLKTRVVSMPSTDVFDRQDAAYRESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFGA
SAPADQLYAYFKITAEHVVAAAKAL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=515, Percent_Identity=28.3495145631068, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI4507521, Length=515, Percent_Identity=28.3495145631068, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI133778974, Length=583, Percent_Identity=25.557461406518, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI48994911, Length=662, Percent_Identity=64.9546827794562, Blast_Score=889, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=659, Percent_Identity=61.9119878603945, Blast_Score=845, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=674, Percent_Identity=25.9643916913947, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=676, Percent_Identity=46.7455621301775, Blast_Score=552, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6319593, Length=668, Percent_Identity=43.4131736526946, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI45551847, Length=686, Percent_Identity=25.0728862973761, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI45550715, Length=686, Percent_Identity=25.0728862973761, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24666278, Length=582, Percent_Identity=24.914089347079, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24645119, Length=646, Percent_Identity=24.7678018575851, Blast_Score=133, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72666; Mature: 72535

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSNGHGSMLQYALLHLSRYHLPIEQLKQFRQLHSKTPGHPERSETPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCLMEGISHEAASLAGTWGLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHHCCCHHHHHHHCCCCCCEE
VAFWDNNQISIDGNTAGWFSDDTPARFQAYGWHVIRDVDGHDADKIKAAIETALENTDKP
EEEECCCEEEECCCCCCCCCCCCCCCEEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGTLRQAEWEQLFDKYSKQYASEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVATDDPDANYVYYGVREFGMTAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPSHAIHVYTHDSIGLGEDGPTHQPVE
HCCCEECCCCCCCCCEEEEEEHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHH
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRNGGPTCLIFSRQNLQHQPRSAEQIKLIE
HHHHEEECCCCCCCCCCHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHEE
RGGYVLADAEGGTPDVILIATGSEVGLAVEAKKTLDTAGLKTRVVSMPSTDVFDRQDAAY
CCCEEEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCEEEEEECCCCCCCCCCHHHH
RESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFGASAPADQLYAYFKITAEHVV
HHHHCHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHEEEHHHHHH
AAAKAL
HHHHCC
>Mature Secondary Structure 
TQPTRRQLANAIRFLAADAVEAAKSGHPGMPMGMADIAEVLWNDFFRHNPNNPQWFNRD
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSNGHGSMLQYALLHLSRYHLPIEQLKQFRQLHSKTPGHPERSETPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
GFANAVGFALAEKLLAQRYNRPELEIVDHRTWVFMGDGCLMEGISHEAASLAGTWGLGKL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECEEEEEECCCHHHHCCCHHHHHHHCCCCCCEE
VAFWDNNQISIDGNTAGWFSDDTPARFQAYGWHVIRDVDGHDADKIKAAIETALENTDKP
EEEECCCEEEECCCCCCCCCCCCCCCEEECCEEEEEECCCCCHHHHHHHHHHHHHCCCCC
TLICCRTKIGFGAPTKAGKESSHGAPLGKDELEGARKALEWPYGPFEIPEEIYAGWRAGG
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCC
TGTLRQAEWEQLFDKYSKQYASEADELTRRSHGELPADFIAKADAYIAKAQEEGQTIASR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KASQLAIEAFAPLLPELIGGSADLAHSNLTLWKASKSVATDDPDANYVYYGVREFGMTAI
HHHHHHHHHHHHHHHHHHCCCCHHCCCCEEEEECCCCCCCCCCCCCEEEEEHHHHHHHHH
ANGLALHGGFIPFDATFLVFSDYARNGVRMSALNPSHAIHVYTHDSIGLGEDGPTHQPVE
HCCCEECCCCCCCCCEEEEEEHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHH
HLASLRYIPNNDVWRPGDAVESAVSWKAAITRNGGPTCLIFSRQNLQHQPRSAEQIKLIE
HHHHEEECCCCCCCCCCHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHEE
RGGYVLADAEGGTPDVILIATGSEVGLAVEAKKTLDTAGLKTRVVSMPSTDVFDRQDAAY
CCCEEEEECCCCCCCEEEEECCCCCCEEEEHHHHHHHCCCEEEEEECCCCCCCCCCHHHH
RESVLPNAVRKRVAVEAGVTGFWRKYVGLDGDVVGIDTFGASAPADQLYAYFKITAEHVV
HHHHCHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHEEEHHHHHH
AAAKAL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8241274; 9278503; 2153656 [H]