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The map label for this gene is gltP [H]

Identifier: 84622726

GI number: 84622726

Start: 1165915

End: 1167243

Strand: Direct

Name: gltP [H]

Synonym: XOO_1069

Alternate gene names: 84622726

Gene position: 1165915-1167243 (Clockwise)

Preceding gene: 84622725

Following gene: 84622727

Centisome position: 23.6

GC content: 62.9

Gene sequence:

>1329_bases
ATGGCGTTTGTTAAGCTCGGTTCTTTCTGTCCACCAAGGCCTGACCAGATGACAGCATCCACAACCACGCCCCGCCCGGG
CCTGCCCCTGCATTGGAAGATGGGGATTGGCTTCGCCGTTGGCCTGTTGTTGGGTCTGGCTGTCTATTACCTGGCCGGCA
GCGATGCCGATTGGGTACGTCTGCTGACCAAGTACGTCACCACGCCGTTTTCGCAGATCTTCCTCAATCTGATCTTCATG
CTGATCGTACCCTTGCTCTTTTCGGCGCTGGTCATGGGCATCTCTGAAATGGGCGACATCCGCGCGCTGGGACGGTTGGG
GTGGCGCACCCTTGGCTATACCGTGGTGCTTTCCGGTGTGGCGGTGTTGCTGGGGTTGGTGCTGGTCAACGTGCTCAAGC
CCGGCGCGGGCGTGGACCCGCAAGTGGCCAATCAGCTGATCCAGGAAAACGCCGAGCGCACCCGCGAGATCATCTCCAGC
TCCGGCACCCAGCCGCAGGGCATGGGCATGCTGCTGTCCATCGTGCCCAGCAACGTGATTGCGGCAGCGTCCAGCAATGG
CGCGATCTTGTCGCTGATGTTTTTTGCGGTGATGTTCGGCGTGGGCATGGTGCTGACTGCCGATGAAAAGGTCGCCACGC
TGCGGCGTGGGATCGAAGGCGTCTTCGAGATTTCGATGACCCTGATCGGGCTGGTGATCCGCCTGGCGCCGTATGCGGTG
GCCTGCTTCATGTTCAACCTGGCGGCATTGTTCGGCTTCGATCTGTTGATTCGCCTGGGCGCTTATGTGGGCGTGGTGGT
GCTGGCGCTGGGCCTGCAGATGGTGGTCAGTTACGGGGTCGCGGTGAAGTTCGCCGGGCGCTCGCCGCTGGTTTTTTTCC
GCCAGACCCAGGAAGCGACGGTGATGGCGTTCTCGACCGCCTCCAGCAACGCCACCCTGCCGACCGCCCTGCGCGTGGCC
GACGAGATGGGCCTGCCGCCGCGCGTGTCGCGTTTCGTGCTGACCGTGGGCGCCACTGCCAACCAGAACGGCACTGCGCT
GTTCGAAGGCGTGACGGTGATCTTCCTGGCGCAGTTCTTCAACGTGGATCTGAGCCTGGGACAGCAGTTCATGGTGATGC
TGGTCTGTATCCTGGGCGGGATCGGCACGGCCGGCGTCCCGTCCGGCTCGCTGCCGGTGGTGGCGCTGATCTGTGCGATG
GTCGGGGTGAACCCGGTCGGCATCGGCATGATCCTGGGCGTGAATCACTTCCTGGATATGTGCCGCACGGCGCTGAACGT
GACCGGGGATCTGGCGCTGACGACCTTGGTGGCCAAGGGTGAGGAATAG

Upstream 100 bases:

>100_bases
TGACTTGCGGGGTGGCAAGCATCATCGAATATCACTCTGCGGTGCCCAGGTAGAGACTTACCGTGCATGCGAGCTATCCC
GGTCAAGGGTGGTCCCATCC

Downstream 100 bases:

>100_bases
GGAATCGGGAATCGGGAATCGGTTAAGCAGGCTGTTGCGAGGGTAAGGCGCGAGGCGGGGTCTGGCCGTCTCGCCGATGC
GGGTTGGGGCGAAGGTGAGT

Product: proton glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MAFVKLGSFCPPRPDQMTASTTTPRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDADWVRLLTKYVTTPFSQIFLNLIFM
LIVPLLFSALVMGISEMGDIRALGRLGWRTLGYTVVLSGVAVLLGLVLVNVLKPGAGVDPQVANQLIQENAERTREIISS
SGTQPQGMGMLLSIVPSNVIAAASSNGAILSLMFFAVMFGVGMVLTADEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLQMVVSYGVAVKFAGRSPLVFFRQTQEATVMAFSTASSNATLPTALRVA
DEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAM
VGVNPVGIGMILGVNHFLDMCRTALNVTGDLALTTLVAKGEE

Sequences:

>Translated_442_residues
MAFVKLGSFCPPRPDQMTASTTTPRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDADWVRLLTKYVTTPFSQIFLNLIFM
LIVPLLFSALVMGISEMGDIRALGRLGWRTLGYTVVLSGVAVLLGLVLVNVLKPGAGVDPQVANQLIQENAERTREIISS
SGTQPQGMGMLLSIVPSNVIAAASSNGAILSLMFFAVMFGVGMVLTADEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLQMVVSYGVAVKFAGRSPLVFFRQTQEATVMAFSTASSNATLPTALRVA
DEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAM
VGVNPVGIGMILGVNHFLDMCRTALNVTGDLALTTLVAKGEE
>Mature_441_residues
AFVKLGSFCPPRPDQMTASTTTPRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDADWVRLLTKYVTTPFSQIFLNLIFML
IVPLLFSALVMGISEMGDIRALGRLGWRTLGYTVVLSGVAVLLGLVLVNVLKPGAGVDPQVANQLIQENAERTREIISSS
GTQPQGMGMLLSIVPSNVIAAASSNGAILSLMFFAVMFGVGMVLTADEKVATLRRGIEGVFEISMTLIGLVIRLAPYAVA
CFMFNLAALFGFDLLIRLGAYVGVVVLALGLQMVVSYGVAVKFAGRSPLVFFRQTQEATVMAFSTASSNATLPTALRVAD
EMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFFNVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAMV
GVNPVGIGMILGVNHFLDMCRTALNVTGDLALTTLVAKGEE

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=434, Percent_Identity=28.3410138248848, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI40254478, Length=417, Percent_Identity=29.0167865707434, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI21314632, Length=411, Percent_Identity=27.7372262773723, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI66773030, Length=397, Percent_Identity=25.9445843828715, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI169790839, Length=413, Percent_Identity=27.6029055690073, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI194239697, Length=415, Percent_Identity=26.5060240963855, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI5032093, Length=383, Percent_Identity=28.7206266318538, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI301601644, Length=156, Percent_Identity=36.5384615384615, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI223468564, Length=251, Percent_Identity=29.8804780876494, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI223468566, Length=251, Percent_Identity=29.8804780876494, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262359914, Length=351, Percent_Identity=26.7806267806268, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1790514, Length=419, Percent_Identity=35.0835322195704, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1789947, Length=376, Percent_Identity=29.7872340425532, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1788024, Length=412, Percent_Identity=25.7281553398058, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789473, Length=308, Percent_Identity=25.974025974026, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=426, Percent_Identity=29.5774647887324, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71996953, Length=450, Percent_Identity=29.1111111111111, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193206505, Length=405, Percent_Identity=30.3703703703704, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71983106, Length=408, Percent_Identity=28.921568627451, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71983099, Length=408, Percent_Identity=28.921568627451, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17541374, Length=405, Percent_Identity=28.3950617283951, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=437, Percent_Identity=25.629290617849, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24583025, Length=435, Percent_Identity=30.1149425287356, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI17137668, Length=435, Percent_Identity=30.1149425287356, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24583023, Length=435, Percent_Identity=30.1149425287356, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281360481, Length=419, Percent_Identity=23.3890214797136, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281360483, Length=419, Percent_Identity=23.3890214797136, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137666, Length=419, Percent_Identity=23.3890214797136, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46638; Mature: 46507

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFVKLGSFCPPRPDQMTASTTTPRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDADWVR
CCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHH
LLTKYVTTPFSQIFLNLIFMLIVPLLFSALVMGISEMGDIRALGRLGWRTLGYTVVLSGV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLLGLVLVNVLKPGAGVDPQVANQLIQENAERTREIISSSGTQPQGMGMLLSIVPSNVI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHE
AAASSNGAILSLMFFAVMFGVGMVLTADEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
EECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLQMVVSYGVAVKFAGRSPLVFFRQTQEAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCE
VMAFSTASSNATLPTALRVADEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFF
EEEEEECCCCCCCHHHHHHHHHCCCCHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHH
NVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGIGMILGVNHFLDM
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRTALNVTGDLALTTLVAKGEE
HHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AFVKLGSFCPPRPDQMTASTTTPRPGLPLHWKMGIGFAVGLLLGLAVYYLAGSDADWVR
CEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCHHHHH
LLTKYVTTPFSQIFLNLIFMLIVPLLFSALVMGISEMGDIRALGRLGWRTLGYTVVLSGV
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVLLGLVLVNVLKPGAGVDPQVANQLIQENAERTREIISSSGTQPQGMGMLLSIVPSNVI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHE
AAASSNGAILSLMFFAVMFGVGMVLTADEKVATLRRGIEGVFEISMTLIGLVIRLAPYAV
EECCCCCHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACFMFNLAALFGFDLLIRLGAYVGVVVLALGLQMVVSYGVAVKFAGRSPLVFFRQTQEAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCE
VMAFSTASSNATLPTALRVADEMGLPPRVSRFVLTVGATANQNGTALFEGVTVIFLAQFF
EEEEEECCCCCCCHHHHHHHHHCCCCHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHH
NVDLSLGQQFMVMLVCILGGIGTAGVPSGSLPVVALICAMVGVNPVGIGMILGVNHFLDM
HCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRTALNVTGDLALTTLVAKGEE
HHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]