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The map label for this gene is flpA

Identifier: 84490205

GI number: 84490205

Start: 1598411

End: 1599076

Strand: Direct

Name: flpA

Synonym: Msp_1423

Alternate gene names: 84490205

Gene position: 1598411-1599076 (Clockwise)

Preceding gene: 84490204

Following gene: 84490216

Centisome position: 90.44

GC content: 28.68

Gene sequence:

>666_bases
ATGCAGATAAAAAATATTGGTGAAAATGTATATCAAATAGATAATCAAATTGCTACTGTAAATCTAACTCCTACAAAACA
AGTGTATCAAGAAAAACTCATACCATATGAAGATAAAGAATTTAGATTATGGAATCCACGTAGATCAAAACTAGCTGCAA
GTATTATTAAAGGTCTTACTATATTTCCATTTAAGAAAGATTCAAATGTATTATATTTAGGAGCTTCTGCAGGAACTACT
CCTTCACATATTTCAGATATATGTACTGAAGGAAAAATTTATTCAGTTGAATTTTCTCCAACAATGATGAGAGAATTCAT
TGAAGTTGCACAAAAAAGAGAAAATTTAATACCATTACTTGAAGATGCTACACATCCCCTTAATTACCAACACTTATTAG
AATCAGTTGATATTGTCTATAGTGATGTGGCTCAAGCACAACAAACAAAACTTTTCATTGATAATTTCAGACTGTTTGCA
AAGGAAGATGCAACTGGAATTATAATGATTAAAGCAAGAAGTATTGATGTAACAATGAATCCAAATACAATTTTTAAACA
GGAAAAAAGAAAGCTTGAAGAAAGTGGCCTAAAAGTTTTAGAAGAAATAAAACTTGACCCTTATGAAAAGGATCATATTG
CATTTATTTGTAAAAAATCATTCTAA

Upstream 100 bases:

>100_bases
GTAAAAAAAGTAAAAAAAATCGTAAAGAACGTAAAAAAAAGAAAAATAGGAAGAAAAAATTAAGAAAAGGAGAATATTCC
TATTAGGGAGTTGATATTAT

Downstream 100 bases:

>100_bases
AAAAAAGATGATAGATTTTTATATTAATTTATAAATTCTATCAATTATTTTTTGAGAAATATGCCATTTAGAATCAAGAC
ATAACTTCTCACAACCATCA

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MQIKNIGENVYQIDNQIATVNLTPTKQVYQEKLIPYEDKEFRLWNPRRSKLAASIIKGLTIFPFKKDSNVLYLGASAGTT
PSHISDICTEGKIYSVEFSPTMMREFIEVAQKRENLIPLLEDATHPLNYQHLLESVDIVYSDVAQAQQTKLFIDNFRLFA
KEDATGIIMIKARSIDVTMNPNTIFKQEKRKLEESGLKVLEEIKLDPYEKDHIAFICKKSF

Sequences:

>Translated_221_residues
MQIKNIGENVYQIDNQIATVNLTPTKQVYQEKLIPYEDKEFRLWNPRRSKLAASIIKGLTIFPFKKDSNVLYLGASAGTT
PSHISDICTEGKIYSVEFSPTMMREFIEVAQKRENLIPLLEDATHPLNYQHLLESVDIVYSDVAQAQQTKLFIDNFRLFA
KEDATGIIMIKARSIDVTMNPNTIFKQEKRKLEESGLKVLEEIKLDPYEKDHIAFICKKSF
>Mature_221_residues
MQIKNIGENVYQIDNQIATVNLTPTKQVYQEKLIPYEDKEFRLWNPRRSKLAASIIKGLTIFPFKKDSNVLYLGASAGTT
PSHISDICTEGKIYSVEFSPTMMREFIEVAQKRENLIPLLEDATHPLNYQHLLESVDIVYSDVAQAQQTKLFIDNFRLFA
KEDATGIIMIKARSIDVTMNPNTIFKQEKRKLEESGLKVLEEIKLDPYEKDHIAFICKKSF

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family [H]

Homologues:

Organism=Homo sapiens, GI12056465, Length=208, Percent_Identity=41.8269230769231, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17563672, Length=209, Percent_Identity=42.5837320574163, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6320190, Length=217, Percent_Identity=41.9354838709677, Blast_Score=176, Evalue=3e-45,
Organism=Drosophila melanogaster, GI17647425, Length=208, Percent_Identity=42.3076923076923, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24646406, Length=208, Percent_Identity=32.6923076923077, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000692
- InterPro:   IPR020813 [H]

Pfam domain/function: PF01269 Fibrillarin [H]

EC number: NA

Molecular weight: Translated: 25435; Mature: 25435

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIKNIGENVYQIDNQIATVNLTPTKQVYQEKLIPYEDKEFRLWNPRRSKLAASIIKGLT
CCCCHHCCHHHHHCCEEEEEEECCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHCCCE
IFPFKKDSNVLYLGASAGTTPSHISDICTEGKIYSVEFSPTMMREFIEVAQKRENLIPLL
EEEEECCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCCHH
EDATHPLNYQHLLESVDIVYSDVAQAQQTKLFIDNFRLFAKEDATGIIMIKARSIDVTMN
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEEEEEEEEEC
PNTIFKQEKRKLEESGLKVLEEIKLDPYEKDHIAFICKKSF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MQIKNIGENVYQIDNQIATVNLTPTKQVYQEKLIPYEDKEFRLWNPRRSKLAASIIKGLT
CCCCHHCCHHHHHCCEEEEEEECCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHCCCE
IFPFKKDSNVLYLGASAGTTPSHISDICTEGKIYSVEFSPTMMREFIEVAQKRENLIPLL
EEEEECCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCCHH
EDATHPLNYQHLLESVDIVYSDVAQAQQTKLFIDNFRLFAKEDATGIIMIKARSIDVTMN
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEEEEEEEEEEEC
PNTIFKQEKRKLEESGLKVLEEIKLDPYEKDHIAFICKKSF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11544247 [H]