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The map label for this gene is hemA

Identifier: 84490190

GI number: 84490190

Start: 1582342

End: 1583529

Strand: Direct

Name: hemA

Synonym: Msp_1408

Alternate gene names: 84490190

Gene position: 1582342-1583529 (Clockwise)

Preceding gene: 84490189

Following gene: 84490192

Centisome position: 89.53

GC content: 28.11

Gene sequence:

>1188_bases
ATGTTAGTTAATATTCGTATAGATTTTAAAATAGCAGATATAGAAACAATGGAAAAATCATATGCTAAACTAGATATGAT
AAACGCTGAATTACATGAGAAATTAGATATTTTAGAAGAAGTTACACTAAAAACATGTAATAGATATGAAATTTATCTTC
TAATTGATGAAGAAGTTAATATTCCCACAACTACTTTTATTGTTGAAAAGAATGATATGGCTATAAATCATTTGTTAAGA
TTAGCCTCTGGACTTGAATCAATGATTATGGGTGAAGATCAAATATTAGGACAAATAAAAACTGCCCGTAAAAATGCCAT
AAAAAATAAGACTATTGGCCCAAAGCTTGAGAAGGTTTTTACAAAGGCTATACATGTTGGTCAGACCATACGTAAAAATA
CCCATATAAATGAAGGTGGTGTATCTGTAGGTAGTGGTGCTGTAGAACTTATTGAAGAAAAGTATGGTTCATTGAAAGGA
AAAAATGTTCTTATAATTGGTGCTGGAGAAATGGGTACTGTTGTTTCTAAGGCTTTGCTTGAAAAAGAAACAAATACAAT
AGTTGTTGCTAATAGAACATATGATAAGGCAAGACAGTTAGCTCAAGAATTAGATGGTGAAGCTATAAAATTTGATGAAA
TGAATAATGAACTTGTAAATATTGATATTGTAATTAGTTCTACTGGTGCTCCTCATAGTATAATAAGTAAAGAACGTATA
GCATTTTTACCTGAAGAACATTTACATGACATGATTATGTTAGATTTAGCTAACCCTCATGATATTGAAAATGATGTTCA
GGAATTAGGTGTTAAATTATATAACCTTGATGATTTAAGATATGTTACTGATAAAAATAAGGAACGTCGTAACAAGGAAG
CTATTAAGGCTGAGGCTATTATTGAAGATGAAACCCTTCTTCTTAAAGAATCTTTAAAACAAATGGAAATAACTCCGATT
TTATCTTCATTAAATATTGAAGCTGAAAAAATTAGAAAACAAGAACTTGATAAAACATTACACATGCTTGATTTAGATAA
AAAATCATCTAAAAAGGTAGATTATTTAACAAGAAGTATTACTGATAAACTATTATATAATATAATTAACAATTTAAAAG
AAGCAGCTGCTAATAATGATAAAGACACTATTAGAAATGCTAAAAAAATACTCCTTGAATATAACTAA

Upstream 100 bases:

>100_bases
TATGGTAATGAAATTAGATAAATGTATTTTAATTAAATATGAGTATGTGAAGCTTATTTGAATGATACATTGAAATAAAA
ATCTAATAAGGGGATTGTGA

Downstream 100 bases:

>100_bases
CCAATAGGATTTCCCTATTTCTTTTTTTAAAAATATTTGAAAAAATATTATTAAATTTAATGCATGTCTGATAGTTGTTT
TCCACCCACTCCAACATTAT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MLVNIRIDFKIADIETMEKSYAKLDMINAELHEKLDILEEVTLKTCNRYEIYLLIDEEVNIPTTTFIVEKNDMAINHLLR
LASGLESMIMGEDQILGQIKTARKNAIKNKTIGPKLEKVFTKAIHVGQTIRKNTHINEGGVSVGSGAVELIEEKYGSLKG
KNVLIIGAGEMGTVVSKALLEKETNTIVVANRTYDKARQLAQELDGEAIKFDEMNNELVNIDIVISSTGAPHSIISKERI
AFLPEEHLHDMIMLDLANPHDIENDVQELGVKLYNLDDLRYVTDKNKERRNKEAIKAEAIIEDETLLLKESLKQMEITPI
LSSLNIEAEKIRKQELDKTLHMLDLDKKSSKKVDYLTRSITDKLLYNIINNLKEAAANNDKDTIRNAKKILLEYN

Sequences:

>Translated_395_residues
MLVNIRIDFKIADIETMEKSYAKLDMINAELHEKLDILEEVTLKTCNRYEIYLLIDEEVNIPTTTFIVEKNDMAINHLLR
LASGLESMIMGEDQILGQIKTARKNAIKNKTIGPKLEKVFTKAIHVGQTIRKNTHINEGGVSVGSGAVELIEEKYGSLKG
KNVLIIGAGEMGTVVSKALLEKETNTIVVANRTYDKARQLAQELDGEAIKFDEMNNELVNIDIVISSTGAPHSIISKERI
AFLPEEHLHDMIMLDLANPHDIENDVQELGVKLYNLDDLRYVTDKNKERRNKEAIKAEAIIEDETLLLKESLKQMEITPI
LSSLNIEAEKIRKQELDKTLHMLDLDKKSSKKVDYLTRSITDKLLYNIINNLKEAAANNDKDTIRNAKKILLEYN
>Mature_395_residues
MLVNIRIDFKIADIETMEKSYAKLDMINAELHEKLDILEEVTLKTCNRYEIYLLIDEEVNIPTTTFIVEKNDMAINHLLR
LASGLESMIMGEDQILGQIKTARKNAIKNKTIGPKLEKVFTKAIHVGQTIRKNTHINEGGVSVGSGAVELIEEKYGSLKG
KNVLIIGAGEMGTVVSKALLEKETNTIVVANRTYDKARQLAQELDGEAIKFDEMNNELVNIDIVISSTGAPHSIISKERI
AFLPEEHLHDMIMLDLANPHDIENDVQELGVKLYNLDDLRYVTDKNKERRNKEAIKAEAIIEDETLLLKESLKQMEITPI
LSSLNIEAEKIRKQELDKTLHMLDLDKKSSKKVDYLTRSITDKLLYNIINNLKEAAANNDKDTIRNAKKILLEYN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=407, Percent_Identity=30.2211302211302, Blast_Score=174, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_METST (Q2NEH4)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_448422.1
- ProteinModelPortal:   Q2NEH4
- SMR:   Q2NEH4
- STRING:   Q2NEH4
- GeneID:   3854884
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_1408
- NMPDR:   fig|339860.6.peg.1346
- eggNOG:   arNOG04783
- HOGENOM:   HBG732626
- OMA:   IVANRTY
- PhylomeDB:   Q2NEH4
- ProtClustDB:   PRK00045
- BioCyc:   MSTA339860:MSP_1408-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 44733; Mature: 44733

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 46-46 BINDING 87-87 BINDING 98-98

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVNIRIDFKIADIETMEKSYAKLDMINAELHEKLDILEEVTLKTCNRYEIYLLIDEEVN
CEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
IPTTTFIVEKNDMAINHLLRLASGLESMIMGEDQILGQIKTARKNAIKNKTIGPKLEKVF
CCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TKAIHVGQTIRKNTHINEGGVSVGSGAVELIEEKYGSLKGKNVLIIGAGEMGTVVSKALL
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
EKETNTIVVANRTYDKARQLAQELDGEAIKFDEMNNELVNIDIVISSTGAPHSIISKERI
HCCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCHHHHCCHHH
AFLPEEHLHDMIMLDLANPHDIENDVQELGVKLYNLDDLRYVTDKNKERRNKEAIKAEAI
HCCCHHHHHHEEEEECCCCCCHHHHHHHHCCEEECCCCHHEECCCCHHHHHHHHHHHHHH
IEDETLLLKESLKQMEITPILSSLNIEAEKIRKQELDKTLHMLDLDKKSSKKVDYLTRSI
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TDKLLYNIINNLKEAAANNDKDTIRNAKKILLEYN
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECC
>Mature Secondary Structure
MLVNIRIDFKIADIETMEKSYAKLDMINAELHEKLDILEEVTLKTCNRYEIYLLIDEEVN
CEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCC
IPTTTFIVEKNDMAINHLLRLASGLESMIMGEDQILGQIKTARKNAIKNKTIGPKLEKVF
CCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TKAIHVGQTIRKNTHINEGGVSVGSGAVELIEEKYGSLKGKNVLIIGAGEMGTVVSKALL
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHH
EKETNTIVVANRTYDKARQLAQELDGEAIKFDEMNNELVNIDIVISSTGAPHSIISKERI
HCCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEECCCCCHHHHCCHHH
AFLPEEHLHDMIMLDLANPHDIENDVQELGVKLYNLDDLRYVTDKNKERRNKEAIKAEAI
HCCCHHHHHHEEEEECCCCCCHHHHHHHHCCEEECCCCHHEECCCCHHHHHHHHHHHHHH
IEDETLLLKESLKQMEITPILSSLNIEAEKIRKQELDKTLHMLDLDKKSSKKVDYLTRSI
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TDKLLYNIINNLKEAAANNDKDTIRNAKKILLEYN
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA