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The map label for this gene is top6A [H]

Identifier: 84490128

GI number: 84490128

Start: 1508152

End: 1509225

Strand: Direct

Name: top6A [H]

Synonym: Msp_1340

Alternate gene names: 84490128

Gene position: 1508152-1509225 (Clockwise)

Preceding gene: 84490127

Following gene: 84490129

Centisome position: 85.33

GC content: 32.96

Gene sequence:

>1074_bases
ATGATGAAACATAAAGAAATAGCTTTAAATAAACTAAGAGGTATGGGGGATGAAGTTCTTGAAAAGATACTTCAAGAAGA
AGTACCTAGTTTAAAAATTCCATCAAGAGGAACAGGAAATATCATCTATAATCAAGATAAAAGATATTTTGAATTAGGTG
AAAGAAAAGGTACTAGATCTTTAGGTAATGTAAAACAAATAAAGAAAATGGCACAGATGATGTGTGTTGGTAATTTCTGT
AAGGAATTAGTAAATATACAAAAAACTGCTACTATGAGGGAGATGTACTATGTATCTGAAGGATGGGATGTTGGATTTGA
TAACCAGCAAGAATCAAACAACATAACAGAAGATATAGAAGTAACTCTTGGTGTATCTCGTGAAAATCTAGGATTATTAC
CAGAGGAAGATGGTGCTTCAGTATATGGTGATATAACTCTACGTGATGATGATGTTGAATTTAATGCTAAAAAACTTGGA
AAATCAGGTTATACCATTCCTCCAACGATTGATGATGTTGAATTTGTTGATTCAAATGTAGAAAGAATTATTGCAGTGGA
AACCATGGGGATGTATCATCGTATGGTTCAAGAAAAAGCATATGATAGATTTAATACATTGATTGTAGGATTAAAAGGAC
AAGCTGCACGTGCAACACGTAGATTTATTAGAAGAGCCAGTGATGAATTACAAGTTCCTGTTTATATTTGTAACGACGGA
GATCCATGGGGTTTCCACATTGCTATGGTAATTATATCAGGTAGTGCAAAATTAGCTCACGTAAATCATGACCTTGCAAC
TCCAGATGCTAAATTCCTTGGAGTAACAGCATCAGATATTGAAAATTATGATCTTCCTACTGATAAACTAAAAGATATTG
ATGTAGCACGTCTTAAAGAATTAGCTGCTGATCCTAGATATAAGGCTGATTTCTGGCAGACAGAAATTAAGAAAATGATT
AAACTTGGACGTAAGGCAGAACAGCAATCATTCTCCAAATATGGTCTTGAATATATTGTAGATAATTATTTCCCAAATAA
AATAAGTGCTATTGAAGGTAAACCAATAGAATAG

Upstream 100 bases:

>100_bases
CCTATGGAAGTAAAAACTGAAGAACCAGAAATGAGAATAAAAACTGAAATAGAGGAAGAATTATCTGAGGATGAAAATTT
CTAAGTAGGAGAGATAGACA

Downstream 100 bases:

>100_bases
GTAAATAATTATTTACTTATATTCTTTTTTTTGGAGGGATGAAAATAAATATAAAAAATATTTTTTCAGGAAAAACTATA
CCTTTAACTATTTTAATGAT

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MMKHKEIALNKLRGMGDEVLEKILQEEVPSLKIPSRGTGNIIYNQDKRYFELGERKGTRSLGNVKQIKKMAQMMCVGNFC
KELVNIQKTATMREMYYVSEGWDVGFDNQQESNNITEDIEVTLGVSRENLGLLPEEDGASVYGDITLRDDDVEFNAKKLG
KSGYTIPPTIDDVEFVDSNVERIIAVETMGMYHRMVQEKAYDRFNTLIVGLKGQAARATRRFIRRASDELQVPVYICNDG
DPWGFHIAMVIISGSAKLAHVNHDLATPDAKFLGVTASDIENYDLPTDKLKDIDVARLKELAADPRYKADFWQTEIKKMI
KLGRKAEQQSFSKYGLEYIVDNYFPNKISAIEGKPIE

Sequences:

>Translated_357_residues
MMKHKEIALNKLRGMGDEVLEKILQEEVPSLKIPSRGTGNIIYNQDKRYFELGERKGTRSLGNVKQIKKMAQMMCVGNFC
KELVNIQKTATMREMYYVSEGWDVGFDNQQESNNITEDIEVTLGVSRENLGLLPEEDGASVYGDITLRDDDVEFNAKKLG
KSGYTIPPTIDDVEFVDSNVERIIAVETMGMYHRMVQEKAYDRFNTLIVGLKGQAARATRRFIRRASDELQVPVYICNDG
DPWGFHIAMVIISGSAKLAHVNHDLATPDAKFLGVTASDIENYDLPTDKLKDIDVARLKELAADPRYKADFWQTEIKKMI
KLGRKAEQQSFSKYGLEYIVDNYFPNKISAIEGKPIE
>Mature_357_residues
MMKHKEIALNKLRGMGDEVLEKILQEEVPSLKIPSRGTGNIIYNQDKRYFELGERKGTRSLGNVKQIKKMAQMMCVGNFC
KELVNIQKTATMREMYYVSEGWDVGFDNQQESNNITEDIEVTLGVSRENLGLLPEEDGASVYGDITLRDDDVEFNAKKLG
KSGYTIPPTIDDVEFVDSNVERIIAVETMGMYHRMVQEKAYDRFNTLIVGLKGQAARATRRFIRRASDELQVPVYICNDG
DPWGFHIAMVIISGSAKLAHVNHDLATPDAKFLGVTASDIENYDLPTDKLKDIDVARLKELAADPRYKADFWQTEIKKMI
KLGRKAEQQSFSKYGLEYIVDNYFPNKISAIEGKPIE

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI6912680, Length=349, Percent_Identity=23.7822349570201, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI38201680, Length=290, Percent_Identity=25.5172413793103, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI45552753, Length=330, Percent_Identity=23.9393939393939, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 40497; Mature: 40497

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKHKEIALNKLRGMGDEVLEKILQEEVPSLKIPSRGTGNIIYNQDKRYFELGERKGTRS
CCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHCCCCCC
LGNVKQIKKMAQMMCVGNFCKELVNIQKTATMREMYYVSEGWDVGFDNQQESNNITEDIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCEEE
VTLGVSRENLGLLPEEDGASVYGDITLRDDDVEFNAKKLGKSGYTIPPTIDDVEFVDSNV
EEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHCCCH
ERIIAVETMGMYHRMVQEKAYDRFNTLIVGLKGQAARATRRFIRRASDELQVPVYICNDG
HHEEEHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCC
DPWGFHIAMVIISGSAKLAHVNHDLATPDAKFLGVTASDIENYDLPTDKLKDIDVARLKE
CCCCEEEEEEEEECCCEEEECCCCCCCCCCCEEECCHHHCCCCCCCHHHHCCCCHHHHHH
LAADPRYKADFWQTEIKKMIKLGRKAEQQSFSKYGLEYIVDNYFPNKISAIEGKPIE
HHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMKHKEIALNKLRGMGDEVLEKILQEEVPSLKIPSRGTGNIIYNQDKRYFELGERKGTRS
CCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHCCCCCC
LGNVKQIKKMAQMMCVGNFCKELVNIQKTATMREMYYVSEGWDVGFDNQQESNNITEDIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCEEE
VTLGVSRENLGLLPEEDGASVYGDITLRDDDVEFNAKKLGKSGYTIPPTIDDVEFVDSNV
EEEECCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCCCCCCCCHHHHCCCH
ERIIAVETMGMYHRMVQEKAYDRFNTLIVGLKGQAARATRRFIRRASDELQVPVYICNDG
HHEEEHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCC
DPWGFHIAMVIISGSAKLAHVNHDLATPDAKFLGVTASDIENYDLPTDKLKDIDVARLKE
CCCCEEEEEEEEECCCEEEECCCCCCCCCCCEEECCHHHCCCCCCCHHHHCCCCHHHHHH
LAADPRYKADFWQTEIKKMIKLGRKAEQQSFSKYGLEYIVDNYFPNKISAIEGKPIE
HHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]