Click here to switch to the map view.

The map label for this gene is top6B [H]

Identifier: 84490127

GI number: 84490127

Start: 1506471

End: 1508135

Strand: Direct

Name: top6B [H]

Synonym: Msp_1339

Alternate gene names: 84490127

Gene position: 1506471-1508135 (Clockwise)

Preceding gene: 84490126

Following gene: 84490128

Centisome position: 85.24

GC content: 31.41

Gene sequence:

>1665_bases
TTGGAACGTGATACATCAGAATTATTTGAAGAATTTAAGGAATTAACAGCATCTGAATTTTTCAGACGAAATAAACAAAT
GTTAGGTTTTTCTGGAAAAATAAGATCATTAACAATAGTATTTCACGAACTTATAACAAACAGTCTAGATGCATGTGAAG
AAGTAGGAATACTGCCTGATATAACAATAGAATTAAAAAGATTAGGAAAAGATCATTACCTACTCAAACATGCAGATAAT
GGACCTGGTATTCCTGAAGATTACATAACAAAGGTATACTGTCAAATGTTTGCTGGAAGTAAATTCAGAAATATACAATC
TAGAGGTCAACAAGGTCTAGGATGTAGTGGATGTGTATTATTATCACAGATGACTACAGGACAACCAGTAAAAATAAGAT
CAAGATACAAAGATGGAAATGAATTAAAAGGCATTGAAATGACTGTAAAACTTGATGTTAAAAAGAATACTGGAATAATT
CTTAATAAAAAAGAATTTGAAACAGATAGAACCGGATCTGGAATAGAAATAGAATTTAAAGATGTATCTTATTCCATGAG
TGAACAAGGTGCTTATGAATACATAAGACGTACTGTTATTGGAAATCCCCATGCAAGAATAGTATTTAAAGATCCAACAG
GTAGAAAATACACTTTTGAAAGAGCAACAGATAAAATACCACCATTACCTAAAGAAGTATTACCTCATCCAAAAGGTGTA
ACAGCAGATGATATAATATACCTATGTAAAGGTACAAATAAAAAACGATTTAAAAATCTACTAATGGATTCCCTATCAAG
AGTATCTGCAGCAAAAATAAAAGAAATACAAGAAGCTACAGGTATTGATATGAACAAACGACCAAAAAGCATAACATGGA
AAGAAGCTGAAGCTGTTGTTCAACAATTTGATAAAATGAAATTCATGGCACCACCAACAAATGGTCTTAAGCCAATAGGT
AGTGAACAAATAGAAAAAGGTATAAATGAAATTCTCTTACCAGAATTTTCAACTGCTATAACAAGAAAACCTCAAGCATA
CCGTGGAGGAGTATCATTTATTGTAGAAGCAGGAATTGCATATGGTGGTAATTCTGGAAGATTAATTGGAAGTCAAAGAA
AAGCAGAAATTATGAGATTTGCTAACAGAGTTCCTTTAACATTTGACCAGGGAAGTTGTGCAATAACTGAAGCTTTAAAA
AGTATTGACTGGAGACGATATGGTGTACGGGACTTAGATAATGCACCAATATCAGTATTTGTAAATATTATTTCAACAAA
TGTACCATACCTTTCAACAGGAAAACAAAGTGTTGCACCTGAAGAAGAAATTGTACGTGAAATAAGACAAGCAACAATGA
AAATAGCTCGTAAACTAGAAAAATACATACGAACTAAAAAAGCAGCAAAAAATGAAGAAATGAGAGCTAAAATATTTGAA
GATTTAGTCCCTGTTGTAATTAAACAATCTGCATTACTTGCTGAAAAAGATGTTCCAGAATATAATAAGGTAATGGATGA
AGTTACACACAAAGCTAAGATTATGGATATGAAAAATCGTCTTAAACAACCAGAAATCAAACCTATGGAAGTAAAAACTG
AAGAACCAGAAATGAGAATAAAAACTGAAATAGAGGAAGAATTATCTGAGGATGAAAATTTCTAA

Upstream 100 bases:

>100_bases
ATATTTAGAGAAGGAATTAACTTAAAACTATAACTTAGAGAAATACAAAATTTAATACTATTTAAAATAAAAGTAATAAT
TTATCGGAGGAATGAAATCC

Downstream 100 bases:

>100_bases
GTAGGAGAGATAGACAATGATGAAACATAAAGAAATAGCTTTAAATAAACTAAGAGGTATGGGGGATGAAGTTCTTGAAA
AGATACTTCAAGAAGAAGTA

Product: DNA topoisomerase VI subunit B

Products: NA

Alternate protein names: Type II DNA topoisomerase VI subunit B; TopoVI-B [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MERDTSELFEEFKELTASEFFRRNKQMLGFSGKIRSLTIVFHELITNSLDACEEVGILPDITIELKRLGKDHYLLKHADN
GPGIPEDYITKVYCQMFAGSKFRNIQSRGQQGLGCSGCVLLSQMTTGQPVKIRSRYKDGNELKGIEMTVKLDVKKNTGII
LNKKEFETDRTGSGIEIEFKDVSYSMSEQGAYEYIRRTVIGNPHARIVFKDPTGRKYTFERATDKIPPLPKEVLPHPKGV
TADDIIYLCKGTNKKRFKNLLMDSLSRVSAAKIKEIQEATGIDMNKRPKSITWKEAEAVVQQFDKMKFMAPPTNGLKPIG
SEQIEKGINEILLPEFSTAITRKPQAYRGGVSFIVEAGIAYGGNSGRLIGSQRKAEIMRFANRVPLTFDQGSCAITEALK
SIDWRRYGVRDLDNAPISVFVNIISTNVPYLSTGKQSVAPEEEIVREIRQATMKIARKLEKYIRTKKAAKNEEMRAKIFE
DLVPVVIKQSALLAEKDVPEYNKVMDEVTHKAKIMDMKNRLKQPEIKPMEVKTEEPEMRIKTEIEEELSEDENF

Sequences:

>Translated_554_residues
MERDTSELFEEFKELTASEFFRRNKQMLGFSGKIRSLTIVFHELITNSLDACEEVGILPDITIELKRLGKDHYLLKHADN
GPGIPEDYITKVYCQMFAGSKFRNIQSRGQQGLGCSGCVLLSQMTTGQPVKIRSRYKDGNELKGIEMTVKLDVKKNTGII
LNKKEFETDRTGSGIEIEFKDVSYSMSEQGAYEYIRRTVIGNPHARIVFKDPTGRKYTFERATDKIPPLPKEVLPHPKGV
TADDIIYLCKGTNKKRFKNLLMDSLSRVSAAKIKEIQEATGIDMNKRPKSITWKEAEAVVQQFDKMKFMAPPTNGLKPIG
SEQIEKGINEILLPEFSTAITRKPQAYRGGVSFIVEAGIAYGGNSGRLIGSQRKAEIMRFANRVPLTFDQGSCAITEALK
SIDWRRYGVRDLDNAPISVFVNIISTNVPYLSTGKQSVAPEEEIVREIRQATMKIARKLEKYIRTKKAAKNEEMRAKIFE
DLVPVVIKQSALLAEKDVPEYNKVMDEVTHKAKIMDMKNRLKQPEIKPMEVKTEEPEMRIKTEIEEELSEDENF
>Mature_554_residues
MERDTSELFEEFKELTASEFFRRNKQMLGFSGKIRSLTIVFHELITNSLDACEEVGILPDITIELKRLGKDHYLLKHADN
GPGIPEDYITKVYCQMFAGSKFRNIQSRGQQGLGCSGCVLLSQMTTGQPVKIRSRYKDGNELKGIEMTVKLDVKKNTGII
LNKKEFETDRTGSGIEIEFKDVSYSMSEQGAYEYIRRTVIGNPHARIVFKDPTGRKYTFERATDKIPPLPKEVLPHPKGV
TADDIIYLCKGTNKKRFKNLLMDSLSRVSAAKIKEIQEATGIDMNKRPKSITWKEAEAVVQQFDKMKFMAPPTNGLKPIG
SEQIEKGINEILLPEFSTAITRKPQAYRGGVSFIVEAGIAYGGNSGRLIGSQRKAEIMRFANRVPLTFDQGSCAITEALK
SIDWRRYGVRDLDNAPISVFVNIISTNVPYLSTGKQSVAPEEEIVREIRQATMKIARKLEKYIRTKKAAKNEEMRAKIFE
DLVPVVIKQSALLAEKDVPEYNKVMDEVTHKAKIMDMKNRLKQPEIKPMEVKTEEPEMRIKTEIEEELSEDENF

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP [H]

COG id: COG1389

COG function: function code L; DNA topoisomerase VI, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR010979
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005734
- InterPro:   IPR015320
- ProDom:   PD013790 [H]

Pfam domain/function: PF02518 HATPase_c; PF09239 Topo-VIb_trans [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 62870; Mature: 62870

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERDTSELFEEFKELTASEFFRRNKQMLGFSGKIRSLTIVFHELITNSLDACEEVGILPD
CCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
ITIELKRLGKDHYLLKHADNGPGIPEDYITKVYCQMFAGSKFRNIQSRGQQGLGCSGCVL
CHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHH
LSQMTTGQPVKIRSRYKDGNELKGIEMTVKLDVKKNTGIILNKKEFETDRTGSGIEIEFK
HHHCCCCCCEEEHHHCCCCCCCCCEEEEEEEEEECCCCEEEECHHCCCCCCCCCCEEEEE
DVSYSMSEQGAYEYIRRTVIGNPHARIVFKDPTGRKYTFERATDKIPPLPKEVLPHPKGV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHCCCCCCCCHHHCCCCCCC
TADDIIYLCKGTNKKRFKNLLMDSLSRVSAAKIKEIQEATGIDMNKRPKSITWKEAEAVV
CHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
QQFDKMKFMAPPTNGLKPIGSEQIEKGINEILLPEFSTAITRKPQAYRGGVSFIVEAGIA
HHHHHCEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHCCHHHHHHHHHH
YGGNSGRLIGSQRKAEIMRFANRVPLTFDQGSCAITEALKSIDWRRYGVRDLDNAPISVF
CCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHH
VNIISTNVPYLSTGKQSVAPEEEIVREIRQATMKIARKLEKYIRTKKAAKNEEMRAKIFE
HHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DLVPVVIKQSALLAEKDVPEYNKVMDEVTHKAKIMDMKNRLKQPEIKPMEVKTEEPEMRI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHH
KTEIEEELSEDENF
HHHHHHHHHCCCCC
>Mature Secondary Structure
MERDTSELFEEFKELTASEFFRRNKQMLGFSGKIRSLTIVFHELITNSLDACEEVGILPD
CCCCHHHHHHHHHHHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
ITIELKRLGKDHYLLKHADNGPGIPEDYITKVYCQMFAGSKFRNIQSRGQQGLGCSGCVL
CHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHH
LSQMTTGQPVKIRSRYKDGNELKGIEMTVKLDVKKNTGIILNKKEFETDRTGSGIEIEFK
HHHCCCCCCEEEHHHCCCCCCCCCEEEEEEEEEECCCCEEEECHHCCCCCCCCCCEEEEE
DVSYSMSEQGAYEYIRRTVIGNPHARIVFKDPTGRKYTFERATDKIPPLPKEVLPHPKGV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHCCCCCCCCHHHCCCCCCC
TADDIIYLCKGTNKKRFKNLLMDSLSRVSAAKIKEIQEATGIDMNKRPKSITWKEAEAVV
CHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
QQFDKMKFMAPPTNGLKPIGSEQIEKGINEILLPEFSTAITRKPQAYRGGVSFIVEAGIA
HHHHHCEEECCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHCCHHHHHHHHHH
YGGNSGRLIGSQRKAEIMRFANRVPLTFDQGSCAITEALKSIDWRRYGVRDLDNAPISVF
CCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCHHHCCCCCCCCCCHHHH
VNIISTNVPYLSTGKQSVAPEEEIVREIRQATMKIARKLEKYIRTKKAAKNEEMRAKIFE
HHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DLVPVVIKQSALLAEKDVPEYNKVMDEVTHKAKIMDMKNRLKQPEIKPMEVKTEEPEMRI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHH
KTEIEEELSEDENF
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]