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The map label for this gene is hisC

Identifier: 84490114

GI number: 84490114

Start: 1492459

End: 1493562

Strand: Direct

Name: hisC

Synonym: Msp_1326

Alternate gene names: 84490114

Gene position: 1492459-1493562 (Clockwise)

Preceding gene: 84490113

Following gene: 84490116

Centisome position: 84.44

GC content: 28.44

Gene sequence:

>1104_bases
ATGGTAAAAACAAGAGCAATATTAGAGGAATACAAAACTTACGTTCCAGGTAGATCTAAAAAGGAAATTGCTGAAGAATA
TGGTGTTGCTGAAGAAAGTATTATTAAACTTGGATCTAATGAAAATCCATGGGGACCTTCACCTAAAGCAAAACAAGCAA
TTATTGATTCTATTGATGAAATAAATAGATACCCTGAATCTAATCATGAATATATTAAAGAACAAATTGCTAAATATGCT
AATGTAACAAAAGATCAAGTTATTATTGGTGGAGATGGAGCTGATGAATTATTTGAAGTATTAGCAAAAACTGTTATTGA
TGAAGGTGATGAATTTATAGTACATCAACCTACATATACATATTATGAATATACCTTCAAACAATCTAATGCTAAAGCTG
TTTATGCTACATGGAATATTGAAGAAAATAAATTAGATGTGGACTCTGTCCTTAATAACATTACAGATAAAACAAAAGTA
ATTTTCTTATGTACTCCAAACAATCCTACAGGAGGACTTATTCCACAAGAAGATATTGTTAGAATTATTGAAGCTACAGA
TGCTCTTGTTGTAATAGATGAAGCATATTGGGAATTTTCTGAAGTTAATAATGTGAACTTACTTAAAAAATACAATAACA
TATTCATAATAAGAACCTTCTCTAAAGTAATGGGTCTTGCAGGTTTAAGAATTGGATATGGTCTTTCAAATCCAGATTTT
ATAGAAAAAATGTCAAGAATAAAACCAGTATTTAGTGTAACAGTTCCTTCTCAAAAAGCTGTTATTGCAACATTAAATGA
TGAAGAATTTATTAAAGAATCCACAGAAAAAGCAATTACTGAGAGAGAATACTTGTATGAAAGTGTTAATAGTATAGATA
ACATTCATATTTATAAATCCAAATCTAATTATTTGTTAATGGATGTTCGAAAAACAGGATACACAGCAGCAGAATTAACT
TCAAAGTTAATGTCTAGGGGTGTAATTGTACGTGACTGTACAAGTTTTGTTGGTCTTGATGAATATTATATTCGCATTAG
TGTTGAAACACATCCAAAAAATGAAAAATTTATTGAAATATTAAAAGAAATAGTAGAAAATTAA

Upstream 100 bases:

>100_bases
AGCTGTACGCGAATTAACTAAAGAAGAAATTAAAGAAATTACTGAAAATGCTGATGAATACGTTGAATTAGCATTTGAAA
AAGAATAAAAAAGGGATTAT

Downstream 100 bases:

>100_bases
AATATTTCTATTATTTTTTCATTATCTAATTTTTTTTTAGTGTCTTATAGGATCATGATATATCAAAGCAGCAACTACAC
TTGCCTTATCTATTACTTTA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MVKTRAILEEYKTYVPGRSKKEIAEEYGVAEESIIKLGSNENPWGPSPKAKQAIIDSIDEINRYPESNHEYIKEQIAKYA
NVTKDQVIIGGDGADELFEVLAKTVIDEGDEFIVHQPTYTYYEYTFKQSNAKAVYATWNIEENKLDVDSVLNNITDKTKV
IFLCTPNNPTGGLIPQEDIVRIIEATDALVVIDEAYWEFSEVNNVNLLKKYNNIFIIRTFSKVMGLAGLRIGYGLSNPDF
IEKMSRIKPVFSVTVPSQKAVIATLNDEEFIKESTEKAITEREYLYESVNSIDNIHIYKSKSNYLLMDVRKTGYTAAELT
SKLMSRGVIVRDCTSFVGLDEYYIRISVETHPKNEKFIEILKEIVEN

Sequences:

>Translated_367_residues
MVKTRAILEEYKTYVPGRSKKEIAEEYGVAEESIIKLGSNENPWGPSPKAKQAIIDSIDEINRYPESNHEYIKEQIAKYA
NVTKDQVIIGGDGADELFEVLAKTVIDEGDEFIVHQPTYTYYEYTFKQSNAKAVYATWNIEENKLDVDSVLNNITDKTKV
IFLCTPNNPTGGLIPQEDIVRIIEATDALVVIDEAYWEFSEVNNVNLLKKYNNIFIIRTFSKVMGLAGLRIGYGLSNPDF
IEKMSRIKPVFSVTVPSQKAVIATLNDEEFIKESTEKAITEREYLYESVNSIDNIHIYKSKSNYLLMDVRKTGYTAAELT
SKLMSRGVIVRDCTSFVGLDEYYIRISVETHPKNEKFIEILKEIVEN
>Mature_367_residues
MVKTRAILEEYKTYVPGRSKKEIAEEYGVAEESIIKLGSNENPWGPSPKAKQAIIDSIDEINRYPESNHEYIKEQIAKYA
NVTKDQVIIGGDGADELFEVLAKTVIDEGDEFIVHQPTYTYYEYTFKQSNAKAVYATWNIEENKLDVDSVLNNITDKTKV
IFLCTPNNPTGGLIPQEDIVRIIEATDALVVIDEAYWEFSEVNNVNLLKKYNNIFIIRTFSKVMGLAGLRIGYGLSNPDF
IEKMSRIKPVFSVTVPSQKAVIATLNDEEFIKESTEKAITEREYLYESVNSIDNIHIYKSKSNYLLMDVRKTGYTAAELT
SKLMSRGVIVRDCTSFVGLDEYYIRISVETHPKNEKFIEILKEIVEN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=340, Percent_Identity=28.8235294117647, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1788627, Length=240, Percent_Identity=24.5833333333333, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=370, Percent_Identity=26.4864864864865, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_METST (Q2NEQ0)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_448346.1
- ProteinModelPortal:   Q2NEQ0
- SMR:   Q2NEQ0
- STRING:   Q2NEQ0
- GeneID:   3855954
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_1326
- NMPDR:   fig|339860.6.peg.1272
- eggNOG:   arNOG04897
- HOGENOM:   HBG646350
- OMA:   MSARYHH
- PhylomeDB:   Q2NEQ0
- ProtClustDB:   PRK00950
- BioCyc:   MSTA339860:MSP_1326-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41830; Mature: 41830

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKTRAILEEYKTYVPGRSKKEIAEEYGVAEESIIKLGSNENPWGPSPKAKQAIIDSIDE
CCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
INRYPESNHEYIKEQIAKYANVTKDQVIIGGDGADELFEVLAKTVIDEGDEFIVHQPTYT
HHCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCEE
YYEYTFKQSNAKAVYATWNIEENKLDVDSVLNNITDKTKVIFLCTPNNPTGGLIPQEDIV
EEEEEEECCCCEEEEEEECCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHH
RIIEATDALVVIDEAYWEFSEVNNVNLLKKYNNIFIIRTFSKVMGLAGLRIGYGLSNPDF
HHHHHCCEEEEEEHHHHHHHHCCCCCEEEECCCEEEEEEHHHHHHHCCCEECCCCCCHHH
IEKMSRIKPVFSVTVPSQKAVIATLNDEEFIKESTEKAITEREYLYESVNSIDNIHIYKS
HHHHHHCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
KSNYLLMDVRKTGYTAAELTSKLMSRGVIVRDCTSFVGLDEYYIRISVETHPKNEKFIEI
CCCEEEEEECCCCCCHHHHHHHHHHCCCEEEHHHHHHCCCEEEEEEEEEECCCCHHHHHH
LKEIVEN
HHHHHCC
>Mature Secondary Structure
MVKTRAILEEYKTYVPGRSKKEIAEEYGVAEESIIKLGSNENPWGPSPKAKQAIIDSIDE
CCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
INRYPESNHEYIKEQIAKYANVTKDQVIIGGDGADELFEVLAKTVIDEGDEFIVHQPTYT
HHCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCEE
YYEYTFKQSNAKAVYATWNIEENKLDVDSVLNNITDKTKVIFLCTPNNPTGGLIPQEDIV
EEEEEEECCCCEEEEEEECCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHH
RIIEATDALVVIDEAYWEFSEVNNVNLLKKYNNIFIIRTFSKVMGLAGLRIGYGLSNPDF
HHHHHCCEEEEEEHHHHHHHHCCCCCEEEECCCEEEEEEHHHHHHHCCCEECCCCCCHHH
IEKMSRIKPVFSVTVPSQKAVIATLNDEEFIKESTEKAITEREYLYESVNSIDNIHIYKS
HHHHHHCCCEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
KSNYLLMDVRKTGYTAAELTSKLMSRGVIVRDCTSFVGLDEYYIRISVETHPKNEKFIEI
CCCEEEEEECCCCCCHHHHHHHHHHCCCEEEHHHHHHCCCEEEEEEEEEECCCCHHHHHH
LKEIVEN
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA