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The map label for this gene is lon

Identifier: 84490116

GI number: 84490116

Start: 1494353

End: 1496830

Strand: Direct

Name: lon

Synonym: Msp_1328

Alternate gene names: 84490116

Gene position: 1494353-1496830 (Clockwise)

Preceding gene: 84490114

Following gene: 84490117

Centisome position: 84.55

GC content: 31.44

Gene sequence:

>2478_bases
ATGACCCAAGAGATGGAAAATGAAAACCTATCATTTACACAACAACTGAGAAAAGATGGATTCATAAAAGATATAGACAC
CAATCCCACATGTTTTGATGATACTGATAGCCAAAATCAATTACCAATAATTTTCATACCAAATACAATACTCTTACCAC
ATACAGATATAACACTTAACCTTGACAAACAACACACAGACAACCTACTACACACAGTAGATGATAATAATCATGGAATT
ATATTAACACCAAAAAAATTAGAAGAAGGAAATGGAAATGTAGAATTCTATGATGTGGGGGTAATTCTAGAAATAAAAAG
TTTAACAGAAGACAAAGAAAATGAATTACTACCAGAAGAATATGTACTTGAATTAAAAGTTAAAGATAAAGTATATGTTA
ATAAAATCCTTAAAAAAGATGGATTCTTCCATGCTCAATATAAAATACTTCCAGAAGAAAATACTCTAACAGAAGATGAA
ATAACAGAATTAAACAAAAACATAGATGAAACAGTACTTGAAATAGCAAAATTCCTACCAAATACAGATAAATATACAAG
AAAAATACTTGGAAAACTAGATACACAAGATAAACTTGCAGAAGTATTTCCATTTCTAAAAGTTCCAATTAATAAAAAAC
AAGAACTACTTGAGTTAGATTCTGTTAAAATAAGAGCTCTTAAAGTTATACAACTACTTCTTGAACAAAAAGATGCAATA
GGCATACAAATGGAACTTGCTAAAAAACTTAACAAAAAAATGAATGAAACACATAAAAACACTCTCTTGAGAGAACAAAT
GAAGTTGATTCAAGAAGAACTTAACATGACAGATGATACTCCAGCACATAAAACCTACAGAGAACGTATAAAAGATGCCC
AACTTCCAAAAGAAGTTGAAGAAGCTGCACTTGAGGAAGTAACAAAATTAGAAAGACAAGGACAAAACAATGCAGAAGAA
AATATAATAAGAAACTATCTTGATACCATACTTCAACTACCATGGCATAAAGAAGAAAATCCTACAATTGACATAGTAAA
AGCTAAAAAACAATTAAATGATGATCATTATGGATTAAAAAAGGTAAAAACTAGAATTATACAACATTTAACTGTTCTTA
AAATGAAAAAAGACAAACAAGGATCTATTCTACTATTTGTTGGACCACCAGGAACTGGAAAAACAAGTCTTGGAAAAAGT
ATTGCGGCAGCACTTGAGAGACCATATGTAAGAGTAAGTCTAGGTGGAGTAAATGATGAATCTGAAATTAGAGGACATAG
AAGAACGTATCTTGGAGCTCTACCTGGACGTATAATCAATGGAATGAAAAAAGCTGGAAAAACAAATCCAGTATTTGTTC
TTGATGAAATTGATAAAATGACTGAATCTCTTAATGGAAATCCAACTAGTGCACTACTTGAAGTTCTAGATCCTGAACAG
AATGATTCATTCTCAGACAACTACCTTGAAGTACCATATGATCTATCAGACGTATTCTTTATAGGAACTGCTAATTCATT
ACAAGACATACCAGGACCACTAAGAGATAGACTAGAAATAATTGAATTAGATAGTTATACAAACACTGAAAAACATCATA
TTGCAGATGAACACTTAATTAAAGAAGTTCTCCTAGAACATGGCCTAACAGAGGACGATCTTAAAATAACATACGATGCT
ATTGATTGTTTAATTGAAAAATACACACGAGAATCTGGTGTAAGAGGTCTTAAAAGAGAAATTGCAGCAATTGCAAGATA
TGTTACTGAAAAGATTGTTGTTGATAATGTTGAAAGACCCTATGTTGTAGATGAAAACATGCTCTATGACATATTAGGTC
ATGAAAAATCACATTATGATAAAGTTCCAGATAGTAATCCACCAGGTGTTGTTACAGGTCTTGCATGGACACCTATAGGT
GGAGACATATTATTTATAGAAGCTGTACTCTTACCTGGAGAGGAAAAATTAAAATTAACAGGACAACTTGGTGATGTTAT
GAAAGAATCTGCACAGATTGCACAAAGTTTAATAAAATCAAGACTTGCAACTGTACTTAAAGATTCAGATATTGAAAAAA
GAGATATTCACATCCATGTACCTGCAGGATCAATACCCAAAGATGGTCCATCTGCAGGAGTAACACTACTTACAACAATA
GCATCCCTTGTAACAAATACTCCTGTTGATTCCACACTAGCTATGACTGGTGAAATTTCATTAAGAGGAAAAGTTCTACC
TGTAGGTGGAATAAAAGAAAAGGTAATAGCTGCACATAGATCTGGTATAAAAACAGTTTTACTTCCAGAAGAAAATATGA
AGGATCTTGATGATGTACCATGTGAAGTTAAAGATGATATGACATTCAAACCAATGAAAACTGTTGATGAAGTATTATAT
GAAGCTCTTGGACTAAAATTACCTGAAAATAAACCTTTAAATATTTCCATTGATGAAATAAATAAAGTAACACCCTAA

Upstream 100 bases:

>100_bases
TAAATAAAAGCTTAAGAAGATTATAAAAAATAAAATAAAAGTTAATTATTATAATGAAGATTAATTTTATTAATTCATAA
AAAACAAAAGGAGTAAAAAC

Downstream 100 bases:

>100_bases
TCCCCTTATTTTTTTTAATTAAATAATTTCCAATTAGAAAAATCTTTTTTTGATAATATATGCTAATTTTATAATAAATT
AATTACAATATATTATATAA

Product: putative ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 825; Mature: 824

Protein sequence:

>825_residues
MTQEMENENLSFTQQLRKDGFIKDIDTNPTCFDDTDSQNQLPIIFIPNTILLPHTDITLNLDKQHTDNLLHTVDDNNHGI
ILTPKKLEEGNGNVEFYDVGVILEIKSLTEDKENELLPEEYVLELKVKDKVYVNKILKKDGFFHAQYKILPEENTLTEDE
ITELNKNIDETVLEIAKFLPNTDKYTRKILGKLDTQDKLAEVFPFLKVPINKKQELLELDSVKIRALKVIQLLLEQKDAI
GIQMELAKKLNKKMNETHKNTLLREQMKLIQEELNMTDDTPAHKTYRERIKDAQLPKEVEEAALEEVTKLERQGQNNAEE
NIIRNYLDTILQLPWHKEENPTIDIVKAKKQLNDDHYGLKKVKTRIIQHLTVLKMKKDKQGSILLFVGPPGTGKTSLGKS
IAAALERPYVRVSLGGVNDESEIRGHRRTYLGALPGRIINGMKKAGKTNPVFVLDEIDKMTESLNGNPTSALLEVLDPEQ
NDSFSDNYLEVPYDLSDVFFIGTANSLQDIPGPLRDRLEIIELDSYTNTEKHHIADEHLIKEVLLEHGLTEDDLKITYDA
IDCLIEKYTRESGVRGLKREIAAIARYVTEKIVVDNVERPYVVDENMLYDILGHEKSHYDKVPDSNPPGVVTGLAWTPIG
GDILFIEAVLLPGEEKLKLTGQLGDVMKESAQIAQSLIKSRLATVLKDSDIEKRDIHIHVPAGSIPKDGPSAGVTLLTTI
ASLVTNTPVDSTLAMTGEISLRGKVLPVGGIKEKVIAAHRSGIKTVLLPEENMKDLDDVPCEVKDDMTFKPMKTVDEVLY
EALGLKLPENKPLNISIDEINKVTP

Sequences:

>Translated_825_residues
MTQEMENENLSFTQQLRKDGFIKDIDTNPTCFDDTDSQNQLPIIFIPNTILLPHTDITLNLDKQHTDNLLHTVDDNNHGI
ILTPKKLEEGNGNVEFYDVGVILEIKSLTEDKENELLPEEYVLELKVKDKVYVNKILKKDGFFHAQYKILPEENTLTEDE
ITELNKNIDETVLEIAKFLPNTDKYTRKILGKLDTQDKLAEVFPFLKVPINKKQELLELDSVKIRALKVIQLLLEQKDAI
GIQMELAKKLNKKMNETHKNTLLREQMKLIQEELNMTDDTPAHKTYRERIKDAQLPKEVEEAALEEVTKLERQGQNNAEE
NIIRNYLDTILQLPWHKEENPTIDIVKAKKQLNDDHYGLKKVKTRIIQHLTVLKMKKDKQGSILLFVGPPGTGKTSLGKS
IAAALERPYVRVSLGGVNDESEIRGHRRTYLGALPGRIINGMKKAGKTNPVFVLDEIDKMTESLNGNPTSALLEVLDPEQ
NDSFSDNYLEVPYDLSDVFFIGTANSLQDIPGPLRDRLEIIELDSYTNTEKHHIADEHLIKEVLLEHGLTEDDLKITYDA
IDCLIEKYTRESGVRGLKREIAAIARYVTEKIVVDNVERPYVVDENMLYDILGHEKSHYDKVPDSNPPGVVTGLAWTPIG
GDILFIEAVLLPGEEKLKLTGQLGDVMKESAQIAQSLIKSRLATVLKDSDIEKRDIHIHVPAGSIPKDGPSAGVTLLTTI
ASLVTNTPVDSTLAMTGEISLRGKVLPVGGIKEKVIAAHRSGIKTVLLPEENMKDLDDVPCEVKDDMTFKPMKTVDEVLY
EALGLKLPENKPLNISIDEINKVTP
>Mature_824_residues
TQEMENENLSFTQQLRKDGFIKDIDTNPTCFDDTDSQNQLPIIFIPNTILLPHTDITLNLDKQHTDNLLHTVDDNNHGII
LTPKKLEEGNGNVEFYDVGVILEIKSLTEDKENELLPEEYVLELKVKDKVYVNKILKKDGFFHAQYKILPEENTLTEDEI
TELNKNIDETVLEIAKFLPNTDKYTRKILGKLDTQDKLAEVFPFLKVPINKKQELLELDSVKIRALKVIQLLLEQKDAIG
IQMELAKKLNKKMNETHKNTLLREQMKLIQEELNMTDDTPAHKTYRERIKDAQLPKEVEEAALEEVTKLERQGQNNAEEN
IIRNYLDTILQLPWHKEENPTIDIVKAKKQLNDDHYGLKKVKTRIIQHLTVLKMKKDKQGSILLFVGPPGTGKTSLGKSI
AAALERPYVRVSLGGVNDESEIRGHRRTYLGALPGRIINGMKKAGKTNPVFVLDEIDKMTESLNGNPTSALLEVLDPEQN
DSFSDNYLEVPYDLSDVFFIGTANSLQDIPGPLRDRLEIIELDSYTNTEKHHIADEHLIKEVLLEHGLTEDDLKITYDAI
DCLIEKYTRESGVRGLKREIAAIARYVTEKIVVDNVERPYVVDENMLYDILGHEKSHYDKVPDSNPPGVVTGLAWTPIGG
DILFIEAVLLPGEEKLKLTGQLGDVMKESAQIAQSLIKSRLATVLKDSDIEKRDIHIHVPAGSIPKDGPSAGVTLLTTIA
SLVTNTPVDSTLAMTGEISLRGKVLPVGGIKEKVIAAHRSGIKTVLLPEENMKDLDDVPCEVKDDMTFKPMKTVDEVLYE
ALGLKLPENKPLNISIDEINKVTP

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=561, Percent_Identity=45.2762923351159, Blast_Score=499, Evalue=1e-141,
Organism=Homo sapiens, GI21396489, Length=586, Percent_Identity=44.0273037542662, Blast_Score=495, Evalue=1e-140,
Organism=Escherichia coli, GI1786643, Length=787, Percent_Identity=39.135959339263, Blast_Score=549, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17505831, Length=639, Percent_Identity=42.566510172144, Blast_Score=449, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI17556486, Length=661, Percent_Identity=36.7624810892587, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=610, Percent_Identity=41.4754098360656, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI221513036, Length=571, Percent_Identity=44.1330998248687, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24666867, Length=571, Percent_Identity=44.1330998248687, Blast_Score=482, Evalue=1e-136,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_METST (Q2NEP8)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_448348.1
- ProteinModelPortal:   Q2NEP8
- SMR:   Q2NEP8
- STRING:   Q2NEP8
- GeneID:   3855651
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_1328
- NMPDR:   fig|339860.6.peg.1274
- eggNOG:   arNOG05305
- HOGENOM:   HBG566281
- OMA:   NEKFAIA
- BioCyc:   MSTA339860:MSP_1328-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 92971; Mature: 92840

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 711-711 ACT_SITE 754-754

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQEMENENLSFTQQLRKDGFIKDIDTNPTCFDDTDSQNQLPIIFIPNTILLPHTDITLN
CCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEEEECCEEEECCCCEEEE
LDKQHTDNLLHTVDDNNHGIILTPKKLEEGNGNVEFYDVGVILEIKSLTEDKENELLPEE
ECCHHHCCHHEEECCCCCEEEEECHHHHCCCCCEEEEEEEEEEEEHHHCCCHHCCCCCHH
YVLELKVKDKVYVNKILKKDGFFHAQYKILPEENTLTEDEITELNKNIDETVLEIAKFLP
HEEEEEECCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCC
NTDKYTRKILGKLDTQDKLAEVFPFLKVPINKKQELLELDSVKIRALKVIQLLLEQKDAI
CCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GIQMELAKKLNKKMNETHKNTLLREQMKLIQEELNMTDDTPAHKTYRERIKDAQLPKEVE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHH
EAALEEVTKLERQGQNNAEENIIRNYLDTILQLPWHKEENPTIDIVKAKKQLNDDHYGLK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHCCCCCCHHH
KVKTRIIQHLTVLKMKKDKQGSILLFVGPPGTGKTSLGKSIAAALERPYVRVSLGGVNDE
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCH
SEIRGHRRTYLGALPGRIINGMKKAGKTNPVFVLDEIDKMTESLNGNPTSALLEVLDPEQ
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHCCCC
NDSFSDNYLEVPYDLSDVFFIGTANSLQDIPGPLRDRLEIIELDSYTNTEKHHIADEHLI
CCCCCCCEEECCCCCCCEEEEECCCCHHHCCCHHHCCEEEEEECCCCCCHHHHHHHHHHH
KEVLLEHGLTEDDLKITYDAIDCLIEKYTRESGVRGLKREIAAIARYVTEKIVVDNVERP
HHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YVVDENMLYDILGHEKSHYDKVPDSNPPGVVTGLAWTPIGGDILFIEAVLLPGEEKLKLT
EEECCCHHHHHHCCCCHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCEEEC
GQLGDVMKESAQIAQSLIKSRLATVLKDSDIEKRDIHIHVPAGSIPKDGPSAGVTLLTTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHH
ASLVTNTPVDSTLAMTGEISLRGKVLPVGGIKEKVIAAHRSGIKTVLLPEENMKDLDDVP
HHHHHCCCCCCEEEEEEEEEECCEEEECCCCHHHHHHHHHCCCEEEEECCCCCCHHHCCC
CEVKDDMTFKPMKTVDEVLYEALGLKLPENKPLNISIDEINKVTP
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHCCCCC
>Mature Secondary Structure 
TQEMENENLSFTQQLRKDGFIKDIDTNPTCFDDTDSQNQLPIIFIPNTILLPHTDITLN
CCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEEEECCEEEECCCCEEEE
LDKQHTDNLLHTVDDNNHGIILTPKKLEEGNGNVEFYDVGVILEIKSLTEDKENELLPEE
ECCHHHCCHHEEECCCCCEEEEECHHHHCCCCCEEEEEEEEEEEEHHHCCCHHCCCCCHH
YVLELKVKDKVYVNKILKKDGFFHAQYKILPEENTLTEDEITELNKNIDETVLEIAKFLP
HEEEEEECCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCC
NTDKYTRKILGKLDTQDKLAEVFPFLKVPINKKQELLELDSVKIRALKVIQLLLEQKDAI
CCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GIQMELAKKLNKKMNETHKNTLLREQMKLIQEELNMTDDTPAHKTYRERIKDAQLPKEVE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHH
EAALEEVTKLERQGQNNAEENIIRNYLDTILQLPWHKEENPTIDIVKAKKQLNDDHYGLK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHCCCCCCHHH
KVKTRIIQHLTVLKMKKDKQGSILLFVGPPGTGKTSLGKSIAAALERPYVRVSLGGVNDE
HHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCH
SEIRGHRRTYLGALPGRIINGMKKAGKTNPVFVLDEIDKMTESLNGNPTSALLEVLDPEQ
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHHCCCC
NDSFSDNYLEVPYDLSDVFFIGTANSLQDIPGPLRDRLEIIELDSYTNTEKHHIADEHLI
CCCCCCCEEECCCCCCCEEEEECCCCHHHCCCHHHCCEEEEEECCCCCCHHHHHHHHHHH
KEVLLEHGLTEDDLKITYDAIDCLIEKYTRESGVRGLKREIAAIARYVTEKIVVDNVERP
HHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YVVDENMLYDILGHEKSHYDKVPDSNPPGVVTGLAWTPIGGDILFIEAVLLPGEEKLKLT
EEECCCHHHHHHCCCCHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCCCEEEC
GQLGDVMKESAQIAQSLIKSRLATVLKDSDIEKRDIHIHVPAGSIPKDGPSAGVTLLTTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHH
ASLVTNTPVDSTLAMTGEISLRGKVLPVGGIKEKVIAAHRSGIKTVLLPEENMKDLDDVP
HHHHHCCCCCCEEEEEEEEEECCEEEECCCCHHHHHHHHHCCCEEEEECCCCCCHHHCCC
CEVKDDMTFKPMKTVDEVLYEALGLKLPENKPLNISIDEINKVTP
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA