Click here to switch to the map view.

The map label for this gene is fixC [C]

Identifier: 84490095

GI number: 84490095

Start: 1471966

End: 1473159

Strand: Direct

Name: fixC [C]

Synonym: Msp_1307

Alternate gene names: 84490095

Gene position: 1471966-1473159 (Clockwise)

Preceding gene: 84490093

Following gene: 84490096

Centisome position: 83.28

GC content: 32.24

Gene sequence:

>1194_bases
ATGAATATAAAAGAAGTTGATGTATTAATCATAGGGGCAGGACCAGCAGGATCATTAGCTGCAAGAGAAGCTAGCAAAAA
TGGTGCAAAAACATTAATCATAGATAAAAAATCAGAAATTGGTACACCAAAAAGATGTGCTGAAGGAATTATGAGTGGTG
TTCTTGAAAGAGTACATATTACACCAGATGAACGTTGGATTGCAAGGAAAATTGATGGAGCTAGAATAGTTTCACCAAAT
AATACAAGTGCATGGTTTACACCAGAAACATTAGAAACACCTGCTACAGGTATAATATTAGAACGTAAAGTTTTTGATAA
ACATATGACAATGGATGCTATTAGAGAAGGTGCTGAAGTTATGATAAAAACCGAAGCATTATCCATGAAACGTGAGGGCG
ATGGATACTTAGTTGATATTAAAAGTTTTAACAAAGAATATAATCAAATTAAAGCACATATTGTTATTGGAGCAGATGGC
CCTGAAGGTCATGTTGCTAGATGGGCAGAACTTAATACTAAAGTACCTCTTGCAGAGATGGAATCTGGCCTACAGTATGA
GATGACCAATCTTAAAATGAAAAATAACTCAGTAATTCAATTTTTCTTTGGAAGTGTAGCTCCTGGAGGATATGCATGGA
TTTTTCCTAAGGGATATGATACTGCAAATGTAGGAATTGACATATCTGGAATTAAAGCCGAAAAAAGTGCTGTTAAATAT
TTAAATGATTTTATAGCTAATTGTGATGAAACAAAAGATGGTCAGATTGTTGAAATTAATGCTGGAGGAAATCCACTATG
TGGTATATTTGATAAAATTATCACAGATAATGTTATGCTAGTTGGAGATGCTGCAGGATGTGTTAGTCCAATAACTGGTG
GTGGAATTGACACTGCATTAGAAAGTGGTATGATTGCAGGTAGAGTTGCAGCAAAAGCAATAAAGAATCGTGATTATTCT
GAAGAAAAATTACAAGAATATGCTGATTATATAGATAGTCACTTAGGTAAAAAATTTAAGAAATATATTGCAATAAGAGA
TGTATTATATAATTCAAGTGATGAAGATTTAGATGAATATATTACTGCATTAGCCAATGCTAATATTACAAAGCTCTCTA
CCAAATCATTAATCAAAGTAGTAATGAAAATTTCACCAAGAAAACTATTTAAATTACGTAAAATCTTATTATAA

Upstream 100 bases:

>100_bases
TTACTTCAAATACAAAACACTAATAATTCATATTGTTATATATAATAATAGATTATGTTAATTTTAATTAACTCATAGAC
AAAAATCAAGGAAATAAAAC

Downstream 100 bases:

>100_bases
TATGATTTTTACATAACTTCTTTTTTATAACCTTTTTTTTTGAAAATACAATATTTAATAATACTTTAAAGAAAATCAAT
TAAAAATATTTTCTAAAGAA

Product: dehydrogenase

Products: NA

Alternate protein names: DGGGPL reductase 3; 2,3-di-O-geranylgeranylglyceryl phosphate reductase 3; Geranylgeranyl reductase 3; GGR 3

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNIKEVDVLIIGAGPAGSLAAREASKNGAKTLIIDKKSEIGTPKRCAEGIMSGVLERVHITPDERWIARKIDGARIVSPN
NTSAWFTPETLETPATGIILERKVFDKHMTMDAIREGAEVMIKTEALSMKREGDGYLVDIKSFNKEYNQIKAHIVIGADG
PEGHVARWAELNTKVPLAEMESGLQYEMTNLKMKNNSVIQFFFGSVAPGGYAWIFPKGYDTANVGIDISGIKAEKSAVKY
LNDFIANCDETKDGQIVEINAGGNPLCGIFDKIITDNVMLVGDAAGCVSPITGGGIDTALESGMIAGRVAAKAIKNRDYS
EEKLQEYADYIDSHLGKKFKKYIAIRDVLYNSSDEDLDEYITALANANITKLSTKSLIKVVMKISPRKLFKLRKILL

Sequences:

>Translated_397_residues
MNIKEVDVLIIGAGPAGSLAAREASKNGAKTLIIDKKSEIGTPKRCAEGIMSGVLERVHITPDERWIARKIDGARIVSPN
NTSAWFTPETLETPATGIILERKVFDKHMTMDAIREGAEVMIKTEALSMKREGDGYLVDIKSFNKEYNQIKAHIVIGADG
PEGHVARWAELNTKVPLAEMESGLQYEMTNLKMKNNSVIQFFFGSVAPGGYAWIFPKGYDTANVGIDISGIKAEKSAVKY
LNDFIANCDETKDGQIVEINAGGNPLCGIFDKIITDNVMLVGDAAGCVSPITGGGIDTALESGMIAGRVAAKAIKNRDYS
EEKLQEYADYIDSHLGKKFKKYIAIRDVLYNSSDEDLDEYITALANANITKLSTKSLIKVVMKISPRKLFKLRKILL
>Mature_397_residues
MNIKEVDVLIIGAGPAGSLAAREASKNGAKTLIIDKKSEIGTPKRCAEGIMSGVLERVHITPDERWIARKIDGARIVSPN
NTSAWFTPETLETPATGIILERKVFDKHMTMDAIREGAEVMIKTEALSMKREGDGYLVDIKSFNKEYNQIKAHIVIGADG
PEGHVARWAELNTKVPLAEMESGLQYEMTNLKMKNNSVIQFFFGSVAPGGYAWIFPKGYDTANVGIDISGIKAEKSAVKY
LNDFIANCDETKDGQIVEINAGGNPLCGIFDKIITDNVMLVGDAAGCVSPITGGGIDTALESGMIAGRVAAKAIKNRDYS
EEKLQEYADYIDSHLGKKFKKYIAIRDVLYNSSDEDLDEYITALANANITKLSTKSLIKVVMKISPRKLFKLRKILL

Specific function: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily

Homologues:

Organism=Escherichia coli, GI1786227, Length=378, Percent_Identity=26.4550264550265, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GGR3_METST (Q2NER9)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_448327.1
- ProteinModelPortal:   Q2NER9
- SMR:   Q2NER9
- GeneID:   3855935
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_1307
- NMPDR:   fig|339860.6.peg.1254
- eggNOG:   arNOG04976
- HOGENOM:   HBG626912
- ProtClustDB:   CLSK797878
- BioCyc:   MSTA339860:MSP_1307-MONOMER
- HAMAP:   MF_01287
- InterPro:   IPR011777
- InterPro:   IPR002938
- InterPro:   IPR003042
- PRINTS:   PR00420
- TIGRFAMs:   TIGR02032

Pfam domain/function: PF01494 FAD_binding_3

EC number: NA

Molecular weight: Translated: 43443; Mature: 43443

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKEVDVLIIGAGPAGSLAAREASKNGAKTLIIDKKSEIGTPKRCAEGIMSGVLERVHI
CCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHEEC
TPDERWIARKIDGARIVSPNNTSAWFTPETLETPATGIILERKVFDKHMTMDAIREGAEV
CCCHHHHHHCCCCCEEECCCCCCEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEE
MIKTEALSMKREGDGYLVDIKSFNKEYNQIKAHIVIGADGPEGHVARWAELNTKVPLAEM
EEEEHHHHHEECCCCEEEEHHHHCCHHCEEEEEEEEECCCCCCCHHHHHHCCCCCCHHHH
ESGLQYEMTNLKMKNNSVIQFFFGSVAPGGYAWIFPKGYDTANVGIDISGIKAEKSAVKY
HCCCEEEEEEEEECCCCEEEEEECCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHH
LNDFIANCDETKDGQIVEINAGGNPLCGIFDKIITDNVMLVGDAAGCVSPITGGGIDTAL
HHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHH
ESGMIAGRVAAKAIKNRDYSEEKLQEYADYIDSHLGKKFKKYIAIRDVLYNSSDEDLDEY
HCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ITALANANITKLSTKSLIKVVMKISPRKLFKLRKILL
HHHHHCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHC
>Mature Secondary Structure
MNIKEVDVLIIGAGPAGSLAAREASKNGAKTLIIDKKSEIGTPKRCAEGIMSGVLERVHI
CCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHEEC
TPDERWIARKIDGARIVSPNNTSAWFTPETLETPATGIILERKVFDKHMTMDAIREGAEV
CCCHHHHHHCCCCCEEECCCCCCEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEE
MIKTEALSMKREGDGYLVDIKSFNKEYNQIKAHIVIGADGPEGHVARWAELNTKVPLAEM
EEEEHHHHHEECCCCEEEEHHHHCCHHCEEEEEEEEECCCCCCCHHHHHHCCCCCCHHHH
ESGLQYEMTNLKMKNNSVIQFFFGSVAPGGYAWIFPKGYDTANVGIDISGIKAEKSAVKY
HCCCEEEEEEEEECCCCEEEEEECCCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHHHH
LNDFIANCDETKDGQIVEINAGGNPLCGIFDKIITDNVMLVGDAAGCVSPITGGGIDTAL
HHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHH
ESGMIAGRVAAKAIKNRDYSEEKLQEYADYIDSHLGKKFKKYIAIRDVLYNSSDEDLDEY
HCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ITALANANITKLSTKSLIKVVMKISPRKLFKLRKILL
HHHHHCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a quinone or similar compound as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA