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The map label for this gene is serA

Identifier: 84489937

GI number: 84489937

Start: 1318133

End: 1319707

Strand: Direct

Name: serA

Synonym: Msp_1145

Alternate gene names: 84489937

Gene position: 1318133-1319707 (Clockwise)

Preceding gene: 84489935

Following gene: 84489942

Centisome position: 74.58

GC content: 31.3

Gene sequence:

>1575_bases
ATGCCAAAAGTATTAGTAGCTGATAAGATTAATGAAAAAGGTGTTGAAGTATTAGAAGGATCTGCTGAAATAGTAAACAA
TCCTAAAATAACACCAGAAGAACTATTAAAAACAATTGATCAATATGATGGAATAATTGTAAGAAGTAGAACAAAAATGA
CAAAAGAAGTCATTGAAAATGCTAAAAACTTAAAAATTATTGCAAGAGCAGGAGTTGGAGTAGATAATATAGATGTTCAA
GCTGCAACAGACCATGGAATTCTTGTAGTAAATGCTCCTCAATCTACATCCATCACAGTAGCAGAACATGCAATGGGTTT
AATGCTCTCATTAAGTAGAAAAATAGCTATAGCTGATGCTTCTGTAAAAGCAGGCAAATGGGAAAAAAGTAAATTCATGG
GTATGGAATTAAGAAACAAAACTCTTGGTGTAATTGGTATGGGTAGAATCGGAAGTCAAGTTGTAAAAAGAGCAAAAGCT
TTCGAAATGGATGTTATTGTATATGATCCATACATAACAGAAGACGTTGCAAAAGAATTAGGTGTTGAAATAACAACATT
AGACTATCTTGTTGAAAATGCAGATGTAATGACAATACACGTTCCATTAACACCTGAAACAAAAGGTTTAATATCCAAAC
CAGAATTAACAAAAATGAAAGATCATGCAATTCTATTAAACTGTGCTAGAGGTGGAATAATCAATGAAGCAGATCTTTAT
GAAGTATTAAAAGAAAGACCTGAATTAAAAGCAGGACTTGATGTGTATGAAAATGAACCTCTAGAAAACAGTCCTCTTGT
AACATTAGATAATGTTGTATTAACACCACATATTGCTGCATCTACCAAAGAAGCTCAACGTGATGCTGCAATCATAGTTG
CAAAAGAAGTTAAAGAAGTAATCAACGGAAACATACCAAACAACGTATTGAACATGCCGGTTGTTGATAATGAAACCTTT
CAAACCCTCAAACCTTACTTCCAATTAACTGAAAAATTAGGACAAATACTAGTTCAAACTACAACCTCTAACATATCAGA
ATTAAACATAGTATATAGTGGTGAAATCTCTGGTAAAGCTAAAGAACCACTAACAAGAGAATTATTAAAAGAATTCTTAA
ACCCTATCTTAACAGAACCTGTTAACTCTGTAAATGCTAAAGCTGTTGCAAAAGAAAGAGGTATAAAAATTACTGAAGGA
GAAACAGAAGATAGTGGAAAATATGATGCAACAATAAAAATTGATGTATTCTATGATAATGCTGAAATGAAAATAGAAGG
TGTTGTTGAAAATAATGAAGCTAAAATTATTTCCATAGATGATTATGATGTAAGATTAACTCTTGAAGGTAAAATGGCTA
TCATTAAATATGTAGATCTTCCAGGCACTATTGGAAAAATTGGTAAAATATTAGGTGATTATAAAATCAATATTGCAGAA
ATGCAAGTAGGAAGACAAACTGAAGGTGGAGAAGCTATAATGGTTCTTAAAGTAGACCAAGAAATAACTGAAGAAGTAGT
TTCAAAACTCGAAGATGATAATGATATTGACTTTGTAAAACCAGTAAAATTATAA

Upstream 100 bases:

>100_bases
AACTAATATTTTGCAATATAATGTTAAAATACAATATTAATTTTATAAATGGAATGGATTTTCCAAAATTCAAGTATAAT
ATAAATAAAGGAGATCAAAA

Downstream 100 bases:

>100_bases
TATTTTACTAAATCCTTTATCTTTTTTTATAAGAATATTTCAAAAAAAATTAAAAAGAGAATAGAATACTTATTTATTTA
ATTCTCGTAAACGTTTATTT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MPKVLVADKINEKGVEVLEGSAEIVNNPKITPEELLKTIDQYDGIIVRSRTKMTKEVIENAKNLKIIARAGVGVDNIDVQ
AATDHGILVVNAPQSTSITVAEHAMGLMLSLSRKIAIADASVKAGKWEKSKFMGMELRNKTLGVIGMGRIGSQVVKRAKA
FEMDVIVYDPYITEDVAKELGVEITTLDYLVENADVMTIHVPLTPETKGLISKPELTKMKDHAILLNCARGGIINEADLY
EVLKERPELKAGLDVYENEPLENSPLVTLDNVVLTPHIAASTKEAQRDAAIIVAKEVKEVINGNIPNNVLNMPVVDNETF
QTLKPYFQLTEKLGQILVQTTTSNISELNIVYSGEISGKAKEPLTRELLKEFLNPILTEPVNSVNAKAVAKERGIKITEG
ETEDSGKYDATIKIDVFYDNAEMKIEGVVENNEAKIISIDDYDVRLTLEGKMAIIKYVDLPGTIGKIGKILGDYKINIAE
MQVGRQTEGGEAIMVLKVDQEITEEVVSKLEDDNDIDFVKPVKL

Sequences:

>Translated_524_residues
MPKVLVADKINEKGVEVLEGSAEIVNNPKITPEELLKTIDQYDGIIVRSRTKMTKEVIENAKNLKIIARAGVGVDNIDVQ
AATDHGILVVNAPQSTSITVAEHAMGLMLSLSRKIAIADASVKAGKWEKSKFMGMELRNKTLGVIGMGRIGSQVVKRAKA
FEMDVIVYDPYITEDVAKELGVEITTLDYLVENADVMTIHVPLTPETKGLISKPELTKMKDHAILLNCARGGIINEADLY
EVLKERPELKAGLDVYENEPLENSPLVTLDNVVLTPHIAASTKEAQRDAAIIVAKEVKEVINGNIPNNVLNMPVVDNETF
QTLKPYFQLTEKLGQILVQTTTSNISELNIVYSGEISGKAKEPLTRELLKEFLNPILTEPVNSVNAKAVAKERGIKITEG
ETEDSGKYDATIKIDVFYDNAEMKIEGVVENNEAKIISIDDYDVRLTLEGKMAIIKYVDLPGTIGKIGKILGDYKINIAE
MQVGRQTEGGEAIMVLKVDQEITEEVVSKLEDDNDIDFVKPVKL
>Mature_523_residues
PKVLVADKINEKGVEVLEGSAEIVNNPKITPEELLKTIDQYDGIIVRSRTKMTKEVIENAKNLKIIARAGVGVDNIDVQA
ATDHGILVVNAPQSTSITVAEHAMGLMLSLSRKIAIADASVKAGKWEKSKFMGMELRNKTLGVIGMGRIGSQVVKRAKAF
EMDVIVYDPYITEDVAKELGVEITTLDYLVENADVMTIHVPLTPETKGLISKPELTKMKDHAILLNCARGGIINEADLYE
VLKERPELKAGLDVYENEPLENSPLVTLDNVVLTPHIAASTKEAQRDAAIIVAKEVKEVINGNIPNNVLNMPVVDNETFQ
TLKPYFQLTEKLGQILVQTTTSNISELNIVYSGEISGKAKEPLTRELLKEFLNPILTEPVNSVNAKAVAKERGIKITEGE
TEDSGKYDATIKIDVFYDNAEMKIEGVVENNEAKIISIDDYDVRLTLEGKMAIIKYVDLPGTIGKIGKILGDYKINIAEM
QVGRQTEGGEAIMVLKVDQEITEEVVSKLEDDNDIDFVKPVKL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=398, Percent_Identity=36.6834170854271, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI61743967, Length=296, Percent_Identity=33.7837837837838, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4557497, Length=296, Percent_Identity=33.7837837837838, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI145580578, Length=300, Percent_Identity=33, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI4557499, Length=300, Percent_Identity=33, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI145580575, Length=300, Percent_Identity=33, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI6912396, Length=314, Percent_Identity=31.2101910828025, Blast_Score=145, Evalue=8e-35,
Organism=Escherichia coli, GI1789279, Length=323, Percent_Identity=34.0557275541796, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI87082289, Length=276, Percent_Identity=32.6086956521739, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI1787645, Length=269, Percent_Identity=32.7137546468402, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI87081824, Length=239, Percent_Identity=27.6150627615063, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788660, Length=248, Percent_Identity=28.6290322580645, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=286, Percent_Identity=45.8041958041958, Blast_Score=238, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=34.9264705882353, Blast_Score=161, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6320925, Length=329, Percent_Identity=36.1702127659575, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6322116, Length=329, Percent_Identity=35.258358662614, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324055, Length=240, Percent_Identity=28.75, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=308, Percent_Identity=29.2207792207792, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6324980, Length=226, Percent_Identity=27.8761061946903, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921140, Length=323, Percent_Identity=40.2476780185758, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24646446, Length=303, Percent_Identity=35.973597359736, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24646448, Length=303, Percent_Identity=35.973597359736, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24646452, Length=303, Percent_Identity=35.973597359736, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24646450, Length=303, Percent_Identity=35.973597359736, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI62472511, Length=303, Percent_Identity=35.973597359736, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28574286, Length=312, Percent_Identity=32.0512820512821, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24585514, Length=313, Percent_Identity=33.2268370607029, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28574282, Length=313, Percent_Identity=33.2268370607029, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28574284, Length=313, Percent_Identity=33.2268370607029, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45552429, Length=313, Percent_Identity=33.2268370607029, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45551003, Length=313, Percent_Identity=33.2268370607029, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28571528, Length=304, Percent_Identity=31.25, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24585516, Length=310, Percent_Identity=25.4838709677419, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57602; Mature: 57471

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVLVADKINEKGVEVLEGSAEIVNNPKITPEELLKTIDQYDGIIVRSRTKMTKEVIEN
CCCEEEECCCCCCCHHEECCCHHHCCCCCCCHHHHHHHHHHHCCEEEECHHHHHHHHHCC
AKNLKIIARAGVGVDNIDVQAATDHGILVVNAPQSTSITVAEHAMGLMLSLSRKIAIADA
CCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHCCEEEEEEC
SVKAGKWEKSKFMGMELRNKTLGVIGMGRIGSQVVKRAKAFEMDVIVYDPYITEDVAKEL
CCCCCCCCHHHCCCEEECCCEEEEEEECHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHH
GVEITTLDYLVENADVMTIHVPLTPETKGLISKPELTKMKDHAILLNCARGGIINEADLY
CCEEEEEHHHHCCCCEEEEEEECCCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCHHHHH
EVLKERPELKAGLDVYENEPLENSPLVTLDNVVLTPHIAASTKEAQRDAAIIVAKEVKEV
HHHHCCCCCCCCCCHHCCCCCCCCCEEEECCEEECCCCCCCCHHHCCCEEEEEHHHHHHH
INGNIPNNVLNMPVVDNETFQTLKPYFQLTEKLGQILVQTTTSNISELNIVYSGEISGKA
HCCCCCCCEEECCEECCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEECCCCCCC
KEPLTRELLKEFLNPILTEPVNSVNAKAVAKERGIKITEGETEDSGKYDATIKIDVFYDN
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEECCCCCCCCCEEEEEEEEEEECC
AEMKIEGVVENNEAKIISIDDYDVRLTLEGKMAIIKYVDLPGTIGKIGKILGDYKINIAE
CEEEEEEEEECCCEEEEEECCCEEEEEECCCEEEEEEECCCCCHHHHHHHHCCCEEEEEE
MQVGRQTEGGEAIMVLKVDQEITEEVVSKLEDDNDIDFVKPVKL
EEECCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCEECCCC
>Mature Secondary Structure 
PKVLVADKINEKGVEVLEGSAEIVNNPKITPEELLKTIDQYDGIIVRSRTKMTKEVIEN
CCEEEECCCCCCCHHEECCCHHHCCCCCCCHHHHHHHHHHHCCEEEECHHHHHHHHHCC
AKNLKIIARAGVGVDNIDVQAATDHGILVVNAPQSTSITVAEHAMGLMLSLSRKIAIADA
CCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHCCEEEEEEC
SVKAGKWEKSKFMGMELRNKTLGVIGMGRIGSQVVKRAKAFEMDVIVYDPYITEDVAKEL
CCCCCCCCHHHCCCEEECCCEEEEEEECHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHH
GVEITTLDYLVENADVMTIHVPLTPETKGLISKPELTKMKDHAILLNCARGGIINEADLY
CCEEEEEHHHHCCCCEEEEEEECCCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCHHHHH
EVLKERPELKAGLDVYENEPLENSPLVTLDNVVLTPHIAASTKEAQRDAAIIVAKEVKEV
HHHHCCCCCCCCCCHHCCCCCCCCCEEEECCEEECCCCCCCCHHHCCCEEEEEHHHHHHH
INGNIPNNVLNMPVVDNETFQTLKPYFQLTEKLGQILVQTTTSNISELNIVYSGEISGKA
HCCCCCCCEEECCEECCCHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEECCCCCCC
KEPLTRELLKEFLNPILTEPVNSVNAKAVAKERGIKITEGETEDSGKYDATIKIDVFYDN
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEECCCCCCCCCEEEEEEEEEEECC
AEMKIEGVVENNEAKIISIDDYDVRLTLEGKMAIIKYVDLPGTIGKIGKILGDYKINIAE
CEEEEEEEEECCCEEEEEECCCEEEEEECCCEEEEEEECCCCCHHHHHHHHCCCEEEEEE
MQVGRQTEGGEAIMVLKVDQEITEEVVSKLEDDNDIDFVKPVKL
EEECCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]