Click here to switch to the map view.

The map label for this gene is mre11

Identifier: 84489888

GI number: 84489888

Start: 1239131

End: 1240312

Strand: Direct

Name: mre11

Synonym: Msp_1094

Alternate gene names: 84489888

Gene position: 1239131-1240312 (Clockwise)

Preceding gene: 84489887

Following gene: 84489889

Centisome position: 70.11

GC content: 26.06

Gene sequence:

>1182_bases
ATGACAATTAAAATAGCACACATGGCAGATACACATTTAGGTTACAAACAATACGGCTTAAATGAACGAGAAAATGATTT
TTATAAAACATTTGAAAAAATTATTGATGATATAATTAGTAAAGATGTGGATTATGTTCTACATGCAGGAGATTTATTTG
AACATCCAAAACCTCCAATTAAAGCATTACTTGTTGCCCAAAAAGGATTTGAGAAGTTATTAGAAAATAATATTCCCATA
TTTGTTATTGCAGGAAATCATGATTCTATACAAAGAAAAAACACATCCATTCCCCAGGAATTATATAAAAATGAAAACTT
CCATATTATTAATCATAAAAATTATAATTTCACATTAGATGAGGATATATTTTTAGTAGGACTTGAATACTTTAATAGAA
GTTATGAGGGAGTAGAACCTTTTCTTAAAAATACATTAGATGAAGCTAAAAAACATAGAATAAAGTTATTGATGTTACAT
GGTTCTGTTAGTAAATATTTTGATTTTGAACCAGAATTTGAATTAAAAACTATTCCTGAAGGATATGATTACTATGCAAT
GGGACATCTACATGGACGTATAAATGATAAATTTAAGGGTGGAATATTATCATATCCAGGGTCTACTGAAATTAGAACTA
AATCTGAGATACCGAATTACCAAAAAAATGGTAAAGGATACAATCTTGTTACAATAGGTGATGATAATAAAATAGATGTT
GAATTTATTAACATACCACTTGAGAGGAAATTTATTATTAAAAGTATAGAATATCCTAAGTTAGATGAAACACTCAATAA
ATTAAGTGAAAAATTAGAAAGTATGGATAGTTCTAAAAAACCAGTAGTTTATTTAACTATTAAAAATGGTAACTTTGAAA
GAAGTGAAGTTGCACAACAAATCTATGATAAATTAGAAGAAAAAGTTCTAACTCTCAGAATAAAATATGAACCTACCCAA
GTAATAGAAAACCTACCTGAAACTATTGATAAAGAGAATATAACACCAGAAAATATTATAAAAGAAAAAATAGAAGACCA
ATTTAATGAAGATGTTGCATCACTAGCAGTAGAATTATATAAAAACTTATCTGAAAAAAATATTCCAGAAGCTCAAAATG
TTGCTGATAAATATTATAATAAATTCTATAATAACATAGGAGAAGAACATGATAATAAATAA

Upstream 100 bases:

>100_bases
ATATATTATCATTATGGAAGAAAAGTAAAGAAGAAAAAGAAGAAAAAATTAAAAGAGATTTAGCTCAAATGGATGAATTC
CTTTAAAAAAATAGATGAAT

Downstream 100 bases:

>100_bases
CATAGAATTAACAAATTTTAAGTCACATAAATCCACAAAAATAGAATTTAAGAAGGGAATTTCATTAATACTCGGAGAAA
ATGGTGCTGGAAAATCAAGT

Product: DNA double-strand break repair protein Mre11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTIKIAHMADTHLGYKQYGLNERENDFYKTFEKIIDDIISKDVDYVLHAGDLFEHPKPPIKALLVAQKGFEKLLENNIPI
FVIAGNHDSIQRKNTSIPQELYKNENFHIINHKNYNFTLDEDIFLVGLEYFNRSYEGVEPFLKNTLDEAKKHRIKLLMLH
GSVSKYFDFEPEFELKTIPEGYDYYAMGHLHGRINDKFKGGILSYPGSTEIRTKSEIPNYQKNGKGYNLVTIGDDNKIDV
EFINIPLERKFIIKSIEYPKLDETLNKLSEKLESMDSSKKPVVYLTIKNGNFERSEVAQQIYDKLEEKVLTLRIKYEPTQ
VIENLPETIDKENITPENIIKEKIEDQFNEDVASLAVELYKNLSEKNIPEAQNVADKYYNKFYNNIGEEHDNK

Sequences:

>Translated_393_residues
MTIKIAHMADTHLGYKQYGLNERENDFYKTFEKIIDDIISKDVDYVLHAGDLFEHPKPPIKALLVAQKGFEKLLENNIPI
FVIAGNHDSIQRKNTSIPQELYKNENFHIINHKNYNFTLDEDIFLVGLEYFNRSYEGVEPFLKNTLDEAKKHRIKLLMLH
GSVSKYFDFEPEFELKTIPEGYDYYAMGHLHGRINDKFKGGILSYPGSTEIRTKSEIPNYQKNGKGYNLVTIGDDNKIDV
EFINIPLERKFIIKSIEYPKLDETLNKLSEKLESMDSSKKPVVYLTIKNGNFERSEVAQQIYDKLEEKVLTLRIKYEPTQ
VIENLPETIDKENITPENIIKEKIEDQFNEDVASLAVELYKNLSEKNIPEAQNVADKYYNKFYNNIGEEHDNK
>Mature_392_residues
TIKIAHMADTHLGYKQYGLNERENDFYKTFEKIIDDIISKDVDYVLHAGDLFEHPKPPIKALLVAQKGFEKLLENNIPIF
VIAGNHDSIQRKNTSIPQELYKNENFHIINHKNYNFTLDEDIFLVGLEYFNRSYEGVEPFLKNTLDEAKKHRIKLLMLHG
SVSKYFDFEPEFELKTIPEGYDYYAMGHLHGRINDKFKGGILSYPGSTEIRTKSEIPNYQKNGKGYNLVTIGDDNKIDVE
FINIPLERKFIIKSIEYPKLDETLNKLSEKLESMDSSKKPVVYLTIKNGNFERSEVAQQIYDKLEEKVLTLRIKYEPTQV
IENLPETIDKENITPENIIKEKIEDQFNEDVASLAVELYKNLSEKNIPEAQNVADKYYNKFYNNIGEEHDNK

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 45836; Mature: 45705

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKIAHMADTHLGYKQYGLNERENDFYKTFEKIIDDIISKDVDYVLHAGDLFEHPKPPI
CEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHEEECCHHHCCCCCHH
KALLVAQKGFEKLLENNIPIFVIAGNHDSIQRKNTSIPQELYKNENFHIINHKNYNFTLD
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCCHHHHCCCCEEEEECCCCCEEEC
EDIFLVGLEYFNRSYEGVEPFLKNTLDEAKKHRIKLLMLHGSVSKYFDFEPEFELKTIPE
CCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCEEEEEEEECCHHHHCCCCCCCCEEECCC
GYDYYAMGHLHGRINDKFKGGILSYPGSTEIRTKSEIPNYQKNGKGYNLVTIGDDNKIDV
CCCEEEEEEECCCCCCCCCCCEEECCCCCCCEEHHCCCCCCCCCCCEEEEEECCCCEEEE
EFINIPLERKFIIKSIEYPKLDETLNKLSEKLESMDSSKKPVVYLTIKNGNFERSEVAQQ
EEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHH
IYDKLEEKVLTLRIKYEPTQVIENLPETIDKENITPENIIKEKIEDQFNEDVASLAVELY
HHHHHHHCEEEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KNLSEKNIPEAQNVADKYYNKFYNNIGEEHDNK
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TIKIAHMADTHLGYKQYGLNERENDFYKTFEKIIDDIISKDVDYVLHAGDLFEHPKPPI
EEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHEEECCHHHCCCCCHH
KALLVAQKGFEKLLENNIPIFVIAGNHDSIQRKNTSIPQELYKNENFHIINHKNYNFTLD
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCCHHHHCCCCEEEEECCCCCEEEC
EDIFLVGLEYFNRSYEGVEPFLKNTLDEAKKHRIKLLMLHGSVSKYFDFEPEFELKTIPE
CCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCEEEEEEEECCHHHHCCCCCCCCEEECCC
GYDYYAMGHLHGRINDKFKGGILSYPGSTEIRTKSEIPNYQKNGKGYNLVTIGDDNKIDV
CCCEEEEEEECCCCCCCCCCCEEECCCCCCCEEHHCCCCCCCCCCCEEEEEECCCCEEEE
EFINIPLERKFIIKSIEYPKLDETLNKLSEKLESMDSSKKPVVYLTIKNGNFERSEVAQQ
EEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHH
IYDKLEEKVLTLRIKYEPTQVIENLPETIDKENITPENIIKEKIEDQFNEDVASLAVELY
HHHHHHHCEEEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KNLSEKNIPEAQNVADKYYNKFYNNIGEEHDNK
HHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]