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The map label for this gene is rad50

Identifier: 84489889

GI number: 84489889

Start: 1240299

End: 1243007

Strand: Direct

Name: rad50

Synonym: Msp_1095

Alternate gene names: 84489889

Gene position: 1240299-1243007 (Clockwise)

Preceding gene: 84489888

Following gene: 84489892

Centisome position: 70.18

GC content: 23.77

Gene sequence:

>2709_bases
ATGATAATAAATAACATAGAATTAACAAATTTTAAGTCACATAAATCCACAAAAATAGAATTTAAGAAGGGAATTTCATT
AATACTCGGAGAAAATGGTGCTGGAAAATCAAGTATTCTTGAAGCAATAAGTTATGCTTTTTTCAAACAAGTAAATGGTA
AACTTGAAGAAAATATTCGTAAACCTCAAAATAGAAAAGATATTGTAGATAAAATGGAGGTGTGTGTTCAATTTCAACAT
AATGGTCGTCTATATAAGATAGCTCGTGGAAGAAACAAGAGTAAGAGTGTTGCTAAATTAGAATTATTAGATAAAAATGG
AATACATCTCCTAAGTAAAGGAGATAGAAATGTTACAAATGATATTGAAAGTATTCTAGAAATGGATTCAAAATCATTCT
TAAATGCAATCTATATAAGACAAGGGGAAATAACAAACTTAATTGAAAAAACTGCTGCAGAGAGAAAGGAACTTATTACA
AAACTATTGAATATTGATTCATTAGAAGTAGCATGGGATGAAATAAAAAATATTATAAATATTTATGAAACACAAAAAAA
TGTTAATGAAGGAAAACTTGCTAATATCAATGAAATAAGAGAAAAAAATACTGAATTACTTCAAAATATTAGTGAAAAAG
AAAGACAAATCAAAGAATATGAAACTGAAATTAACACAAAAAAATCCCAGTTAACCATTATTGAGGAAGATATTAAAAAA
GAGGATATTATCAAGAACAAACATGAAAAATTAACTAATGATTATCAATTTAAGAAAGAAGAATCAAATCATTTGGAAGA
CCTTGAAAATAAATACACATATGAACTTAATGAAATTAACAAAAACAAAGAAAAAATAAGAATATTAGAAAAAGAAATTA
GTCCACTTAATAAATTAAGAGAAATAAAAGATCTTAAAACAAAAATAAATTCTTATAAGAAAGATTCATTGAATAAAGAA
AATATTATTCGTGAAATAAATGAAAATAAAGGAATTATTATAGATAATAAAGAAAATTATGAGAAATATATTCAGTTAAA
GAAAGAAAAAGAGGATATTTCCAAAGAATTAGAGAAATTAACAGAAAAAAAATTGAAAGAAATGGAAGTTGAAAGTGAAA
TAAAACACTTAACAGACCAAGTTAATATATTATATTATAAAATCAATCAAATTTCAGAGAAAGCCCGTAAACTATTTAAA
AAGAATATTAATAATCCTATAGATATTCAAAAAATTACTATTAGAGAAAAAACAAAAACTGGAGAATTAATAAAAATATT
AGAAAAGAAGATTCTTAAGAAAAAAAAAGAAATCAGTGTCTGTGAAACTGAACTTAATAGTACTAAAAAATCCCTCGAAG
ATCTTGAAAAAACTGAGGATATTTGTCCAATTTGTCAATCAGAAATTAGTCATGATAAACATGCAGAACTTTCTGATAAA
TATAAAAATACTATTGTGACTTATGAATTAAGAATAGAAGAACTTAGCAAAGCAAATAACAATCAGGAAATAGAACTTCA
AGAATTAAAGGAATATGAACAAAATATAAATGATATTAATATTCAAAAATTAAAAGAAGAACATGCTGAATATACACAAC
TTTGTGATACCATACATGAGAAAAAGAAATTAAAACCTATTATTGAAGAAACAAAAGCTAAGATAGAAGAAATTAAAAAT
AAAGAAAATGATTGTAATCAGTCAATTGAATCTCTTGAAGAAGATTATAATAAATATAACTTTGCAAAAATTAGATTAAA
TCAACTGCCACAAGTAGATGAAGCTAATAAAGAAAAAGAGATTATTGATAATAAAATCAGTGAAAATACCCTGAAAATTA
AGAAAATTTCACAAACAGTACGTATTGGTGATGATATTGAAAGAAAAATAAAATATCTTGAAAAAAAACAGAATGACTAT
AATCAATTAATTGGTACTGTTTTAAATGAAGAGAAAATAATTCAGGAAAAAGAAGAAACTACAACTAAAATACATAAAGT
TAAATTGGAACTTTCAAATATTAAAAGTCAAATTAATGAATTATCATTTGACTATGAAAAATATGAAAAAATAAATAATA
AATACACACTATGTCAAGAAAATATTGAAAGTATTAGTAGAAATTATATTGTCAAAAAAACAGAACTTAAAAAAGACAAA
CAACAACAAGAAAAATATGTTGAAGAAATAAAAAATCTTAAAGAAATAGAAAAACAACAAGTTCATATTGGAGATTATAT
TCAACTACTAAATGAGATTAGAAGTACATATAGTAAAGATGGAGTTCAAAAAGATCTAAGAAATATAGTACGTCCAGAAA
TTGAAAAAAATACCATGGATATATTTAGTGAATTTGGATTTGATTATTCAGCTATAAATCTAGATGAAGACTATAATTTA
ATAGTACAAACAAGACAAGAACAAATAGATTTAAATATGCTTAGTGGTGGAGAAAAAATAGTTATTGCACTGGCATTAAG
ACTTGGAATTGCAAAGGCCATATCTAAAAATAAGATGGAATTACTAGTTTTAGATGAACCTACAATTCATCTGGATAGTG
AACGTAGAACAGAATTAATTGATATTATTCGTAAAATTAATGTTGTTCCTCAAATGATTGTTGTTAGTCATGATGAAGAA
ATGGAAGCATTATCTACAAATATTATAAAAATCTCAAAAAATAATGGAATATCAACATGTAACAGTTAA

Upstream 100 bases:

>100_bases
GTAGAATTATATAAAAACTTATCTGAAAAAAATATTCCAGAAGCTCAAAATGTTGCTGATAAATATTATAATAAATTCTA
TAATAACATAGGAGAAGAAC

Downstream 100 bases:

>100_bases
GAAAATATTTTTCTTAATTTAGATATTTCATATAATATCTCTTTTTAAAAATAGAATTTTAATAAAAAAAGTAATAGATT
TGTTTCAAAAAAATGAAACA

Product: DNA double-strand break repair protein Rad50

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 902; Mature: 902

Protein sequence:

>902_residues
MIINNIELTNFKSHKSTKIEFKKGISLILGENGAGKSSILEAISYAFFKQVNGKLEENIRKPQNRKDIVDKMEVCVQFQH
NGRLYKIARGRNKSKSVAKLELLDKNGIHLLSKGDRNVTNDIESILEMDSKSFLNAIYIRQGEITNLIEKTAAERKELIT
KLLNIDSLEVAWDEIKNIINIYETQKNVNEGKLANINEIREKNTELLQNISEKERQIKEYETEINTKKSQLTIIEEDIKK
EDIIKNKHEKLTNDYQFKKEESNHLEDLENKYTYELNEINKNKEKIRILEKEISPLNKLREIKDLKTKINSYKKDSLNKE
NIIREINENKGIIIDNKENYEKYIQLKKEKEDISKELEKLTEKKLKEMEVESEIKHLTDQVNILYYKINQISEKARKLFK
KNINNPIDIQKITIREKTKTGELIKILEKKILKKKKEISVCETELNSTKKSLEDLEKTEDICPICQSEISHDKHAELSDK
YKNTIVTYELRIEELSKANNNQEIELQELKEYEQNINDINIQKLKEEHAEYTQLCDTIHEKKKLKPIIEETKAKIEEIKN
KENDCNQSIESLEEDYNKYNFAKIRLNQLPQVDEANKEKEIIDNKISENTLKIKKISQTVRIGDDIERKIKYLEKKQNDY
NQLIGTVLNEEKIIQEKEETTTKIHKVKLELSNIKSQINELSFDYEKYEKINNKYTLCQENIESISRNYIVKKTELKKDK
QQQEKYVEEIKNLKEIEKQQVHIGDYIQLLNEIRSTYSKDGVQKDLRNIVRPEIEKNTMDIFSEFGFDYSAINLDEDYNL
IVQTRQEQIDLNMLSGGEKIVIALALRLGIAKAISKNKMELLVLDEPTIHLDSERRTELIDIIRKINVVPQMIVVSHDEE
MEALSTNIIKISKNNGISTCNS

Sequences:

>Translated_902_residues
MIINNIELTNFKSHKSTKIEFKKGISLILGENGAGKSSILEAISYAFFKQVNGKLEENIRKPQNRKDIVDKMEVCVQFQH
NGRLYKIARGRNKSKSVAKLELLDKNGIHLLSKGDRNVTNDIESILEMDSKSFLNAIYIRQGEITNLIEKTAAERKELIT
KLLNIDSLEVAWDEIKNIINIYETQKNVNEGKLANINEIREKNTELLQNISEKERQIKEYETEINTKKSQLTIIEEDIKK
EDIIKNKHEKLTNDYQFKKEESNHLEDLENKYTYELNEINKNKEKIRILEKEISPLNKLREIKDLKTKINSYKKDSLNKE
NIIREINENKGIIIDNKENYEKYIQLKKEKEDISKELEKLTEKKLKEMEVESEIKHLTDQVNILYYKINQISEKARKLFK
KNINNPIDIQKITIREKTKTGELIKILEKKILKKKKEISVCETELNSTKKSLEDLEKTEDICPICQSEISHDKHAELSDK
YKNTIVTYELRIEELSKANNNQEIELQELKEYEQNINDINIQKLKEEHAEYTQLCDTIHEKKKLKPIIEETKAKIEEIKN
KENDCNQSIESLEEDYNKYNFAKIRLNQLPQVDEANKEKEIIDNKISENTLKIKKISQTVRIGDDIERKIKYLEKKQNDY
NQLIGTVLNEEKIIQEKEETTTKIHKVKLELSNIKSQINELSFDYEKYEKINNKYTLCQENIESISRNYIVKKTELKKDK
QQQEKYVEEIKNLKEIEKQQVHIGDYIQLLNEIRSTYSKDGVQKDLRNIVRPEIEKNTMDIFSEFGFDYSAINLDEDYNL
IVQTRQEQIDLNMLSGGEKIVIALALRLGIAKAISKNKMELLVLDEPTIHLDSERRTELIDIIRKINVVPQMIVVSHDEE
MEALSTNIIKISKNNGISTCNS
>Mature_902_residues
MIINNIELTNFKSHKSTKIEFKKGISLILGENGAGKSSILEAISYAFFKQVNGKLEENIRKPQNRKDIVDKMEVCVQFQH
NGRLYKIARGRNKSKSVAKLELLDKNGIHLLSKGDRNVTNDIESILEMDSKSFLNAIYIRQGEITNLIEKTAAERKELIT
KLLNIDSLEVAWDEIKNIINIYETQKNVNEGKLANINEIREKNTELLQNISEKERQIKEYETEINTKKSQLTIIEEDIKK
EDIIKNKHEKLTNDYQFKKEESNHLEDLENKYTYELNEINKNKEKIRILEKEISPLNKLREIKDLKTKINSYKKDSLNKE
NIIREINENKGIIIDNKENYEKYIQLKKEKEDISKELEKLTEKKLKEMEVESEIKHLTDQVNILYYKINQISEKARKLFK
KNINNPIDIQKITIREKTKTGELIKILEKKILKKKKEISVCETELNSTKKSLEDLEKTEDICPICQSEISHDKHAELSDK
YKNTIVTYELRIEELSKANNNQEIELQELKEYEQNINDINIQKLKEEHAEYTQLCDTIHEKKKLKPIIEETKAKIEEIKN
KENDCNQSIESLEEDYNKYNFAKIRLNQLPQVDEANKEKEIIDNKISENTLKIKKISQTVRIGDDIERKIKYLEKKQNDY
NQLIGTVLNEEKIIQEKEETTTKIHKVKLELSNIKSQINELSFDYEKYEKINNKYTLCQENIESISRNYIVKKTELKKDK
QQQEKYVEEIKNLKEIEKQQVHIGDYIQLLNEIRSTYSKDGVQKDLRNIVRPEIEKNTMDIFSEFGFDYSAINLDEDYNL
IVQTRQEQIDLNMLSGGEKIVIALALRLGIAKAISKNKMELLVLDEPTIHLDSERRTELIDIIRKINVVPQMIVVSHDEE
MEALSTNIIKISKNNGISTCNS

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of mre11 by unwinding and

COG id: COG0419

COG function: function code L; ATPase involved in DNA repair

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 zinc-hook domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR022982
- InterPro:   IPR007517
- InterPro:   IPR013134 [H]

Pfam domain/function: PF04423 Rad50_zn_hook [H]

EC number: NA

Molecular weight: Translated: 105902; Mature: 105902

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIINNIELTNFKSHKSTKIEFKKGISLILGENGAGKSSILEAISYAFFKQVNGKLEENIR
CEECCEEECCCCCCCCCCEEHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHC
KPQNRKDIVDKMEVCVQFQHNGRLYKIARGRNKSKSVAKLELLDKNGIHLLSKGDRNVTN
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHEEECCCCCEEEECCCCCHHH
DIESILEMDSKSFLNAIYIRQGEITNLIEKTAAERKELITKLLNIDSLEVAWDEIKNIIN
HHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IYETQKNVNEGKLANINEIREKNTELLQNISEKERQIKEYETEINTKKSQLTIIEEDIKK
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHHHHHCCH
EDIIKNKHEKLTNDYQFKKEESNHLEDLENKYTYELNEINKNKEKIRILEKEISPLNKLR
HHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHCEEEHHHHCCCHHHHHHHHHHHHHHHHHH
EIKDLKTKINSYKKDSLNKENIIREINENKGIIIDNKENYEKYIQLKKEKEDISKELEKL
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
TEKKLKEMEVESEIKHLTDQVNILYYKINQISEKARKLFKKNINNPIDIQKITIREKTKT
HHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCH
GELIKILEKKILKKKKEISVCETELNSTKKSLEDLEKTEDICPICQSEISHDKHAELSDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
YKNTIVTYELRIEELSKANNNQEIELQELKEYEQNINDINIQKLKEEHAEYTQLCDTIHE
HCCCEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KKKLKPIIEETKAKIEEIKNKENDCNQSIESLEEDYNKYNFAKIRLNQLPQVDEANKEKE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHH
IIDNKISENTLKIKKISQTVRIGDDIERKIKYLEKKQNDYNQLIGTVLNEEKIIQEKEET
HHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TTKIHKVKLELSNIKSQINELSFDYEKYEKINNKYTLCQENIESISRNYIVKKTELKKDK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHEEEHHHHHHHH
QQQEKYVEEIKNLKEIEKQQVHIGDYIQLLNEIRSTYSKDGVQKDLRNIVRPEIEKNTMD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHH
IFSEFGFDYSAINLDEDYNLIVQTRQEQIDLNMLSGGEKIVIALALRLGIAKAISKNKME
HHHHHCCCEEEECCCCCCHHHHCCHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
LLVLDEPTIHLDSERRTELIDIIRKINVVPQMIVVSHDEEMEALSTNIIKISKNNGISTC
EEEECCCCEEECCHHHHHHHHHHHHHHHCHHHEEECCCHHHHHHHCCEEEEECCCCCCCC
NS
CC
>Mature Secondary Structure
MIINNIELTNFKSHKSTKIEFKKGISLILGENGAGKSSILEAISYAFFKQVNGKLEENIR
CEECCEEECCCCCCCCCCEEHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHC
KPQNRKDIVDKMEVCVQFQHNGRLYKIARGRNKSKSVAKLELLDKNGIHLLSKGDRNVTN
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHEEECCCCCEEEECCCCCHHH
DIESILEMDSKSFLNAIYIRQGEITNLIEKTAAERKELITKLLNIDSLEVAWDEIKNIIN
HHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IYETQKNVNEGKLANINEIREKNTELLQNISEKERQIKEYETEINTKKSQLTIIEEDIKK
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHHHHHCCH
EDIIKNKHEKLTNDYQFKKEESNHLEDLENKYTYELNEINKNKEKIRILEKEISPLNKLR
HHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHCEEEHHHHCCCHHHHHHHHHHHHHHHHHH
EIKDLKTKINSYKKDSLNKENIIREINENKGIIIDNKENYEKYIQLKKEKEDISKELEKL
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHH
TEKKLKEMEVESEIKHLTDQVNILYYKINQISEKARKLFKKNINNPIDIQKITIREKTKT
HHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCH
GELIKILEKKILKKKKEISVCETELNSTKKSLEDLEKTEDICPICQSEISHDKHAELSDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
YKNTIVTYELRIEELSKANNNQEIELQELKEYEQNINDINIQKLKEEHAEYTQLCDTIHE
HCCCEEEEEEEHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KKKLKPIIEETKAKIEEIKNKENDCNQSIESLEEDYNKYNFAKIRLNQLPQVDEANKEKE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHH
IIDNKISENTLKIKKISQTVRIGDDIERKIKYLEKKQNDYNQLIGTVLNEEKIIQEKEET
HHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TTKIHKVKLELSNIKSQINELSFDYEKYEKINNKYTLCQENIESISRNYIVKKTELKKDK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHEEEHHHHHHHH
QQQEKYVEEIKNLKEIEKQQVHIGDYIQLLNEIRSTYSKDGVQKDLRNIVRPEIEKNTMD
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHH
IFSEFGFDYSAINLDEDYNLIVQTRQEQIDLNMLSGGEKIVIALALRLGIAKAISKNKME
HHHHHCCCEEEECCCCCCHHHHCCHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
LLVLDEPTIHLDSERRTELIDIIRKINVVPQMIVVSHDEEMEALSTNIIKISKNNGISTC
EEEECCCCEEECCHHHHHHHHHHHHHHHCHHHEEECCCHHHHHHHCCEEEEECCCCCCCC
NS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]