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The map label for this gene is thiD

Identifier: 84489806

GI number: 84489806

Start: 1154821

End: 1155600

Strand: Direct

Name: thiD

Synonym: Msp_1007

Alternate gene names: 84489806

Gene position: 1154821-1155600 (Clockwise)

Preceding gene: 84489805

Following gene: 84489814

Centisome position: 65.34

GC content: 27.82

Gene sequence:

>780_bases
ATGTCTATAGAAAAAATGAATAAAAAATGTAGTATGACTATTGCAGGACTTGATCCTTCTGGTGGAGCTGGTATTATTGC
TGACTGTAAAACATTTCATGCTCATGGTATTTATGCAACATGTGTAGTTACAGCAGTTACTGCTCAAAATCCATATTGTG
TTACTGGTATTGATGGTGTTGATTTAGATTTAATTGAATCTGAAATTGATGAAATTTTATCTGTTTATCCAATTAGATAT
ATTAAGACTGGTATGTTATATTCTGGTGATATTATAAAGCTTGTATCTAGAAAGATTAAGGAGTATGATTTAAGGGCTGT
TGTTGATCCTGTTATGGTCTCTGAGTCTGGTGGTGATTTAACTGGTAATTCTTTTATTGAATATATGAATAAATATTTAG
TTAAAAATTCATTTATTATTACACCCAATATACATGAAGCAGAAAAATTATCAAATAAAACAATTACATCTGAGGAAGAT
ATGATATCTGTTGCAGAAAAATTAAGTAAAGATAATTCTGTTGTAATTACTGGTGGACATATGCAAGGAAATGATATACT
CTATTGTGATGATGAAATATTTAGAATTGAAGGTAAATTAATAAATTCAGATAACACCCATGGAACAGGATGCACATATT
CCTCAGCAATTACAAGTAGATTAATAGAAGGCTATAATTTATATGAATCATGTAAAAAAAGTAATGAATTTATTAGAAAC
AGTATAAAATATGGATTTAATAAAACACCATATCAATTCTGGAAAAATATAGAATTCTAA

Upstream 100 bases:

>100_bases
TTAGGTGAGATTTTATTACATGGAAGAAATACCCATACATATAATTATCTTAGTAATTTAAATATTGGTGTTGAAAGTAA
TCATGGAAAGGAGCGACTTT

Downstream 100 bases:

>100_bases
AAAAAATAATAGCATATACTTACAATGTATATGCTTCATCCTGATTTAATAATGAAAAACCATTACTAGTTAAAATTTCT
TGAGATTTATCATTATTTTC

Product: hypothetical protein

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSIEKMNKKCSMTIAGLDPSGGAGIIADCKTFHAHGIYATCVVTAVTAQNPYCVTGIDGVDLDLIESEIDEILSVYPIRY
IKTGMLYSGDIIKLVSRKIKEYDLRAVVDPVMVSESGGDLTGNSFIEYMNKYLVKNSFIITPNIHEAEKLSNKTITSEED
MISVAEKLSKDNSVVITGGHMQGNDILYCDDEIFRIEGKLINSDNTHGTGCTYSSAITSRLIEGYNLYESCKKSNEFIRN
SIKYGFNKTPYQFWKNIEF

Sequences:

>Translated_259_residues
MSIEKMNKKCSMTIAGLDPSGGAGIIADCKTFHAHGIYATCVVTAVTAQNPYCVTGIDGVDLDLIESEIDEILSVYPIRY
IKTGMLYSGDIIKLVSRKIKEYDLRAVVDPVMVSESGGDLTGNSFIEYMNKYLVKNSFIITPNIHEAEKLSNKTITSEED
MISVAEKLSKDNSVVITGGHMQGNDILYCDDEIFRIEGKLINSDNTHGTGCTYSSAITSRLIEGYNLYESCKKSNEFIRN
SIKYGFNKTPYQFWKNIEF
>Mature_258_residues
SIEKMNKKCSMTIAGLDPSGGAGIIADCKTFHAHGIYATCVVTAVTAQNPYCVTGIDGVDLDLIESEIDEILSVYPIRYI
KTGMLYSGDIIKLVSRKIKEYDLRAVVDPVMVSESGGDLTGNSFIEYMNKYLVKNSFIITPNIHEAEKLSNKTITSEEDM
ISVAEKLSKDNSVVITGGHMQGNDILYCDDEIFRIEGKLINSDNTHGTGCTYSSAITSRLIEGYNLYESCKKSNEFIRNS
IKYGFNKTPYQFWKNIEF

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=244, Percent_Identity=32.7868852459016, Blast_Score=138, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6325378, Length=256, Percent_Identity=32.8125, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324997, Length=255, Percent_Identity=34.9019607843137, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324517, Length=255, Percent_Identity=33.7254901960784, Blast_Score=118, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28806; Mature: 28675

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEKMNKKCSMTIAGLDPSGGAGIIADCKTFHAHGIYATCVVTAVTAQNPYCVTGIDGV
CCHHHHCCEEEEEEEECCCCCCCCEEECCHHHHCCCHHHHHHEEHEECCCCEEEECCCCC
DLDLIESEIDEILSVYPIRYIKTGMLYSGDIIKLVSRKIKEYDLRAVVDPVMVSESGGDL
CHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHCHHEEECCCCCC
TGNSFIEYMNKYLVKNSFIITPNIHEAEKLSNKTITSEEDMISVAEKLSKDNSVVITGGH
CHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCE
MQGNDILYCDDEIFRIEGKLINSDNTHGTGCTYSSAITSRLIEGYNLYESCKKSNEFIRN
ECCCEEEEECCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
SIKYGFNKTPYQFWKNIEF
HHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
SIEKMNKKCSMTIAGLDPSGGAGIIADCKTFHAHGIYATCVVTAVTAQNPYCVTGIDGV
CHHHHCCEEEEEEEECCCCCCCCEEECCHHHHCCCHHHHHHEEHEECCCCEEEECCCCC
DLDLIESEIDEILSVYPIRYIKTGMLYSGDIIKLVSRKIKEYDLRAVVDPVMVSESGGDL
CHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHHCHHEEECCCCCC
TGNSFIEYMNKYLVKNSFIITPNIHEAEKLSNKTITSEEDMISVAEKLSKDNSVVITGGH
CHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEECCE
MQGNDILYCDDEIFRIEGKLINSDNTHGTGCTYSSAITSRLIEGYNLYESCKKSNEFIRN
ECCCEEEEECCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
SIKYGFNKTPYQFWKNIEF
HHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]