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The map label for this gene is uvrD [H]

Identifier: 84488957

GI number: 84488957

Start: 143874

End: 146069

Strand: Direct

Name: uvrD [H]

Synonym: Msp_0128

Alternate gene names: 84488957

Gene position: 143874-146069 (Clockwise)

Preceding gene: 84488956

Following gene: 84488958

Centisome position: 8.14

GC content: 28.37

Gene sequence:

>2196_bases
ATGATATCACAAGAAAAATACATTGAATTGGTTGAAACAATACTAAATAGAAGTATGGCTAATAGTAGTCAAAAAGAAGC
AATTATGGCACCAGTTGATGAGAGTCAGTACATTGTTGCAGGACCAGGTAGTGGAAAAACAACAGTACTTGTTTTAAAGA
TATTAAAATACTACTTTGTTGATGATATTAGCTTTGATGATGTTATAGTAACTACCTTTACAAAGAAGGCTGCAAGAGAA
TTAAAAAATAGAACTATTCTTTGGGCTAAAATGATTTCTGAAGCATTGGATTATGATCTTAATTATGATTTTAATAGAAT
GGTTATTGGTACCTTGGATAGTATTGCTGAGGATATTGTCTGTGATGGTGAATCTATTGAAGTTATAGATAATTTCACAT
CATCAGCTCTTATGATGCAAACATTACTTTTAGATAATAAGAATTCTAATAAGAAATTAAAACAATTTCTTAAAAAACTT
AAAAACAGTGTCGGTGGTGTAAATACTACTGAGATGAACAATCAAATAAGATCTATTAGAGAACGTATTTATTATGATAT
TGTTGATTATGATAAATTAAAAGAAAATTCTAATAATGAATACATATTATTTGATATTATTGATGCATATAACATGACTC
TTAAAGAAAGGGGAATACTTGATTATCCTATGCTTGAAACTAGGTTGTATGATATGTTATGTGATTGTAAAGTTTCTAGA
TTGAATCATTTTAAAGTACTTCTAATTGATGAGTACCAGGATACTAATTATCTACAAGAACAAATCTACTTTAAAATGGC
AGGATATGTCTTGGAAAATAATGGTAACATCACTGTAGTAGGTGATGATGATCAGTCATTGTATCGTTTTAGAGGAGCAA
CAATTGATCTTTTTACAGAGTATTTAAAAAGAATAAATGATTATATGGGTATTACACCTAAGAGCATTTTTTTAAAGAAA
AATTACAGGTCAACTGTTAATATCATTAACTTTGTTAATGAATTCATACATTTAGATAAGAAGTATGAATCATCTCGTAG
TATAAATAAGCCATTAATAGAACCAGATTCTAATTCACCTAATGGTTTACCTGTAATGGGCATGTTTAGAAACAACATTG
AAGAATTAACAACTGATCTGTCCAATCTTATCTATGATTTAAAAATTGGAAAAGATACTTCCCGAAGAGTTGGTAGTAAA
ATATATGATTTAAAACAAAAAGATAATCCTTCAATAGCAATTCTTACAAATTCTCCAAAGGAAATAAGTGCATATAATAG
ACATAGGTTACCATTCTATGTAAGAGAATCTATAACTGGAAGAAGTGAGGATATTGCAGTATTTAATCCTAGGGGTCAAA
ATATAGAGGCCACAGATATTGTTTCATTAATTTGTGGTTTAATACTTGTTTCTATTGATTCTGATGCTACTATTGAAAAT
AATTTAGATAACATACCACCTCATACAAAGAAAATACTAAAAGATTGGAGAAAAAAGGTGGAAAATTATTTATCTTGTAA
AGAAAAAGAAGTACCATTATATGAGGATGATATAGTCTTATCTGATTTATTAGATGATATAGAAGTAGAATGTAGTGATT
TAATTAAGGAATCTAGTGAAAATAGTATTTATCATGATATAATTATGGAAACTATAAATCAGACTAACAATGCAATAAGT
GATGAAGGTAGACTCTCTGCTAATCAAATATTCTGGCACATACTTGTACCTATTGCATCAGGTGCTGTTAATGTGGATGA
TGACATGTTTGATGTTAGTATTGATGAAAATATAAATATCATGTCTATTCATCAGGCAAAGGGTTTGGAATTTGATATTG
TTATTGTTGATGTTGGATGTGATATTTATAAAAATGATGCATCATCTGCCTTTAAAAGATTTCCAAGAAATGGTGGTAAA
ACACATAGTATTGAGAAATATCTTGGTGATTATTCTAAGTTATCACTTTCTAATGAAAATAAGGGTTTGGACAATGCTTT
TAATGATCTTATTAGACGATACTTTGTTGCATATACTCGTGCTAAGTCATTGTTAATTCTTGTTGGATTAAATAGTATGC
GTTATGGTTATAAGGGTGATTTTCAGGATAATATTAAAATACCTAATGTTGCAACAGGATGGTCTCGAGATAAAATATGT
CATTGGGTAAATTTAGATAATTTAATTCATATATAA

Upstream 100 bases:

>100_bases
TACCTTACTTTAGAGGTTTAGCAAATCAATTTAAGGAATTTGATGAAGAATTAAGATTAAATTCCTATTAATTCTTCAGA
TATTCTTTAGGAGTTATATT

Downstream 100 bases:

>100_bases
AAAAATAGTATTTGTATTTAAAAAGAAATAAAGAGTAAAGATTTCACTCTATCCGTGGTATCTTTTTTCTCTAACTCCTC
TTCCTTTTTTATTTCCTTGT

Product: helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 731; Mature: 731

Protein sequence:

>731_residues
MISQEKYIELVETILNRSMANSSQKEAIMAPVDESQYIVAGPGSGKTTVLVLKILKYYFVDDISFDDVIVTTFTKKAARE
LKNRTILWAKMISEALDYDLNYDFNRMVIGTLDSIAEDIVCDGESIEVIDNFTSSALMMQTLLLDNKNSNKKLKQFLKKL
KNSVGGVNTTEMNNQIRSIRERIYYDIVDYDKLKENSNNEYILFDIIDAYNMTLKERGILDYPMLETRLYDMLCDCKVSR
LNHFKVLLIDEYQDTNYLQEQIYFKMAGYVLENNGNITVVGDDDQSLYRFRGATIDLFTEYLKRINDYMGITPKSIFLKK
NYRSTVNIINFVNEFIHLDKKYESSRSINKPLIEPDSNSPNGLPVMGMFRNNIEELTTDLSNLIYDLKIGKDTSRRVGSK
IYDLKQKDNPSIAILTNSPKEISAYNRHRLPFYVRESITGRSEDIAVFNPRGQNIEATDIVSLICGLILVSIDSDATIEN
NLDNIPPHTKKILKDWRKKVENYLSCKEKEVPLYEDDIVLSDLLDDIEVECSDLIKESSENSIYHDIIMETINQTNNAIS
DEGRLSANQIFWHILVPIASGAVNVDDDMFDVSIDENINIMSIHQAKGLEFDIVIVDVGCDIYKNDASSAFKRFPRNGGK
THSIEKYLGDYSKLSLSNENKGLDNAFNDLIRRYFVAYTRAKSLLILVGLNSMRYGYKGDFQDNIKIPNVATGWSRDKIC
HWVNLDNLIHI

Sequences:

>Translated_731_residues
MISQEKYIELVETILNRSMANSSQKEAIMAPVDESQYIVAGPGSGKTTVLVLKILKYYFVDDISFDDVIVTTFTKKAARE
LKNRTILWAKMISEALDYDLNYDFNRMVIGTLDSIAEDIVCDGESIEVIDNFTSSALMMQTLLLDNKNSNKKLKQFLKKL
KNSVGGVNTTEMNNQIRSIRERIYYDIVDYDKLKENSNNEYILFDIIDAYNMTLKERGILDYPMLETRLYDMLCDCKVSR
LNHFKVLLIDEYQDTNYLQEQIYFKMAGYVLENNGNITVVGDDDQSLYRFRGATIDLFTEYLKRINDYMGITPKSIFLKK
NYRSTVNIINFVNEFIHLDKKYESSRSINKPLIEPDSNSPNGLPVMGMFRNNIEELTTDLSNLIYDLKIGKDTSRRVGSK
IYDLKQKDNPSIAILTNSPKEISAYNRHRLPFYVRESITGRSEDIAVFNPRGQNIEATDIVSLICGLILVSIDSDATIEN
NLDNIPPHTKKILKDWRKKVENYLSCKEKEVPLYEDDIVLSDLLDDIEVECSDLIKESSENSIYHDIIMETINQTNNAIS
DEGRLSANQIFWHILVPIASGAVNVDDDMFDVSIDENINIMSIHQAKGLEFDIVIVDVGCDIYKNDASSAFKRFPRNGGK
THSIEKYLGDYSKLSLSNENKGLDNAFNDLIRRYFVAYTRAKSLLILVGLNSMRYGYKGDFQDNIKIPNVATGWSRDKIC
HWVNLDNLIHI
>Mature_731_residues
MISQEKYIELVETILNRSMANSSQKEAIMAPVDESQYIVAGPGSGKTTVLVLKILKYYFVDDISFDDVIVTTFTKKAARE
LKNRTILWAKMISEALDYDLNYDFNRMVIGTLDSIAEDIVCDGESIEVIDNFTSSALMMQTLLLDNKNSNKKLKQFLKKL
KNSVGGVNTTEMNNQIRSIRERIYYDIVDYDKLKENSNNEYILFDIIDAYNMTLKERGILDYPMLETRLYDMLCDCKVSR
LNHFKVLLIDEYQDTNYLQEQIYFKMAGYVLENNGNITVVGDDDQSLYRFRGATIDLFTEYLKRINDYMGITPKSIFLKK
NYRSTVNIINFVNEFIHLDKKYESSRSINKPLIEPDSNSPNGLPVMGMFRNNIEELTTDLSNLIYDLKIGKDTSRRVGSK
IYDLKQKDNPSIAILTNSPKEISAYNRHRLPFYVRESITGRSEDIAVFNPRGQNIEATDIVSLICGLILVSIDSDATIEN
NLDNIPPHTKKILKDWRKKVENYLSCKEKEVPLYEDDIVLSDLLDDIEVECSDLIKESSENSIYHDIIMETINQTNNAIS
DEGRLSANQIFWHILVPIASGAVNVDDDMFDVSIDENINIMSIHQAKGLEFDIVIVDVGCDIYKNDASSAFKRFPRNGGK
THSIEKYLGDYSKLSLSNENKGLDNAFNDLIRRYFVAYTRAKSLLILVGLNSMRYGYKGDFQDNIKIPNVATGWSRDKIC
HWVNLDNLIHI

Specific function: May process damage occurring in non-replicating regions of DNA to produce recombinational intermediates for sister strand recombinational exchange [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=327, Percent_Identity=26.9113149847095, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=339, Percent_Identity=28.023598820059, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 83817; Mature: 83817

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISQEKYIELVETILNRSMANSSQKEAIMAPVDESQYIVAGPGSGKTTVLVLKILKYYFV
CCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
DDISFDDVIVTTFTKKAARELKNRTILWAKMISEALDYDLNYDFNRMVIGTLDSIAEDIV
CCCCCCCEEEEHHHHHHHHHHHCCEEHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHC
CDGESIEVIDNFTSSALMMQTLLLDNKNSNKKLKQFLKKLKNSVGGVNTTEMNNQIRSIR
CCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ERIYYDIVDYDKLKENSNNEYILFDIIDAYNMTLKERGILDYPMLETRLYDMLCDCKVSR
HHHHHHHCCHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHC
LNHFKVLLIDEYQDTNYLQEQIYFKMAGYVLENNGNITVVGDDDQSLYRFRGATIDLFTE
CCCEEEEEEECCCCHHHHHHHHHHHHCCEEEECCCCEEEEECCCHHHHHHCCCHHHHHHH
YLKRINDYMGITPKSIFLKKNYRSTVNIINFVNEFIHLDKKYESSRSINKPLIEPDSNSP
HHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NGLPVMGMFRNNIEELTTDLSNLIYDLKIGKDTSRRVGSKIYDLKQKDNPSIAILTNSPK
CCCEEHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECCCH
EISAYNRHRLPFYVRESITGRSEDIAVFNPRGQNIEATDIVSLICGLILVSIDSDATIEN
HHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHEEECCCCCCCCC
NLDNIPPHTKKILKDWRKKVENYLSCKEKEVPLYEDDIVLSDLLDDIEVECSDLIKESSE
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
NSIYHDIIMETINQTNNAISDEGRLSANQIFWHILVPIASGAVNVDDDMFDVSIDENINI
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEEEHHCCCEECCCCEEEEEECCCCCE
MSIHQAKGLEFDIVIVDVGCDIYKNDASSAFKRFPRNGGKTHSIEKYLGDYSKLSLSNEN
EEEECCCCCEEEEEEEEECCCEECCCHHHHHHHCCCCCCCCCHHHHHHCCHHEEEECCCC
KGLDNAFNDLIRRYFVAYTRAKSLLILVGLNSMRYGYKGDFQDNIKIPNVATGWSRDKIC
CCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
HWVNLDNLIHI
EEECCCCEECC
>Mature Secondary Structure
MISQEKYIELVETILNRSMANSSQKEAIMAPVDESQYIVAGPGSGKTTVLVLKILKYYFV
CCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
DDISFDDVIVTTFTKKAARELKNRTILWAKMISEALDYDLNYDFNRMVIGTLDSIAEDIV
CCCCCCCEEEEHHHHHHHHHHHCCEEHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHC
CDGESIEVIDNFTSSALMMQTLLLDNKNSNKKLKQFLKKLKNSVGGVNTTEMNNQIRSIR
CCCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
ERIYYDIVDYDKLKENSNNEYILFDIIDAYNMTLKERGILDYPMLETRLYDMLCDCKVSR
HHHHHHHCCHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHC
LNHFKVLLIDEYQDTNYLQEQIYFKMAGYVLENNGNITVVGDDDQSLYRFRGATIDLFTE
CCCEEEEEEECCCCHHHHHHHHHHHHCCEEEECCCCEEEEECCCHHHHHHCCCHHHHHHH
YLKRINDYMGITPKSIFLKKNYRSTVNIINFVNEFIHLDKKYESSRSINKPLIEPDSNSP
HHHHHHHHHCCCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NGLPVMGMFRNNIEELTTDLSNLIYDLKIGKDTSRRVGSKIYDLKQKDNPSIAILTNSPK
CCCEEHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECCCH
EISAYNRHRLPFYVRESITGRSEDIAVFNPRGQNIEATDIVSLICGLILVSIDSDATIEN
HHHHCCCCCCCEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHEEECCCCCCCCC
NLDNIPPHTKKILKDWRKKVENYLSCKEKEVPLYEDDIVLSDLLDDIEVECSDLIKESSE
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
NSIYHDIIMETINQTNNAISDEGRLSANQIFWHILVPIASGAVNVDDDMFDVSIDENINI
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEEEHHCCCEECCCCEEEEEECCCCCE
MSIHQAKGLEFDIVIVDVGCDIYKNDASSAFKRFPRNGGKTHSIEKYLGDYSKLSLSNEN
EEEECCCCCEEEEEEEEECCCEECCCHHHHHHHCCCCCCCCCHHHHHHCCHHEEEECCCC
KGLDNAFNDLIRRYFVAYTRAKSLLILVGLNSMRYGYKGDFQDNIKIPNVATGWSRDKIC
CCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
HWVNLDNLIHI
EEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8294031; 7542800; 3259573 [H]