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The map label for this gene is hdrA2

Identifier: 84488956

GI number: 84488956

Start: 141529

End: 143844

Strand: Direct

Name: hdrA2

Synonym: Msp_0127

Alternate gene names: 84488956

Gene position: 141529-143844 (Clockwise)

Preceding gene: 84488955

Following gene: 84488957

Centisome position: 8.01

GC content: 32.21

Gene sequence:

>2316_bases
ATGACTAATCAACATAAAATAGGAGTATTTCTATGTCATTGTGGTGGAAACATATCTGATGTACTGAAATTAGATAAAAT
AGAAAAACAACTCATTAAAAACAATGAAGTAGTATCAATTAAACATCATGAAAATCTATGTTCACTAGAAGGAAGGAAGA
TAATTAAGGATCAGATTCTTAGAGAAAATCTAGATCGTGTAGTGATTGCTGCATGTTCAAGAGTAACTCATGGAGAAACA
TTTCAAAACTATATAAAACCATTAAATCCATACTTATTTGAAATGCCAAATGTAAGGGAACAATGTTCATGGGTTACTAA
AAATCATGAAGAAGCAACAAATAAGGCATTATCTCTAATAAACTCTGCAATAGAATCAGTAAAATATGATGAACCACTTG
AAAAAATTCCAACACAAGTAAAAAACAGTGTACTTGTTATAGGAGCAGGAATTTCTGGGATAACAACAGCAGTATCACTT
GCAAAACAGGGAATGAAAGTAACACTCATTGAAAAGAGACCAGCAGTAGGAGGCGCAATGGTACAGGTAGGTAAAGTATT
TTCACCAGAAAAACTCACAGAAGACTGTGCTGCATGTCTTTTAAATCCTGTTATAGATGAAATGGTTCATAATAAAAATA
TAAGATTATTAACCAATACAAAACTTGAACGTTCAGAAAGAAGAGCAGGAAACTTTGATGTAATACTTAGAAAAAAACCA
GTCTATGTTGATACACAGAAATGTACTAGTTGTGGGAGATGTACAAGTGCCTGTCCAACAGTAGTTCCTGATGAATGGAA
TGAAGGATTAATAAATAGAAAAGCAATATATAAACCATTTCCACAGGCAGTTCCAAGTACATACACATTAGATGATGAAC
ACTGTATTAAATGTGGGATATGTACAAATGTCTGTCCTACAAATGCAATAGATCTTGATGCTATAGATGATATTATTTCA
TTAACAGTAGGTTCTGTTGTAATTGCAACTGGACATCAAAGATTTGATACAAGTAAAAGACCAGAATATGGTCATGAGTT
GTATGAGGATGTATTAAGTCAAATGGAACTGGCAAGAGTAATGGGAGTAAATGGTCCAACACATGGAAAACTTCTTGTTC
CTTCAACAGGTAAAGTTCCACGTCGTGTTGTAATGATACAATGTGTAGGTTCAAGAGACCAACTACCTGGAGGTCATAAA
TACTGTTCAAAGGTCTGTTGTATGGTAGCACTAAAGAGTGCAAATCTAATAAGAACACATTATCCTGATACAGAAGTTAT
AATCTGTTATACTGATATAAGAACTCCTGGTGTCTATGAAAAATATTATAAATATGGACAAGATAATGGTATTGAATTAA
TACGTGGAAGACCAGGAGAGATTGCACGTGAAGATGATCATATGATTGTAAGGATAGAGGATACTTTAACAGGAATTAGA
GAAGAAATTCCTACAGATTTAATAGTATTATCTGCAGCTTTAGAATCATCTAAAGGTACAATTGAAGTTGCAAAAACATT
AAATGTGGCTTTAACAGAGGATAACTTTATTAAAGAAAAACATCCAAAAATGAAACCAGTAACAACTGATATTGAAGGAA
TATTTGTTTGTGGTACAGCACAGGGACCAAAAGATATAACAGATAGTATTATTCAGGCAAATGCTGCAGCAACTAAAATA
TCAGAACTAGTAAATGGTGGGCTTGAAGTTGAACCATTTATTGCATCTATAAATGTTAAAAAATGTGTTCTATGTGGAAG
TTGTGTTGAAAACTGTGTATATCAGGCAATAACATTAAATAGAAATTCAATACATGTTGATGCAATATCATGTACTGGTT
GTGGAGATTGTATAATCACATGTCCTCAGGAGGCAATAAGTATTCAAGGACAAAGTGATGATAAATTAGAAGCTAGTATT
AGGGGAATATTAAAGAATAAAAAAGATGATGAACGTATTATCATAGCATTTCTCGATGATATTGGTAATGTTTCTGCAAA
TAACATGGGAATTAATAGGGTGTCCTGTCCAAGTTCTGTAAGAATTATTAATGTACCATTTATAAATCGTGTAAAATATA
GGCATGTCTTATATGCCCTAACACATGGTGCCGATGGAGTATTCATTGGGGAATATCCAGATACACCTAAACATAAGGAA
ATACGTGAAAATGTAAATATTATGAAGAAACATTTAGAAGAAGAAGGAATTAATCCAAATAGACTAATAATACACAGTGT
ATTTATACCTTACTTTAGAGGTTTAGCAAATCAATTTAAGGAATTTGATGAAGAATTAAGATTAAATTCCTATTAA

Upstream 100 bases:

>100_bases
CATCCATATAAAACAGTAGGAATACAGACACACACAACAAATGTAGAACCAATTCTTGATAAACTAGGTATAGAATATGA
TAGTGGGGAGGATTCATTAC

Downstream 100 bases:

>100_bases
TTCTTCAGATATTCTTTAGGAGTTATATTATGATATCACAAGAAAAATACATTGAATTGGTTGAAACAATACTAAATAGA
AGTATGGCTAATAGTAGTCA

Product: HdrA2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MTNQHKIGVFLCHCGGNISDVLKLDKIEKQLIKNNEVVSIKHHENLCSLEGRKIIKDQILRENLDRVVIAACSRVTHGET
FQNYIKPLNPYLFEMPNVREQCSWVTKNHEEATNKALSLINSAIESVKYDEPLEKIPTQVKNSVLVIGAGISGITTAVSL
AKQGMKVTLIEKRPAVGGAMVQVGKVFSPEKLTEDCAACLLNPVIDEMVHNKNIRLLTNTKLERSERRAGNFDVILRKKP
VYVDTQKCTSCGRCTSACPTVVPDEWNEGLINRKAIYKPFPQAVPSTYTLDDEHCIKCGICTNVCPTNAIDLDAIDDIIS
LTVGSVVIATGHQRFDTSKRPEYGHELYEDVLSQMELARVMGVNGPTHGKLLVPSTGKVPRRVVMIQCVGSRDQLPGGHK
YCSKVCCMVALKSANLIRTHYPDTEVIICYTDIRTPGVYEKYYKYGQDNGIELIRGRPGEIAREDDHMIVRIEDTLTGIR
EEIPTDLIVLSAALESSKGTIEVAKTLNVALTEDNFIKEKHPKMKPVTTDIEGIFVCGTAQGPKDITDSIIQANAAATKI
SELVNGGLEVEPFIASINVKKCVLCGSCVENCVYQAITLNRNSIHVDAISCTGCGDCIITCPQEAISIQGQSDDKLEASI
RGILKNKKDDERIIIAFLDDIGNVSANNMGINRVSCPSSVRIINVPFINRVKYRHVLYALTHGADGVFIGEYPDTPKHKE
IRENVNIMKKHLEEEGINPNRLIIHSVFIPYFRGLANQFKEFDEELRLNSY

Sequences:

>Translated_771_residues
MTNQHKIGVFLCHCGGNISDVLKLDKIEKQLIKNNEVVSIKHHENLCSLEGRKIIKDQILRENLDRVVIAACSRVTHGET
FQNYIKPLNPYLFEMPNVREQCSWVTKNHEEATNKALSLINSAIESVKYDEPLEKIPTQVKNSVLVIGAGISGITTAVSL
AKQGMKVTLIEKRPAVGGAMVQVGKVFSPEKLTEDCAACLLNPVIDEMVHNKNIRLLTNTKLERSERRAGNFDVILRKKP
VYVDTQKCTSCGRCTSACPTVVPDEWNEGLINRKAIYKPFPQAVPSTYTLDDEHCIKCGICTNVCPTNAIDLDAIDDIIS
LTVGSVVIATGHQRFDTSKRPEYGHELYEDVLSQMELARVMGVNGPTHGKLLVPSTGKVPRRVVMIQCVGSRDQLPGGHK
YCSKVCCMVALKSANLIRTHYPDTEVIICYTDIRTPGVYEKYYKYGQDNGIELIRGRPGEIAREDDHMIVRIEDTLTGIR
EEIPTDLIVLSAALESSKGTIEVAKTLNVALTEDNFIKEKHPKMKPVTTDIEGIFVCGTAQGPKDITDSIIQANAAATKI
SELVNGGLEVEPFIASINVKKCVLCGSCVENCVYQAITLNRNSIHVDAISCTGCGDCIITCPQEAISIQGQSDDKLEASI
RGILKNKKDDERIIIAFLDDIGNVSANNMGINRVSCPSSVRIINVPFINRVKYRHVLYALTHGADGVFIGEYPDTPKHKE
IRENVNIMKKHLEEEGINPNRLIIHSVFIPYFRGLANQFKEFDEELRLNSY
>Mature_770_residues
TNQHKIGVFLCHCGGNISDVLKLDKIEKQLIKNNEVVSIKHHENLCSLEGRKIIKDQILRENLDRVVIAACSRVTHGETF
QNYIKPLNPYLFEMPNVREQCSWVTKNHEEATNKALSLINSAIESVKYDEPLEKIPTQVKNSVLVIGAGISGITTAVSLA
KQGMKVTLIEKRPAVGGAMVQVGKVFSPEKLTEDCAACLLNPVIDEMVHNKNIRLLTNTKLERSERRAGNFDVILRKKPV
YVDTQKCTSCGRCTSACPTVVPDEWNEGLINRKAIYKPFPQAVPSTYTLDDEHCIKCGICTNVCPTNAIDLDAIDDIISL
TVGSVVIATGHQRFDTSKRPEYGHELYEDVLSQMELARVMGVNGPTHGKLLVPSTGKVPRRVVMIQCVGSRDQLPGGHKY
CSKVCCMVALKSANLIRTHYPDTEVIICYTDIRTPGVYEKYYKYGQDNGIELIRGRPGEIAREDDHMIVRIEDTLTGIRE
EIPTDLIVLSAALESSKGTIEVAKTLNVALTEDNFIKEKHPKMKPVTTDIEGIFVCGTAQGPKDITDSIIQANAAATKIS
ELVNGGLEVEPFIASINVKKCVLCGSCVENCVYQAITLNRNSIHVDAISCTGCGDCIITCPQEAISIQGQSDDKLEASIR
GILKNKKDDERIIIAFLDDIGNVSANNMGINRVSCPSSVRIINVPFINRVKYRHVLYALTHGADGVFIGEYPDTPKHKEI
RENVNIMKKHLEEEGINPNRLIIHSVFIPYFRGLANQFKEFDEELRLNSY

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR003813
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4; PF02662 FlpD [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 85541; Mature: 85409

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQHKIGVFLCHCGGNISDVLKLDKIEKQLIKNNEVVSIKHHENLCSLEGRKIIKDQIL
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHH
RENLDRVVIAACSRVTHGETFQNYIKPLNPYLFEMPNVREQCSWVTKNHEEATNKALSLI
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
NSAIESVKYDEPLEKIPTQVKNSVLVIGAGISGITTAVSLAKQGMKVTLIEKRPAVGGAM
HHHHHHCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCHHH
VQVGKVFSPEKLTEDCAACLLNPVIDEMVHNKNIRLLTNTKLERSERRAGNFDVILRKKP
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEEEECCC
VYVDTQKCTSCGRCTSACPTVVPDEWNEGLINRKAIYKPFPQAVPSTYTLDDEHCIKCGI
CEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHCCCCEEECCCCEEEECC
CTNVCPTNAIDLDAIDDIISLTVGSVVIATGHQRFDTSKRPEYGHELYEDVLSQMELARV
CCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHHHH
MGVNGPTHGKLLVPSTGKVPRRVVMIQCVGSRDQLPGGHKYCSKVCCMVALKSANLIRTH
HCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEE
YPDTEVIICYTDIRTPGVYEKYYKYGQDNGIELIRGRPGEIAREDDHMIVRIEDTLTGIR
CCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHH
EEIPTDLIVLSAALESSKGTIEVAKTLNVALTEDNFIKEKHPKMKPVTTDIEGIFVCGTA
HHCCHHHEEHHHHHHCCCCEEEEEEEEEEEECCCCHHHHCCCCCCCCEECCCEEEEEECC
QGPKDITDSIIQANAAATKISELVNGGLEVEPFIASINVKKCVLCGSCVENCVYQAITLN
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHEEC
RNSIHVDAISCTGCGDCIITCPQEAISIQGQSDDKLEASIRGILKNKKDDERIIIAFLDD
CCEEEEEEEEECCCCCEEEECCHHHHEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECC
IGNVSANNMGINRVSCPSSVRIINVPFINRVKYRHVLYALTHGADGVFIGEYPDTPKHKE
CCCCCCCCCCCCEECCCCCEEEEECCCHHHHHHHHHEEHEECCCCEEEECCCCCCCCHHH
IRENVNIMKKHLEEEGINPNRLIIHSVFIPYFRGLANQFKEFDEELRLNSY
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TNQHKIGVFLCHCGGNISDVLKLDKIEKQLIKNNEVVSIKHHENLCSLEGRKIIKDQIL
CCCCEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHH
RENLDRVVIAACSRVTHGETFQNYIKPLNPYLFEMPNVREQCSWVTKNHEEATNKALSLI
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHH
NSAIESVKYDEPLEKIPTQVKNSVLVIGAGISGITTAVSLAKQGMKVTLIEKRPAVGGAM
HHHHHHCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCHHH
VQVGKVFSPEKLTEDCAACLLNPVIDEMVHNKNIRLLTNTKLERSERRAGNFDVILRKKP
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCEEEEEECCC
VYVDTQKCTSCGRCTSACPTVVPDEWNEGLINRKAIYKPFPQAVPSTYTLDDEHCIKCGI
CEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHCCCCEEECCCCEEEECC
CTNVCPTNAIDLDAIDDIISLTVGSVVIATGHQRFDTSKRPEYGHELYEDVLSQMELARV
CCCCCCCCCCCHHHHHHHHHHHHHHEEEECCCHHCCCCCCCCHHHHHHHHHHHHHHHHHH
MGVNGPTHGKLLVPSTGKVPRRVVMIQCVGSRDQLPGGHKYCSKVCCMVALKSANLIRTH
HCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEE
YPDTEVIICYTDIRTPGVYEKYYKYGQDNGIELIRGRPGEIAREDDHMIVRIEDTLTGIR
CCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHHHHH
EEIPTDLIVLSAALESSKGTIEVAKTLNVALTEDNFIKEKHPKMKPVTTDIEGIFVCGTA
HHCCHHHEEHHHHHHCCCCEEEEEEEEEEEECCCCHHHHCCCCCCCCEECCCEEEEEECC
QGPKDITDSIIQANAAATKISELVNGGLEVEPFIASINVKKCVLCGSCVENCVYQAITLN
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHEEC
RNSIHVDAISCTGCGDCIITCPQEAISIQGQSDDKLEASIRGILKNKKDDERIIIAFLDD
CCEEEEEEEEECCCCCEEEECCHHHHEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECC
IGNVSANNMGINRVSCPSSVRIINVPFINRVKYRHVLYALTHGADGVFIGEYPDTPKHKE
CCCCCCCCCCCCEECCCCCEEEEECCCHHHHHHHHHEEHEECCCCEEEECCCCCCCCHHH
IRENVNIMKKHLEEEGINPNRLIIHSVFIPYFRGLANQFKEFDEELRLNSY
HHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]