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The map label for this gene is lysC [H]

Identifier: 84488937

GI number: 84488937

Start: 118181

End: 119407

Strand: Direct

Name: lysC [H]

Synonym: Msp_0107

Alternate gene names: 84488937

Gene position: 118181-119407 (Clockwise)

Preceding gene: 84488936

Following gene: 84488938

Centisome position: 6.69

GC content: 31.46

Gene sequence:

>1227_bases
ATGGGAATAGTTGTGGCAAAATTTGGTGGAACATCAGTTGGTTCTGGTGAAAGAATTTATAAAGCAGCTAATTCAGTTGT
TAATGAATACATGCAAGGAAATCAAGTAGTGGTAGTAGTATCTGCTATTAATAAAACTACTGATGAGTCAATTAAATTAG
TAAATGAATCAATAGGCGAATTAGTAACAGAAAAACAATTAGCAGGCATATTAAGCATGGGTGAAATGCAAAGTGTACGT
ATAATGGCAGCAACAATAGAATCATTAGGTGTCAAAGCAGAATTTATAGATCCATTTAGTGAAAAATGGCCTGTAATTAC
AGATAGTAACTATTTAAATGCTAAAATTGATAAAAAAGAAACTCAAAAACGTGTAACAAAGTATATAAAGAAATTATTAA
ATCAGGGAATAATTCCGGTGGTTTGTGGTTTCTTAGGATGTGATGTTGATGGTTCTGTAACTACTCTTGGAAGGGGTGGA
AGTGATGTATCAGCATTTTTAATAGGACATTGTTTAGGTGCTGATGAAGTTGTTATAGTTACTGATGTAAAGGGTGTAAT
GTCTACCGATCCACGTAAATTAAACACAGCTAGAAAATTAGATAAAATCACCGTTGAAGAAATGATAGACTTAGCTAACT
ATGGAGCACAAGTATTACATCCTAATGCTTTAAGATACAAAGATCCTAATATAAAAGCAAAAATAATAAGTTTCGAATAT
GGAGATTTAAGAGTGCAGGGAACTGATATTATAGGTCCAGCACATGAAGAATATGATGTTATTACAATTACAAAATGTGA
TGATAAATTATCAGTTCTTGCAGTTGTTGGCGAAAATTTAATGAATCAACAGTGTATTATAGCACAAATAACACAAAAGG
TTTGTGAAAATAAATTAAATATATATGGCATATCTACTGGTGAAAGCTCAATAACTTTGTTTTTCAAAGAGGATGAGGCC
ATAAAAGCTCATGAAAAACTACATGATCTAGTTATTGGTGGAGATACATTAAGTTCAATCTCTTTAGGTCAGAAAATTGC
AATGATTTCTGTGGTAAGTCATGATTTTATAGATACACCAGGCATTATAGCCAGTATAACAAAACCATTACATGAAAATG
AAATAAATATTGTTGAATTATCATCTAGTCAAACAGCAGTTGTTGTATTTGTAGATTGGAACGATGGTGATAAGGCATAT
GACTTAATTAAGGAGACTTTACAATGA

Upstream 100 bases:

>100_bases
TAATACTATAAAATCATATATATTTTTAAGAATACTTTATTGTTATAATCTTTTTAATAAAACAATAAAAAAAATAATAT
ATTATAATAAAGGTGAATTT

Downstream 100 bases:

>100_bases
ATTTAGAAGGAACACATGTAGCAATGATAACACCTTTTAATAATGATAACACAATAAATGAAGAAAAATATAGGGAATTT
ATTGATTTTTTAATAGAAGG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MGIVVAKFGGTSVGSGERIYKAANSVVNEYMQGNQVVVVVSAINKTTDESIKLVNESIGELVTEKQLAGILSMGEMQSVR
IMAATIESLGVKAEFIDPFSEKWPVITDSNYLNAKIDKKETQKRVTKYIKKLLNQGIIPVVCGFLGCDVDGSVTTLGRGG
SDVSAFLIGHCLGADEVVIVTDVKGVMSTDPRKLNTARKLDKITVEEMIDLANYGAQVLHPNALRYKDPNIKAKIISFEY
GDLRVQGTDIIGPAHEEYDVITITKCDDKLSVLAVVGENLMNQQCIIAQITQKVCENKLNIYGISTGESSITLFFKEDEA
IKAHEKLHDLVIGGDTLSSISLGQKIAMISVVSHDFIDTPGIIASITKPLHENEINIVELSSSQTAVVVFVDWNDGDKAY
DLIKETLQ

Sequences:

>Translated_408_residues
MGIVVAKFGGTSVGSGERIYKAANSVVNEYMQGNQVVVVVSAINKTTDESIKLVNESIGELVTEKQLAGILSMGEMQSVR
IMAATIESLGVKAEFIDPFSEKWPVITDSNYLNAKIDKKETQKRVTKYIKKLLNQGIIPVVCGFLGCDVDGSVTTLGRGG
SDVSAFLIGHCLGADEVVIVTDVKGVMSTDPRKLNTARKLDKITVEEMIDLANYGAQVLHPNALRYKDPNIKAKIISFEY
GDLRVQGTDIIGPAHEEYDVITITKCDDKLSVLAVVGENLMNQQCIIAQITQKVCENKLNIYGISTGESSITLFFKEDEA
IKAHEKLHDLVIGGDTLSSISLGQKIAMISVVSHDFIDTPGIIASITKPLHENEINIVELSSSQTAVVVFVDWNDGDKAY
DLIKETLQ
>Mature_407_residues
GIVVAKFGGTSVGSGERIYKAANSVVNEYMQGNQVVVVVSAINKTTDESIKLVNESIGELVTEKQLAGILSMGEMQSVRI
MAATIESLGVKAEFIDPFSEKWPVITDSNYLNAKIDKKETQKRVTKYIKKLLNQGIIPVVCGFLGCDVDGSVTTLGRGGS
DVSAFLIGHCLGADEVVIVTDVKGVMSTDPRKLNTARKLDKITVEEMIDLANYGAQVLHPNALRYKDPNIKAKIISFEYG
DLRVQGTDIIGPAHEEYDVITITKCDDKLSVLAVVGENLMNQQCIIAQITQKVCENKLNIYGISTGESSITLFFKEDEAI
KAHEKLHDLVIGGDTLSSISLGQKIAMISVVSHDFIDTPGIIASITKPLHENEINIVELSSSQTAVVVFVDWNDGDKAYD
LIKETLQ

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=458, Percent_Identity=25.764192139738, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790455, Length=446, Percent_Identity=23.3183856502242, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790376, Length=194, Percent_Identity=30.9278350515464, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=427, Percent_Identity=26.2295081967213, Blast_Score=93, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44356; Mature: 44224

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIVVAKFGGTSVGSGERIYKAANSVVNEYMQGNQVVVVVSAINKTTDESIKLVNESIGE
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHH
LVTEKQLAGILSMGEMQSVRIMAATIESLGVKAEFIDPFSEKWPVITDSNYLNAKIDKKE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEECCCCEEEEECHHH
TQKRVTKYIKKLLNQGIIPVVCGFLGCDVDGSVTTLGRGGSDVSAFLIGHCLGADEVVIV
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEE
TDVKGVMSTDPRKLNTARKLDKITVEEMIDLANYGAQVLHPNALRYKDPNIKAKIISFEY
EECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEECCCCCEEEEEEEEC
GDLRVQGTDIIGPAHEEYDVITITKCDDKLSVLAVVGENLMNQQCIIAQITQKVCENKLN
CCEEEECCCEECCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCE
IYGISTGESSITLFFKEDEAIKAHEKLHDLVIGGDTLSSISLGQKIAMISVVSHDFIDTP
EEEEECCCCEEEEEEECCCHHHHHHHHHHEEECCCCHHHHHHCCCEEEEEEHHHCCCCCC
GIIASITKPLHENEINIVELSSSQTAVVVFVDWNDGDKAYDLIKETLQ
CHHHHHHCCCCCCCCEEEEECCCCEEEEEEEEECCCCHHHHHHHHHCC
>Mature Secondary Structure 
GIVVAKFGGTSVGSGERIYKAANSVVNEYMQGNQVVVVVSAINKTTDESIKLVNESIGE
CEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHH
LVTEKQLAGILSMGEMQSVRIMAATIESLGVKAEFIDPFSEKWPVITDSNYLNAKIDKKE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEECCCCCCCCCEEECCCCEEEEECHHH
TQKRVTKYIKKLLNQGIIPVVCGFLGCDVDGSVTTLGRGGSDVSAFLIGHCLGADEVVIV
HHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEEE
TDVKGVMSTDPRKLNTARKLDKITVEEMIDLANYGAQVLHPNALRYKDPNIKAKIISFEY
EECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEECCCCCEEEEEEEEC
GDLRVQGTDIIGPAHEEYDVITITKCDDKLSVLAVVGENLMNQQCIIAQITQKVCENKLN
CCEEEECCCEECCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCE
IYGISTGESSITLFFKEDEAIKAHEKLHDLVIGGDTLSSISLGQKIAMISVVSHDFIDTP
EEEEECCCCEEEEEEECCCHHHHHHHHHHEEECCCCHHHHHHCCCEEEEEEHHHCCCCCC
GIIASITKPLHENEINIVELSSSQTAVVVFVDWNDGDKAYDLIKETLQ
CHHHHHHCCCCCCCCEEEEECCCCEEEEEEEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1444390 [H]