Click here to switch to the map view.

The map label for this gene is dapA

Identifier: 84488938

GI number: 84488938

Start: 119404

End: 120297

Strand: Direct

Name: dapA

Synonym: Msp_0108

Alternate gene names: 84488938

Gene position: 119404-120297 (Clockwise)

Preceding gene: 84488937

Following gene: 84488939

Centisome position: 6.76

GC content: 29.53

Gene sequence:

>894_bases
ATGAATTTAGAAGGAACACATGTAGCAATGATAACACCTTTTAATAATGATAACACAATAAATGAAGAAAAATATAGGGA
ATTTATTGATTTTTTAATAGAAGGAGGAGTTGATGGTATTCTTGCTGCAGGAACAACTGGTGAATCAGCAACATTAACAC
TAGAAGAACATCAAAAAGTAATAGATATAATGGTAGATCAAGCAAATGGTAGAGTAACTACAATTGCTGGTGCTGGTAGT
AATGCAACATCTGAAGCACTGGATTTAGTAAACTATTCTAAAGATGCTGGTGCAGATGTAGCACTAGTTATAACACCATA
CTATAATAAACCTCAACAAAGTGGTTTGTATAATCATTTTAAATTATTAAATGATCAATGTGATATGCCAATAATTGCAT
ATAATGTACCTTCAAGAACTGGTGTGGATTTATCTGTAGATAACATAATAAATCTTGCTAAATTAGATAATATTGTAGCA
ATTAAAGAAGCAAATCCTGATTTAAATAAATTGGCTCATGTATTTAGTAGGTTGAATTCTGAAAATTTATTAGATGACTT
TACAGTATTGTCTGGTAATGATTCATTAACTCTACCTATGATATCTCAGGGATCTAAAGGAGTAATTAGTGTAGTGGCCA
ATATAATGCCTAATAAAACATCAACAATGGTAAATAATGCATTAAATGGAAATTATGATGAAGCAAGAACTTTATCAAAT
GAATTATTTAATTTAATGGATGTTCTATTTATTGAAGCAAGCCCAGCACCAACAAAAAGAGCACTTAACCTTATGGGTAT
GGATGTTGGTGGACTTAGAATGCCAATAAATGAAATCTGTGATGAAAATGAAGTAATATTAAAAGAGATTCTTAAAGAAA
ATAACTTAATATAA

Upstream 100 bases:

>100_bases
TAAATATTGTTGAATTATCATCTAGTCAAACAGCAGTTGTTGTATTTGTAGATTGGAACGATGGTGATAAGGCATATGAC
TTAATTAAGGAGACTTTACA

Downstream 100 bases:

>100_bases
AAAGGAGTGTAATACATGATAAGAGTAGCAGTTACAGGTTGTGCAGGAAATATGGGTTCTAAAATCATTAAAACTGTACA
AGCACAAGATAATATGGAAG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNLEGTHVAMITPFNNDNTINEEKYREFIDFLIEGGVDGILAAGTTGESATLTLEEHQKVIDIMVDQANGRVTTIAGAGS
NATSEALDLVNYSKDAGADVALVITPYYNKPQQSGLYNHFKLLNDQCDMPIIAYNVPSRTGVDLSVDNIINLAKLDNIVA
IKEANPDLNKLAHVFSRLNSENLLDDFTVLSGNDSLTLPMISQGSKGVISVVANIMPNKTSTMVNNALNGNYDEARTLSN
ELFNLMDVLFIEASPAPTKRALNLMGMDVGGLRMPINEICDENEVILKEILKENNLI

Sequences:

>Translated_297_residues
MNLEGTHVAMITPFNNDNTINEEKYREFIDFLIEGGVDGILAAGTTGESATLTLEEHQKVIDIMVDQANGRVTTIAGAGS
NATSEALDLVNYSKDAGADVALVITPYYNKPQQSGLYNHFKLLNDQCDMPIIAYNVPSRTGVDLSVDNIINLAKLDNIVA
IKEANPDLNKLAHVFSRLNSENLLDDFTVLSGNDSLTLPMISQGSKGVISVVANIMPNKTSTMVNNALNGNYDEARTLSN
ELFNLMDVLFIEASPAPTKRALNLMGMDVGGLRMPINEICDENEVILKEILKENNLI
>Mature_297_residues
MNLEGTHVAMITPFNNDNTINEEKYREFIDFLIEGGVDGILAAGTTGESATLTLEEHQKVIDIMVDQANGRVTTIAGAGS
NATSEALDLVNYSKDAGADVALVITPYYNKPQQSGLYNHFKLLNDQCDMPIIAYNVPSRTGVDLSVDNIINLAKLDNIVA
IKEANPDLNKLAHVFSRLNSENLLDDFTVLSGNDSLTLPMISQGSKGVISVVANIMPNKTSTMVNNALNGNYDEARTLSN
ELFNLMDVLFIEASPAPTKRALNLMGMDVGGLRMPINEICDENEVILKEILKENNLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=307, Percent_Identity=23.7785016286645, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI13540533, Length=314, Percent_Identity=24.8407643312102, Blast_Score=88, Evalue=7e-18,
Organism=Escherichia coli, GI1788823, Length=294, Percent_Identity=39.1156462585034, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI1789620, Length=249, Percent_Identity=28.1124497991968, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI87082415, Length=269, Percent_Identity=28.2527881040892, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786463, Length=278, Percent_Identity=28.4172661870504, Blast_Score=113, Evalue=1e-26,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_METST (Q2NHW2)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_447170.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q2NHW2
- SMR:   Q2NHW2
- STRING:   Q2NHW2
- GeneID:   3855388
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_0108
- NMPDR:   fig|339860.6.peg.106
- eggNOG:   arNOG05039
- HOGENOM:   HBG358848
- OMA:   QKGLIEH
- PhylomeDB:   Q2NHW2
- ProtClustDB:   PRK03170
- BioCyc:   MSTA339860:MSP_0108-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32319; Mature: 32319

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 162-162 BINDING 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLEGTHVAMITPFNNDNTINEEKYREFIDFLIEGGVDGILAAGTTGESATLTLEEHQKV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEHHHHHHE
IDIMVDQANGRVTTIAGAGSNATSEALDLVNYSKDAGADVALVITPYYNKPQQSGLYNHF
EHHEEECCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHH
KLLNDQCDMPIIAYNVPSRTGVDLSVDNIINLAKLDNIVAIKEANPDLNKLAHVFSRLNS
HHHCCCCCCCEEEEECCCCCCCCEEHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCC
ENLLDDFTVLSGNDSLTLPMISQGSKGVISVVANIMPNKTSTMVNNALNGNYDEARTLSN
CCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHH
ELFNLMDVLFIEASPAPTKRALNLMGMDVGGLRMPINEICDENEVILKEILKENNLI
HHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLEGTHVAMITPFNNDNTINEEKYREFIDFLIEGGVDGILAAGTTGESATLTLEEHQKV
CCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEHHHHHHE
IDIMVDQANGRVTTIAGAGSNATSEALDLVNYSKDAGADVALVITPYYNKPQQSGLYNHF
EHHEEECCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHH
KLLNDQCDMPIIAYNVPSRTGVDLSVDNIINLAKLDNIVAIKEANPDLNKLAHVFSRLNS
HHHCCCCCCCEEEEECCCCCCCCEEHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCC
ENLLDDFTVLSGNDSLTLPMISQGSKGVISVVANIMPNKTSTMVNNALNGNYDEARTLSN
CCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHH
ELFNLMDVLFIEASPAPTKRALNLMGMDVGGLRMPINEICDENEVILKEILKENNLI
HHHHHHHHHEEECCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA