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The map label for this gene is 84488864

Identifier: 84488864

GI number: 84488864

Start: 36512

End: 37447

Strand: Direct

Name: 84488864

Synonym: Msp_0034

Alternate gene names: NA

Gene position: 36512-37447 (Clockwise)

Preceding gene: 84488863

Following gene: 84488866

Centisome position: 2.07

GC content: 25.53

Gene sequence:

>936_bases
TTGGTGTTTATAATGTTTAGTGGAGAATTTATAGTAGATTTCAATGAATATGTGGGTGATTTTGATTTAATTTTAACAAT
GAATTCTGGTCAGACAAGTCAACCGCCATGGAAAATGGATGATAATAACTACTATGAAATAATACTGATTGATAATATTG
ATGTTTTAGTAAAAATAAGTCAAGAAAAATTAAATGATCCTCTAATTGTAAAATATTTCTCTAAAGAGGAATTTAATGTA
GAAAAACTTAGAACTAAACTATTTTATATCTTTGATTTAGATTATAATATTAATGAAGTTTATGATTTTCTTGAAGAAAA
TAGTCAGTTAAGTGATGTTTATGAATTTAATAGGGGTTTAAGGTTATTTAAGTCACAATTTCCATTTGAATGTATTATTT
CCTCTATCTGTTCTGCAAATAATTCAATAAAACGTTGGACAAAATCACTGTATGATATACGTAGATTTTGTGGTAGAAGT
GTGGTTTTTGGTAAAGATACATACTATGTATTTCCAAGAGAGGAAGTCTTTATTAATATGAGTCTTGATGAATTAAAGAA
TTGTGGTGTGGGATATAGAAATAAGTATATGTTAAATTCCACAGAAAAAATAAGGGATTCTATAGATTTTCATGAAAATA
TCTTTAAATTATCATATAAAAAAGCATATAATGAAATTATAAAACTTGAGGGTGTTGGTCCAAAGGTAGCAGATTGTATA
TTGCTCTATGGTTATAATAAACATGAAGCATATCCTGTTGATGTTTGGATTAATAGAATAACAACATATCTTTATTTTAA
AAATCAGAAAGTATCTAATGGAAAAATATCTTCATTTGCACATGAAACATTTGGTATGTATGCAGGTTATATTCAGTTAT
ATCTTTTTAATTATGCAAGATTATCTGGTTTAATGAGTAAATTAAAAGAAATCTAA

Upstream 100 bases:

>100_bases
TAGATGTTGCTATAATAACTAGAAAGGATGGAATCAATTGGATAAAACAAAAACAAGTGATTTATCCTTCATTTGATTAA
AAACTTTTTTTTTATTTTTT

Downstream 100 bases:

>100_bases
TCTTCTAAAAGGAAATGTATTTTAGGGGGTCAGGGTAGAATGAATATTACATAAATTCTATATAATAATATGTTTTTCTT
AATATATTAATGTTGTTTTA

Product: putative 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MVFIMFSGEFIVDFNEYVGDFDLILTMNSGQTSQPPWKMDDNNYYEIILIDNIDVLVKISQEKLNDPLIVKYFSKEEFNV
EKLRTKLFYIFDLDYNINEVYDFLEENSQLSDVYEFNRGLRLFKSQFPFECIISSICSANNSIKRWTKSLYDIRRFCGRS
VVFGKDTYYVFPREEVFINMSLDELKNCGVGYRNKYMLNSTEKIRDSIDFHENIFKLSYKKAYNEIIKLEGVGPKVADCI
LLYGYNKHEAYPVDVWINRITTYLYFKNQKVSNGKISSFAHETFGMYAGYIQLYLFNYARLSGLMSKLKEI

Sequences:

>Translated_311_residues
MVFIMFSGEFIVDFNEYVGDFDLILTMNSGQTSQPPWKMDDNNYYEIILIDNIDVLVKISQEKLNDPLIVKYFSKEEFNV
EKLRTKLFYIFDLDYNINEVYDFLEENSQLSDVYEFNRGLRLFKSQFPFECIISSICSANNSIKRWTKSLYDIRRFCGRS
VVFGKDTYYVFPREEVFINMSLDELKNCGVGYRNKYMLNSTEKIRDSIDFHENIFKLSYKKAYNEIIKLEGVGPKVADCI
LLYGYNKHEAYPVDVWINRITTYLYFKNQKVSNGKISSFAHETFGMYAGYIQLYLFNYARLSGLMSKLKEI
>Mature_311_residues
MVFIMFSGEFIVDFNEYVGDFDLILTMNSGQTSQPPWKMDDNNYYEIILIDNIDVLVKISQEKLNDPLIVKYFSKEEFNV
EKLRTKLFYIFDLDYNINEVYDFLEENSQLSDVYEFNRGLRLFKSQFPFECIISSICSANNSIKRWTKSLYDIRRFCGRS
VVFGKDTYYVFPREEVFINMSLDELKNCGVGYRNKYMLNSTEKIRDSIDFHENIFKLSYKKAYNEIIKLEGVGPKVADCI
LLYGYNKHEAYPVDVWINRITTYLYFKNQKVSNGKISSFAHETFGMYAGYIQLYLFNYARLSGLMSKLKEI

Specific function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-1 OGG1 family [H]

Homologues:

Organism=Homo sapiens, GI4505495, Length=293, Percent_Identity=27.3037542662116, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI8670534, Length=295, Percent_Identity=27.1186440677966, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI8670532, Length=294, Percent_Identity=26.8707482993197, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI8670540, Length=288, Percent_Identity=27.0833333333333, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI8670542, Length=288, Percent_Identity=27.0833333333333, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI8670530, Length=288, Percent_Identity=27.0833333333333, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323580, Length=253, Percent_Identity=27.6679841897233, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24640654, Length=223, Percent_Identity=30.9417040358744, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR004577
- InterPro:   IPR012904 [H]

Pfam domain/function: PF00730 HhH-GPD; PF07934 OGG_N [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 36797; Mature: 36797

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFIMFSGEFIVDFNEYVGDFDLILTMNSGQTSQPPWKMDDNNYYEIILIDNIDVLVKIS
CEEEEECCCEEEEHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEE
QEKLNDPLIVKYFSKEEFNVEKLRTKLFYIFDLDYNINEVYDFLEENSQLSDVYEFNRGL
HHHCCCCEEEEEECCCCCCHHHHHEEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHH
RLFKSQFPFECIISSICSANNSIKRWTKSLYDIRRFCGRSVVFGKDTYYVFPREEVFINM
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCEEEEEE
SLDELKNCGVGYRNKYMLNSTEKIRDSIDFHENIFKLSYKKAYNEIIKLEGVGPKVADCI
CHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHEE
LLYGYNKHEAYPVDVWINRITTYLYFKNQKVSNGKISSFAHETFGMYAGYIQLYLFNYAR
EEEECCCCCCEEHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LSGLMSKLKEI
HHHHHHHHHCC
>Mature Secondary Structure
MVFIMFSGEFIVDFNEYVGDFDLILTMNSGQTSQPPWKMDDNNYYEIILIDNIDVLVKIS
CEEEEECCCEEEEHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEE
QEKLNDPLIVKYFSKEEFNVEKLRTKLFYIFDLDYNINEVYDFLEENSQLSDVYEFNRGL
HHHCCCCEEEEEECCCCCCHHHHHEEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHH
RLFKSQFPFECIISSICSANNSIKRWTKSLYDIRRFCGRSVVFGKDTYYVFPREEVFINM
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCEEEEEE
SLDELKNCGVGYRNKYMLNSTEKIRDSIDFHENIFKLSYKKAYNEIIKLEGVGPKVADCI
CHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHEE
LLYGYNKHEAYPVDVWINRITTYLYFKNQKVSNGKISSFAHETFGMYAGYIQLYLFNYAR
EEEECCCCCCEEHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LSGLMSKLKEI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]